佐藤 滋（さとう しげる）
自治医科大学分子病態治療研究センター
細胞生物研究部 講師
研究課題
1）頭部プラコードと感覚器の発生
2）頭部プラコードと感覚器の進化
研究歴
1989年 東北大学理学部生物学科卒業（指導教官：竹内拓司先生）
1995年 東北大学大学院理学研究科博士課程修了（生物学専攻）
（指導教官：竹内拓司先生、井出宏之先生、山本博章先生）
1995年 東北大学大学院理学研究科研究生（指導教官：山本博章先生）
1995年 英国Marie Curie研究所の真核生物転写研究室で博士研究員（Dr. Colin R. Godingの研究室）
1996年 日本学術振興会特別研究員（東北大学大学院理学研究科山本博章先生の研究室）
1998年 自治医科大学医学部生物学教室助手
2000年 自治医科大学医学部生物学教室講師
2002年 自治医科大学分子病態治療研究センター細胞生物研究部講師
発表論文
原著論文（査読あり，括弧内の数字はISI Web of Knowledgeによる引用回数）
1. Yamamoto, H., Kudo, T., Masuko, N., Miura, H., Sato, S., Tanaka, M., Tanaka, S., Takeuchi, S., Shibahara, S. and Takeuchi, T. (1992). Phylogeny of regulatory regions of vertebrate tyrosinase genes. Pigment Cell Res 5, 284−294. (25)
2. Sato, S., Miura, H., Yamamoto, H. and Takeuchi, T. (1994). Identification of nuclear factors that bind to the mouse tyrosinase gene regulatory region. Pigment Cell Res 7, 279−284. (2)
3. Sato, S., Masuya, H., Numakunai, T., Satoh, N., Ikeo, K., Gojobori, T., Tamura, K., Ide, H., Takeuchi, T. and Yamamoto, H. (1997). Ascidian tyrosinase gene: its unique structure and expression in the developing brain. Dev Dyn 208, 363−374. (35)
4. Sato, S.*, Roberts, K.*, Gambino, G., Cook, A., Kouzarides, T. and Goding, C.R. (1997). CBP/p300 as a co-factor for the Microphthalmia transcription factor. Oncogene 14, 3083−3092. (*equal contribution) (84)
5. Wada, H., Holland, P.W., Sato, S., Yamamoto, H. and Satoh, N. (1997). Neural tube is partially dorsalized by overexpression of HrPax-37: the ascidian homologue of Pax-3 and Pax-7. Dev Biol 187, 240−252. (83)
6. Yuasa, H.J., Sato, S., Yamamoto, H. and Takagi, T. (1997). Structure of the ascidian, Halocynthia roretzi, troponin C gene. J Biochem (Tokyo) 121, 671−676. (11)
7. Yuasa, H.J., Sato, S., Yamamoto, H. and Takagi, T. (1997). Primary structure of troponin I isoforms from the ascidian Halocynthia roretzi. J Biochem (Tokyo) 122, 374−380. (9)
8. Amae, S., Fuse, N., Yasumoto, K., Sato, S., Yajima, I., Yamamoto, H., Udono, T., Durlu, Y.K., Tamai, M., Takahashi, K. and Shibahara, S. (1998). Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium. Biochem Biophys Res Commun 247, 710−715. (70)
9. Ohto, H., Kamada, S., Tago, K., Tominaga, S.I., Ozaki, H., Sato, S. and Kawakami, K. (1999). Cooperation of Six and Eya in Activation of Their Target Genes through Nuclear Translocation of Eya. Mol Cell Biol 19, 6815−6824. (135)
10. Sato, S., Toyoda, R., Katsuyama, Y., Saiga, H., Numakunai, T., Ikeo, K., Gojobori, T., Yajima, I. and Yamamoto, H. (1999). Structure and developmental expression of the ascidian TRP gene: insights into the evolution of pigment cell-specific gene expression. Dev Dyn 215, 225−237. (24)
11. Yajima, I.*, Sato, S.*, Kimura, T., Yasumoto, K., Shibahara, S., Goding, C.R. and Yamamoto, H. (1999). An L1 element intronic insertion in the black-eyed white (Mitfmi-bw) gene: the loss of a single Mitf isoform responsible for the pigmentary defect and inner ear deafness. Hum Mol Genet 8, 1431−1441. (*equal contribution) (59)
12. Toyoda, R., Sato, S., Ikeo, K., Gojobori, T., Numakunai, T., Goding, C.R. and Yamamoto, H. (2000). Pigment cell-specific expression of the tyrosinase gene in ascidians has a different regulatory mechanism from vertebrates. Gene 259, 159−170. (6)
13. Sato, S., Tanaka, M., Miura, H., Ikeo, K., Gojobori, T., Takeuchi, T. and Yamamoto, H. (2001). Functional conservation of the promoter regions of vertebrate tyrosinase genes. J Investig Dermatol Symp Proc 6, 10−18. (7)
14. Sato, S., Nakamura, M., Cho, D.H., Tapscott, S.J., Ozaki, H. and Kawakami, K. (2002). Identification of transcriptional targets for Six5: Implication for the pathogenesis of myotonic dystrophy type 1. Hum Mol Genet 11, 1045−1058. (16)
15. Kumasaka, M., Sato, S., Yajima, I. and Yamamoto, H. (2003). Isolation and developmental expression of tyrosinase family genes in Xenopus laevis. Pigment Cell Res 16, 455−462. (11)
16. Yajima, I., Endo, K., Sato, S., Toyoda, R., Wada, H., Shibahara, S., Numakunai, T., Ikeo, K., Gojobori, T., Goding, C.R. and Yamamoto, H. (2003). Cloning and functional analysis of ascidian Mitf in vivo: insights into the origin of vertebrate pigment cells. Mech Dev 120, 1489−1504. (1)
17. Kumasaka, M., Sato, H., Sato, S., Yajima, I. and Yamamoto, H. (2004). Isolation and developmental expression of Mitf in Xenopus laevis. Dev Dyn 230, 107−113, 2004. (5)
18. Toyoda, R., Kasai, A., Sato, S., Wada, S., Saiga, H., Ikeo, K., Gojobori, T., Numakunai, T. and Yamamoto, H. (2004). Pigment cell lineage-specific expression activity of the ascidian tyrosinase-related gene. Gene 332, 61−69. (2)
19. Ando, Z-I., Sato, S., Ikeda, K. and Kawakami, K. (2005). Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4. FEBS J 27, 3026−3041. (8)
20. Kumasaka, M., Sato, S., Yajima, I., Goding, C.R. and Yamamoto, H. (2005). Regulation of melanoblast and retinal pigment epithelium development by Xenopus laevis Mitf. Dev Dyn 234, 523−534. (7)
21. Ikeda, K., Ookawara, S., Sato, S., Ando, Z., Kageyama, R. and Kawakami, K. (2007). Six1 is essential for early neurogenesis in the development of olfactory epithelium. Dev Biol 311, 53-68. (10)
22. Ishihara, T., Ikeda, K., Sato, S., Yajima, H. and Kawakami, K. (2008). Differential expression of Eya1 and Eya2 during chick early embryonic development. Gene Expr Patterns 8, 357-67. (5)
23. Ishihara, T., Sato, S., Ikeda, K., Yajima, H. and Kawakami, K. (2008). Multiple evolutionarily conserved enhancers control expression of Eya1. Dev Dyn 237, 3142-56. (0)
24. Sato, S.**, Ikeda, K., Shioi, G., Ochi, H, Ogino, H. Yajima, H. and Kawakami, K. Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR. Dev Biol 344, 158-171 (2010). (**corresponding author)
25. Yajima, H., Motohashi, N., Sato, S., Ikeda, K., Masuda, S., Yada, E., Suzuki, Y., Takeda, S. and Kawakami, K. Six family genes control the proliferation and differentiation of muscle satellite cells. submitted for publication.
総 説（査読あり，括弧内の数字はISI Web of Knowledgeによる引用回数）
26. Kawakami, K., Sato, S., Ozaki, H. and Ikeda, K. (2000). Six family genes-structure and function as transcription factors and their roles in development. Bioessays 22, 616−626. (134)
27. Sato, S. and Yamamoto, H. (2001). Development of pigment cells in the brain of ascidian tadpole larvae: insights into the origins of vertebrate pigment cells. Pigment Cell Res 14, 428−436. (9)
その他（査読あり，括弧内の数字はISI Web of Knowledgeによる引用回数）
28. The International Myotonic Dystrophy Consortium (IDMC). (2000). New nomenclature and DNA testing guidelines for myotonic dystrophy type 1 (DM1). Neurology 54, 1218-1221. (73)
著書
29. 川上 潔，佐藤 滋．(2004)．ホメオタンパク質Six1と感覚器の形成．実験医学 22，1702-1708．