Inflammation Reserch

Principal Investigator (PI): Masafumi Takahashi, MD, PhD
Role of Inflammation and Regeneration in Disease
Our laboratory was newly established in April 2009 to understand the molecular pathogenesis and to develop novel effective therapies in various types of diseases such as atherosclerosis, ischemic heart disease, heart failure, hypertension, diabetes mellitus, kidney and liver dysfunction, and metabolic syndrome. To achieve this goal, we employ various kinds of experimental techniques in molecular and cellular biology, bioimaging technology, as well as animal models. We are currently focusing on inflammation and regeneration in human disease. Specific research interests are as follows:
1. Inflammasome: a large multiprotein complex which plays an important role in innate immunity by participating in the production of IL-1beta and IL-18
(Circulation 117: 3079 -3087, 2008; Circulation 126:594-604, 2011).
2. SDF-1/CXCR4 system: a chemokine and its receptor system involved in the processes of chemotaxis, cell proliferation and survival, angiogenesis and tissue regeneration
(Cardiovasc Res 81: 169-177, 2009; Circ J 74: 418-423, 2010).
3. Th17 cells and IL-17: Th17 cells are a newly identified subset of effector CD4- positive T cells that produces IL-17 and plays a key role in multiple forms of inflammatory and autoimmune diseases (Cardiovasc Res 90: 364-372, 2011).

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