自治医科大学 医学部 環境予防医学講座

Dpartment of Environmental and Preventive Medicine,
School of Medicine, Jichi Medical University


Horiguchi H, Oguma E, Kayama F, Sato M, and Fukushima M. Dexamethasone prevents acute cadmium-induced hepatic injury but exacerbates kidney dysfunciton in rabbits. Toxicol Appli Pharmacol 174:225-234, 2001

Kayama F, Hamamatsu A, Sagisaka K, Brown D, Clark G, and Suzuki. CALUX assay is applicable to human epidemiological studies. Organohalogen Compouns 54:48-50, 2001

Mori C, Hamamatsu A, Fukata H, Koh KB, Nakamura N, Takeichi S, Kusakabe T, Saito T, Morita M, Tanihara S, Kayama F, Shiyomi M, Yoshimura J, Sagisaka K. Temporal changes in testis weight during the past 50 years in Japan. Anat Sci Int 77(2):109-116, 2002

Nomoto S, Arao Y, Horiguchi H, Ikeda K, Kayama F. Oestrogen causes G2/M arrest and apoptosis in breast cancer cells MDA-MB-231. Oncol Rep 9(4):773-776, 2002

Kayama F,Arao Y, Horiguchi H,and Nomoto S.  Naturally Occurring and Synthetic Xenoestrogens. Environmental Science 9 (1): 51-55, 2002

Arao Y, Kikuchi A, Ikeda K, Nomoto S, Horiguchi H, and Kayama F. A+U-rich-element RNA-binding factor 1/heterogeneous nuclear ribonucleoprotein D gene expression is regulated by oestrogen in the rat uterus. Biochem J 361: 125-132, 2002

Ikeda K, Arao Y, Otsuka H, Nomoto S, Horiguchi H, Kato S, Kayama F.Terpenoids found in the umbelliferae family act as agonists/antagonists for ERα and ERβ: differential transcription activity between ferutinine-liganded ERα and ERβ. Biochem Biophys Res Commun 291(2):354-360, 2002

Kanno S, Hirano S, and Kayama F. Effects of 17β-Estradiol ,Phytoestrogens and Environmental Estrogens on Osteoblastic. Differentiation in MC3T3-E1 Cells. Biomed Res Trace Elements 13(4):328-329, 2002

Jin YH, Chen HC, Tang HJ, Jin XH, Liu HF, Li Z, Kayama F, Humamatsu A, Sagisaka K, Brown D, Clark G, Nakamura M. A survey on the dioxin level in breast milk in coastal and inland region. Zhonghua Yu Fang Yi Xue Za Zhi 37(6):439-441,2003

Kayama F, Horiguchi H. and Hamamatsu A. Potential health effects of alkylphenols in Japan. JMAJ 46 (3):108-114, 2003

Kayama, F., Ikeda K, Arao Y, Otsuka H, Nomoto S, Horiguchi, H. Mechanisms of action and physiological functions of naturally occurring and man-made xenoestrogens. J UOEH 25 (supp 1): 161-167, 2003

Kayama F, Murata K, Nagano K, Nasu T, Takebayashi T, Takeshita T, Yokoyama K; Recommendation of occupational exposure limits (2003-2004). J Occup Health 45(4):254-69, 2003

Kanno S, Hirano S, Kayama F. Effects of the phytoestrogen coumestrol on RANK-ligand-induced differentiation of osteoclasts. Toxicology 203(1-3):211-220, 2004

Ikeda K, Arao Y, Otsuka H, Kikuchi A, Kayama F. Estrogen and phytoestrogen regulate the mRNA expression of adrenomedullin and adrenomedullin receptor components in the rat uterus. Mol Cell Endocrinol 223(1-2):27-34, 2004

Horiguchi H, Oguma E, Nomoto S, Arao Y, Ikeda K, Kayama F. Acute exposure to cobalt induces transient methemoglobinuria in rats.Toxicol Lett 151(3):459-466, 2004

Kunisue T, Someya M, Kayama F, Jin Y, Tanabe S. Persistent organochlorines in human breast milk collected from primiparae in Dalian and Shenyang, China. Environ Pollut 131(3):381-392, 2004

Arao Y, Kikuchi A, Kishida M, Yonekura M, Inoue A, Yasuda S, Wada S, Ikeda K, Kayama F. Stability of A+U-rich element binding factor 1 (AUF1)-binding messenger ribonucleic acid correlates with the subcellular relocalization of AUF1 in the rat uterus upon estrogen treatment. Mol Endocrinol 18(9):2255-2267, 2004

Horiguchi H, Oguma E, Sasaki S, Miyamoto K, Ikeda Y, Machida M, Kayama F. Dietary exposure to cadmium at close to the current provisional tolerable weekly intake does not affect renal function among female Japanese farmers. Environ Res 95(1):20-31, 2004

Horiguchi H, Oguma E, Sasaki S, Miyamoto K, Ikeda Y, Machida M, Kayama F. Comprehensive study of the effects of age, iron deficiency, diabetes mellitus, and cadmium burden on dietary cadmium absorption in cadmium-exposed female Japanese farmers. Toxicol Appl Pharmacol 196(1):114-123, 2004

Kanno S, Hirano S, Kayama F. Effects of phytoestrogens and environmental estrogens on osteoblastic differentiation in MC3T3-E1 cells. Toxicology 196(1-2):137-45, 2004

Yasuda S, Wada S, Arao Y, Kogawa M, Kayama F, Katayama S. Interaction between 3' untranslated region of calcitonin receptor messenger ribonucleic acid (RNA) and adenylate/uridylate (AU)-rich element binding proteins (AU-rich RNA-binding factor 1 and Hu antigen R). Endocrinology 145(4):1730-1738, 2004

Horiguchi H, Oguma E, Sasaki S, Miyamoto K, Ikeda Y, Machida M, Kayama F. Environmental exposure to cadmium at a level insufficient to induce renal tubular dysfunction does not affect bone density among female Japanese farmers.Environ Res 97 (1): 83-92, 2005

Kayama F, Yamamoto T. [Usefulness of reporter gene assay for AhR agonists, CALUX assay]Nippon Eiseigaku Zasshi 60(1):23-9, 2005, Japanese

Tien PG, Kayama F, Konishi F, Tamemoto H, Kasono K, Hung NT, Kuroki M, Ishikawa SE, Van CN, Kawakami M. Inhibition of tumor growth and angiogenesis by water extract of Gac fruit (Momordica cochinchinensis Spreng). Int J Oncol 26(4):881-889, 2005

Horoguchi H, Oguma E, Kayama F. The effects of iron deficiency on estradiol-induced suppression of erythropoietin induction in rats: implications of pregnancy-related anemia. Blood 106(1):67-74, 2005

Su-Ju Sun, Jian-Hong Zhao, Minoru Koga, Yu-Xia Ma, Dian-Wu Liu, Masafumi Nakamura, Huai-Jun Liu, Hyogo Horiguchi, George C. Clark, Fujio Kayama. Persistent Organic Pollutants in Human Milk in Women from Urban and Rural Areas in Northern China. Environ Res 99(3):285-293, 2005

Jian-Hong Zhao, Su-Ju Sun, Yukimoto Arao, Etsuko Oguma, Koji Yamada, Hyogo Horiguchi, Satoshi Sasaki and Fujio Kayama. A soy diet accelerates renal damage in autoimmune MRL/Mp-lpr/lpr mice. Int Immunopharmacol 5(11):1601-1610, 2005

Su-Ju Sun, Jian-Hong Zhao, Huai-Jun Liu, Dian-Wu Liu, Yu-Xia Ma, Li Li, Hyogo Horiguchi, Hideyuki Uno , Takao Iida, Minoru Koga, Yasuhiro Kiyonari, Masafumi Nakamura, Satoshi Sasaki, Hideo Fukatu, George C Clark, Fujio Kayama Dioxin concentration in human milk in Hebei Province in China and Tokyo, Japan: potential dietary risk factors and determination of possible sources. Chemosphere 62(11):1879-1888, 2006

Zhao J-H, Arao Y, Sun SJ, Kikuchi A, and Kayama F. Oral administration of soy-derived genistin suppresses lipopolysaccharide-induced acute liver inflammation but does not induce thymic atrophy in the rat. Life Sciences 78(8): 812-819, 2006

Zhao J-H, Sun SJ, Arao Y, Oguma E, Yamada K, Horiguchi H, Sasaki S and Kayama F. Identification of equol producers in a Japanese population by High Performance Liquid Chromatography with coulometric array for determining serum isoflavones.  Phytomedicine 13:304-309, 2006

Okubo H, Sasaki S, Horiguchi H, Oguma E, Miyamoto K, Hosoi Y, Kim MK, and Fujio Kayama. Dietary patterns associated with bone mineral density in premenopausal Japanese female farmers. Am J Clin Nutr 83:1185-1192, 2006

Murakami K, Sasaki S, Takahashi Y, Okubo H, Hosoi Y, Horiguchi H, Oguma E, and Kayama F. Dietary glycemic index and load in relation to metabolic risk factors in Japanese female farmers with traditional dietary habits. Am J Clin Nutr 83: 1161-1169, 2006

Horiguchi, H., Oguma, E, Kayama, F. Cadmium and cisplatin damage erythropoietin-producing proximal renal tubular cells. Arch. Toxicol 80:680-686, 2006
Sasaki, K; Tawarada, K; Arakane, Okuyama A, Maruyama Y, Okuhata H, Kayama F, Abe, K, Miyasaka H, Fujikawa T, Glass TR, Ohmura N. Screening method for cadmium in brown rice grain using immunochromatography. BUNSEKI KAGAKU 57(2):105-112, 2008

Dakeshita, S; Kawai, T; Uemura, H, Mineyoshi H, Oguma E, Horiguchi H, Kayama F, Aoshima K, Shirahama S, Rokutan K and Arisawa K. Gene expression signatures in peripheral blood cells from Japanese women exposed to environmental cadmium. Toxicology 257(1-2):25-32, 2009

Leng JH, Kayama F, Wang PY, Nakamura M, Nakata T, Wang Y. Levels of persistent organic pollutants in human milk in two Chinese coastal cities, Tianjin and Yantai:Influence of fish consumption. Chemosphere 75(5): 634-639, 2009

Arao Y, Hakamata Y, Igarashi Y, Sato Y, Kayama F, Takahashi M, Kobayashi E, Murakami T. Characterization of hepatic sexual dimorphism in Alb-DsRed2 transgenic rats. Biochem Biophys Res Commun 382(1):46-50, 2009

Sasaki K, Yongvongsoontorn N, Tawarada K, Ohnishi Y, Arakane T, Kayama F, Abe K, Oguma S, Ohmura N. Cadmium purification and quantification using immunochromatography. J Agric Food Chem. 57(11):4514-4519, 2009

Machida M, Sun SJ, Oguma E, Kayama F. High bone matrix turnover predicts blood levels of lead among perimenopausal women. Environ Res, 2009 109(7):880-6.

Sakamoto T, Horiguchi H, Oguma E, Kayama F. Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen receptor-positive breast cancer cells. J Nutr Biochem 21:856-864, 2010.

Furuya H, Kayama F, Hasegawa M, Nagai M, Suzuki T. A Longitudinal Study of Trends in Blood Dioxins and Dioxin-Like Compounds Levels in Residents from Two Locations in Japan During 2002-2006. Arch Environ Contam Toxicol. 2010 58: 892-900

Horiguchi H, Aoshima K, Oguma E, Sasaki S, Miyamoto K, Hosoi Y, Katoh T, Kayama F. Latest status of cadmium accumulation and its effects on kidneys, bone, and erythropoiesis in inhabitants of the formerly cadmium-polluted Jinzu River Basin in Toyama, Japan, after restoration of rice paddies. Int Arch Occup Environ Health 83: 953-970, 2010.

Jingbin W, Ndong M, Kai H, Matsuno K, Kayama F. Placental transfer of melamine and its effects on rat dams and foetuses. Food Chem Toxicol. 2010. In press

Ogawa M, Suzuki Y, Endo Y, Kawamoto T, Kayama F. Influence of coffee intake on urinary hippuric acid concentration. Industrial Health, 49, 195-202, 2011







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