統合病理学部門

最近の発表論文

  • Tomoyuki Nakano, Yoshihiko Kanai, Tomoko Tamura, Sachiko Oguni, Yusuke Amano, Taichiro Yoshimoto, Daisuke Matsubara, Takeshi Ito, Yoshinori Murakami, Masashi Fukayama, Takashi Murakami, Shunsuke Endo, and Toshiro Niki.Establishment of Highly Metastatic KRAS Mutant Lung Cancer Cell Sublines by Long-term Three-dimensional Low Attachment Culture. Plos One 2017. in press

  • Daisuke Matsubara, Manabu Soda, Taichiro Yoshimoto, Yusuke Amano, Yuji Sakuma, Azusa Yamato, Toshihide Ueno, Shinya Kojima, Tomoki Shibano, Yasuyuki Hosono4, Masahito Kawazu, Yoshihiro Yamashita, Shunsuke Endo, Koichi Hagiwara, Masashi Fukayama, Takashi Takahashi, Hiroyuki Mano, Toshiro Niki. Inactivating mutations and hypermethylation of the NKX2-1/TTF-1 gene in non-TRU-type lung adenocarcinomas. Cancer Sci, 2017 Jul 5. doi: 10.1111/cas.13313.

  • Takeshi Ito, Daisuke Matsubara, Ichidai Tanaka, Kanae Makiya, Zen-ichi Tanei, Yuki Kumagai, Sue-Jen Shiu, Hiroki J. Nakaoka, Shumpei Ishikawa, Takayuki Isagawa, Teppei Morikawa, Aya Shinozaki-Ushiku, Yasushi Goto, Tomoyuki Nakano, Takehiro Tsuchiya, Hiroyoshi Tsubochi, Daisuke Komura, Hiroyuki Aburatani, Yoh Dobashi, Jun Nakajima, Shunsuke Endo, Masashi Fukayama, Yoshitaka Sekido, Toshiro Niki, and Yoshinori Murakami. Loss of YAP1 Defines Neuroendocrine Differentiation of Lung Tumors. Cancer Sci, 2016;107:1527-1538. doi: 10.1111/cas.13013.

  • Yoshimoto T, Matsubara D, Nakano T, Tamura T, Endo S, Sugiyama Y, Niki T. Frequent loss of the expression of multiple subunits of the SWI/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung. Pathol Int, 2015;65:595-602. doi: 10.1111/pin.12350..

  • Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Alan T. Lefor, Yasuda Y and Niki T. The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma. BMC cancer, 2015, Feb 25;15:82.

  • Matsubara D, Kishaba Y, Yoshimoto T, Sakuma Y, Sakatani T, Tamura T, Endo S, Sugiyama Y, Murakami Y, Niki T. Immunohistochemical analysis of the expression of E-cadherin and ZEB1 in non-small cell lung cancer. Pathol Int, 64: 560-8, 2014.

  • Saito S, Morishima K, Ui T, Matsubara D, Tamura T, Oguni S, Hosoya Y, Sata N, Alan T. Lefor, Yasuda Y and Niki T. Stromal fibroblasts are predictors of disease-related mortality in esophageal squamous cell carcinoma. Oncology Reports, 32: 348-354, 2014

  • Ibrahim R, Matsubara D, Osman Y, Morikawa T, Goto A, Morita S, Ishikawa S, Aburatani H, Takai D, Nakajima J, Fukayama M, Niki T, Murakami Y. Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition. Human Pathol, 45: 1397-1405, 2014

  • Ui T, Morishima K, Saito S, Sakuma Y, Fujii H, Hosoya Y, Niki T, Yasuda Y. The HSP90 inhibitor 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway. Oncology Reports, 31: 619-24, 2014

  • Matsubara D, Kishaba Y, Ishikawa S, Sakatani T, Oguni S, Tamura T, Hoshino H, Sugiyama Y, Endo S, Murakami Y, Aburatani H, Fukayama M, Niki T. Lung Cancer with Loss of BRG1/BRM, shows Epithelial Mesenchymal Transition Phenotype and Distinct Histologic and Genetic Features. Cancer Science 2013;104(2):266-73.

  • Ohzawa H, Sakatani T, Niki T, Yasuda Y, Hozumi Y. Pathological responses and survival of patients with human epidermal growth factor receptor 2-positive breast cancer who received neoadjuvant chemotherapy including trastuzumab.Breast Cancer 2012;Oct 30

  • Matsubara D, Kanai Y, Ishikawa S,Ohara S, Yoshimoto T, Sakatani T, Oguni S,Tamura T, Kataoka H, Endo S, Murakami Y, Aburatani H, Fukayama M and Niki T. Identification of CCDC6-RET Fusion in a Human Lung Adenocarcinoma Cell Line, LC-2/ad.J Thorac Oncol. 2012;7(12):1872-6.

  • Saito S, Hosoya Y, Morishima K, Ui T, Haruta H, Kurashina K, Meguro Y, Zuiki T, Sata N, Fujii H, Matsubara D, Niki T, Lefor AT, Yasuda Y. A clinicopathological and immunohistochemical study of gastric cancer with squamous cell carcinoma components: a clinically aggressive tumor.J Dig Dis 2012;13(8):407-13.


  • Matsubara D, Niki T. (Letter to the Editor) Epidermal Growth Factor Receptor Mutation and Chemosensitivity. J Thorac Oncol. 2012;7(4):771-772,

  • Matsubara D, Ishikawa S, Oguni S, Aburatani H, Fukayama M, Niki T. Co-activation of epidermal growth factor receptor and c-MET defines a distinct subset of lung adenocarcinomas. Am J Pathol. 2010;177(5):2191-2204.

  • Matsubara D, Ishikawa S, Oguni S, Aburatani H, Fukayama M, Niki T. Molecular predictors of sensitivity to the MET inhibitor PHA665752 in lung carcinoma cells. J Thorac Oncol. 2010;5:1317-24.

  • Kishaba Y, Matsubara D and Niki T. Heterogenous Expression of Nestin in Myofibroblasts of Various Human Tissues. Pathol Int. 2010;60:378-85.

  • Matsubara D, Morikawa T, Goto A, Nakajima J, Fukayama M, Niki T. Subepithelial myofibroblast in lung adenocarcinoma: a histologic indicator of excellent prognosis. Mod Pathol. 2009;22:776-85.

  • 学位論文

    1.森嶋 計 「食道扁平上皮癌おけるhistone deacetylase 阻害効果と阻害剤の感受性予測マーカーの検討」 2012
    2.齊藤 心「食道扁平上皮癌の増殖・浸潤における線維芽細胞の役割」 2011
    3.高橋 真依「クロマチンリモデリング因子 SWI/SNF のコアサブユニットBRG1/BRM による肺癌細胞の分化形質の制御とその分子機構」2017