池田 啓子（いけだ けいこ）（旧姓 飯野 啓子）
Keiko Ikeda, MD PhD
kikeda@jichi.ac.jp
自治医科大学分子病態治療研究センター細胞生物研究部准教授
Division of Biology, Center for Molecular Medicine, Jichi Medical University
略歴
1981年 東京都立竹早高校卒
1987年 自治医大卒
1987年 東京都立墨東病院 レジデント
1990年 東京都立城北福祉センター（通称：山谷診療所）医員
自治医大生理学教室（故 前川杏二先生）研究員
1994年 自治医大大学院（生体制御系）修了
1994年 自治医大生物学助手
1996年 自治医大生物学講師
1997年 米国ペンシルバニア州立大学分子生物学部門（Dr. Jerry Workman）留学
1998年 独国ルードウィッヒマクシミリアン大学 Genzentrum 分子生物学（Dr. Michael Meisterernst）留学
2002年 自治医大分子病態治療研究センター細胞生物研究部講師
2003年 自治医大分子病態治療研究センター細胞生物研究部助教授
2007年 自治医大分子病態治療研究センター細胞生物研究部准教授
2010年 生理学研究所 生体情報研究系 神経シグナル研究部門 センター流動連携研究室客員准教授 http://www.nips.ac.jp/huinfo/
I 著 書
1. Ikeda K, Nagano K, Kawakami K. In Schoner W, Bamberg E. editors. The Sodium Pump-Structure mechanism, hormonal control and its role in disease. New York: Springer; 1994. pp33-36.
2. Kawakami K, Suzuki-Yagawa Y, Watanabe Y, Ikeda K, Nagano K. In Schoner W, Bamberg E. editors. The Sodium Pump-Structure mechanism, hormonal control and its role in disease. New York: Springer; 1994. pp1-10
II 総 説
1. 池田啓子：山谷地域の未治療高血圧患者の病識調査. 月刊地域医学 1996; 10:157-160.
2. 池田啓子：T細胞の活性化/アナジーと転写因子. 臨床免疫 1996; 28:1398-1404.
3. Kawakami, K., Satoh, S., Ozaki, H., Ikeda, K.: Six family gene-Structure and function as transcription factor and their role in development. BioEssay 2000; 22:616-626.
4. 池田啓子, 川上潔：新しい分子標的. Pharma Medica 2000; 20:67-73.
5. 池田啓子, 川上潔：Naポンプ遺伝子欠損マウスの情動異常．月刊臨床神経科学 2004; 22:246-247.
6. 池田啓子, 鬼丸洋, 川上潔：ナトリウムポンプの新機能. 蛋白質核酸酵素 2005; 50:434-439.
7. 池田啓子：ナトリウムポンプ（Na,K-ATPase）α２サブユニットの生体内での役割．日本女性科学者の会学術年報 2005; 6:16-21.
III 原 著 論 文
1. Kano M, Iino K, Kano M-S. Functional reorganization of adult cat somatosensory cortex is dependent on NMDA receptors. NeuroReport 1991;2:77-80.
2. Kano M, Iino K, Maekawa K, Kano M-S. Optokinetic response of cells in the nucleus reticularis tegmenti pontis of the pigmented rabbit. Exp Brain Res 1991;87:239-244.
3. Ikeda K, Nagano K, Kawakami K. Possible implication of Sp1-induced bending of DNA on synergistic activation of transcription. Gene 1993;136:341-343.
4. Ikeda K, Nagano K, Kawakami K. Anomalous interaction of Sp1 and specific binding of an E-Box binding protein with the regulatory elements of the Na,K-ATPase alpha 2 subunit gene promoter. Eur J Biochem 1993;218:195-204.
5. Ikeda K, Kawakami K. DNA binding through distinct domains of zinc-finger-homeodomain protein AREB6 has different effects on gene transcription. Eur J Biochem 1995;233:73-82.
6. Ikeda K, Kawakami K. Cis-elements involved in differential expression of Na,K-ATPase alpha2 subunit gene in muscle differentiation. Biochim Biophys Acta 1996;130:67-73.
7. Kawakami K, Ohto H, Ikeda K, Roeder RG. Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development. Nucl Acids Res 1996;24:303-310.
8. Murakami, Y., Ikeda, K., Ikeda, U., Shimada, K. and Kawakami, K.: In vivo footprinting analysis of the Na,K-ATPase alpha3 subunit gene promoter in rat cardiocytes. Jichi Medical School J 1997;20:35-43.
9. Ohto H, Takizawa T, Saito T, Kobayashi M, Ikeda K, Kawakami K. Tissue and developmental distribution of Six family gene products. Int J Dev Biol 1998;42:141-148.
10. Ikeda K, Halle J-P, Stzeler G, Meisterernst M, Kawakami K. Involvement of negative co-factor NC2 in active repression by zinc-finger-homeodomain transcription factor AREB6. Mol Cell Biol 1998;18:10-18.
11. Utley RT, Ikeda K, Grant PA, Cote J, Workman JL. Two distinct yeast histone acetyl transcferase complexes are targeted by VP16. Nature 1998;394:498-502.
12. Ikeda K, Steger DJ, Eberharter A, Workman JL. Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexes. Mol Cell Biol 1999;19: 855-863.
13. Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM. Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex. Hum Mol Genet. 2001;10;2651-2660.
14. Ikeda K, Stuehler T, Meisterernst M. The H1 and H2 regions of the activation domain of herpes simplex virion protein 16 stimulate transcription through distinct molecular mechanisms. Genes Cells 2002;7:49-58.
15. Ozaki H, Watanabe Y, Ikeda K, Kawakami K. Impaired interactions between mouse Eyal harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach, and G proteins. J Hum Genet 2002;47:107-116.
16. Ikeda K, Watanabe Y, Ohto H, Kawakami K. Molecular Interaction and Synergistic Activation of a Promoter by Six, Eya, and Dach Proteins Mediated through CBP. Mol Cell Biol 2002;22: 6759-6766.
17. Onaka T, Ikeda K, Yamashita T, Honda K. Facilitative role of endogeno us oxytocin in noradrenaline release in the rat supraoptic nucleus. Eur J Neurosci 2003;18:3018-3026.
18. Ikeda K, Onaka T, Yamakado M, Nakai J, Ishikawa T, Taketo MM, Kawakami K. Degeneration of the amygdala/piriform cortex and enhanced fear/anxiety behaviors in sodium pump alpha2 subunit (Atp1a2) deficient mice. J Neurosci 2003;23:4667-4676.
19. Ozaki H, Nakamura K, Funahashi J, Ikeda K, Yamada G, Tokano H, Okamura HO, Kitamura K, Muto S, Kotaki H, Sudo K, Horai R, Iwakura Y, Kawakami K. Six1 controls patterning of the mouse otic vesicle. Development 2004;131:551-562.
20. Ikeda K, Onimaru H, Yamada J, Inoue K, Ueno S, Onaka T, Toyoda H, Arata A, Ishikawa T, Taketo MM, Fukuda A, Kawakami K. Malfunction of respiratory-related neuronal activity in Na+,K+-ATPase alpha2 subunit-deficient mice is attributable to abnormal Cl- homeostasis in brainstem neurons. J Neurosci 2004;24:10693-10701.
21. Ando Z, Sato S, Ikeda K, Kawakami K. Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4. FEBS J 2005;272:3026-3041.
22. Kawakami K, Onaka T, Iwase M, Homma I, Ikeda K. Hyperphagia and obesity in Na,K-ATPase alpha2 subunit-defective mice. Obes Res 2005;13:1661-1671.
23. Konishi Y, Ikeda K, Iwakura Y, Kawakami K: Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis. Brain Res 1116, 93-102, 2006.
24. Onimaru H, Ikeda K, Kawakami K: Defective interaction between dual oscillators for respiratory rhythm generation in Na,K-ATPase alpha2 subunit-deficient mice. J Physiol 584, 271-284, 2007.
25. Ikeda K, Ookawara S, Sato S, Ando Z, Kageyama R, Kawakami K: Six1 is essential for early neurogenesis in the development of olfactory epithelium. Dev Biol 311, 53-68, 2007.
26. Ishihara T, Ikeda K, Sato S, Yajima H: Differential expression of Eya1 and Eya2 during chick early embryonic development. Gene Expr Patterns 8, 357-367, 2008.
27. Ishihara T, Sato S, Ikeda K, Yajima H, Kawakami K: Multiple evolutionarily conserved enhancers control expression of Eya1. Dev Dyn 237, 3142-3156, 2008.
28. Onimaru H, Ikeda K, Kawakami K: CO2-sensitive preinspiratory neurons of the parafacial respiratory group express Phox2b in the neonatal rat. J Neurosci 28, 12845-12850, 2008.
29. Suzuki Y, Ikeda K, Kawakami K: Regulatory role of Six1 in the development of taste papillae. Cell Tissue Res 339, 513-525, 2010.
30. Ikeda K, Kageyama R, Suzuki Y, Kawakami K: Six1 is indispensable for production of functional apical and basal progenitors during olfactory epithelial development. Int J Developmental Biology 2010, in press.
31. Tani, M., Onimaru, H., Ikeda, K., Kawakam, K., Homma, I, Menthol inhibits respiratory rhythm in the brainstem preparation of newborn rats. Neuro Rep. 21. 1095-1099, 2010.
32. Yamashita,T., Ohuchi, H., Tomonari, S., Ikeda , K., Sakai, K., Shichida, Y. Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein. Proc Natl Acad Sci USA , 107, 22084-22089, 2010.
IV 国際学会のProceedings
1. Steger DJ, Utley RT, Grant PA, John S, Eberharter A, Cote J, Owen-Hughes T, Ikeda K, Workman JL. Regulation of transcription by multisubunit complexes that alter nucleosome structure. Cold Spring Harb Symp Quant Biol 1998; 63: 483-491.
V その他（研究報告書、監修、訳書、教科書、辞典など）
1. 池田啓子:「山谷の女赤ひげ」奮戦す. デニム Vol. 2: 32-34, 1995.
2. 池田啓子: 遺伝子からみた生活習慣病. 学術研究ネット第4回講演会、東京、2004年 5月22日.
3. 川上潔, 池田啓子：“怖がりのもと”発見 下野新聞 2004年2月26日号
4. 池田啓子、川上潔：COLUMN5肥満遺伝子は存在するか？−ナトリウムポンプと行動の関係−． 197頁．
5. 長野敬，牛木辰男 監修．生物総合資料．増補新訂版．東京：実教出版；2006年
Current Research Interest