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自治医科大学 医学部
生理学講座
統合生理学部門

〒329-0498
栃木県下野市薬師寺
3311-1
TEL 0285-58-7320
FAX 0285-44-9962

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論   文 受   賞 特   許

2000 2001 2002 2003 2004 2005 2006 2007 2008 2009
2010 2011 2012 2013 2014 2015 2016 2017



 2017年

原著論文
  1. Suyama S, Ralevski A, Liu ZW, Dietrich MO, Yada T, Simonds SE, Cowley MA, Gao XB, Diano S, Horvath TL.: Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons. Elife 6: e25755, 2017.
  2. Iwasaki Y, Goswami C, Yada T.: Glucagon-like peptide-1 and insulin synergistically activate vagal afferent neurons. Neuropeptides May 25, 2017.[Epub ahead of print]
  3. Yoshii Y, Inoue T, Uemura Y, Iwasaki Y, Yada T, Nakabeppu Y, Noda M.: Complexity of Stomach–Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice. Neurochem Res. May 2, 2017. [Epub ahead of print]
  4. Sasanuma H, Nakata M, Kumari P, Nakae J, Yada T.: PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis. Mol Metab. 6(5):428-39, 2017.
  5. Suyama S, Lei W, Kubota N, Kadowaki T, Yada T.: Adiponectin at physiological level glucose-independently enhances inhibitory postsynaptic current onto NPY neurons in the hypothalamic arcuate nucleus. Neuropeptides March, 2017.[Epub ahead of print]
  6. Santoso P, Nakata M, Shiizaki K, Boyang Z, Parmila K, Otgon-Uul Z, Hashimoto K, Satoh T, Mori M, Kuro-O M, Yada T.: Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states. Scientific reports 7:45819, 2017.
  7. Santoso P, Nakata M, Ueta Y, Toshihiko Yada T.: Suprachiasmatic Vasopressin to Paraventricular Oxytocin Neurocircuit in the Hypothalamus Relays Light Reception to Inhibition of Feeding Behavior. Am J Physiol Endocrinol Metab. Feb 7, 2017. [Epub ahead of print]
  8. Nakata M, Yamamoto S, Okada T, Yada T.: AAV-mediated IL-10 gene transfer counteracts inflammation in the hypothalamic arcuate nucleus and obesity induced by high-fat diet. Neuropeptides 62: 87-92, 2017.
  9. Ito K, Dezaki K, Yoshida M, Yamada H, Miura R, Rita RS, Ookawara S, Tabei K, Kawakami M, Hara K, Morishita Y, Yada T, Kakei M.: Endogenous α2A-Adrenoceptor-Operated Sympathoadrenergic Tones Attenuate Insulin Secretion via cAMP/TRPM2 Signaling. Diabetes 66(3):699-709, 2017

総説
  1. 矢田俊彦:オキシトシンでやせるのは本当ですか?Clinical Neuroscience、35(5), 629, 2017
  2. 岩﨑有作、矢田俊彦:食関連ホルモンの求心性迷走神経を介した情報伝達による摂食調節機構.実験医学、35(6), 917-925, 2017
  3. 山田祐一郎(司会)、矢田俊彦、中川淳:血糖コントロールに自律神経はどのように関与しているのか.(座談会)Diabetes Strategy、7(1), 5-17, 2017

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 2016年

原著論文
  1. Nakata M, Zhang B, Yang Y, Okada T, Shintani N, Hashimoto H, Yada T.: High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance. J Diabetes Res. 9321395, 2016.
  2. Kohno D, Koike M, Ninomiya Y, Kojima I, Kitamura T, Yada T.: Sweet Taste Receptor Serves to Activate Glucose- and Leptin-Responsive Neurons in the Hypothalamic Arcuate Nucleus and Participates in Glucose Responsiveness. Front Neurosci. 10:502, 2016.
  3. Kimura H, Karasawa T, Usui F, Kawashima A, Endo Y, Kobayashi M, Sadatomo A, Nakamura J, Iwasaki Y, Yada T, Tsutsui H, Kasahara T, Takahashi M.: Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity.
    Am J Physiol Endocrinol Metab. 311(5):E881-E890, 2016.
  4. Suyama S, Maekawa F, Maejima Y, Kubota N, Kadowaki T, Yada T.: Glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding. Scientific Reports 6: 30796, 2016.
  5. Li E, Nakata M, Shinozaki A, Yang Y, Zhang B, Yada T.: Betatrophin expression is promoted in obese hyperinsulinemic type 2 but not type 1 diabetic mice. Endocr J. 63(7): 611-9, 2016.
  6. Otogon-Uul Z, Suyama S, Onodera H, Yada T.: Optogenetic activation of leptin-and glucose-regulated GABAergic neurons in dorsomedial hypothalamus promotes food intake via inhibitory synaptic transmission to paraventricular nucleus of hypothalamus. Molecular Metabolism 5(8): 709-715, 2016.
  7. Nakata M, Gantulga D, Santoso P, Zhang B, Masuda C, Mori M, Okada T, Yada T.: Paraventricular NUCB2/nesfatin-1 supports oxytocin and vasopressin neurons to control feeding behavior and fluid balance in male mice. Endocrinology 157(6): 2322-32, 2016.
  8. Taguchi M, Dezaki K, Koizumi M, Kurashina K, Hosoya Y, Lefor AK, Sata N, Yada T.: Total gastrectomy-induced reductions in food intake and weight are counteracted by rikkunshito by attenuating glucagon-like peptide-1 elevation in rats. Surgery 159(5): 1342-50, 2016.
  9. Suyama S, Kodaira-Hirano M, Otgon-Uul Z, Ueta Y, Nakata M, Yada T.: Fasted/fed states regulate postsynaptic hub protein DYNLL2 and glutamatergic transmission in oxytocin neurons in the hypothalamic paraventricular nucleus. Neuropeptides 56: 115-23, 2016.
  10. Yamada H, Yoshida M, Ito K, Dezaki K, Yada T, Ishikawa SE, Kakei M.: Potentiation of Glucose-stimulated Insulin Secretion by the GPR40-PLC-TRPC Pathway in Pancreatic β-Cells. Scientific Reports 6: 25912, 2016.
  11. Nakata M, Yamamoto S, Okada T, Darambazar G, Okano H, Ozawa K, Yada T.: IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin. Int J Obes (Lond) 40(3): 425-33, 2016.
  12. Fujitsuka N, Asakawa A, Morinaga A, Amitani MS, Amitani H, Katsuura G, Sawada Y, Sudo Y, Uezono Y, Mochiki E, Sakata I, Sakai T, Hanazaki K, Yada T, Yakabi K, Sakuma E, Ueki T, Niijima A, Nakagawa K, Okubo N, Takeda H, Asaka M, Inui A.: Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1. Mol Psychiatry 21(11):1613-1623, 2016.

総説
  1. Kakei M, Yoshida M, Dezaki K, Ito K, Yamada H, Funazaki S, Kawakami M, Sugawara H, Yada T.: Glucose and GTP-binding protein-coupled receptor cooperatively regulate transient receptor potential-channels to stimulate insulin secretion. Endocr J. 63(10):867-876, 2016.
  2. Katsurada K, Yada T.: Neural effects of gut- and brain-derived glucagon-like peptide-1 and its receptor agonist. J Diabetes Investig. Suppl 1:64-9, 2016.
  3. 前川文彦, 矢田俊彦:ストレスと肥満.Pharma Medica、34(5), 9-12, 2016
  4. 桂田健一, 矢田俊彦:インクレチンの神経系を介した多様な作用.最新医学、 71(1), 37-43, 2016

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 2015年

原著論文
  1. Kimura H, Usui F, Karasawa T, Kawashima A, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Kasahara T, Suzuki K, Iwasaki Y, Yada T, Caturegli P, Takahashi M.: Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders. Scientific Reports 5:15883, 2015.
  2. Nakata M, Yamamoto S, Okada T, Darambazar G, Okano H, Ozawa K, Yada T.: IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin. Int J Obes (Lond) 40(3):425-33, 2015.
  3. Kurashina T, Dezaki K, Yoshida M, Rita RS, Ito K, Taguchi M, Miura R, Tominaga M, Ishibashi S, Kakei M, Yada T.: The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin. Scientific Reports 5:14041, 2015.
  4. Suyama S, Kodaira-Hirano M, Otgon-Uul Z, Ueta Y, Nakata M, Yada T.: Fasted/fed states regulate postsynaptic hub protein DYNLL2 and glutamatergic transmission in oxytocin neurons in the hypothalamic paraventricular nucleus. Neuropeptides 56:115-23, 2015.
  5. Sasaki T, Kinoshita Y, Matsui S, Kakuta S, Yokota-Hashimoto H, Kinoshita K, Iwasaki Y, Kinoshita T, Yada T, Amano N, Kitamura T.: N-methyl D-aspartate receptor co-agonist D-serine suppresses intake of high-preference food. Am J Physiol Regul Integr Comp Physiol. 309(5):R561-75, 2015.
  6. Kozuka C, Sunagawa S, Ueda R, Higa M, Ohshiro Y, Tanaka H, Shimizu-Okabe C, Takayama C, Matsushita M, Tsutsui M, Ishiuchi S, Nakata M, Yada T, Miyazaki JI, Oyadomari S, Shimabukuro M, Masuzaki H.: A novel insulinotropic mechanism of whole grain-derived ɤ-oryzanol via the suppression of local dopamine D2 receptor signaling in mouse islet. Br J Pharmacol. 2015. [Epub ahead of print]
  7. Kurita H, Xu KY, Maejima Y, Nakata M, Dezaki K, Santoso P, Yang Y, Arai T, Gantulga D, Muroya S, Lefor AK, Kakei M, Watanabe E, Yada T.: Arcuate Na+,K+-ATPase senses systemic energy states and regulates feeding behavior through glucose-inhibited neurons. Am J Physiol Endocrinol Metab. 309(4):E320-E333, 2015.
  8. Iwasaki Y, Dezaki K, Kumari P, Kakei M, Yada T.: Ghrelin counteracts insulin-induced activation of vagal afferent neurons via growth hormone secretagogue receptor. Neuropeptides 52:55-60, 2015.
  9. Kamiide Y, Inomata N, Furuya M, Yada T.: Ghrelin ameliorates catabolic conditions and respiratory dysfunction in a chronic obstructive pulmonary disease model of chronic cigarette smoke-exposed rats. Eur J Pharmacol. 755:88-94, 2015.
  10. Kamiide Y, Furuya M, Inomata N, Yada T.: Chronic exposure to cigarette smoke causes extrapulmonary abnormalities in rats. Environ Toxicol Pharmacol. 39(2):864-870, 2015.
  11. Maejima Y, Rita RS, Santoso P, Aoyama M, Hiraoka Y, Nishimori K, Gantulga D, Shimomura K, Yada T.: Nasal oxytocin administration reduces food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas. Neuroendocrinology 101(1):35-44, 2015.
  12. Iwasaki Y, Maejima Y, Suyama S, Yoshida M, Arai T, Katsurada K, Kumari P, Nakabayashi H, Kakei M, Yada T: Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: A route for ameliorating hyperphagia and obesity. Am J Physiol Regul Integr Comp Physiol. 308(5):R360-R369, 2015.
  13. Darambazar G, Nakata M, Okada T, Wang L, Li E, Shinozaki A, Motoshima M, Mori M, Yada T: Paraventricular NUCB2/nesfatin-1 is directly targeted by leptin and mediates its anorexigenic effect. Biochem Biophys Res Commun. 456(4):913-918, 2015.
  14. Ayush EA, Iwasaki Y, Iwamoto S, Nakabayashi H, Kakei M, Yada T: Glucagon directly interacts with vagal afferent nodose ganglion neurons to induce Ca2+ signaling via glucagon receptors. Biochem Biophys Res Commun. 456(3):727-732, 2015.
  15. Rita R, Dezaki K, Kurashina T, Kakei M, Yada T.: Partial blockade of Kv2.1 channel potentiates GLP-1’s insulinotropic effects in islets and reduces its dose required for improving glucose tolerance in type 2 diabetic male mice. Endocrinology, 1(1):114-123, 2015
総説
  1. 前川文彦, 矢田俊彦:ストレスと食欲の制御分子と肥満.分子精神医学、15(3), 198-205, 2015
  2. 岩﨑有作、桂田健一、河野大輔、矢田俊彦:消化管ホルモンと迷走神経・中枢神経による摂食・代謝・生体恒常性調節.内分泌・糖尿病・代謝内科、41(1), 3-8, 2015.
  3. 前川文彦, 矢田俊彦:病態生理 糖尿病における中枢性摂食・代謝調節の破綻.最新医学3月増刊号、70, 517-523, 2015

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 2014年

原著論文
  1. Sedbazar U, Ayush EA, Maejima Y, Yada T.: Neuropeptide Y and α-melanocyte-stimulating hormone reciprocally regulate nesfatin-1 neurons in the paraventricular nucleus of hypothalamus. NeuroReport 25(18):1453-1458, 2014.
  2. Maejima Y, Sakuma K, Santoso P, Gantulga D, Katsurada K, Ueta Y, Hiraoka Y, Nishimori K, Tanaka S, Shimomura K, Yada T.: Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus. FEBS Letters, 588(23):4404-4412, 2014.
  3. Katsurada K, Maejima Y, Nakata M, Kodaira M, Suyama S, Iwasaki Y, Kario K, Yada T.: Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding: Projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons. Biochem Biophys Res Commun. 451(2):276-281, 2014.
  4. Yoshida M, Dezaki K, Uchida K, Kodera S, Lam N, Ito K, Rita R, Yamada H, Shimomura K, Ishikawa S, Sugawara H, Kawakami M, Tominaga M, Yada T, Kakei M.: Involvement of cAMP-EPAC-TRPM2 activation in glucose- and incretin-induced insulin secretion. Diabetes 63(10):3394-403, 2014.
  5. Yanagida K, Maejima Y, Santoso P, Otgon-Uul Z, Yang Y, Sakuma K, Shimomura K, Yada T.: Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca2+ response to glucose. Aging (Albany NY) 6(3):207-214, 2014.
  6. Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M.: NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of Inflammasomes. J Immunol 192(9):4342-4351, 2014.
  7. Koizumi M, Hosoya Y, Dezaki K, Yada T, Hosoda H, Kangawa K, Nagai H, Lefor AT, Sata N, Yasuda Y: Serum ghrelin levels partially recover with the recovery of appetite and food intake after total gastrectomy. Surg Today 44(11):2131-2137, 2014.
  8. Kawamata R, Suzuki Y, Yada Y, Koike Y, Kono Y, Yada T, Takahashi N: Gut hormone profiles in preterm and term infants during the first 2 months of life. J Pediatr Endocrinol Metab. 27(7-8):717-723, 2014.
  9. Uramura K, Maejima Y, Shimomura K, Santoso P, Katsuda S, Kobayashi D, Jodo E, Kodaira M, Otgon-Uul Z, Yang Y, Sakuma K, Takigawa M, Hazama A, Yada T: Chronic phencyclidine treatment induces long-lasting glutamatergic activation of VTA dopamine neurons. Neuroscience Letters 564C:72-77, 2014.
  10. Ishizuka Y, Nakayama K, Ogawa A, Makishima S, Boonvisut S, Hirao A, Iwasaki Y, Yada T, Yanagisawa Y, Miyashita H, Takahashi M, Iwamoto S: TRIB1 down-regulates hepatic lipogenesis and glycogenesis via multiple molecular interactions. J Mol Endocrinol 52(2):145-58, 2014.
  11. Manaka K, Nakata M, Shimomura K, Rita RS, Maejima Y, Yoshida M, Dezaki K, Kakei M, Yada T.: Chronic exposure to valproic acid promotes insulin release, reduces KATP channel current and does not affect Ca2+ signaling in mouse islets. J Physiol Sci 64(1):77-83, 2014.

総説
  1. Yada T, Damdindorj B, Rita RS, Kurashina T, Ando A, Taguchi M, Koizumi M, Sone H, Nakata M, Kakei M, Dezaki K.: Ghrelin signalling in β-cells regulates insulin secretion and blood glucose. Diabetes Obes Metab. Suppl 1:111-117, 2014.
  2. 中田正範、矢田俊彦:摂食調節機構と神経ペプチド.医学のあゆみ、250(9), 785-789, 2014
  3. 矢田俊彦、片桐秀樹:食いだおれないための臓器間ネットワーク―末梢臓器‐脳双方向情報連絡路と糖代謝・エネルギー代謝調節―.第57回日本糖尿病学会年次学術集会シンポジウム(座長)、DIABETES UPDATE、3(3), 50-53(185-161), 2014
  4. 小田原雅人(司会)、矢田俊彦、八木橋操六、村尾孝児(討論者):スタチンのベネフィットとリスクを考える.(座談会)Pnarma Medica、32(6), 116-125, 2014
  5. 前島裕子、矢田俊彦:オキシトシンの中枢神経作用.内分泌・糖尿病・代謝内科、39(1), 20-25, 2014
  6. 中田正範、矢田俊彦:摂食概日リズムと視床下部.アンチ・エイジング医学、10(2), 46-51, 2014
  7. 栗田英治、矢田俊彦:中枢グルコース感知と摂食調節機構.Diabetes Frontier、25(1), 40-45, 2014

著書
  1. 矢田俊彦:膵臓の内分泌機能と炭水化物代謝の調節(翻訳). In ギャノング生理学.原書24版 岡田泰伸(監訳)、丸善、東京、495-520、2014

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 2013年

原著論文
  1. Maekawa F, Fujiwara K, Toriya M, Maejima Y, Nishio T, Toyoda Y, Nohara K, Yashiro T, Yada T: Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto-Kakizaki rats. Front Synaptic Neurosci 5(7):1-13, 2013.
  2. Maejima Y, Shimomura K, Sakuma K, Yang Y, Arai T, Mori M, Yada T: Paraventricular nucleus nesfatin-1 neurons are regulated by pituitary adenylate cyclase-activating polypeptide (PACAP). Neuroscience Letters 551:39-42, 2013.
  3. Iwasaki Y, Shimomura K, Kohno D, Dezaki K, Ayush EA, Nakabayashi H, Kubota N, Kadowaki T, Kakei M, Nakata M, Yada T.: Insulin activates vagal afferent neurons including those innervating pancreas via insulin cascade and Ca2+ influx: its dysfunction in IRS2-KO mice with hyperphagic obesity. PLoS ONE 8(6):e67198, 2013.
  4. Arai T, Maejima Y, Muroya S, Yada T.: Rikkunshito and isoliquiritigenin counteract 5-HT-induced 2C receptor-mediated activation of pro-opiomelanocortin neurons in the hypothalamic arcuate nucleus. Neuropeptides 47(4):225-30, 2013.
  5. Iwata T, Nakada T, Toyoda F, Yada T, Shioda S, Kikuyama S.: Responsiveness of vomeronasal cells to a newt peptide pheromone, sodefrin as monitored by changes of intracellular calcium concentrations. Peptides 45C:15-21, 2013.
  6. Sedbazar U, Maejima Y, Nakata M, Mori M, Yada T.: Paraventricular NUCB2/nesfatin-1 rises in synchrony with feeding suppression during early light phase in rats. Biochem Biophys Res Commun 434(3):434-438, 2013.
  7. Yang Y, Shimomura K, Sakuma K, Maejima Y, Iwasaki Y, Galvanovskis J, Dezaki K, Nakata M, Yada T.: Bupropion can close KATP channel and induce insulin secretion. J Pediatr Endocrinol Metab 26(3-4): 343-346, 2013.
  8. Takei M, Dezaki K, Ishii H, Nishio SI, Sato Y, Suzuki S, Yada T, Komatsu M: A new experimental model of ATP-sensitive K+ channel-independent insulinotropic action of glucose: a permissive role of cAMP for triggering of insulin release from rat pancreatic β-cells. Endocr J 60(5):599-607, 2013.
  9. Aoki H, Nakata M, Dezaki K, Lu M, Gantulga D, Yamamoto K, Shimada K, Kario K, Yada T: Ghrelin counteracts salt-induced hypertension via promoting diuresis and renal nitric oxide production in Dahl rats. Endocr J 60(5): 571-581, 2013.
  10. Yamato-Kodera S, Yoshida M, Dezaki K, Yada T, Murayama T, Kawakami M, Kakei M: Inhibition of insulin secretion from rat pancreatic islets by dexmedetomidine and medetomidine, two sedatives frequently used in clinical settings. Endocr J 60(3): 337-346, 2013.
  11. Iwasaki Y, Kakei M, Nakabayashi H, Ayush EA, Hirano-Kodaira M, Maejima Y, Yada T: Pancreatic polypeptide and peptide YY3-36 induce Ca2+ signaling in nodose ganglion neurons. Neuropeptides 47(1): 19-23, 2013.

総説
  1. Nakata M, Yada T.: Role of NUBC2/Nesfatin-1 In glucose control: diverse functions in islets, adipocytes and brain. Curr Pharm Des 19(39)6960-6965, 2013.
  2. Mori M, Yamada M, Okada S, Hashimoto K, Satoh T, Shimizu H, Yada T.: Discovery of nesfatin-1 and overview of biological actions and new developments. Curr Pharm Des 19(39)6921-6928, 2013.
  3. 河野大輔、前川文彦、前島裕子、Darambazar Gantulga、矢田俊彦:インスリンの食欲抑制作用とその機序.臨床消化器内科、28(6), 681-689, 2013
  4. 前島裕子、矢田俊彦:オキシトシンによる摂食代謝調節:神経回路、末梢‐中枢連関と肥満治療基盤.血管医学、14(1), 53-57, 2013
  5. 小泉大、出崎克也、田口昌延、安田是和、矢田俊彦:胃全摘と摂食―ラット胃全摘モデルにおける術式と摂食の関係,術後の摂食低下とグレリン感受性の推移―.G. I. Research 21(1), 40-47, 2013
  6. 岩﨑有作、矢田俊彦:迷走神経による消化管情報の中枢伝達と摂食制御.G. I. Research 21(1), 18-24, 2013
  7. 矢田俊彦:特集/摂食制御と消化管 序.G. I. Research 21(1), 1, 2013
  8. 高野英介、荒井健、矢田俊彦:視床下部弓状核・室傍核と摂食・精神.分子精神医学、13(1), 40-44, 2013

著書
  1. Dezak K, Boldbaatar D, Kurashina T, Yada T: Ghrelin’s novel signaling in islet b-cells to inhibit insulin secretion and its blockade as a promising strategy to treat type 2 diabetes. In: Ghrelin in Health and Disease, Springer Science+Business Media, New York, 2013, p51-71
  2. 中田正範、矢田俊彦:セロトニン2c受容体、ドーパミンD2受容体、カンナビノイド受容体. In 糖尿病の分子標的と治療薬事典. 春日雅人(監)、綿田裕孝、松本道宏(編)、羊土社、188-187,190-191,192-193、2013
  3. 倉持素樹、矢田俊彦:モノアミントランスポーター. In 糖尿病の分子標的と治療薬事典. 春日雅人(監)、綿田裕孝、松本道宏(編)、羊土社、186-187、2013
  4. 前島裕子、矢田俊彦:MC4R、Nesfatin-1. In 糖尿病の分子標的と治療薬事典. 春日雅人(監)、綿田裕孝、松本道宏(編)、羊土社、180-181,184-185、2013

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 2012年

原著論文
  1. Damdindorj B, Dezaki K, Kurashina T, Sone H, Rita R, Kakei M, Yada T: Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet β-cells. FEBS Lett 586(16): 2555-2562, 2012.
  2. Gantulga D, Maejima Y, Nakata M, Yada T: Glucose and insulin induce Ca2+ signaling in nesfatin-1 neurons in the hypothalamic paraventricular nucleus. Biochem Biophys Res Commun 420(4): 811-815, 2012.

総説
  1. Dezaki K, Yada T: Islet β-cell ghrelin signaling for inhibition of insulin secretion. In: Methods in Enzymology, 514: 317-331, 2012
  2. Iwasaki Y, Yada T: Vagal afferents sense meal-associated gastrointestinal and pancreatic hormones: mechanism and physiological role. Neuropeptides 46(6): 291-297, 2012.
  3. Kohno D, Yada T: Arcuate NPY neurons sense and integrate peripheral metabolic signals to induce feeding. Neuropeptides 46(6): 315-319, 2012.
  4. Yada T, Kohno D, Maejima Y, Sedbazar U, Arai T, Toriya M, Maekawa F, Kurita H, Niijima A, Yakabi K: Neurohormones, rikkunshito and hypothalamic neurons interactively control appetite and anorexia. Curr Pharm Des 18:4854-4864, 2012.
  5. 中田正範、佐久間和哉(翻訳)、矢田俊彦(監修):2型糖尿病における膵臓由来因子(PANDER)の役割:膵b細胞と肝臓における検証から.栄養学レビューNutrition Reviews 日本語版 autumn(78), 3-10, 2012
  6. 中田正範、矢田俊彦:摂食調節機構:ホメオスターシス系と報酬系.In 最新臨床糖尿病学 上-糖尿病学の最新動向-、日本臨床増刊号、70(3), 74-80, 2012
  7. 栗田英治 , 矢田 俊彦:グルコース感知ニューロンと摂食・代謝制御.内分泌・糖尿病・代謝内科 34(4), 379-384, 2012
  8. 中田正範、岩﨑有作、矢田俊彦:糖尿病のここがわからない!?(第4回)消化管ホルモンの新機軸 : インスリン分泌制御因子,臓器連関の伝令,DPP-4阻害薬標的の視点から.Diabetes strategy : journal of diabetes strategy 2(1), 24-30, 2012
  9. 前島裕子、Udval Sedbazar、矢田俊彦:中枢・末梢ネスファチンによる摂食制御と神経経路.Clinical Neuroscience、30(2), 181-183, 2012
  10. 前島裕子、SedbazarUdval、岩崎有作、矢田俊彦:ホルモンと神経ペプチドによる摂食調節.Annual Review糖尿病・代謝・内分泌2012、91-97, 2012
  11. 前川文彦、鳥谷真佐子、前島裕子、矢田俊彦:Brain-derived neurotrophic factor(BDNF)による摂食調節機構.内分泌・糖尿病・代謝内科、34(1), 59-64, 2012

著書
  1. 川上正舒、野田泰子、矢田俊彦:In からだと病気のしくみ図鑑、監修、法研、2012

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 2011年

原著論文
  1. Maejima Y, Iwasaki Y, Yamahara Y, Kodaira M, Sedbazar U, Yada T: Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging (Albany NY) 3(12): 1169-1177, 2011.
  2. Maejima Y, Kohno D, Iwasaki Y, Yada T: Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y neurons of the hypothalamic arcuate nucleus. Aging (Albany NY) 3(11): 1092-1097, 2011.
  3. Fujitsuka N, Asakawa A, Uezono Y, Minami K, Yamaguchi T, Niijima A, Yada T, Maejima Y, Sedbazar U, Sakai T, Hattori T, Kase Y, Inui A: Potentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival. Translational Psychiatry 1: e23, 2011.
  4. Dezaki K, Boldbataar D, Sone H, Dyachok O, Tengholm A, Gylfe E, Kurashina T, Yoshida M, Kakei M, Yada T: Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells. Diabetes 60(9): 2315-2324, 2011.
  5. Eiki J, Yada T: Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia. Endocr J 58(8): 691-698, 2011.
  6. Kohno D, Sone H, Tanaka S, Kurita H, Gantulga D, Yada T: AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats. Neuroscience Letters 499: 194-198, 2011.
  7. Koizumi M, Hosoya Y, Dezaki K, Yada T, Hosoda H, Kangawa K, Nagai H, Lefor AT, Sata N, Yasuda Y: Postoperative weight loss does not resolve after esophagectomy despite normal serum ghrelin levels. Ann Thorac Surg 91(4): 1032-1037, 2011.
  8. Cao Y, Nakata M, Okamoto S, Takano E, Yada T, Minokoshi Y, Hirata Y, Nakajima K, Iskandar K, Hayashi Y, Oki M, Zhang C, Tateya S, Inoue H, Sunden Y, Sawa H, Ogawa W, Barsh GS, Hosoda H, Kangawa K, Itoh H, Noda T, Kasuga M, Nakae J: PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. PLoS ONE 6(4)e18324, 1-14, 2011
  9. Nakata M, Manaka K, Yamamoto S, Mori M, Yada T: Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca2+ influx through L-type channels in mouse islet β-cells. Endocr J 58(4): 305-313, 2011.
  10. Endo T, Maekawa F, Võikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M: Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage. Behav Brain Res 221(1): 172-181, 2011.
  11. Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori Y, Yada T, Minokoshi Y, Tominaga M: Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes 60(1): 119-126, 2011.

総説
  1. 矢田俊彦:スタチンと糖尿病-基礎研究の発展-.Medical View Point、33(1), 2, 2011
  2. 中田正範、矢田俊彦:脂肪-膵軸による膵β細胞機能の調節.最新医学6月増刊号、66, 1298-1307, 2011
  3. 矢田俊彦:リスク評価と疾患予防に向けた社会と学会への貴重な提言.(会長コメント)Medical Tribune、44(47), 30, 2011
  4. 前島裕子、矢田俊彦:Nesfatin-1による摂食・糖代謝調節の機構と意義.実験医学、29(8), 1240-1241, 2011
  5. 前島裕子、Sedbazar Udval、岩崎有作、高野英介、矢田俊彦:Nesfatin-1の摂食抑制神経経路およびストレス、循環、生殖における役割.日本薬理学雑誌、137(4), 162-165, 2011
  6. 前島裕子、Udval Sedbazar、岩﨑有作、矢田俊彦:Nesfatin-1による食欲と関連機能の制御.Medical Science Digest、37(1), 24-26, 2011
  7. 中田正範、矢田俊彦:中枢インスリンの多様な機能と抵抗性.Inメタボリックシンドローム-基礎・臨床の最新知見-、日本臨床増刊号別刷、69(1), 190-196, 2011

著書
  1. 矢田俊彦:(用語解説)、In 糖尿病学用語集第3版、日本糖尿病学会編、文光堂、東京、2011
  2. 矢田俊彦:膵臓の内分泌機能と炭水化物代謝の調節(翻訳). In ギャノング生理学.原書23版 岡田泰伸(監訳)、丸善、東京、370-396、2011

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 2010年

原著論文
  1. Yoshida N., Maejima Y., Sedbazar U., Ando A., Kurita H., Damdindorj B., Takano E., Gantulga D., Iwasaki Y., Kurashina T., Onaka T., Dezaki K., Nakata M., Mori M., Yada T.: Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis. Aging (Albany NY) 2(11):775-784 ,2010.
  2. Toriya M., Maekawa F., Maejima Y., Onaka T., Fujiwara K., Nakagawa T., Nakata M., Yada T.: Long-term infusion of brain-derived neurotrophic factor reduces food intake and body weight via a corticotropin-releasing hormone pathway in the paraventricular nucleus of the hypothalamus. Journal of Neuroendocrinology 22(9):987-995, 2010.
  3. Nakata M., Shintani N., Hashimoto H., Baba A., Yada T.: Intra-islet PACAP protects pancreatic β-cells against glucotoxicity and lipotoxicity. J. Mol. Neurosci. 42(3):404-410, 2010.
  4. Yoshida M., Nakata M., Yamato S., Dezaki K., Sugawara H., Ishikawa S.E., Kawakami M., Yada T., Kakei M.: Voltage-dependent metabolic regulation of Kv2.1 channels in pancreatic β-cells. Biochem. Biophys. Res. Commun. 396(2):304-309, 2010.
  5. Koizumi M., Dezaki K., Hosoda H., Damdindorj B., Sone H., Ming L., Hosoya Y., Sata N., Kobayashi E., Kangawa K., Nagai H., Yasuda Y., Yada T.: Reconstruction-dependent recovery from anorexia and time-related recovery of regulatory ghrelin system in gastrectomized rats. International J. Peptides 2010:10page, 2010.
  6. Iskandar K., Cao Y., Hayashi Y., Nakata M., Takano E., Yada T., Zhang C., Ogawa W.M.D., Oki M., Chua S.Jr., Itoh H., Noda T., Kasuga M., Nakae J.: PDK1/ FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. Am. J. Physiol. Endocrinol. Metab. 298:E787-E798, 2010.

総説
  1. 前島裕子、Udval Sedbazar、矢田俊彦:視床下部・脳幹による摂食調節機構.Adiposcience、6(3), 215-222, 2010
  2. 前川文彦、Udval Sedbazar、鳥谷真佐子、矢田俊彦:BDNF/TrkB遺伝子異常.In 肥満症-基礎・臨床研究の進歩-、日本臨床増刊号、68, 268-271, 2010
  3. 岩﨑有作、前島裕子、前川文彦、矢田俊彦:末梢臓器による摂食調節.In 肥満症-基礎・臨床研究の進歩-、日本臨床増刊号、68, 64-70, 2010
  4. 矢田俊彦、前島裕子、Udval Sedbazar、岩﨑有作、中田正範:新しい食欲抑制因子Nesfatin-1―摂食中枢経路の解明と肥満治療へのブレークスルー.臨床栄養、116(2), 128-129, 2010

著書
  1. 出崎克也,中田正範,矢田俊彦:インスリン分泌におけるカルシウムシグナリングの役割. In 糖尿病ナビゲーター 第2版. 門脇孝(編)、メディカルビュー社、50-51,2010
  2. 中田正範、矢田俊彦:その他のインクレチン. In DPP-4阻害薬のすべて 清野裕(編集)、先端医学社、47-51、2010

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 2009年

原著論文
  1. Mori S., Takizawa M., Satou M., Sakasai M., Kusuoku H., Nojiri H., Yoshizuka N., Hotta M., Kitahara T., Hase T., Takema Y., Saito M., Yada T.: Enhancement of lipolytic responsiveness of adipocytes by novel plant extract in rat. Exp. Biol. Med. (Maywood) 234:1445-1449, 2009.
  2. Maejima Y., Sedbazar U., Suyama S., Kohno D., Onaka T., Takano E., Yoshida N., Koike M., Uchiyama Y., Fujiwara K., Yashiro T., Horvath T.L., Dietrich M.O., Tanaka S., Dezaki K., Oh-I S., Hashimoto K., Shimizu H., Nakata M., Mori M., Yada T.: Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metabolism 10: 355-365, 2009.
  3. Iwasaki Y., Nakabayashi H., Kakei M., Shimizu H., Mori M., Yada T.: Nesfatin-1 evokes Ca2+ signaling in isolated vagal afferent neurons via Ca2+ influx through N-type channels. Biochem. Biophys. Res. Commun. 390: 958-962, 2009.
  4. Yoshida M., Dezaki K., Yamato S., Aoki A., Sugawara H., Toyoshima H., Ishikawa S.E., Kawakami M., Nakata M., Yada T., Kakei M.: Regulation of voltage-gated K+ channels by glucose metabolism in pancreatic β-cells. FEBS Lett. 583: 2225-2230, 2009.
  5. Eiki J., Saeki K., Nagano N., Iino T., Yonemoto M., Takayenoki-Iino Y., Ito S., Nishimura T., Sato Y., Bamba M., Watanabe H., Sasaki K., Ohyama S., Kanatani A., Nagase T., Yada T.: A selective small molecule GLP-1 secretagogue acting via depolarization and Ca2+ influx. J. Endocrinology 201: 361-367, 2009.
  6. Mori S., Satou M., Kanazawa S., Yoshizuka N., Hase T., Tokimitsu I., Takema Y., Nishizawa Y., Yada T.: Body fat mass reduction and up-regulation of uncoupling protein by novel lipolysis-promoting plant extract. Int. J. Biol. Sci. 5: 311-318, 2009.
  7. Shimizu H., Oh-I S., Hashimoto K., Nakata M., Yamamoto S., Yoshida N., Eguchi H., Kato I., Inoue K., Satoh T., Okada S., Yamada M., Yada T., Mori M.: Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism. Endocrinology 150: 662-671, 2009.

総説
  1. 前川文彦、前島裕子、矢田俊彦:摂食調節の性差―性ステロイドの作用.Clinical Neuroscience、27(10), 1124-1125, 2009
  2. 矢田俊彦、鷺山健一郎、倉持素樹:ストレスによる摂食変調の機序:ヒトの病態とホルモン・中枢ペプチドの変動.循環器科、66(2), 237-242, 2009
  3. 鳥谷真佐子、中田正範、矢田俊彦:脳由来神経栄養因子BDNFによる視床下部室傍核を介した摂食調節.肥満研究、15(1), 97-99, 2009
  4. 矢田俊彦、栗田英治、前川文彦、安藤明彦、室屋真二:中枢グルコース感知と全身代謝・摂食調節:開拓的研究とその継承.肥満研究、15(1), 14-19, 2009
  5. 栗田英治、高野英介、Udval Sedbazar、矢田俊彦:脳によるグルコースセンシングと摂食調節機構.アンチ・エイジング医学、5(2), 22(178)-27(183), 2009
  6. 須山成朝、高野英介、岩﨑有作、中田正範、矢田俊彦:摂食調節における消化管・脳幹・視床下部・大脳辺縁系の役割と機能連関.日本臨床、67(2), 277-286, 2009

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 2008年

原著論文
  1. Takayanagi Y., Matsumoto H., Nakata M., Mera T., Fukusumi S., Hinuma S., Ueta Y., Yada T., Leng G., Onaka T.: Endogenous prolactin-releasing peptide regulates food intake in rodents. J. Clin. Invest. 118: 4014-4024, 2008.
  2. Kohno D., Suyama S., Yada T.: Leptin transiently antagonizes ghrelin and long-lastingly orexin in regulation of Ca2+ signaling in neuropeptide Y neurons of the arcuate nucleus. World J. Gastroenterol. 14: 6347-6354, 2008.
  3. Tomimoto S., Ojika T., Shintani N., Hashimoto H., Hamagami K., Ikeda K., Nakata M., Yada T., Sakurai Y., Shimada T., Morita Y., Ishida C., Baba A.: Markedly reduced white adipose tissue and increased insulin sensitivity in Adcyap1-deficient mice. J. Pharmacological Sciences 107: 41-48, 2008.
  4. Koizumi M, Yada T.: Sub-chronic stimulation of glucocorticoid receptor impairs and mineralcorticoid receptor protects cytosolic Ca2+ responses to glucose in pancreatic β-cells. J. Endocrinology 197: 221-229, 2008.
  5. Kohno D., Nakata M., Maejima Y., Shimizu H., Sedbazar U., Yoshida N., Dezaki K., Onaka T., Mori M., Yada T.: Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology 149: 1295-1301, 2008.
  6. Kohno D., Sone H., Minokoshi Y., Yada T.: Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons. Biochem. Biophys. Res. Commun. 366: 388-392, 2008

総説
  1. Dezaki K., Sone H., Yada T.: Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis. Pharmacol. Ther. 118:239-249, 2008.
  2. Yada T., Dezaki K., Sone H., Koizumi M., Damdindorj B., Nakata M., Kakei M.: Ghrelin regulates insulin release and glycemia: Physiological role and therapeutic potential. Curr. Diab. Rev. 4:18-23, 2008.
  3. 山本早和子、中田正範、矢田俊彦:中枢STAT3の抗肥満作用と治療標的としての可能性.肥満研究、14(3), 268-270, 2008
  4. 前島裕子、須山成朝、Udval Sedbazar、矢田俊彦:オキシトシンによる食欲調節と膵ホルモン分泌作用.Diabetes Frontier別刷、19(4), 465-469, 2008
  5. 出崎克也、曽根英行、矢田俊彦:グレリンによるインスリン分泌.糖尿病学、85-91, 2008
  6. 加計正文、中田正範、出崎克也、矢田俊彦:インスリン分泌のCa2+チャンネル機構.In 新時代の糖尿病学(1)、日本臨床増刊号、66(3), 158-163, 2008
  7. Tamas L. Horvath、矢田俊彦:視床下部ニューロンの可塑性と摂食調節の研究と、ミトコンドリア脱共役蛋白の機能解明をはじめとする神経生物学研究の魅力と展望.Adiposcience、5(1), 90-99, 2008

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 2007年

原著論文
  1. Iwasaki H., Yada T.: Protein arginine methylation regulates insulin signaling in L6 skeletal muscle cells. Biochem. Biophys. Res. Commun. 364: 1015-1021, 2007.
  2. Dezaki K., Kakei M., Yada T.: Ghrelin uses Gαi2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet β-cells: novel signal transduction of ghrelin. Diabetes 56: 2319-2327, 2007.
  3. Maekawa F., Nakamori T., Uchimura M., Fujiwara K., Yada T., Tsukahara S., Kanamatsu T., Tanaka K., Ohki-Hamazaki H.: Activation of cholecystokinin neurons in the dorsal pallium of the telencephalon is indispensable for the acquisition of chick imprinting behavior. Journal of Neurochemistry 102: 1645-1657, 2007.
  4. Fujiwara K., Maekawa F., Dezaki K., Nakata M., Yashiro T., Yada T.: Oleic acid glucose-independently stimulates glucagon secretion by increasing cytoplasmic Ca2+ via ER Ca2+ release and Ca2+ influx in the rat islet α-cells. Endocrinology 148: 2496-2504, 2007.
  5. Kohno D., Nakata M., Maekawa F., Fujiwara K., Maejima Y., Kuramochi M., Shimazaki T., Okano H., Onaka T., Yada T.: Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway. Endocrinology 148: 2251-2263, 2007.
  6. Nakata M., Okada T., Ozawa K., Yada T.: Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release. Biochem. Biophys. Res. Commun. 353: 1046-1051, 2007.
  7. Fujiwara K., Maekawa F., Kikuchi M., Takigami S., Yada T., Yashiro T: Expression of retinaldehyde dehydrogenase (RALDH)2 and RALDH3 but not RALDH1 in the developing anterior pituitary glands of rats. Cell Tissue Res. 328: 129-135, 2007.

総説
  1. Nakata M, Yada T.: PACAP in the glucose and energy homeostasis: physiological role and therapeutic potential. Curr. Pharm. Des. 13:1105-1112. 2007.
  2. 鳥谷真佐子、前島裕子、栗田英治、矢田俊彦:肥満の成因1;摂食調節の中枢神経機構.治療学、41(7), 17-22, 2007
  3. 河野大輔、矢田俊彦:グレリン, レプチンの弓状核NPYニューロンに対する直接作用, シグナル伝達と相互作用.肥満研究、13(2), 215-219, 2007
  4. 出崎克也、矢田俊彦:グレリンによるインスリン分泌・血糖値調節機構.内分泌・糖尿病科、25(3), 239-244, 2007
  5. 栗田英治、矢田俊彦:摂食調節因子とメタボリックシンドローム;中枢グルコースセンサー.ホルモンと臨床、55(9), 31-36, 2007
  6. 中田正範、安藤明彦、河野大輔、矢田俊彦:脂肪‐脳軸による摂食代謝調節と細胞分子機構.内分泌・糖尿病科、25(1), 1-7, 2007

著書
  1. 矢田俊彦、加計正文、中田正範、出崎克也、曽根英行、藤原研:インスリン分泌の細胞生物学(翻訳). In ジョスリン糖尿病学 第2版. 金澤康徳、春日雅人、柏木厚典,門脇孝、河盛隆造、田嶋尚子(監訳)、メディカル・サイエンス・インターナショナル、91-119, 2007

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 2006年

原著論文
  1. Oomura Y., Hori N, Shiraishi T., Fukunaga K., Takeda H., Tsuji M., Matsumiya T., Ishibashi M., Aou S., Li X.L., Kohno D., Uramura K., Sougawa H., Yada T., Wayner M.J., Sasaki K.: Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. Peptides 27: 2738-2749, 2006.
  2. Momose K., Nunomiya S., Nakata M., Yada T., Kikuchi M., Yashiro T.: Immunohistochemical and electron-microscopic observation of β-cells in pancreatic islets of spontaneously diabetic Goto-Kakizaki rats. Med. Mol. Morphol. 39: 146-153, 2006.
  3. Dezaki K., Sone H., Koizumi M., Nakata M., Kakei M., Nagai H., Hosoda H., Kangawa K., Yada T: Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes 55: 3486-3493, 2006.
  4. Maekawa F., Fujiwara K., Kohno D., Kuramochi M., Kurita H., Yada T: Young adult-specific hyperphagia in diabetic Goto-Kakizaki rats is associated with leptin resistance and elevation of neuropeptide Y mRNA in the arcuate nucleus. J. Neuroendocrinology 18: 748-756, 2006.
  5. Nakata M., Nagasaka S., Kusaka I., Matsuoka H., Ishibashi S., Yada T.: Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4) : implication in glycaemic control. Diabetologia 49: 1881-1892, 2006.
  6. Kuramochi M., Onaka T., Kohno D., Kato S., Yada T.: Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rats. Endocrinology 147: 1744-1752, 2006.
  7. Maekawa F., Fujiwara K., Tsukahara S., Yada T.: PACAP neurons of the ventromedial hypothalamus project to midbrain central gray. Neuroreport 17:221-224, 2006.

総説
  1. 栗田英治、室屋真二、河野大輔、三浦善憲 、矢田俊彦:視床下部弓状核ニューロンの低グルコース感知機構—グルコース代謝とNa+/K+ATPaseの役割.肥満研究、12(3), 239-241, 2006
  2. 尾仲達史、倉持素樹、中田正範、矢田俊彦:アディポサイエンスの実験講座11;実験動物摂食行動評価法.アディポサイエンス、3(3), 329-333, 2006
  3. 河野大輔、栗田英治、倉持素樹、鳥谷真佐子、矢田俊彦:視床下部による代謝シグナルの受容と摂食調節機構.Inメタボリックシンドローム-病因解明と予防・治療の最新戦略-、日本臨床増刊号別刷、64(9), 91-97, 2006

著書
  1. 矢田俊彦:膵臓の内分泌機能と炭水化物代謝の調節(翻訳). In ギャノング生理学.原書22版 岡田泰伸(監訳)、丸善、東京、354-377、2006
  2. 矢田俊彦:甲状腺(翻訳). In ギャノング生理学.原書22版 岡田泰伸(監訳)、丸善、東京、338-353、2006

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 2005年

原著論文
  1. Ikeda Y., Iguchi H., Nakata M., Ioka R.X., Tanaka T., Iwasaki S., Magoori K., Takayasu S., Yamamoto T.T., Kodama T., Yada T., Sakurai T., Yanagisawa M., Sakai J.: Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues. Biochem. Biophys. Res. Commun. 333: 778-786, 2005.
  2. Nakata M., Maruyama I., Yada T.: Leptin potentiates ADP-induced Ca2+ increase via JAK2 and tyrosine kinases in a megakaryoblast cell line. Diabetes Res. Clin. Pract. 70: 209-216, 2005.
  3. Fujiwara K., Maekawa F., Yada T.: Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet β-cells: mediation by phospholipase C and L-type Ca2+ channel and link to insulin release. Am. J. Physiol. (Endocrinol. Metab.) 289: E670-677, 2005.
  4. Muroya S., Funahashi H., Uramura K., Shioda S., Yada T.:GABA regulates glucosensitive NPY neurons in arcuate nucleus via A/B receptors. Neuroreport 16: 897-901, 2005.
  5. Onaka T., Kuramochi M., Saito J., Ueta Y., Yada T.: Galanin-like peptide stimulates vasopressin, oxytocin and ACTH release in rats. Neuroreport 16: 243-247, 2005.
  6. Fujiwara K., Matsumoto H., Yada T., Inoue K.: Identification of the prolactin-releasing peptide-producing cell in the rat adrenal gland. Regulatory Peptides 126: 97-102, 2005.
  7. Kuramochi M., Kohno D., Kato S., Yada T.: Galanin-like peptide and ghrelin increases cytosolic Ca2+ in neurons containing growth hormone-releasing hormone in the arcuate nucleus. Regulatory Peptides 126: 85-89, 2005.

総説
  1. 倉持素樹、加藤敏、矢田俊彦:新規生理活性物質GALPと視床下部摂食中枢.内分泌・糖尿病科、21(6), 644-649, 2005
  2. 矢田俊彦:肥満学;代謝オーケストラのハーモニーと不協和音.肥満研究別刷、11(2), 3(117)-4(118), 2005
  3. 河野大輔、矢田俊彦:弓状核NPYニューロンにおけるグレリン・オレキシンとレプチンの相互作用.肥満研究別刷、11(1), 92-93, 2005
  4. 中崎満浩、中田正範、矢田俊彦:インスリン分泌調節ペプチドの生理的意義と治療応用.Annual Review 2005 内分泌代謝、30-37, 2005

著書
  1. 矢田俊彦:(用語解説)、In 糖尿病学用語集第2版、日本糖尿病学会編、文光堂、東京、2005
  2. 矢田俊彦:栄養と代謝にかかわるホルモン、In 人体の構造と機能及び疫病の成り立ち 各論Ⅰ、香川靖雄、近藤和雄、石田均、門脇孝(編)、南江堂、東京、1-11、2005
  3. 矢田俊彦:Ca2+シグナル、In 細胞生物学事典、石川統、黒岩常祥、永田和弘(編)、朝倉書店、東京、108-109、2005
  4. 矢田俊彦:活動電位、In 細胞生物学事典、石川統、黒岩常祥、永田和弘(編)、朝倉書店、東京、106-107、2005

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 2004年

原著論文
  1. Dezaki K., Hosoda H., Kakei M., Hashiguchi S., Watanabe M., Kangawa K., Yada T.: Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in β-cells: implication in the glycemic control in rodents. Diabetes 53: 3142-3151, 2004.
  2. Nakata M., Kohno D., Shintani N., Nemoto Y., Hashimoto H., Baba A., Yada T.: PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus. Neruoscience Lett. 370: 252-256, 2004.
  3. Yamada H., Watanabe M., Yada T.: Cytosolic Ca2+ responses to sub-picomolar and nanomolar PACAP in pancreatic β-cells are mediated by VPAC2 and PAC1 receptors. Regulatory Peptides 123: 147-153, 2004.
  4. Muroya S., Funahashi H., Yamanaka A., Kohno D., Uramura K., Nambu T., Shibahara M., Kuramochi., M, Takigawa M., Yanagisawa M., Sakurai T., Shioda S., Yada T.: Orexins (Hypocretins) directly interacts with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: Orexigenic neuronal pathways in the mediobasal hypothalamus. Eur. J. Neurosci. 19,1524-1534, 2004.

総説
  1. 中田正範、矢田俊彦:膵b細胞のstimulus-secretion coupling.内分泌・糖尿病科、18(5), 426-432, 2004
  2. 矢田俊彦、河野大輔、中田正範:The Brain-Adipose Axisの分子基盤と生理的意義.Adiposcience、1(4), 361-369, 2004
  3. 前川文彦、矢田俊彦:肥満関連ホルモンと摂食調節機構.最新医学別刷、59(9), 117-123, 2004
  4. 中田正範、矢田俊彦:メタボリックシンドロ-ムの成因;インスリン分泌.Progress in Medicine別刷、24(9), 63-67, 2004
  5. 影山晴秋、船橋久幸、管 建蓮、竹ノ谷文子、塩田清二、矢田俊彦:弓状核NPYニュ-ロンの機能調節機構.In 摂食・肥満・糖代謝異常の脳科学、脳21, 7(4), 2004
  6. 出崎克也、矢田俊彦:グレリンと糖脂質代謝.In 臨床分子内分泌学(1)-心血管内分泌代謝系(上)、日本臨床増刊号、62, 358-394, 2004
  7. 加計正文、出崎克也、矢田俊彦:膵島b細胞の単離と機能解析法.日本薬理学雑誌、124, 345-352, 2004
  8. 河野大輔、矢田俊彦:脂肪細胞と摂食調節機構.ホルモンと臨床、52(12), 13-18, 2004
  9. 中田正範、矢田俊彦:糖代謝調節因子PACAPによる糖尿病治療の可能性.日薬理誌(Folia Pharmacol.Jpn)123, 267-273, 2004
  10. 矢田俊彦、中田正範:肥満と摂食調節の基礎,臨床と展望.BIO Clinica、19 (1), 16-17, 2004

著書
  1. 矢田俊彦:膵臓の内分泌機能と炭水化物代謝の調節(翻訳). In ギャノング生理学.原書21版 岡田泰伸(監訳)、丸善、東京、345-368, 2004
  2. 矢田俊彦:甲状腺(翻訳). In ギャノング生理学.原書21版 岡田泰伸(監訳)、丸善、東京、329-344, 2004

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 2003年

原著論文
  1. Rokkaku K., Onaka T., Okada N., Ideno J., Kawakami A., Honda K., Yada T., Ishibashi S.: Neuromedin U facilitates oxytocin release from the pituitary via β adrenoceptors. Neuroreport 14: 1997-2000, 2003.
  2. Nakata M., Yada T.: Nitric oxide-mediated insulin secretion in response to citrulline in islet β-cells. Pancreas 27: 209-213, 2003.
  3. Zhu Y., Miwa Y., Yamanaka A., Yada T., Shibahara M., Abe Y., Sakurai T., Goto K.: Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. J. Pharmacol. Sci. 92: 259-266, 2003.
  4. Kohno D., Gao H.G., Muroya S., Kikuyama S., Yada T.: Ghrelin directly interacts with NPY-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A- and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52: 948-956, 2003.

総説
  1. Funahashi H., Takenoya F., Guan J.L., Kageyama H., Yada T., Shioda S.: Hypothalamic neuronal networks and feeding-related peptides involved in the regulation of feeding. Anat. Sci. Int. 78:123-138, 2003.
  2. Funahashi H., Yada T., Suzuki R., Shioda S.: Distribution, function, and properties of leptin receptors in the brain. Int. Rev. Cytol. 224:1-27, 2003.
  3. 八重倉和朗、藤原研、矢田俊彦:新しいインスリン分泌機構:開口放出制御分子と脂肪酸受容体.内分泌・糖尿病科、17(6), 546-549, 2003
  4. 藤原研、矢田俊彦:NPYと自律神経機能.CLINICAL NEUROSCIENCE、21(12), 1408-1410, 2003
  5. 河野大輔、藤原研、前川文彦、倉持素樹、尾仲達史、矢田俊彦:視床下部・全身代謝・ストレスによる摂食調節.肥満研究、9(3), 235-243, 2003
  6. 笹征史、西昭徳、小林和人、佐野裕美、籾山俊彦、浦村一秀、矢田俊彦、森則夫、鈴木勝昭、三辺義雄:ドパミンによる運動精神機能調節.新たな研究への展開、日薬理誌、122, 215-225, 2003
  7. 中田正範、矢田俊彦:摂食調節因子 コレシストキニン.In 肥満症-生理活性物質と肥満の臨床-、日本臨床増刊号、61, 177-181, 2003
  8. 河野大輔、菊山榮、矢田俊彦:摂食調節因子 Cocaine-and amphetamine-regulated transcript(CART).In 肥満症-生理活性物質と肥満の臨床-、日本臨床増刊号、61, 224-228, 2003
  9. 倉持素樹、加藤敏、矢田俊彦:摂食調節因子 ガラニン.In 肥満症-生理活性物質と肥満の臨床-、日本臨床増刊号、61, 186-190, 2003
  10. 尾仲達史、矢田俊彦:摂食調節因子 ニューロテンシン.In 肥満症-生理活性物質と肥満の臨床-、日本臨床増刊号、61, 191-194, 2003
  11. 矢田俊彦、尾仲達史、河野大輔、倉持素樹:摂食調節因子 エンテロスタチン.In 肥満症-生理活性物質と肥満の臨床-、日本臨床増刊号、61, 182-185, 2003

著書
  1. 宮下洋、矢田俊彦:循環器のしくみと働き. In 疾病の成り立ちと回復の促進4 循環器疾患. 新体系看護学、島田和幸(編)、メジカルフレンド社、6, 3-33, 2003

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 2002年

原著論文
  1. Kakei M., Yada T., Nakagawa A., Nakabayashi H.: Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca2+ in rat nodose ganglion neurons. Auton. Neuroscience 102: 39-44, 2002.
  2. Zhou C.J., Shioda S., Yada T., Inagaki N., Pleasure S.J., Kikuyama S.: PACAP and its receptors exert pleiotropic effects in the nervous system by activating multiple signaling pathways. Current Protein and Peptide Sci. 3: 423-439, 2002.
  3. Zhu L., Onaka T., Sakurai T., Yada T.: Activation of orexin neurons after noxious but not conditioned fear stimuli in rats. Neuroreport 19: 1351-1353, 2002.
  4. Nakazaki M., Kakei M., Ishihara H., Koriyama N., Hashiguchi H., Aso K., Fukudome M., Oka Y., Yada T., Tei C.: Association of upregulated activity of K(ATP) channels with impaired insulin secretion in UCP1-expressing insulinoma cells. J. Physiol. (Lond.) 540: 781-789, 2002.
  5. Yamada S., Komatsu M., Aizawa T., Sato Y., Yajima H., Yada T., Hashiguchi S., Yamauchi K., Hashizume K.: Time-dependent potentiation of the β-cell is a Ca2+-independent phenomenon. J. Endocrinol. 172: 345-354, 2002.
  6. Date Y., Nakazato M., Hashiguchi S., Dezaki K., Mondal M.S., Hosoda H., Kojima M., Kangawa K., Arima T., Matsuo H., Yada T., Matsukura S.: Ghrelin is present in pancreatic α-cells of humans and rats and stimulates insulin secretion. Diabetes 51: 124-129, 2002.
  7. Yanagida K., Yaekura K., Arima T., Yada T.: Glucose-insensitivity induced by Ca2+ toxicity in islet β-cells and its prevention by PACAP. Peptides 23: 135-142, 2002.

総説
  1. Zhou C.J., Shioda S., Yada T., Inagaki N., Pleasure S.J., Kikuyama S.: PACAP and its receptors exert pleiotropic effects in the nervous system by activating multiple signaling pathways. Current Protein and Peptide Science 3:423-439, 2002.
  2. 加計正文、中崎満浩、柳田和弘、八重倉和朗、矢田俊彦:膵β細胞代謝障害とインスリン分泌不全.In 新時代の糖尿病学(1)、日本臨床増刊号、60, 504-510, 2002
  3. 加計正文、郡山暢之、中田正範、出崎克也、矢田俊彦:インスリン分泌のイオンチャンネル機構.In 新時代の糖尿病学(1)、日本臨床増刊号、60, 180-189, 2002
  4. 加計正文、中田正範、矢田俊彦:インスリン分泌の分子機構.Annual review内分泌代謝、中外医学社、46-54, 2002

著書
  1. Shioda S., Zhou C.J., Ohtaki H., Yada T.: PACAP receptor signaling. In: Pituitary Adenylate Cyclase-Activating Polypeptide. Vaudry H and Arimura A (eds), Kluwer Academic Publishers, Massachusetts, USA, 2002, p95-124
  2. 矢田俊彦:甲状腺(翻訳). In 医科生理学展望.原書20版 岡田泰伸(監訳)、丸善、東京、335-351, 2002
  3. 矢田俊彦:膵臓の内分泌機能と炭水化物代謝の調節(翻訳). In 医科生理学展望.原書20版 岡田泰伸(監訳)、丸善、東京、352-376, 2002
  4. 中田正範、出崎克也、矢田俊彦:インスリン分泌におけるカルシウムシグナリングの役割. In 糖尿病ナビゲーター. 門脇孝(編)、メディカルビュー社、38-39, 2002

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 2001年

原著論文
  1. Aizawa T., Kaneko T., Yamauchi K., Yajima H., Nishizawa T., Yada T., Matsukawa H., Nagai M., Yamada S., Sato Y., Komatsu M., Itoh N., Hidaka H., Kajimoto Y., Hashizume K.: Size-related and size-unrelated functional heterogeneity among pancreatic islets. Life Sciences 69: 2627-2639, 2001.
  2. Koriyama N., Kakei M., Nakazaki M., Yaekura K., Hashiguchi H., Aso K., Fukudome M., Yada T., Ito S., Tei C.: Free radical-mediated tolbutamide desensitization of K+ATP channels in rat pancreatic β-cells. Endocr. J. 48: 337-344, 2001.
  3. Muroya S., Uramura K., Sakurai T., Takigawa M., Yada T.: Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus. Neuroscience Lett. 309, 165-168, 2001.
  4. Zhou C.J., Yada T., Kohno D., KikuyamaS., Suzuki R., Mizushima H., Shioda S.: PACAP activates PKA, PKC and Ca2+ signaling cascades in rat neuroepithelial cells. Peptides 22: 1111-1117, 2001.
  5. Uramura K., Funahashi H., Muroya S., Shioda S., Takigawa M., Yada T.: Orexin-A activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area. Neuroreport 12: 1885-1889, 2001.
  6. Hashiguchi S., Yada T., Arima T.: A new hypoglycemic agent, JTT-608, evokes PKA-mediated Ca2+ signaling in rat islet β-cells: strict regulation by glucose, link to release insulin and cooperation with GLP-1 and PACAP. J. Pharmacol. Exp. Therapeut. 296: 22-30, 2001.

総説
  1. 尾仲達史、矢田俊彦:バゾプレシン神経、オキシトシン神経とストレス.Clinical Neuroscience、19, 1145-1148, 2001
  2. 柳田和弘,矢田俊彦:膵β細胞障害とインスリン分泌刺激薬.PharmaMedica、19 (6), 39-44, 2001

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 2000年

原著論文
  1. Shioda S., Yada T., Muroya S., Uramura S., Nakajo S., Ohtaki H., Hori T., Shimoda Y., Funahashi H.: Functional significance of colocalization of PACAP and catecholamine in nerve terminals. Ann. New York Acad. Sci. 921: 211-217, 2000.
  2. Yada T., Nakata M., Shioda S.: Insulinotropin PACAP potentiates insulin action: stimulation of glucose uptake in 3T3-LI adipocytes. Ann. New York Acad. Sci. 921: 473-477, 2000.
  3. Arahira S., Kusao M., Shioda S., Yada T.: PACAP activates pancreatic β-cells in a glucose-independent manner. Ann. New York Acad. Sci. 921: 438-442, 2000.
  4. Yada T., Sakurada M., Filipsson K., Kikuchi M., Ahren B.: Intraperitoneal PACAP administration decreases blood glucose in GK rats, normal and high-fat diet mice. Ann. New York Acad. Sci. 921: 259-263, 2000.
  5. Uramura K., Yada T., Muroya S., Takigawa M.: Ca2+ oscillations in response to methamphetamine in dopamine neurons of the ventral tegmental area in rats subchronically treated with this drug. Ann. New York Acad. Sci. 914: 316-322, 2000.
  6. Koriyama N., Kakei M., Nakazaki M., Yaekura K., Ichinari K., Yada T., Tei C.: PIP2 and ATP cooperatively prevent cytosolic Ca2+-induced modification of ATP-sensitive K+ channels in rat pancreatic β-cells. Diabetes 49: 1830-1839, 2000.
  7. Nakazaki M., Kakei M., Yaekura K., Koriyama N., Morimitsu S., Ichinari K., Yada T., Tei C.: Diverse effects of hydrogen peroxide on cytosolic Ca2+ homeostasis in rat pancreatic β-cells. Cell Struct. Function 25: 187-193, 2000.
  8. Nakamura T., Uramura K., Nambu T., Yada T., Goto K., Yanagisawa M., Sakurai T.: Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system. Brain Res. 873: 181-187, 2000.
  9. Uramura K., Yada T., Muroya S., Shioda S., Shiratani T., Takigawa M.: Methamphetamine induces cytosolic Ca2+ oscillations in the VTA dopamine neurons. Neuroreport 11: 1057-1061, 2000.

総説
  1. 室屋真二、浦村一秀、矢田俊彦:オレキシンによる摂食行動の制御.組織培養工学、26 (12), 10-13, 2000
  2. 矢田俊彦:KATPチャネルの分子制御―インスリン分泌調節と破綻—.医学のあゆみ、192 (5), 348-353, 2000
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