Jichi Med. Univ.Jichi Med. Univ. Graduate School of Med.





<Address>
Division of Integrative Physiology, Department of Physiology,
Jichi Medical University, School of Medicine

3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

TEL +81-285-58-7320
FAX +81-285-44-9962
Publications

2017  2016  2015  2014  2013  2012  2011  2010
2009  2008  2007  2006  2005  2004  2003  2002  2001  2000




Iwasaki Y, Goswami C, Yada T.: Glucagon-like peptide-1 and insulin synergistically activate vagal afferent neurons. Neuropeptides May 25, 2017.[Epub ahead of print]

Yoshii Y, Inoue T, Uemura Y, Iwasaki Y, Yada T, Nakabeppu Y, Noda M.: Complexity of Stomach–Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice. Neurochem Res. May 2, 2017. [Epub ahead of print]

Sasanuma H, Nakata M, Kumari P, Nakae J, Yada T.: PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis. Mol Metab. 6(5):428-39, 2017.

Suyama S, Lei W, Kubota N, Kadowaki T, Yada T.: Adiponectin at physiological level glucose-independently enhances inhibitory postsynaptic current onto NPY neurons in the hypothalamic arcuate nucleus. Neuropeptides March, 2017.[Epub ahead of print]

Santoso P, Nakata M, Shiizaki K, Boyang Z, Parmila K, Otgon-Uul Z, Hashimoto K, Satoh T, Mori M, Kuro-O M, Yada T.: Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states. Scientific reports 7:45819, 2017.

Santoso P, Nakata M, Ueta Y, Toshihiko Yada T.: Suprachiasmatic Vasopressin to Paraventricular Oxytocin Neurocircuit in the Hypothalamus Relays Light Reception to Inhibition of Feeding Behavior. Am J Physiol Endocrinol Metab. Feb 7, 2017. [Epub ahead of print]

Nakata M, Yamamoto S, Okada T, Yada T.: AAV-mediated IL-10 gene transfer counteracts inflammation in the hypothalamic arcuate nucleus and obesity induced by high-fat diet. Neuropeptides 62: 87-92, 2017.

Ito K, Dezaki K, Yoshida M, Yamada H, Miura R, Rita RS, Ookawara S, Tabei K, Kawakami M, Hara K, Morishita Y, Yada T, Kakei M.: Endogenous α2A-adrenoceptor-operated sympathoadrenergic tones attenuate insulin secretion via cAMP/TRPM2 signaling. Diabetes 66(3): 699-709, 2017.


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Nakata M, Zhang B, Yang Y, Okada T, Shintani N, Hashimoto H, Yada T.: High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance. J Diabetes Res. 2016: 9321395, 2016.

Kohno D, Koike M, Ninomiya Y, Kojima I, Kitamura T, Yada T.: Sweet taste receptor serves to activate glucose- and leptin-responsive neurons in the hypothalamic arcuate nucleus and participates in glucose responsiveness. Frontiers in Neuroscience (section Neuroendocrine Science), 10: 502, 2016.

Kimura H, Karasawa T, Usui F, Kawashima A, Endo Y, Kobayashi M, Sadatomo A, Nakamura J, Iwasaki Y, Yada T, Tsutsui H, Kasahara T, Takahashi M.: Caspase-1 Deficiency Promotes High-Fat Diet-Induced Adipose Tissue Inflammation and the Development of Obesity. Am J Physiol Endocrinol Metab. 311(5): E881-E890, 2016.

Suyama S, Maekawa F, Maejima Y, Kubota N, Kadowaki T, Yada T.: Glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding. Scientific Reports 6: 30796, 2016.

Li E, Nakata M, Shinozaki A, Yang Y, Zhang B, Yada T.: Betatrophin expression is promoted in obese hyperinsulinemic type 2 but not type 1 diabetic mice. Endocr J. 63(7): 611-9, 2016.

Otogon-Uul Z, Suyama S, Onodera H, Yada T.: Optogenetic activation of leptin-and glucose-regulated GABAergic neurons in dorsomedial hypothalamus promotes food intake via inhibitory synaptic transmission to paraventricular nucleus of hypothalamus. Molecular Metabolism, 5(8): 709-715, 2016.

Nakata M, Gantulga D, Santoso P, Zhang B, Masuda C, Mori M, Okada T, Yada T.: Paraventricular NUCB2/nesfatin-1 supports oxytocin and vasopressin neurons to control feeding behavior and fluid balance in male mice. Endocrinology 157(6):2322-32, 2016.

Taguchi M, Dezaki K, Koizumi M, Kurashina K, Hosoya Y, Lefor AK, Sata N, Yada T.: Total gastrectomy-induced reductions in food intake and weight are counteracted by rikkunshito by attenuating glucagon-like peptide-1 elevation in rats. Surgery, 159(5):1342-50, 2016.

Suyama S, Kodaira-Hirano M, Otgon-Uul Z, Ueta Y, Nakata M, Yada T.: Fasted/fed states regulate postsynaptic hub protein DYNLL2 and glutamatergic transmission in oxytocin neurons in the hypothalamic paraventricular nucleus. Neuropeptides, 56:115-23, 2016.

Yamada H, Yoshida M, Ito K, Dezaki K, Yada T, Ishikawa SE, Kakei M.: Potentiation of Glucose-stimulated Insulin Secretion by the GPR40-PLC-TRPC Pathway in Pancreatic β-Cells. Scientific Reports 6:25912, 2016.

Nakata M, Yamamoto S, Okada T, Darambazar G, Okano H, Ozawa K, Yada T.: IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin. Int J Obes (Lond) 40(3):425-33, 2016.

Fujitsuka N, Asakawa A, Morinaga A, Amitani MS, Amitani H, Katsuura G, Sawada Y, Sudo Y, Uezono Y, Mochiki E, Sakata I, Sakai T, Hanazaki K, Yada T, Yakabi K, Sakuma E, Ueki T, Niijima A, Nakagawa K, Okubo N, Takeda H, Asaka M, Inui A.: Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1. Mol Psychiatry 21(11): 1613-1623, 2016.

【Review】
Kakei M, Yoshida M, Dezaki K, Ito K, Yamada H, Funazaki S, Kawakami M, Sugawara H, Yada T.: Glucose and GTP-binding protein-coupled receptor cooperatively regulate transient receptor potential-channels to stimulate insulin secretion. Endocr J. 2016 Jun 17. [Epub ahead of print]

Katsurada K, Yada T.: Neural effects of gut- and brain-derived glucagon-like peptide-1 and its receptor agonist. J Diabetes Investig. Suppl 1:64-9, 2016.


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Kimura H, Usui F, Karasawa T, Kawashima A, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Kasahara T, Suzuki K, Iwasaki Y, Yada T, Caturegli P, Takahashi M.: Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders. Scientific Reports 5: 15883, 2015.

Kurashina T, Dezaki K, Yoshida M, Rita RS, Ito K, Taguchi M, Miura R, Tominaga M, Ishibashi S, Kakei M, Yada T.: The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin. Scientific Reports, 5:14041, 2015.

Sasaki T, Kinoshita Y, Matsui S, Kakuta S, Yokota-Hashimoto H, Kinoshita K, Iwasaki Y, Kinoshita T, Yada T, Amano N, Kitamura T.: N-methyl D-aspartate receptor co-agonist D-serine suppresses intake of high-preference food. Am J Physiol Regul Integr Comp Physiol. 309(5):R561-75, 2015.

Kurita H, Xu KY, Maejima Y, Nakata M, Dezaki K, Santoso P, Yang Y, Arai T, Gantulga D, Muroya S, Lefor AK, Kakei M, Watanabe E, Yada T.: Arcuate Na+,K+-ATPase senses systemic energy states and regulates feeding behavior through glucose-inhibited neurons. Am J Physiol Endocrinol Metab. 309(4):E320-E333, 2015.

Iwasaki Y, Dezaki K, Kumari P, Kakei M, Yada T.: Ghrelin counteracts insulin-induced activation of vagal afferent neurons via growth hormone secretagogue receptor. Neuropeptides 52:55-60, 2015.

Kozuka C, Sunagawa S, Ueda R, Higa M, Ohshiro Y, Tanaka H, Shimizu-Okabe C, Takayama C, Matsushita M, Tsutsui M, Ishiuchi S, Nakata M, Yada T, Miyazaki JI, Oyadomari S, Shimabukuro M, Masuzaki H.: A novel insulinotropic mechanism of whole grain-derived γ-oryzanol via the suppression of local dopamine D2 receptor signaling in mouse islet. Br J Pharmacol. 172(18): 4519-34, 2015.

Kamiide Y, Inomata N, Furuya M, Yada T.: Ghrelin ameliorates catabolic conditions and respiratory dysfunction in a chronic obstructive pulmonary disease model of chronic cigarette smoke-exposed rats. Eur J Pharmacol. 755:88-94, 2015.

Kamiide Y, Furuya M, Inomata N, Yada T.: Chronic exposure to cigarette smoke causes extrapulmonary abnormalities in rats. Environ Toxicol Pharmacol. 39(2):864-870, 2015.

Maejima Y, Rita RS, Santoso P, Aoyama M, Hiraoka Y, Nishimori K, Gantulga D, Shimomura K, Yada T.: Nasal oxytocin administration reduces food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas. Neuroendocrinology, 101(1):35-44, 2015.

Iwasaki Y, Maejima Y, Suyama S, Yoshida M, Arai T, Katsurada K, Kumari P, Nakabayashi H, Kakei M, Yada T: Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: A route for ameliorating hyperphagia and obesity. Am J Physiol Regul Integr Comp Physiol, 308(5):R360-R369, 2015.

Darambazar G, Nakata M, Okada T, Wang L, Li E, Shinozaki A, Motoshima M, Mori M, Yada T: Paraventricular NUCB2/nesfatin-1 is directly targeted by leptin and mediates its anorexigenic effect. Biochem Biophys Res Commun, 456(4):913-918, 2015.

Ayush EA, Iwasaki Y, Iwamoto S, Nakabayashi H, Kakei M, Yada T: Glucagon directly interacts with vagal afferent nodose ganglion neurons to induce Ca2+ signaling via glucagon receptors. Biochem Biophys Res Commun. 456(3):727-732, 2015.

Rita R, Dezaki K, Kurashina T, Kakei M, Yada T.: Partial blockade of Kv2.1 channel potentiates GLP-1’s insulinotropic effects in islets and reduces its dose required for improving glucose tolerance in type 2 diabetic male mice. Endocrinology, 1(1):114-123, 2015

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Sedbazar U, Ayush EA, Maejima Y, Yada T.: Neuropeptide Y and α-melanocyte-stimulating hormone reciprocally regulate nesfatin-1 neurons in the paraventricular nucleus of hypothalamus. NeuroReport, 25(18):1453-1458, 2014.

Maejima Y, Sakuma K, Santoso P, Gantulga D, Katsurada K, Ueta Y, Hiraoka Y, Nishimori K, Tanaka S, Shimomura K, Yada T.: Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus. FEBS Letters, 588(23):4404-4412, 2014.

Katsurada K, Maejima Y, Nakata M, Kodaira M, Suyama S, Iwasaki Y, Kario K, Yada T.: Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding: Projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons. Biochem Biophys Res Commun. 451(2):276-281, 2014.

Yoshida M, Dezaki K, Uchida K, Kodera S, Lam N, Ito K, Rita R, Yamada H, Shimomura K, Ishikawa S, Sugawara H, Kawakami M, Tominaga M, Yada T, Kakei M.: Involvement of cAMP-EPAC-TRPM2 activation in glucose- and incretin-induced insulin secretion. Diabetes 63(10):3394-403, 2014.

Yanagida K, Maejima Y, Santoso P, Otgon-Uul Z, Yang Y, Sakuma K, Shimomura K, Yada T.: Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca2+ response to glucose. Aging (Albany NY) 6(3):207-214, 2014.

Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M.: NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of Inflammasomes. J Immunol 192(9):4342-4351, 2014.

Koizumi M, Hosoya Y, Dezaki K, Yada T, Hosoda H, Kangawa K, Nagai H, Lefor AT, Sata N, Yasuda Y: Serum ghrelin levels partially recover with the recovery of appetite and food intake after total gastrectomy. Surg Today 44(11):2131-2137, 2014.

Kawamata R, Suzuki Y, Yada Y, Koike Y, Kono Y, Yada T, Takahashi N: Gut hormone profiles in preterm and term infants during the first 2 months of life. J Pediatr Endocrinol Metab. 27(7-8):717-723, 2014.

Uramura K, Maejima Y, Shimomura K, Santoso P, Katsuda S, Kobayashi D, Jodo E, Kodaira M, Otgon-Uul Z, Yang Y, Sakuma K, Takigawa M, Hazama A, Yada T: Chronic phencyclidine treatment induces long-lasting glutamatergic activation of VTA dopamine neurons. Neuroscience Letters 564C:72-77, 2014.

Ishizuka Y, Nakayama K, Ogawa A, Makishima S, Boonvisut S, Hirao A, Iwasaki Y, Yada T, Yanagisawa Y, Miyashita H, Takahashi M, Iwamoto S: TRIB1 down-regulates hepatic lipogenesis and glycogenesis via multiple molecular interactions. J Mol Endocrinol 52(2):145-58, 2014.


【Review】
Yada T, Damdindorj B, Rita RS, Kurashina T, Ando A, Taguchi M, Koizumi M, Sone H, Nakata M, Kakei M, Dezaki K.: Ghrelin signalling in β-cells regulates insulin secretion and blood glucose. Diabetes Obes Metab. Suppl 1:111-117, 2014.

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Maekawa F, Fujiwara K, Toriya M, Maejima Y, Nishio T, Toyoda Y, Nohara K, Yashiro T, Yada T: Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto-Kakizaki rats. Front Synaptic Neurosci 5(7):1-13, 2013.

Manaka K, Nakata M, Shimomura K, Rita RS, Maejima Y, Yoshida M, Dezaki K, Kakei M, Yada T.: Chronic exposure to valproic acid promotes insulin release, reduces KATP channel current and does not affect Ca2+ signaling in mouse islets. J Physiol Sci 64(1):77-83, 2013.

Maejima Y, Shimomura K, Sakuma K, Yang Y, Arai T, Mori M, Yada T: Paraventricular nucleus nesfatin-1 neurons are regulated by pituitary adenylate cyclase-activating polypeptide (PACAP). Neuroscience Letters 551:39-42, 2013.

Iwasaki Y, Shimomura K, Kohno D, Dezaki K, Ayush EA, Nakabayashi H, Kubota N, Kadowaki T, Kakei M, Nakata M, Yada T.: Insulin activates vagal afferent neurons including those innervating pancreas via insulin cascade and Ca2+ influx: its dysfunction in IRS2-KO mice with hyperphagic obesity. PLoS ONE 8(6):e67198, 2013.

Arai T, Maejima Y, Muroya S, Yada T.: Rikkunshito and isoliquiritigenin counteract 5-HT-induced 2C receptor-mediated activation of pro-opiomelanocortin neurons in the hypothalamic arcuate nucleus. Neuropeptides 47(4):225-30, 2013.

Iwata T, Nakada T, Toyoda F, Yada T, Shioda S, Kikuyama S.: Responsiveness of vomeronasal cells to a newt peptide pheromone, sodefrin as monitored by changes of intracellular calcium concentrations. Peptides 45C:15-21, 2013.

Sedbazar U, Maejima Y, Nakata M, Mori M, Yada T.: Paraventricular NUCB2/nesfatin-1 rises in synchrony with feeding suppression during early light phase in rats. Biochem Biophys Res Commun 434(3):434-438, 2013.

Yang Y, Shimomura K, Sakuma K, Maejima Y, Iwasaki Y, Galvanovskis J, Dezaki K, Nakata M, Yada T.: Bupropion can close KATP channel and induce insulin secretion. J Pediatr Endocrinol Metab 26(3-4): 343-346, 2013.

Takei M, Dezaki K, Ishii H, Nishio SI, Sato Y, Suzuki S, Yada T, Komatsu M: A new experimental model of ATP-sensitive K+ channel-independent insulinotropic action of glucose: a permissive role of cAMP for triggering of insulin release from rat pancreatic β-cells. Endocr J 60(5):599-607, 2013.

Aoki H, Nakata M, Dezaki K, Lu M, Gantulga D, Yamamoto K, Shimada K, Kario K, Yada T: Ghrelin counteracts salt-induced hypertension via promoting diuresis and renal nitric oxide production in Dahl rats. Endocr J 60(5): 571-581, 2013.

Yamato-Kodera S, Yoshida M, Dezaki K, Yada T, Murayama T, Kawakami M, Kakei M: Inhibition of insulin secretion from rat pancreatic islets by dexmedetomidine and medetomidine, two sedatives frequently used in clinical settings. Endocr J 60(3): 337-346, 2013.

Iwasaki Y, Kakei M, Nakabayashi H, Ayush EA, Hirano-Kodaira M, Maejima Y, Yada T: Pancreatic polypeptide and peptide YY3-36 induce Ca2+ signaling in nodose ganglion neurons. Neuropeptides 47(1): 19-23, 2013.


【Review】
Nakata M, Yada T.: Role of NUBC2/Nesfatin-1 In glucose control: diverse functions in islets, adipocytes and brain. Curr Pharm Des 19(39)6960-6965, 2013.

Mori M, Yamada M, Okada S, Hashimoto K, Satoh T, Shimizu H, Yada T.: Discovery of nesfatin-1 and overview of biological actions and new developments. Curr Pharm Des 19(39)6921-6928, 2013.


【Book】
Dezak K, Boldbaatar D, Kurashina T, Yada T: Ghrelin’s novel signaling in islet b-cells to inhibit insulin secretion and its blockade as a promising strategy to treat type 2 diabetes. In: Ghrelin in Health and Disease, Springer Science+Business Media, New York, 2013, p51-71

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Damdindorj B, Dezaki K, Kurashina T, Sone H, Rita R, Kakei M, Yada T: Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet β-cells. FEBS Lett 586(16): 2555-2562, 2012.

Gantulga D, Maejima Y, Nakata M, Yada T: Glucose and insulin induce Ca2+ signaling in nesfatin-1 neurons in the hypothalamic paraventricular nucleus. Biochem Biophys Res Commun 420(4): 811-815, 2012.


【Review】
Dezaki K, Yada T: Islet β-cell ghrelin signaling for inhibition of insulin secretion. In: Methods in Enzymology, 514: 317-331, 2012

Iwasaki Y, Yada T: Vagal afferents sense meal-associated gastrointestinal and pancreatic hormones: mechanism and physiological role. Neuropeptides 46(6): 291-297, 2012.

Kohno D, Yada T: Arcuate NPY neurons sense and integrate peripheral metabolic signals to induce feeding. Neuropeptides 46(6): 315-319, 2012.

Yada T, Kohno D, Maejima Y, Sedbazar U, Arai T, Toriya M, Maekawa F, Kurita H, Niijima A, Yakabi K: Neurohormones, rikkunshito and hypothalamic neurons interactively control appetite and anorexia. Curr Pharm Des 18:4854-4864, 2012.

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Maejima Y, Iwasaki Y, Yamahara Y, Kodaira M, Sedbazar U, Yada T: Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging (Albany NY) 3(12): 1169-1177, 2011.

Maejima Y, Kohno D, Iwasaki Y, Yada T: Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y neurons of the hypothalamic arcuate nucleus. Aging (Albany NY) 3(11): 1092-1097, 2011.

Fujitsuka N, Asakawa A, Uezono Y, Minami K, Yamaguchi T, Niijima A, Yada T, Maejima Y, Sedbazar U, Sakai T, Hattori T, Kase Y, Inui A: Potentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival. Translational Psychiatry 1: e23, 2011.

Dezaki K, Boldbataar D, Sone H, Dyachok O, Tengholm A, Gylfe E, Kurashina T, Yoshida M, Kakei M, Yada T: Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells. Diabetes 60(9): 2315-2324, 2011.

Eiki J, Yada T: Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia. Endocr J 58(8): 691-698, 2011.

Kohno D, Sone H, Tanaka S, Kurita H, Gantulga D, Yada T: AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats. Neuroscience Letters 499: 194-198, 2011.

Koizumi M, Hosoya Y, Dezaki K, Yada T, Hosoda H, Kangawa K, Nagai H, Lefor AT, Sata N, Yasuda Y: Postoperative weight loss does not resolve after esophagectomy despite normal serum ghrelin levels. Ann Thorac Surg 91(4): 1032-1037, 2011.

Cao Y, Nakata M, Okamoto S, Takano E, Yada T, Minokoshi Y, Hirata Y, Nakajima K, Iskandar K, Hayashi Y, Oki M, Zhang C, Tateya S, Inoue H, Sunden Y, Sawa H, Ogawa W, Barsh GS, Hosoda H, Kangawa K, Itoh H, Noda T, Kasuga M, Nakae J: PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. PLoS ONE 6(4)e18324, 1-14, 2011

Nakata M, Manaka K, Yamamoto S, Mori M, Yada T: Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca2+ influx through L-type channels in mouse islet β-cells. Endocr J 58(4): 305-313, 2011.

Endo T, Maekawa F, Võikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M: Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage. Behav Brain Res 221(1): 172-181, 2011.

Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori Y, Yada T, Minokoshi Y, Tominaga M: Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes 60(1): 119-126, 2011.

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Yoshida N., Maejima Y., Sedbazar U., Ando A., Kurita H., Damdindorj B., Takano E., Gantulga D., Iwasaki Y., Kurashina T., Onaka T., Dezaki K., Nakata M., Mori M., Yada T.: Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis. Aging (Albany NY) 2(11):775-784 ,2010.

Toriya M., Maekawa F., Maejima Y., Onaka T., Fujiwara K., Nakagawa T., Nakata M., Yada T.: Long-term infusion of brain-derived neurotrophic factor reduces food intake and body weight via a corticotropin-releasing hormone pathway in the paraventricular nucleus of the hypothalamus. Journal of Neuroendocrinology 22(9):987-995, 2010.

Nakata M., Shintani N., Hashimoto H., Baba A., Yada T.: Intra-islet PACAP protects pancreatic β-cells against glucotoxicity and lipotoxicity. J. Mol. Neurosci. 42(3):404-410, 2010.

Yoshida M., Nakata M., Yamato S., Dezaki K., Sugawara H., Ishikawa S.E., Kawakami M., Yada T., Kakei M.: Voltage-dependent metabolic regulation of Kv2.1 channels in pancreatic β-cells. Biochem. Biophys. Res. Commun. 396(2):304-309, 2010.

Koizumi M., Dezaki K., Hosoda H., Damdindorj B., Sone H., Ming L., Hosoya Y., Sata N., Kobayashi E., Kangawa K., Nagai H., Yasuda Y., Yada T.: Reconstruction-dependent recovery from anorexia and time-related recovery of regulatory ghrelin system in gastrectomized rats. International J. Peptides 2010:10page, 2010.

Iskandar K., Cao Y., Hayashi Y., Nakata M., Takano E., Yada T., Zhang C., Ogawa W.M.D., Oki M., Chua S.Jr., Itoh H., Noda T., Kasuga M., Nakae J.: PDK1/ FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. Am. J. Physiol. Endocrinol. Metab. 298:E787-E798, 2010.

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Mori S., Takizawa M., Satou M., Sakasai M., Kusuoku H., Nojiri H., Yoshizuka N., Hotta M., Kitahara T., Hase T., Takema Y., Saito M., Yada T.: Enhancement of lipolytic responsiveness of adipocytes by novel plant extract in rat. Exp. Biol. Med. (Maywood) 234:1445-1449, 2009.

Maejima Y., Sedbazar U., Suyama S., Kohno D., Onaka T., Takano E., Yoshida N., Koike M., Uchiyama Y., Fujiwara K., Yashiro T., Horvath T.L., Dietrich M.O., Tanaka S., Dezaki K., Oh-I S., Hashimoto K., Shimizu H., Nakata M., Mori M., Yada T.: Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metabolism 10: 355-365, 2009.

Iwasaki Y., Nakabayashi H., Kakei M., Shimizu H., Mori M., Yada T.: Nesfatin-1 evokes Ca2+ signaling in isolated vagal afferent neurons via Ca2+ influx through N-type channels. Biochem. Biophys. Res. Commun. 390: 958-962, 2009.

Yoshida M., Dezaki K., Yamato S., Aoki A., Sugawara H., Toyoshima H., Ishikawa S.E., Kawakami M., Nakata M., Yada T., Kakei M.: Regulation of voltage-gated K+ channels by glucose metabolism in pancreatic β-cells. FEBS Lett. 583: 2225-2230, 2009.

Eiki J., Saeki K., Nagano N., Iino T., Yonemoto M., Takayenoki-Iino Y., Ito S., Nishimura T., Sato Y., Bamba M., Watanabe H., Sasaki K., Ohyama S., Kanatani A., Nagase T., Yada T.: A selective small molecule GLP-1 secretagogue acting via depolarization and Ca2+ influx. J. Endocrinology 201: 361-367, 2009.

Mori S., Satou M., Kanazawa S., Yoshizuka N., Hase T., Tokimitsu I., Takema Y., Nishizawa Y., Yada T.: Body fat mass reduction and up-regulation of uncoupling protein by novel lipolysis-promoting plant extract. Int. J. Biol. Sci. 5: 311-318, 2009.

Shimizu H., Oh-I S., Hashimoto K., Nakata M., Yamamoto S., Yoshida N., Eguchi H., Kato I., Inoue K., Satoh T., Okada S., Yamada M., Yada T., Mori M.: Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism. Endocrinology 150: 662-671, 2009.

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Takayanagi Y., Matsumoto H., Nakata M., Mera T., Fukusumi S., Hinuma S., Ueta Y., Yada T., Leng G., Onaka T.: Endogenous prolactin-releasing peptide regulates food intake in rodents. J. Clin. Invest. 118: 4014-4024, 2008.

Kohno D., Suyama S., Yada T.: Leptin transiently antagonizes ghrelin and long-lastingly orexin in regulation of Ca2+ signaling in neuropeptide Y neurons of the arcuate nucleus. World J. Gastroenterol. 14: 6347-6354, 2008.

Tomimoto S., Ojika T., Shintani N., Hashimoto H., Hamagami K., Ikeda K., Nakata M., Yada T., Sakurai Y., Shimada T., Morita Y., Ishida C., Baba A.: Markedly reduced white adipose tissue and increased insulin sensitivity in Adcyap1-deficient mice. J. Pharmacological Sciences 107: 41-48, 2008.

Koizumi M, Yada T.: Sub-chronic stimulation of glucocorticoid receptor impairs and mineralcorticoid receptor protects cytosolic Ca2+ responses to glucose in pancreatic β-cells. J. Endocrinology 197: 221-229, 2008.

Kohno D., Nakata M., Maejima Y., Shimizu H., Sedbazar U., Yoshida N., Dezaki K., Onaka T., Mori M., Yada T.: Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology 149: 1295-1301, 2008.

Kohno D., Sone H., Minokoshi Y., Yada T.: Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons. Biochem. Biophys. Res. Commun. 366: 388-392, 2008


【Reviw】
Dezaki K., Sone H., Yada T.: Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis. Pharmacol. Ther. 118:239-249, 2008.

Yada T., Dezaki K., Sone H., Koizumi M., Damdindorj B., Nakata M., Kakei M.: Ghrelin regulates insulin release and glycemia: Physiological role and therapeutic potential. Curr. Diab. Rev. 4:18-23, 2008.

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Iwasaki H., Yada T.: Protein arginine methylation regulates insulin signaling in L6 skeletal muscle cells. Biochem. Biophys. Res. Commun. 364: 1015-1021, 2007.

Dezaki K., Kakei M., Yada T.: Ghrelin uses Gαi2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet β-cells: novel signal transduction of ghrelin. Diabetes 56: 2319-2327, 2007.

Maekawa F., Nakamori T., Uchimura M., Fujiwara K., Yada T., Tsukahara S., Kanamatsu T., Tanaka K., Ohki-Hamazaki H.: Activation of cholecystokinin neurons in the dorsal pallium of the telencephalon is indispensable for the acquisition of chick imprinting behavior. Journal of Neurochemistry 102: 1645-1657, 2007.

Fujiwara K., Maekawa F., Dezaki K., Nakata M., Yashiro T., Yada T.: Oleic acid glucose-independently stimulates glucagon secretion by increasing cytoplasmic Ca2+ via ER Ca2+ release and Ca2+ influx in the rat islet α-cells. Endocrinology 148: 2496-2504, 2007.

Kohno D., Nakata M., Maekawa F., Fujiwara K., Maejima Y., Kuramochi M., Shimazaki T., Okano H., Onaka T., Yada T.: Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway. Endocrinology 148: 2251-2263, 2007.

Nakata M., Okada T., Ozawa K., Yada T.: Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release. Biochem. Biophys. Res. Commun. 353: 1046-1051, 2007.

Fujiwara K., Maekawa F., Kikuchi M., Takigami S., Yada T., Yashiro T: Expression of retinaldehyde dehydrogenase (RALDH)2 and RALDH3 but not RALDH1 in the developing anterior pituitary glands of rats. Cell Tissue Res. 328: 129-135, 2007.


【Review】

Nakata M, Yada T.: PACAP in the glucose and energy homeostasis: physiological role and therapeutic potential. Curr. Pharm. Des. 13:1105-1112. 2007.

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Oomura Y., Hori N, Shiraishi T., Fukunaga K., Takeda H., Tsuji M., Matsumiya T., Ishibashi M., Aou S., Li X.L., Kohno D., Uramura K., Sougawa H., Yada T., Wayner M.J., Sasaki K.: Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. Peptides 27: 2738-2749, 2006.

Momose K., Nunomiya S., Nakata M., Yada T., Kikuchi M., Yashiro T.: Immunohistochemical and electron-microscopic observation of β-cells in pancreatic islets of spontaneously diabetic Goto-Kakizaki rats. Med. Mol. Morphol. 39: 146-153, 2006.

Dezaki K., Sone H., Koizumi M., Nakata M., Kakei M., Nagai H., Hosoda H., Kangawa K., Yada T: Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes 55: 3486-3493, 2006.

Maekawa F., Fujiwara K., Kohno D., Kuramochi M., Kurita H., Yada T: Young adult-specific hyperphagia in diabetic Goto-Kakizaki rats is associated with leptin resistance and elevation of neuropeptide Y mRNA in the arcuate nucleus. J. Neuroendocrinology 18: 748-756, 2006.

Nakata M., Nagasaka S., Kusaka I., Matsuoka H., Ishibashi S., Yada T.: Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4) : implication in glycaemic control. Diabetologia 49: 1881-1892, 2006.

Kuramochi M., Onaka T., Kohno D., Kato S., Yada T.: Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rats. Endocrinology 147: 1744-1752, 2006.

Maekawa F., Fujiwara K., Tsukahara S., Yada T.: PACAP neurons of the ventromedial hypothalamus project to midbrain central gray. Neuroreport 17:221-224, 2006.

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Ikeda Y., Iguchi H., Nakata M., Ioka R.X., Tanaka T., Iwasaki S., Magoori K., Takayasu S., Yamamoto T.T., Kodama T., Yada T., Sakurai T., Yanagisawa M., Sakai J.: Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues. Biochem. Biophys. Res. Commun. 333: 778-786, 2005.

Nakata M., Maruyama I., Yada T.: Leptin potentiates ADP-induced Ca2+ increase via JAK2 and tyrosine kinases in a megakaryoblast cell line. Diabetes Res. Clin. Pract. 70: 209-216, 2005.

Fujiwara K., Maekawa F., Yada T.: Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet β-cells: mediation by phospholipase C and L-type Ca2+ channel and link to insulin release. Am. J. Physiol. (Endocrinol. Metab.) 289: E670-677, 2005.

Muroya S., Funahashi H., Uramura K., Shioda S., Yada T.:GABA regulates glucosensitive NPY neurons in arcuate nucleus via A/B receptors. Neuroreport 16: 897-901, 2005.

Onaka T., Kuramochi M., Saito J., Ueta Y., Yada T.: Galanin-like peptide stimulates vasopressin, oxytocin and ACTH release in rats. Neuroreport 16: 243-247, 2005.

Fujiwara K., Matsumoto H., Yada T., Inoue K.: Identification of the prolactin-releasing peptide-producing cell in the rat adrenal gland. Regulatory Peptides 126: 97-102, 2005.

Kuramochi M., Kohno D., Kato S., Yada T.: Galanin-like peptide and ghrelin increases cytosolic Ca2+ in neurons containing growth hormone-releasing hormone in the arcuate nucleus. Regulatory Peptides 126: 85-89, 2005.

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Dezaki K., Hosoda H., Kakei M., Hashiguchi S., Watanabe M., Kangawa K., Yada T.: Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in β-cells: implication in the glycemic control in rodents. Diabetes 53: 3142-3151, 2004.

Nakata M., Kohno D., Shintani N., Nemoto Y., Hashimoto H., Baba A., Yada T.: PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus. Neruoscience Lett. 370: 252-256, 2004.

Yamada H., Watanabe M., Yada T.: Cytosolic Ca2+ responses to sub-picomolar and nanomolar PACAP in pancreatic β-cells are mediated by VPAC2 and PAC1 receptors. Regulatory Peptides 123: 147-153, 2004.

Muroya S., Funahashi H., Yamanaka A., Kohno D., Uramura K., Nambu T., Shibahara M., Kuramochi., M, Takigawa M., Yanagisawa M., Sakurai T., Shioda S., Yada T.: Orexins (Hypocretins) directly interacts with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: Orexigenic neuronal pathways in the mediobasal hypothalamus. Eur. J. Neurosci. 19,1524-1534, 2004.

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Rokkaku K., Onaka T., Okada N., Ideno J., Kawakami A., Honda K., Yada T., Ishibashi S.: Neuromedin U facilitates oxytocin release from the pituitary via β adrenoceptors. Neuroreport 14: 1997-2000, 2003.

Nakata M., Yada T.: Nitric oxide-mediated insulin secretion in response to citrulline in islet β-cells. Pancreas 27: 209-213, 2003.

Zhu Y., Miwa Y., Yamanaka A., Yada T., Shibahara M., Abe Y., Sakurai T., Goto K.: Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. J. Pharmacol. Sci. 92: 259-266, 2003.

Kohno D., Gao H.G., Muroya S., Kikuyama S., Yada T.: Ghrelin directly interacts with NPY-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A- and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52: 948-956, 2003.

【Review】
Funahashi H., Takenoya F., Guan J.L., Kageyama H., Yada T., Shioda S.: Hypothalamic neuronal networks and feeding-related peptides involved in the regulation of feeding. Anat. Sci. Int. 78:123-138, 2003.

Funahashi H., Yada T., Suzuki R., Shioda S.: Distribution, function, and properties of leptin receptors in the brain. Int. Rev. Cytol. 224:1-27, 2003.

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Kakei M., Yada T., Nakagawa A., Nakabayashi H.: Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca2+ in rat nodose ganglion neurons. Auton. Neuroscience 102: 39-44, 2002.

Zhou C.J., Shioda S., Yada T., Inagaki N., Pleasure S.J., Kikuyama S.: PACAP and its receptors exert pleiotropic effects in the nervous system by activating multiple signaling pathways. Current Protein and Peptide Sci. 3: 423-439, 2002.

Zhu L., Onaka T., Sakurai T., Yada T.: Activation of orexin neurons after noxious but not conditioned fear stimuli in rats. Neuroreport 19: 1351-1353, 2002.

Nakazaki M., Kakei M., Ishihara H., Koriyama N., Hashiguchi H., Aso K., Fukudome M., Oka Y., Yada T., Tei C.: Association of upregulated activity of K(ATP) channels with impaired insulin secretion in UCP1-expressing insulinoma cells. J. Physiol. (Lond.) 540: 781-789, 2002.

Yamada S., Komatsu M., Aizawa T., Sato Y., Yajima H., Yada T., Hashiguchi S., Yamauchi K., Hashizume K.: Time-dependent potentiation of the β-cell is a Ca2+-independent phenomenon. J. Endocrinol. 172: 345-354, 2002.

Date Y., Nakazato M., Hashiguchi S., Dezaki K., Mondal M.S., Hosoda H., Kojima M., Kangawa K., Arima T., Matsuo H., Yada T., Matsukura S.: Ghrelin is present in pancreatic α-cells of humans and rats and stimulates insulin secretion. Diabetes 51: 124-129, 2002.

Yanagida K., Yaekura K., Arima T., Yada T.: Glucose-insensitivity induced by Ca2+ toxicity in islet β-cells and its prevention by PACAP. Peptides 23: 135-142, 2002.

【Review】
Zhou C.J., Shioda S., Yada T., Inagaki N., Pleasure S.J., Kikuyama S.: PACAP and its receptors exert pleiotropic effects in the nervous system by activating multiple signaling pathways. Current Protein and Peptide Science 3:423-439, 2002.

【Book】
Shioda S., Zhou C.J., Ohtaki H., Yada T.: PACAP receptor signaling. In: Pituitary Adenylate Cyclase-Activating Polypeptide. Vaudry H and Arimura A (eds), Kluwer Academic Publishers, Massachusetts, USA, 2002, p95-124

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Aizawa T., Kaneko T., Yamauchi K., Yajima H., Nishizawa T., Yada T., Matsukawa H., Nagai M., Yamada S., Sato Y., Komatsu M., Itoh N., Hidaka H., Kajimoto Y., Hashizume K.: Size-related and size-unrelated functional heterogeneity among pancreatic islets. Life Sciences 69: 2627-2639, 2001.

Koriyama N., Kakei M., Nakazaki M., Yaekura K., Hashiguchi H., Aso K., Fukudome M., Yada T., Ito S., Tei C.: Free radical-mediated tolbutamide desensitization of K+ATP channels in rat pancreatic β-cells. Endocr. J. 48: 337-344, 2001.

Muroya S., Uramura K., Sakurai T., Takigawa M., Yada T.: Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus. Neuroscience Lett. 309, 165-168, 2001.

Zhou C.J., Yada T., Kohno D., KikuyamaS., Suzuki R., Mizushima H., Shioda S.: PACAP activates PKA, PKC and Ca2+ signaling cascades in rat neuroepithelial cells. Peptides 22: 1111-1117, 2001.

Uramura K., Funahashi H., Muroya S., Shioda S., Takigawa M., Yada T.: Orexin-A activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area. Neuroreport 12: 1885-1889, 2001.

Hashiguchi S., Yada T., Arima T.: A new hypoglycemic agent, JTT-608, evokes PKA-mediated Ca2+ signaling in rat islet β-cells: strict regulation by glucose, link to release insulin and cooperation with GLP-1 and PACAP. J. Pharmacol. Exp. Therapeut. 296: 22-30, 2001.

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Shioda S., Yada T., Muroya S., Uramura S., Nakajo S., Ohtaki H., Hori T., Shimoda Y., Funahashi H.: Functional significance of colocalization of PACAP and catecholamine in nerve terminals. Ann. New York Acad. Sci. 921: 211-217, 2000.

Yada T., Nakata M., Shioda S.: Insulinotropin PACAP potentiates insulin action: stimulation of glucose uptake in 3T3-LI adipocytes. Ann. New York Acad. Sci. 921: 473-477, 2000.

Arahira S., Kusao M., Shioda S., Yada T.: PACAP activates pancreatic β-cells in a glucose-independent manner. Ann. New York Acad. Sci. 921: 438-442, 2000.

Yada T., Sakurada M., Filipsson K., Kikuchi M., Ahren B.: Intraperitoneal PACAP administration decreases blood glucose in GK rats, normal and high-fat diet mice. Ann. New York Acad. Sci. 921: 259-263, 2000.

Uramura K., Yada T., Muroya S., Takigawa M.: Ca2+ oscillations in response to methamphetamine in dopamine neurons of the ventral tegmental area in rats subchronically treated with this drug. Ann. New York Acad. Sci. 914: 316-322, 2000.

Koriyama N., Kakei M., Nakazaki M., Yaekura K., Ichinari K., Yada T., Tei C.: PIP2 and ATP cooperatively prevent cytosolic Ca2+-induced modification of ATP-sensitive K+ channels in rat pancreatic β-cells. Diabetes 49: 1830-1839, 2000.

Nakazaki M., Kakei M., Yaekura K., Koriyama N., Morimitsu S., Ichinari K., Yada T., Tei C.: Diverse effects of hydrogen peroxide on cytosolic Ca2+ homeostasis in rat pancreatic β-cells. Cell Struct. Function 25: 187-193, 2000.

Nakamura T., Uramura K., Nambu T., Yada T., Goto K., Yanagisawa M., Sakurai T.: Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system. Brain Res. 873: 181-187, 2000.

Uramura K., Yada T., Muroya S., Shioda S., Shiratani T., Takigawa M.: Methamphetamine induces cytosolic Ca2+ oscillations in the VTA dopamine neurons. Neuroreport 11: 1057-1061, 2000.

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