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英文原著、総説

1985-1989 (6)

1990-1994 (10)

1995-1999 (16)

2000-2004 (13)

2005-2009 (14)

2010-2014 (18)

2015- (11)

1985-1989 (6)

1. "Primary structure of the alpha-subunit of Torpedo californica (Na+ K+)-ATPase deduced from cDNA sequence." Nature 316:733-736 (1985) Kawakami, K., Noguchi, S., Noda, M., Takahashi, H., Ohta, T., Kawamura, M., Nojima, H., Nagano, K., Hirose, T., Inayama, S., Hayashida, H., Miyata, T. and Numa, S.

2. "Molecular cloning and sequence analysis of human Na,K-ATPase beta-subunit." Nucl. Acids Res. 14:2833-2844 (1986) Kawakami, K., Nojima, H., Ohta, T. and Nagano, K.

3. "Primary structure of the alpha-subunit of human Na,K-ATPase deduced from cDNA sequence." J. Biochem. 100:389-397 (1986) Kawakami, K., Ohta, T., Nojima, H. and Nagano, K.

4. "The transmembrane segment of human Na,K-ATPase beta-subunit acts as the membrane insertion signal." J. Biochem. 103, 54-60 (1988) Kawakami, K. and Nagano, K.

5. "Identification and purification of a human immunoglobulin enhancer binding protein (NF-kB) that activates transcription from a human immunodeficiency virus 1 (HIV-1) promoter in vitro." Proc. Natl. Acad. Sci. 85:4700-4704 (1988) Kawakami, K., Scheidereit, C. and Roeder, R. G.

6. "Location of signal sequences for membrane insertion of the Na+,K+-ATPase alpha subunit." Molec. Cell. Biol. 9:5742-5745 (1989) Homareda, H., Kawakami, K., Nagano, K. and Matsui H.
Kawakami, K., Suzuki-Yagawa, Y., Watanabe, Y. and Nagano, K.

1990-1994 (10)

7. "Regulation of Na+,K+-ATPases I. Cloning and analysis of the 5'-flanking region of the rat NKAA2 gene encoding alpha 2 subunit." Gene 91:267-270 (1990) Kawakami, K., Yagawa, Y. and Nagano, K.

8. "Regulation of Na+,K+-ATPases II. Cloning and analysis of the 5'-flanking region of the rat NKAB2 gene encoding beta 2 subunit." Gene 91:271-274 (1990) Kawakami, K., Okamoto, H., Yagawa, Y. and Nagano, K.

9. "Cloning and analysis of 5'-flanking region of rat Na+/K+-ATPase alpha 1 subunit gene." Biochim. Biophys. Acta 1049:286-292 (1990) Yagawa, Y., Kawakami, K. and Nagano, K.

10. "Identification and characterization of the cis-elements regulating the rat AMOG (Adhesion Molecule on Glia)/Na,K-ATPase beta 2 subunit gene." J. Biochem. 111:515-522 (1992) Kawakami, K., Suzuki-Yagawa, Y., Watanabe, Y. and Nagano, K.

11. "Housekeeping Na,K-ATPase alpha 1 subunit gene promoter is composed of multiple cis-elements to which common and cell type specific factors bind." Molec. Cell. Biol. 12:4046-4055 (1992) Suzuki-Yagawa, Y., Kawakami, K. and Nagano, K.

12. "Sp1 binds to the Adhesion Molecule on Glia regulatory element that functions as a positive transcription regulatory element in astrocytes." J. Neurosci. Res. 35:138-146 (1993) Kawakami, K., Watanabe, Y., Araki, M. and Nagano, K.

13. "Anomalous interaction of Sp1 and specific binding of an E-box-binding protein with the regulatory elements of the Na,K-ATPase alpha 2 subunit gene promoter." Eur. J. Biochem. 218:195-204 (1993) Ikeda, K., Nagano, K. and Kawakami, K.

14. "Possible implications of Sp1-induced bending of DNA on synergistic activation of transcription." Gene 136:341-343 (1993) Ikeda, K., Nagano, K. and Kawakami, K.

15. "Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene." J. Biochem. 114:849-855 (1993) Watanabe, Y., Kawakami, K., Hirayama, Y. and Nagano, K.

16. "Different factors bind to the regulatory region of Na+,K+-ATPase alpha 1-subunit gene in cell cycle." FEBS Lett. 335:251-254 (1993) Kawakami, K., Yanagisawa, K., Watanabe, Y., Tominaga, S. and Nagano, K.

1995-1999 (16)

17. "ATF-1/CREB heterodimer is involved in constitutive expression of the housekeeping Na,K-ATPase alpha 1 subunit gene." Nucl. Acids Res. 23, 2848-2855 (1995) Kobayashi, M. and Kawakami, K.

18. "DNA binding through distinct domains of zinc-finger-homeodomain protein AREB6 has different effects on gene transcription." Eur. J. Biochem. 233, 73-82 (1995) Ikeda, K. and Kawakami, K.

19. "Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development." Nucl. Acids Res. 24, 303-310 (1996) Kawakami, K., Ohto, H., Ikeda, K., and Roeder R. G.

20. "Characterization of the core promoter of the Na+/K+-ATPase alpha 1 subunit gene: Elements required for transcription by RNA polymerase II and III in vitro." Eur. J. Biochem. 237, 440-446 (1996) Kawakami, K., Masuda, K., Nagano, K., Ohkuma, Y. and Roeder, R. G.

21. "Cis-elements involved in differential expression of Na,K-ATPase alpha 2 subunit gene in muscle differentiation." Biochim. Biophys. Acta. 1308, 67-73 (1996) Ikeda, K. and Kawakami, K.

22. "Identification and expression of six family genes in mouse retina" FEBS Lett. 393, 259-263 (1996) Kawakami, K., Ohto, H., Takizawa, T. and Saito, T.

23. "Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na,K-ATPase alpha 1 subunit gene promoter." Nucl. Acids Res. 25, 877-882 (1997) Kobayashi, M., Shimomura, A., Hagiwara, M. and Kawakami, K.

24. "Promoter of the Na,K-ATPase alpha 3 subunit gene is composed of cis-elements to which NF-Y and Sp1/Sp3 bind in cardiac myocyte." Biochim. Biophys. Acta. 1352, 311-324 (1997) Murakami, Y., Ikeda, U., Shimada, K. and Kawakami, K.

25. "Synergism of the ATF/CRE site and GC box in the housekeeping Na,K-ATPase alpha 1 subunit gene is essential for constitutive expression." Biochem. Biophys. Res. Comm. 241, 169-174 (1997) Kobayashi, M. and Kawakami, K.

26. "Involvement of negative co-factor NC2 in active repression by zinc-finger-homeodomain transcription factor AREB6." Molec. Cell. Biol. 18, 10-18 (1998) Ikeda, K., Halle, J-P., Stzeler, G., Meisterernst, M. and Kawakami, K.

27. "Tissue and developmental distribution of Six family gene products." Int. J. Dev. Biol. 42, 141-148 (1998) Ohto, H., Takizawa, T., Saito, T., Kobayashi, M., Ideda, K. and Kawakami, K.

28. "Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish." Development, 125, 2973-2982 (1998) Kobayashi, M., Toyama, R., Takeda, H., Dawid, I. B. and Kawakami, K.

29. "Promoter of mDMAHP/Six5: differential utilization of multiple transcription initiation sites and positive/negative regulatory elements." Hum. Molec. Genet. 7, 2103-2112 (1998) Murakami, Y., Ohto, H., Ikeda, U., Shimada, K., Momoi, T. and Kawakami, K.

30. "Localization of Six4/AREC3 in the developing retina; implications in mammalian retinal development." Exp. Eye Res., 67, 699-707 (1998) Niiya, A., Ohto, H., Kawakami, K. and Araki, M.

31. "Cooperation of Eya and Six in transactivation of their target genes through nuclear translocation of Eya." Mol. Cell. Biol. 19, 6815-6824 (1999) Ohto, H., Kamada, S., Tago, K., Tominaga, S., Ozaki, H., Sato, S. and Kawakami, K.

32. "Structure and chromosomal mapping of human SIX4 and mouse Six4 genes." Cytogenet. Cell Genet. 87, 108-122 (1999) Ozaki, H., Yamada, K., Kobayashi, M., Asakawa S., Minoshima S., Shimizu N., Kajitani, M., and Kawakami, K.

2000-2004 (13)

33. "Six family genes-Structure and Function as transcription factors and their roles in development" BioEssays 22, 616-626 (2000) Kawakami, K., Sato, S., Ozaki, H. and Ikeda, K.

34. "Expression of three zebrafish Six4 genes in the cranial sensory placodes and the developing somites." Mech. Dev. 98, 151-155 (2000) Kobayashi, M., Osanai, H., Kawakami, K. and Yamamoto, M.

35. "Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development." Mol. Cell. Biol. 21, 3343-3350 (2001) Ozaki, H., Watanabe, Y., Takahashi, K., Kitamura, K., Tanaka, A., Urase, K., Momoi, T., Sudo, K., Sakagami, J., Asano, M., Iwakura, Y. and Kawakami, K.

36. "Impaired interactions between mouse Eya1 harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach and G proteins. " J. Hum. Genet. 47, 107-116 (2002) Ozaki, H., Watanabe, Y., Ikeda, K. and Kawakami, K.

37. "Identification of transcriptional targets for Six5: Implication for the pathogenesis of myotonic dystrophy type 1." Hum. Mol. Genet. 11, 1045-1058 (2002) Sato, S., Nakamura, M., Cho, D. H., Tapscott, S. J., Ozaki, H. and Kawakami, K.

38. "Molecular interaction and synergistic activation of a promoter by Six, Eya and Dach proteins mediated through CBP." Mol. Cell. Biol. 22, 6759-6766 (2002) Ikeda, K., Watanabe, Y., Ohto, H. and Kawakami, K.

39. Six and Eya expression during human somitogenesis and MyoD gene family activation. J. Muscle Res. Cell Motil. 223, 255-264 (2002) Fougerousse, F., Durand, M., Lopez, S., Suel, L., Demignon, J., Thornton, C., Ozaki, H., Kawakami, K., Barbet, P., Beckmann, J.S., Maire, P.

40. "Degeneration of the amygdala/piriform cortex and enhanced fear/anxiety behaviors in sodium pump alpha 2 subunit (Atp1a2) defective mice." J. Neurosci. 23, 4667-4676. (2003) Ikeda, K., Onaka, T., Yamakado, M., Nakai, J., Ishikawa, T., Taketo, M. M. and Kawakami, K.

41. "Six1 controls patterning of the mouse otic vesicle.." Development 131, 551-562. (2004) Ozaki, H., Nakamura, K., Funahashi, J, Ikeda, K., Yamada, G., Tokano, H., Okamura, H., Kitamura, K., Muto, S., Kotaki, H., Sudo, K., Horai, R., Iwakura, Y. and Kawakami, K.

42. "Malfunction of respiratory related neuronal activity in Na+, K+-ATPase alpha 2 subunit-deficient mice is due to abnormal Cl- homeostasis in brainstem neurons." J. Neurosci., 24, 10693-10701. (2004) Ikeda, K., Onimaru, H., Yamada, J., Inoue, K., Ueno, S., Onaka, T., Toyoda, H., Arata, A., Ishikawa, T., Taketo, M. M., Fukuda, A. and Kawakami, K.

43. Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype. Mol. Cell. Biol. 24, 6253-6267. (2004) Grifone, R., Laclef, C., Spitz, F., Llpez, S., Demingon, J., Guidotti, J-E., Kawakami, K., Xu, P., Kelly, R., Petrof, B. J., Daegelen, D., Concordet, J-P. and Maire, P.

44. The Six1 homeoprotein stimulates tumorigenesis via reactivation of the germ line and embryonic specific cyclin A1. Proc. Natl. Acad. Sci., USA, 101, 6478-6483. (2004) Coletta, R. D., Christensen, K., Reichenberger, K. J., Lamb, J., Micomonaco, D., Huang, L., Wolf, D.M., Müller-Tidow, C., Golub, T.R., Kawakami, K. and Ford, H.L.


2005-2009 (14)

45. "Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4." FEBS J. 272, 3026-3041. (2005) Ando, Z., Sato, S., Ikeda, K. and Kawakami, K.

46. "Hyperphagia and obesity in Na,K-ATPase alpha 2 Subunit defective mice." Obesity Res. 13, 1661-1671. (2005) Kawakami K., Onaka T., Iwase M., Homma, I. and Ikeda K.

47. "Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis." Brain Res. 1116, 93-102. (2006) Konishi, Y., Ikeda, K., Iwakura, Y. and Kawakami, K.

48. Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development. J. Biol. Chem. 281, 18918-18926 (2006) Chai, L., Yang, J., Di, C., Cui, W., Kawakami, K., Lai, R. and Ma, Y.

49. Divergent signaling pathways mediate induction of Na,K-ATPase a1 and b1 subunit gene transcription by low potassium. Mol. Cell. Biochem. 294, 73-85. (2006) Wang, G., Kawakami, K. and Gick, G.

50. Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric tubule defects. Mech. Dev. 124, 290-303. (2007) Kobayashi, H., Kawakami, K., Asashima, M. and Nishinakamura, R.

51. Regulation of Na,K-ATPase alpha1 subunit gene transcription in response to low K(+): Role of CRE/ATF- and GC box-binding proteins. J. Cell. Physiol. 213, 167-176. (2007) Wang, G., Kawakami, K. and Gick, G.

52. "Six1 is essential for early neruogenesis in the development of olfactory epithelium." Dev. Biol. 311, 53-68. (2007) Ikeda, K., Ookawara, S., Sato, S., Ando, Z., Kageyema, R. and Kawakami, K.

53. "Defective interaction between dual oscillators for respiratory rhythm generation in Na+, K+-ATPase alpha 2 subunit-deficient mice." J. Physiol. 584, 271-84 (2007) Onimaru, H., Ikeda, K., and Kawakami, K.

54. "Differential expression of Eya1 and Eya2 during chick early embryonic development." Gene Exp. Patterns, 8, 357-367. (2008) Ishihara, T., Ikeda, K., Sato, S., Yajima, H., and Kawakami, K.

55. "Multiple Evolutionarily Conserved Enhancers Control Expression of Eya1." Dev. Dyn. 237, 3142-3156. (2008) Ishihara, T., Sato, S., Ikeda, K., Yajima, H., and Kawakami, K.

56. "CO2 sensitive preinspiratory neurons of the parafacial respiratory group express Phox2b in the neonatal rat. " J. Neurosci. 28, 12845-12850. (2008) Onimaru, H., Ikeda, K., and Kawakami, K.

57. "Phox2b, RTN/pFRG neurons and respiratory rythmogenesis." Resp. Physiol. Neurobiol., 168, 13-18. (2009) Onimaru, H. Ikeda, K., and Kawakami, K.

58. Expression of Six1 homeobox gene during development of the mouse submandibular salivary gland. Oral Diseases, 15, 407-413. (2009) Mccoy, E.L., Kawakami, K., Ford, H. L., and Coletta, R.D.



2010-2014 (18)

59. Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis. BMC Dev. Biol. 10:4. (2010) Coletta, R.D, Mccoy, E.L., Burns, V., Kawakami, K., McManaman, J., Wysolmerski, J.J., and Ford, H.L.

60. "Regulatory role of Six1 in the development of taste papillae. " Cell Tissue Res. 339, 513-25. (2010) Suzuki, Y., Ikeda, K., and Kawakami, K. .

61. "Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development. " Int. J. Dev. Biol. 54, 1453-1464. (2010) Ikeda. K., Kageyama, R., and Kawakami, K.

62. "Expression of Six1 and Six4 in mouse taste buds." J. Mol. Histol. 41, 205-214. (2010) Suzuki, Y., Ikeda, K, and Kawakami, K.

63. "Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR." Dev. Biol. 344, 158-171. (2010) Sato, S., Ikeda, K., Shioi, G., Ochi, H, Ogino, H. Yajima, H., and Kawakami, K.

64. "Six family genes control the proliferation and differentiation of muscle satellite cells." Exp. Cell Res. 316, 2932-2944. (2010) Yajima, H., Motohashi, N., Sato, S., Ikeda, K., Masuda, S., Yada, E., Suzuki, Y., Takeda, S. and Kawakami, K.

65. "Menthol inhibits respiratory rhythm in the brainstem preparation of newborn rats." Neuro Rep. 21. 1095-1099. (2010) Tani, M., Onimaru, H., Ikeda, K., Kawakam, K., Homma, I,

66. "Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein." Proc Natl Acad Sci USA , 107, 22084-22089 . (2010) Yamashita,T., Ohuchi, H., Tomonari, S., Ikeda , K., Sakai, K., Shichida, Y.

67. "Phox2b expressing neurons in the most rostral medulla of newborn rats." Adv Exp Med Biol. 669, 87-90. (2010) Onimaru, H, Ikeda, K, Kawakami, K.

68. Development of gustatory papillae in the absence of Six1 and Six4. J. Anatomy, 219, 710-721. Suzuki, Y., Ikeda, K, and Kawakami, K. (2011)

69. Postsynaptic mechanisms of CO2 responses in parafacial pre-inspiratory neurons of newborn rats. J. Phys. 590, 1615-1624. Onimaru, H. Ikeda, K. and Kawakami, K. (2012)

70. Relationship between the distribution of the paired-like homeobox gene (Phox2b) expressing cells and blood vessels in the parafacial region of the ventral medulla of neonatal rats. Neurosci. 212, 131-139. Onimaru, H. Ikeda, K. and Kawakami, K. (2012)

71. Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods. Dev. Biol. 368, 95-108. Sato, S., Ikeda, K., Shioi, G., Nakao, K., Yajima, H. and Kawakami, K. (2012)

72. Enhanced inhibitory neurotransmission in the cerebellar cortex of the Atp1a3-deficient heterozygous mice. J Physiol. 2013 Jul 1;591(Pt 13):3433-49. Ikeda K, Satake S, Onaka T, Sugimoto H, Takeda N, Imoto K, Kawakami K.

73. Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development.Dev Cell. 2013 Aug 26;26(4):416-30. Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R.

74. FGFR1-Frs2/3 signaling maintains sensory progenitor during inner ear hair cell formation.
PLoS Genet. 2014 e1004118. Ono, K., Kita, T., Sato, S., O'Neill P., Mak, SS., Paschaki, M., Ito,M., Gotoh, N., Kawakami, K., Sasai, Y., Ladher, RK.

75. Six1 is a key regulator of the developmental and evolutionary architecture of sensory neurons in craniates. BMC Biology 2014, 12:40 Yajima,H., Suzuki, M., Ochi, H., Ikeda, K., Sato,S., Yamamura, K., Ogino, H., Ueno, N. and Kawakami, K.

76. Heterozygous mice deficient in Atpa3 exhibit motor deficits by chronic restraint stress. Behavioural Brain Research 272, 100-110 (2014) Sugimoto, H., Ikeda, K., and Kawakami, K.

2015- (11)

77. A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry. PLoS One 10(7):e0132475 (2015). Ikeda K, Takahashi M, Sato S, Igarashi H, Ishizuka T, Yawo H, Arata S, Southard-Smith EM, Kawakami K, Onimaru H.

78. Activation of Six1 Expression in Vertebrate Sensory Neurons. PLoS One. 10(8):e0136666 (2015). Sato S, Yajima H, Furuta Y, Ikeda K, Kawakami K.

79. Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice. Dev. Growth Diff. 58: 546-561 (2016) Yajima, H. and Kawakami, K.

80. Six1 is required for mouse dental follicle cell and human periodontal ligament-derived cell proliferation. Dev. Growth Diff. 58: 530-545 (2016) Kawasaki, T., Takahashi, M., Yajima, H., Mori. Y. and Kawakami, K.

81. The respiratory control mechanisms in the brainstem and spinal cord: integrative views of the neuroanatomy and neurophysiology. J Physiol Sci. (review) in press, Ikeda K, Kawakami K, Onimaru H, Okada Y, Yokota S, Koshiya N, Oku Y, Iizuka M, Koizumi H.

82. Effects of a TRPV1 agonist capsaicin on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats. Pflugers Arch. 469(2):327-338 (2017). Tani M, Kotani S, Hayakawa C, Lin ST, Irie S, Ikeda K, Kawakami K, Onimaru H.

83. Knockout of sodium pump α3 subunit gene (Atp1a3-/-) results in perinatal seizure and defective respiratory rhythm generation.Brain Res. 1666:27-37 (2017). Ikeda K, Onimaru H, Kawakami K.

84. Distinctive features of Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus. Neuroscience. 358:211-226 (2017) .Nagoya K, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Nakayama K, Mochizuki A, Kiyomoto M, Sato F, Kawakami K, Takahashi K, Inoue T.

85. Enhanced susceptibility to cortical spreading depression in two types of Na+,K+-ATPase α2 subunit-deficient mice as a model of familial hemiplegic migraine 2. Cephalalgia. 333102417738249 (2017). Unekawa M, Ikeda K, Tomita Y, Kawakami K, Suzuki N.

86. Atp1a3 deficient heterozygous mice show lower rank in the hierarchy and altered social behavior. Genes Brain Behav. 2017 Oct 23. Sugimoto H, Ikeda K, Kawakami K.

87. Regulation of continuous but complex expression pattern of Six1 during early sensory development. Dev Dyn. 2017 Nov 6. Sato S, Furuta Y, Kawakami K.







英文図書

Ikeda K, Nagano K, Kawakami K. In Schoner W, Bamberg E. editors. The Sodium Pump-Structure mechanism, hormonal control and its role in disease. New York: Springer; 1994. pp33-36.

Kawakami K, Suzuki-Yagawa Y, Watanabe Y, Ikeda K, Nagano K. In Schoner W, Bamberg E. editors. The Sodium Pump-Structure mechanism, hormonal control and its role in disease. New York: Springer; 1994. pp1-10

Hiroshi Onimaru, Keiko Ikeda, Tani Mariho, Kiyoshi Kawakami. Chapter 4 – Cytoarchitecture and CO2 Sensitivity of Phox2b-Positive Parafacial Neurons in the Newborn Rat Medulla. Progress in Brain Research Vol. 209 p57-71, 2014, The Central Nervous System Control of Respiration. Elsevier.

和文総説

川上潔、小林麻己人:新規ホメオボックス遺伝子Sixの構造と機能および発生/分化へのかかわり
蛋白質・核酸・酵素 43(14), 66-69 1998年

池田啓子、川上潔:新しい分子標的. Pharma Medica 2000; 20:67-73.

川上潔、佐藤滋:ホメオタンパク質Six1と感覚器の形成。実験医学 22(12): 1702-1708, 2004.

池田啓子、川上潔:Naポンプ遺伝子欠損マウスの情動異常.月刊臨床神経科学 2004; 22:246-247.

池田啓子、鬼丸洋、川上潔:ナトリウムポンプの新機能. 蛋白質核酸酵素 2005; 50:434-439.