研究業績

   全432編 (2017/10/28現在)
 
Researcher ID: H-4371-2011 

2017

1. Yamazaki Y, Naganuma A, Arai Y, Takeuchi S, Kobayashi T, Takakusaki S, Hatanaka T, Hoshino T, Namikawa M, Hashizume H, Takizawa D, Ohyama T, Suzuki H, Horiguchi N, Takagi H, Sato K, Kakizaki S, Kusano M, Nagashima S, Takahashi M, Okamoto H, Yamada M. Clinical and virological features of acute hepatitis E in Gunma prefecture, Japan between 2004 and 2015. Hepatol Res. 2016 Jun 20. doi: 10.1111/hepr.12765. [Epub ahead of print] PubMed PMID: 27322051.

2. Miura Y, Kanda T, Yasui S, Takahashi K, Haga Y, Sasaki R, Nakamura M, Wu S, Nakamoto S, Arai M, Nishizawa T, Okamoto H, Yokosuka O. Hepatitis A virus genotype IA-infected patient with marked elevation of aspartate aminotransferase levels. Clin J Gastroenterol. 2016 Nov 15. [Epub ahead of print] PubMed PMID: 27848147.

3. Miura M, Inoue J, Tsuruoka M, Nishizawa T, Nagashima S, Takahashi M, Shimosegawa T, Okamoto H. Full-length genomic sequence analysis of new subtype 3k hepatitis E virus isolates with 99.97% nucleotide identity obtained from two consecutive acute hepatitis patients in a city in northeast Japan. J Med Virol. 2016 Dec 6. doi: 10.1002/jmv.24743. [Epub ahead of print] PubMed PMID: 27922191.

4. Nwe Win N, Kanda T, Nakamura M, Nakamoto S, Okamoto H, Yokosuka O, Shirasawa H. Free fatty acids or high-concentration glucose enhances hepatitis A virus replication in association with a reduction in glucose-regulated protein 78 expression. Biochem Biophys Res Commun. 2016 Dec 13. pii: S0006-291X(16)32124-6. doi: 10.1016/j.bbrc.2016.12.080. [Epub ahead of print] PubMed PMID: 27986562.

5. Sato K, Hosonuma K, Yamazaki Y, Kobayashi T, Takakusagi S, Horiguchi N, Kakizaki S, Kusano M, Ohnishi H, Okamoto H, Yamada M. Combination Therapy with Ombitasvir/Paritaprevir/Ritonavir for Dialysis Patients Infected with Hepatitis C Virus: A Prospective Multi-Institutional Study. Tohoku J Exp Med. 2017;241(1):45-53. doi: 10.1620/tjem.241.45. PubMed PMID: 28090038.

6. Satake M, Matsubayashi K, Hoshi Y, Taira R, Furui Y, Kokudo N, Akamatsu N, Yoshizumi T, Ohkohchi N, Okamoto H, Miyoshi M, Tamura A, Fuse K, Tadokoro K. Unique clinical courses of transfusion-transmitted hepatitis E in patients with immunosuppression. Transfusion. 2017 Jan 31. doi: 10.1111/trf.13994. [Epub ahead of print] PubMed PMID: 28144952.

7. Yamaguchi Y, Takagi H, Suzuki Y, Maruhashi K, Kosone T, Kakizaki S, Sato K, Yamada M, Nagashima S, Takahashi M, Okamoto H. Autochthonous sporadic acute hepatitis E caused by two distinct subgenotype 3b hepatitis E virus strains with only 90% nucleotide identity. Clin J Gastroenterol. 2017 Feb 15. doi: 10.1007/s12328-017-0718-3. [Epub ahead of print] PubMed PMID: 28205112.

8. Suzuki K, Kumagai I, Yoshida Y, Miyasaka A, Takikawa Y, Kamiya R, Kondo K, Kato A, Chiba T, Okamoto H. Asymptomatic acute hepatitis E in a female patient with ulcerative colitis. Clin J Gastroenterol. 2017 Mar 28. doi: 10.1007/s12328-017-0730-7. [Epub ahead of print] PubMed PMID: 28353200.

9. Jiang X, Kanda T, Haga Y, Sasaki R, Nakamura M, Wu S, Nakamoto S, Shirasawa H, Okamoto H, Yokosuka O. Glucose-regulated protein 78 is an antiviral against hepatitis A virus replication. Exp Ther Med. 2017 Jun;13(6):3305-3308. doi: 10.3892/etm.2017.4407. Epub 2017 Apr 28. PubMed PMID: 28587404; PubMed Central PMCID: PMC5450597.

10. Yokoyama K, Kumagai H, Takahashi M, Nagashima S, Okamoto H, Yamagata T. Occult hepatitis B virus infection in immunized children born to carrier mothers. Pediatr Int. 2017 Jun 28. doi: 10.1111/ped.13352. [Epub ahead of print] PubMed PMID: 28658511.

11. Suzuki K, Tatemichi Y, Yoshida Y, Miyamoto Y, Kuroda H, Miyasaka A, Takikawa Y, Masuda T, Kumagai I, Okamoto H. Hepatic histological comparison between acute self-limiting hepatitis A and hepatitis E. Arch Hepat Res 2017; 3(2): 041-048.

12. Tsatsralt-Od B, Primadharsini PP, Nishizawa T, Ohnishi H, Nagashima S, Takahashi M, Jirintai S, Nyamkhuu D, Okamoto H. Distinct changing profiles of hepatitis A and E virus infection among patients with acute hepatitis in Mongolia: The first report of the full genome sequence of a novel genotype 1 hepatitis E virus strain. J Med Virol. 2017 Aug 4. doi: 10.1002/jmv.24907. [Epub ahead of print] PubMed PMID: 28776712.

13. Primadharsini PP, Miyake M, Kunita S, Nishizawa T, Takahashi M, Nagashima S, Tanggis, Ohnishi H, Kobayashi T, Nishiyama T, Jirintai S, Okamoto H. Full-length genome of a novel genotype 3 hepatitis E virus strain obtained from domestic pigs in Japan. Virus Res. 2017 Aug 16. pii: S0168-1702(17)30506-3. doi: 10.1016/j.virusres.2017.08.003. [Epub ahead of print] PubMed PMID: 28822700.

14. Yoshida Y, Okada Y, Suzuki A, Kakisaka K, Miyamoto Y, Miyasaka A, Takikawa Y, Nishizawa T, Okamoto H. Fatal acute hepatic failure in a family infected with the hepatitis A virus subgenotype IB: A case report. Medicine (Baltimore). 2017 Sep;96(35):e7847. doi: 10.1097/MD.0000000000007847. PubMed PMID: 28858094.

15. Nagashima S, Takahashi M, Kobayashi T, Tanggis, Nishizawa T, Nishiyama T, Primadharsini PP, Okamoto H. The characterization of the quasi-enveloped hepatitis E virus particles released by the cellular exosomal pathway. J Virol. 2017 Sep 6. pii: JVI.00822-17. doi: 10.1128/JVI.00822-17. [Epub ahead of print] PubMed PMID: 28878075.

16. Nishizawa T, Primadharsini PP, Namikawa M, Yamazaki Y, Uraki S, Okano H, Horiike S, Nakano T, Takaki S, Kawakami M, Nagashima S, Takahashi M, Okamoto H. Full-length genomic sequences of new subtype 1g hepatitis E virus strains obtained from four patients with imported or autochthonous acute hepatitis E in Japan. Infect Genet Evol. 2017 Oct 5;55:343-349. doi: 10.1016/j.meegid.2017.10.007. [Epub ahead of print] PubMed PMID: 28987806.

17. Purdy MA, Harrison TJ, Jameel S, Meng XJ, Okamoto H, Van der Poel WHM, Smith DB, Ictv Report Consortium. ICTV Virus Taxonomy Profile: Hepeviridae. J Gen Virol. 2017 Oct 12. doi: 10.1099/jgv.0.000940. [Epub ahead of print] PubMed PMID: 29022866.

18. Nakano T, Takahashi M, Takahashi K, Nagashima S, Suzuki Y, Nishigaki Y, Tomita E, Okano H, Oya Y, Shiraki K, Takase K, Sugimoto K, Koyama J, Mizuo H, Ikezawa K, Aikawa T, Arai M, Okamoto H. Hepatitis E virus subtype 3f strains isolated from Japanese hepatitis patients with no history of travel to endemic areas - The origin analyzed by molecular evolution. Virology. 2017 Oct 24;513:146-152. doi: 10.1016/j.virol.2017.08.008. [Epub ahead of print] PubMed PMID: 29078116.

 
2016
1. Tsatsralt-Od B, Baasanjav N, Nyamkhuu D, Ohnishi H, Takahashi M, Okamoto H. Prevalence of hepatitis viruses in patients with acute hepatitis and characterization of the detected genotype 4 hepatitis E virus sequences in Mongolia. J Med Virol. 2015 Jul 3. doi: 10.1002/jmv.24319. [Epub ahead of print] PubMed PMID: 26147664.

2. Nakano T, Takahashi K, Takahashi M, Nishigaki Y, Watanabe N, Ishida S, Fujimoto S, Kato H, Okano H, Takei Y, Ayada M, Tomita E, Arai M, Okamoto H, Mishiro S. Investigating the origin and global dispersal history of hepatitis E virus genotype 4 using phylogeographical analysis. Liver Int. 2015 Jun 2. doi:10.1111/liv.12880. [Epub ahead of print] PubMed PMID: 26037061.

3. Tsatsralt-Od B, Baasanjav N, Nyamkhuu D, Ohnishi H, Takahashi M, Kobayashi T, Nagashima S, Nishizawa T, Okamoto H. Molecular analysis of hepatitis A virus strains obtained from patients with acute hepatitis A in Mongolia, 2004-2013. J Med Virol. 2015 Sep 15. doi: 10.1002/jmv.24380. [Epub ahead of print] PubMed PMID: 26369542.

4. Tanaka T, Akamatsu N, Sakamoto Y, Inagaki Y, Oshiro Y, Ohkohchi N, Okamoto H, Kokudo N. Treatment with ribavirin for chronic hepatitis E following living donor liver transplantation: A case report. Hepatol Res. 2016 Jan 4. doi:10.1111/hepr.12641. [Epub ahead of print] PubMed PMID: 26725743.

5. Smith DB, Simmonds P, Izopet J, Oliveira-Filho EF, Ulrich RG, Johne R, Koenig M, Jameel S, Harrison TJ, Meng XJ, Okamoto H, van der Poel WH, Purdy MA. Proposed reference sequences for Hepatitis E virus subtypes. J Gen Virol. 2016 Jan 7. doi:10.1099/jgv.0.000393. [Epub ahead of print] PubMed PMID: 26743685.

6. Kobayashi T, Takahashi M, Tanggis, Mulyanto, Jirintai S, Nagashima S, Nishizawa T, Okamoto H. Characterization and epitope mapping of monoclonal antibodies raised against rat hepatitis E virus capsid protein: An evaluation of their neutralizing activity in a cell culture system. J Virol Methods. 2016 Mar 15. pii: S0166-0934(16)30040-4. doi: 10.1016/j.jviromet.2016.03.004. [Epub ahead of print] PubMed PMID: 26992654.

7. Kurihara T, Yoshizumi T, Itoh S, Harimoto N, Harada N, Ikegami T, Inagaki Y, Oshiro Y, Ohkohchi N, Okamoto H, Maehara Y. Chronic hepatitis E virus infection after living donor liver transplantation via blood transfusion: a case report. Surg Case Rep. 2016 Dec;2(1):32. doi: 10.1186/s40792-016-0159-0. Epub 2016 Apr 8. PubMed PMID: 27059470.

8. Hoshino T, Takagi H, Suzuki Y, Naganuma A, Sato K, Kakizaki S, Nishizawa T, Okamoto H, Yamada M. Fatal fulminant hepatitis caused by infection with subgenotype A1 hepatitis B virus with C1766T/T1768A core promoter mutations. Clin J Gastroenterol. 2016 Jun;9(3):160-7. doi: 10.1007/s12328-016-0649-4. Epub 2016 May 10. PubMed PMID: 27165167.

9. Nishizawa T, Hoshino T, Naganuma A, Kobayashi T, Nagashima S, Takahashi M, Takagi H, Okamoto H. Enhanced pregenomic RNA levels and lowered precore mRNA transcription efficiency in a genotype A hepatitis B virus genome with C1766T and T1768A mutations obtained from a fulminant hepatitis patient. J Gen Virol. 2016 Jul 28. doi: 10.1099/jgv.0.000566. [Epub ahead of print] PubMed PMID: 27473751.

10. Nagashima S, Kobayashi T, Tanaka T, Tanggis, Jirintai S, Takahashi M, Nishizawa T, Okamoto H. Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone. Virus Res. 2016 Jul 30. pii: S0168-1702(16)30391-4. doi: 10.1016/j.virusres.2016.07.011. [Epub ahead of print] PubMed PMID: 27485920.

11. Nagashima S, Morishima K, Okamoto H, Ishibashi S. Possible involvement of PCSK9 overproduction in hyperlipoproteinemia associated with hepatocellular carcinoma: A case report. J Clin Lipidol. 2016 Jul-Aug;10(4):1045-9. doi: 10.1016/j.jacl.2016.05.004. Epub 2016 May 14. PubMed PMID: 27578139.

12. Takahashi M, Kobayashi T, Tanggis, Jirintai S, Mulyanto, Nagashima S, Nishizawa T, Kunita S, Okamoto H. Production of monoclonal antibodies against the ORF3 protein of rat hepatitis E virus (HEV) and demonstration of the incorporation of the ORF3 protein into enveloped rat HEV particles. Arch Virol. 2016 Sep 8. [Epub ahead of print] PubMed PMID: 27638774.


2015
1. Li C, Barnes E, Newton PN, Fu Y, Vongsouvath M, Klenerman P, Okamoto H, Abe K, Pybus OG, Lu L. An expanded taxonomy of hepatitis C virus genotype 6: Characterization of 22 new full-length viral genomes. Virology. 2015 Jan 9;476C:355-363. doi: 10.1016/j.virol.2014.12.025. [Epub ahead of print] PubMed PMID: 25589238.

2. Kamitsukasa H, Iri M, Tanaka A, Nagashima S, Takahashi M, Nishizawa T, Okamoto H. Spontaneous reactivation of hepatitis B virus (HBV) infection in patients with resolved or occult HBV infection. J Med Virol. 2015 Jan 21. doi: 10.1002/jmv.24115. [Epub ahead of print] PubMed PMID: 25612181.

3. Suzuki K, Kataoka K, Miyamoto Y, Miyasaka A, Kumagai I, Takikawa Y, Takahashi M, Okamoto H Clinical and Molecular Analyses of Sporadic Acute Hepatitis A and E and the Specific Viral Genotypes Isolated in Iwate and Three Neighboring Prefectures in the Northern Part of Honshu, Japan from 2004-2013. Hepatol Res. 2014 Aug 22. doi: 10.1111/hepr.12406. [Epub ahead of print] PubMed PMID: 25146162.

4. Mawatari S, Uto H, Moriuchi A, Tabu K, Muromachi K, Tabu E, Oda K, Imanaka D, Oshige A, Nakazawa J, Kumagai K, Tamai T, Okamoto H, Tsubouchi H, Ido A. Horizontal transmission of de novo hepatitis B between spouses: A case report. Hepatol Res. 2014 Sep 11. doi: 10.1111/hepr.12422. [Epub ahead of print] PubMed PMID: 25211282.

5. Jiang X, Kanda T, Nakamoto S, Saito K, Nakamura M, Wu S, Haga Y, Sasaki R, Sakamoto N, Shirasawa H, Okamoto H, Yokosuka O. The JAK2 inhibitor AZD1480 inhibits hepatitis A virus replication in Huh7 cells. Biochem Biophys Res Commun. 2015 Mar 20;458(4):908-12. doi: 10.1016/j.bbrc.2015.02.058. Epub 2015 Feb 19. PubMed PMID: 25704089.

6. Takeuchi S, Yamazaki Y, Sato K, Takizawa D, Yamada M, Okamoto H. Full genome analysis of a European-type genotype 3 hepatitis E virus variant obtained from a Japanese patient with autochthonous acute hepatitis E. J Med Virol. 2015 Mar 16. doi: 10.1002/jmv.24191. [Epub ahead of print] PubMed PMID: 25777997.

7. Inagaki Y, Oshiro Y, Hasegawa N, Fukuda K, Abei M, Nishi M, Okamoto H, Ohkohchi N. Clinical Features of Hepatitis E Virus Infection in Ibaraki, Japan: Autochthonous Hepatitis E and Acute-on-Chronic Liver Failure. Tohoku J Exp Med. 2015;235(4):275-82. doi: 10.1620/tjem.235.275. PubMed PMID: 25797216.

8. Bando M, Nakayama M, Takahashi M, Hosono T, Mato N, Yamasawa H, Okamoto H, Sugiyama Y. Serum torque teno virus DNA titer in idiopathic pulmonary fibrosis patients with acute respiratory worsening. Intern Med. 2015;54(9):1015-9. doi: 10.2169/internalmedicine.54.3610. Epub 2015 May 1. PubMed PMID: 25948340.

9. Inagaki Y, Oshiro Y, Imanishi M, Ishige K, Takahashi M, Okamoto H, Ohkohchi N. Acute infection by hepatitis E virus with a slight immunoglobulin M antibody response. Clin J Gastroenterol. 2015 Jul 28. [Epub ahead of print] PubMed PMID: 26215116.

10. Yazaki Y, Sugawara K, Honda M, Ohnishi H, Nagashima S, Takahashi M, Okamoto H. Characteristics of 20 Patients with Autochthonous Acute Hepatitis E in Hokkaido, Japan: First Report of Bilateral Facial Palsy Following the Infection with Genotype 4 Hepatitis E Virus. Tohoku J Exp Med. 2015;236(4):263-271. PubMed PMID: 26228039.

11. Kanda T, Sasaki R, Nakamoto S, Haga Y, Nakamura M, Shirasawa H, Okamoto H, Yokosuka O. The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity. Biochem Biophys Res Commun. 2015 Sep 21. pii: S0006-291X(15)30600-8. doi:
10.1016/j.bbrc.2015.09.083. [Epub ahead of print] PubMed PMID: 26388050.


12. Kanda T, Yasui S, Nakamura M, Arai M, Sasaki R, Haga Y, Wu S, Nakamoto S, Okamoto H, Yokosuka O. Recent Trend of Hepatitis E Virus Infection in Chiba Area, Japan: 3 of 5 Cases with Rheumatoid Arthritis. Case Rep Gastroenterol. 2015 Oct 17;9(3):317-326. eCollection 2015 Sep-Dec. PubMed PMID: 26600768; PubMed Central PMCID: PMC4649734.

13. Inagaki Y, Oshiro Y, Tanaka T, Yoshizumi T, Okajima H, Ishiyama K, Nakanishi C, Hidaka M, Wada H, Hibi T, Takagi K, Honda M, Kuramitsu K, Tanaka H, Toyama T, Ikegami T, Imura S, Shimamura T, Nakayama Y, Urahashi T, Yamagishi K, Ohnishi H, Nagashima S, Takahashi M, Shirabe K, Kokudo N, Okamoto H, Ohkohchi N. A nationwide survey of hepatitis E virus infection and chronic hepatitis E in liver transplant recipients in Japan. EBioMedicine 2(11):1607-12, 2015. Commentary
 
2014
1: Takahashi M, Okamoto H. Features of hepatitis E virus infection in humans and animals in Japan. Hepatol Res. 2014 Jan;44(1):43-58. doi: 10.1111/hepr.12175. Epub 2013 Jun 20. PubMed PMID: 23721425.

2: Takahashi M, Nishizawa T, Nagashima S, Jirintai S, Kawakami M, Sonoda Y,Suzuki T, Yamamoto S, Shigemoto K, Ashida K, Sato Y, Okamoto H. Molecular characterization of a novel hepatitis E virus (HEV) strain obtained from a wild boar in Japan that is highly divergent from the previously recognized HEV strains. Virus Res. 2014 Feb 13;180:59-69. doi: 10.1016/j.virusres.2013.12.014. Epub 2013 Dec 24. PubMed PMID: 24370869.

3: Mulyanto, Suparyatmo JB, Andayani IG, Khalid, Takahashi M, Ohnishi H, Jirintai S, Nagashima S, Nishizawa T, Okamoto H. Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis. Virus Res. 2014 Jan 22;179:102-12. doi: 10.1016/j.virusres.2013.10.029. Epub 2013 Nov 11. PubMed PMID: 24231359.

4: Watanabe S, Isoda N, Ohtake T, Hirosawa T, Morimoto N, Aoki K, Ohnishi H, Takahashi M, Sugano K, Okamoto H. Full genome analysis of Philippine indigenous subgenotype IA hepatitis A virus strains from Japanese patients with imported acute hepatitis A. Hepatol Res. 2014 Mar;44(3):270-279. doi: 10.1111/hepr.12124. Epub 2013 Apr 29. PubMed PMID: 23607583

5: Okano H, Nakano T, Sugimoto K, Takahashi K, Nagashima S, Takahashi M, Arai M, Okamoto H. High genomic similarity between European type hepatitis E virus subgenotype 3e strains isolated from an acute hepatitis patient and a wild boar in Mie, Japan. Hepatol Res. 2013 May 2. doi: 10.1111/hepr.12155. [Epub ahead of print] PubMed PMID: 23639180.

6: Okano H, Takahashi M, Isono Y, Tanaka H, Nakano T, Oya Y, Sugimoto K, Ito K, Ohmori S, Maegawa T, Kobayashi M, Nagashima S, Nishizawa T, Okamoto H. Characterization of sporadic acute hepatitis E and comparison of hepatitis E virus genomes in acute hepatitis patients and pig liver sold as food in Mie, Japan. Hepatol Res. 2013 Aug 8. doi: 10.1111/hepr.12216. [Epub ahead of print] PubMed PMID: 23927634.

7: Mulyanto, Wibawa ID, Suparyatmo JB, Amirudin R, Ohnishi H, Takahashi M, Nishizawa T, Okamoto H. The complete genomes of subgenotype IA hepatitis A virus strains from four different islands in Indonesia form a phylogenetic cluster. Arch Virol. 2013 Nov 9. [Epub ahead of print] PubMed PMID: 24212885.

8: Nagashima S, Takahashi M, Jirintai S, Tanggis, Kobayashi T, Nishizawa T, Okamoto H. The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2. Arch Virol. 2013 Nov 13. [Epub ahead of print] PubMed PMID: 24221250

9: Jirintai S, Gis T, Anto M, Suparyatmo JB, Takahashi M, Kobayashi T, Nagashima S, Nishizawa T, Okamoto H. Rat hepatitis E virus derived from wild rats (Rattus rattus) propagates efficiently in human hepatoma cell lines. Virus Res. 2014 Mar 11. pii: S0168-1702(14)00087-2. doi: 10.1016/j.virusres.2014.03.002. [Epub ahead of print] PubMed PMID: 24631787.

10. Li C, Lu L, Murphy DG, Negro F, Okamoto H. The origin of HCV genotype 3 in Africa as estimated through an evolutionary analysis of the full-length genomes of nine subtypes, including the newly sequenced 3d and 3e. J Gen Virol. 2014 May 2. doi: 10.1099/vir.0.065128-0. [Epub ahead of print] PubMed PMID: 24795446.

11. Nagashima S, Jirintai S, Takahashi M, Kobayashi T, Tanggis, Nishizawa T, Kouki T, Yashiro T, Okamoto H. Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies. J Gen Virol. 2014 Jun 26. pii: vir.0.066910-0. doi: 10.1099/vir.0.066910-0. [Epub ahead of print] PubMed PMID: 24970738.

12. Smith DB, Simmonds P, Jameel S, Emerson SU, Harrison TJ, Meng XJ, Okamoto H,
Van der Poel WH, Purdy MA. CONSENSUS PROPOSALS FOR CLASSIFICATION OF THE FAMILY
HEPEVIRIDAE. J Gen Virol. 2014 Jul 2. pii: vir.0.068429-0. doi:
10.1099/vir.0.068429-0. [Epub ahead of print] PubMed PMID: 24989172.


13. Jiang X, Kanda T, Wu S, Nakamoto S, Saito K, Shirasawa H, Kiyohara T, Ishii K, Wakita T, Okamoto H, Yokosuka O. Suppression of La Antigen Exerts Potential Antiviral Effects against Hepatitis A Virus. PLoS One. 2014 Jul 7;9(7):e101993. doi: 10.1371/journal.pone.0101993. eCollection 2014. PubMed PMID: 24999657.

14. Okamoto D, Nakayama H, Ikeda T, Ikeya S, Nagashima S, Takahashi M, Sugai Y, Okamoto H Molecular analysis of the interspousal transmission of hepatitis B virus in two Japanese patients who acquired fulminant hepatitis B after 50 and 49 years of marriage. J Med Virol. 2014 Aug 13. doi: 10.1002/jmv.24040. [Epub ahead of print] PubMed PMID: 25132075.

2013
1: Mulyanto, Depamede SN, Sriasih M, Takahashi M, Nagashima S, Jirintai S, Nishizawa T, Okamoto H. Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia. Arch Virol. 2013 Jan;158(1):87-96. doi: 10.1007/s00705-012-1462-0. Epub 2012 Sep 15. PubMed PMID: 22983110.

2: Okamoto H. Culture systems for hepatitis E virus. J Gastroenterol. 2013 Feb;48(2):147-58. doi: 10.1007/s00535-012-0682-0. Epub 2012 Oct 27. Review. PubMed PMID: 23104469.

3: Lu L, Li C, Yuan J, Lu T, Okamoto H, Murphy DG. Full-length genome sequences of five hepatitis C virus isolates representing subtypes 3g, 3h, 3i, and 3k, and a unique genotype 3 variant. J Gen Virol. 2013 Mar;94(Pt 3):543-8. doi: 10.1099/vir.0.049668-0. Epub 2012 Nov 14. PubMed PMID: 23152370.

4: Minekawa T, Takehara S, Takahashi M, Okamoto H. Development of a highly sensitive bioluminescent enzyme immunoassay for hepatitis B virus surface antigen capable of detecting divergent mutants. Clin Vaccine Immunol. 2013 Aug;20(8):1255-65. doi: 10.1128/CVI.00186-13. Epub 2013 Jun 12. PubMed PMID:23761660.

5: Nakano T, Takahashi K, Arai M, Okano H, Kato H, Ayada M, Okamoto H, Mishiro S. Identification of European-type hepatitis E virus subtype 3e isolates in Japanese wild boars: molecular tracing of HEV from swine to wild boars. Infect Genet Evol. 2013 Aug;18:287-98. doi: 10.1016/j.meegid.2013.06.004. Epub 2013 Jun 12. PubMed PMID: 23770142.

6: Takagi H, Hoshino T, Naganuma A, Koitabashi E, Uehara S, Sakamoto N, Kudo T, Ryusaki K, Kakizaki S, Okamoto H. Drug induced hypersensitivity syndrome by triple therapy of peginterferon alpha2b, ribavirin and telaprevir in patient with double positive for HBV and HCV. Hepatogastroenterology. 2013
Oct;60(127):1557-60. PubMed PMID: 24627926
.

2012
1: Mulyanto, Pancawardani P, Depamede SN, Wahyono A, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Okamoto H. Identification of four novel subgenotypes (C13-C16) and two inter-genotypic recombinants (C12/G and C13/B3) of hepatitis B virus in Papua province, Indonesia. Virus Res. 2012 Jan;163(1):129-40. doi: 10.1016/j.virusres.2011.09.002. Epub 2011 Sep 8. PubMed PMID: 21925554.

2: Takahashi H, Tanaka T, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Mizuo H, Yazaki Y, Okamoto H. A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food. Arch Virol. 2012 Feb;157(2):235-46. doi: 10.1007/s00705-011-1153-2. Epub 2011 Nov 3. PubMed PMID: 22048607.

3: Nakano T, Takahashi K, Pybus OG, Hashimoto N, Kato H, Okano H, Kobayashi M, Fujita N, Shiraki K, Takei Y, Ayada M, Arai M, Okamoto H, Mishiro S. New findings regarding the epidemic history and population dynamics of Japan-indigenous genotype 3 hepatitis E virus inferred by molecular evolution. Liver Int. 2012 Apr;32(4):675-88. doi: 10.1111/j.1478-3231.2011.02728.x. Epub 2011 Dec 18. PubMed PMID: 22181032.

4: Ikeda T, Morimoto A, Nakamura S, Yokoyama K, Hayase T, Oh Y, Kashii Y, Yotsumoto S, Okamoto H, Y Momoi M. A marked decrease in CD4-positive lymphocytes at the onset of hepatitis in a patient with hepatitis-associated aplastic anemia. J Pediatr Hematol Oncol. 2012 Jul;34(5):375-7. doi: 10.1097/MPH.0b013e31822bf699. PubMed PMID: 22246160.

5: Nakano T, Okano H, Kobayashi M, Ito K, Ohmori S, Nomura T, Kato H, Ayada M, Nakano Y, Akachi S, Sugimoto K, Fujita N, Shiraki K, Takei Y, Takahashi M, Okamoto H. Molecular epidemiology and genetic history of European-type genotype 3 hepatitis E virus indigenized in the central region of Japan. Infect Genet Evol. 2012 Oct;12(7):1524-34. doi: 10.1016/j.meegid.2012.06.002. Epub 2012 Jun 15. PubMed PMID: 22706162.

6: Takikawa Y, Miyamoto Y, Onodera M, Kuroda H, Kasai K, Miyasaka A, Takahashi M, Okamoto H, Suzuki K. Icteric acute hepatitis E with no response of immunoglobulin M class anti-hepatitis E virus antibody. Hepatol Res. 2012 Nov;42(11):1146-9. doi: 10.1111/j.1872-034X.2012.01023.x. PubMed PMID: 23094855.

7: Jirintai S, Jinshan, Tanggis, Manglai D, Mulyanto, Takahashi M, Nagashima S, Kobayashi T, Nishizawa T, Okamoto H. Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells. Virus Res. 2012 Dec;170(1-2):126-37. doi: 10.1016/j.virusres.2012.09.015. Epub 2012 Oct 5. PubMed PMID: 23041252.

2011
1. Mulyanto, Depamede SN, Wahyono A, Jirintai, Nagashima S, Takahashi M, Okamoto H: Analysis of the full-length genomes of novel hepatitis B virus subgenotypes C11 and C12 in Papua, Indonesia. J Med Virol 83:54-64, 2011.

2. Nagashima S, Takahashi M, Jirintai, Tanaka T, Yamada K, Nishizawa T, Okamoto H: A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells. J Gen Virol 92:269-287, 2011.

3. Okamoto H: Efficient cell culture systems for hepatitis E virus strains in feces and circulating blood. Rev Med Virol 21:18-31, 2011.

4. Takahashi M, Nishizawa T, Sato H, Sato Y, Jirintai, Nagashima S, Okamoto H: Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype. J Gen Virol 92:902-908, 2011.

5. Okamoto H: Hepatitis E virus cell culture models. Virus Res 161:65-77, 2011.

6. Sato Y, Sato H, Naka K, Furuya S, Tsukiji H, Kitagawa K, Sonoda Y, Usui T, Sakamoto H, Yoshino S, Shimizu Y, Takahashi M, Nagashima S, Jirintai, Nishizawa T, Okamoto H: A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes. Arch Virol 156:1345-1358, 2011.

7. Yokoyama K, Takahashi M, Nishizawa T, Nagashima S, Jirintai S, Yotsumoto S, Okamoto H, Momoi MY: Identification and characterization of a natural inter-genotypic (2b/1b) recombinant hepatitis C virus in Japan. Arch Virol 156:1591-1601, 2011.

8. Nagashima S, Takahashi M, Jirintai S, Tanaka T, Nishizawa T, Yasuda J, Okamoto H: Tsg101 and the vacuolar protein sorting pathway are required for release of hepatitis E virions. J Gen Virol 92: 2838-2848, 2011.

2010
1. Takahashi M, Tamura K, Hoshino Y, Nagashima S, Yazaki Y, Mizuo H, Iwamoto S, Okayama M, Nakamura Y, Kajii E, Okamoto H: A nationwide survey of hepatitis E virus infection in the general population of Japan. J Med Virol 82:271-281, 2010

2. Ohto H, Ishii T, Kitazawa J, Sugiyama S, Ujiie N, Fujimori K, Ariga H, Satoh T, Nollet KE, Okamoto H, Hoshi T: Declining hepatitis C virus (HCV) prevalence in pregnant women: impact of anti-HCV screening of donated blood. Transfusion 50:693-700, 2010

3. Nishimura N, Isoda N, Higashizawa T, Otake T, Tsukui M, Nagashima S, Takahashi M, Okamoto H, Sugano K: A case of acute hepatitis C caused by interspousal transmission after 30 years of marriage. Clin J Gastroenterol 3:50-56, 2010

4. Ishimura M, Ohga S, Ichiyama M, Kusuhara K, Takada H, Hara T, Takahashi M, Okamoto H: Hepatitis-associated aplastic anemia during a primary infection of genotype 1a torque teno virus. Eur J Pediatr 169:899-902, 2010.

5. Takahashi M, Tanaka T, Takahashi H, Hoshino Y, Takagi T, Azuma M, Kusano E, Isoda N, Sugano K, Okamoto H: Hepatitis E virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: characterization of HEV virions in blood circulation. J Clin Microbiol 48:1112-1125, 2010.

6. Mulyanto, Depamede SN, Surayah K, Tjahyono AAH, Jirintai, Nagashima S, Takahashi M, Okamoto H: Identification and characterization of hepatitis B virus subgenotype C10 in Nusa Tenggara, Indonesia. Arch Virol 155:705-715, 2010.

7. Jinshan, Jirintai, Manglai D, Takahashi M, Nagashima S, Okamoto H: Molecular and serological survey of hepatitis E virus infection among domestic pigs in Inner Mongolia, China. Arch Virol 155:1217-1226, 2010.

2009
1. Okamoto H: History of discoveries and pathogenicity of TT viruses. Curr Top Microbiol Immunol 331: 1-20, 2009 (E..-M. de Villiers, H. Zur Hausen eds., Torque Teno Virus: the Still Elusive Human Pathogens)

2. Okamoto H: TT viruses in animals. Curr Top Microbiol Immunol 331: 35-52, 2009 (E..-M. de Villiers, H. Zur Hausen eds., Torque Teno Virus: the Still Elusive Human Pathogens)

3. Ninomiya M, Takahashi M, Hoshino Y, Ichiyama K, Simmonds P, Okamoto H: Analysis of the entire genomes of torque teno midi virus variants in chimpanzees: infrequent cross-species infection between humans and chimpanzees. J Gen Virol 90:347-358, 2009

4. Yamada K, Takahashi M, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H: Construction of an infectious cDNA clone of hepatitis E virus strain JE03-1760F that can propagate effciently in cultured cells. J Gen Virol 90:457-462, 2009

5. Inoue J, Ueno Y, Nagasaki F, Akahane T, Fukushima K, Kogure T, Kondo Y, Kakazu E, Tamai K, Kido O, Nakagome Y, Ninomiya M, Obara N, Wakui Y, Takahashi M, Okamoto H, Shimosegawa T: Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan. J Gastroenterol 44:329-337, 2009

6. Takahashi K, Okamoto H, Abe N, Kawakami M, Matsuda H, Mochida S, Sakugawa H, Suginoshita Y, Watanabe S, Yamamoto K, Miyakawa Y, Mishiro S: Virulent strain of hepatitis E virus genotype 3, Japan. Emerg Infect Dis 15(5):704-709, 2009

7. Yamada K, Takahashi M, Hoshino Y, Takahashi H, Ichiyama K, Nagashima S, Tanaka T, Okamoto H: ORF3 protein of hepatitis E virus is essential for virion release from infected cells. J Gen Virol 90:1880-1891, 2009

8. Tanaka T, Takahashi M, Takahashi H, Ichiyama K, Hoshino Y, Nagashima S, Mizuo H, Okamoto H: Development and characterization of a genotype 4 hepatitis E virus cell culture system using a HE-JF5/15F strain recovered from a fulminant hepatitis patient. J Clin Microbiol 47(6):1906-1910, 2009

9. Mulyanto, Depamede SN, Surayah K, Tsuda F, Ichiyama K, Takahashi M, Okamoto H: A nationwide molecular epidemiological study on hepatitis B virus in Indonesia: identification of two novel subgenotypes, B8 and C7. Arch Virol 154:1047-1059, 2009

10. Toda T, Mitsui T, Tsukamoto Y, Ebara T, Masuko K, Takahashi M, Okamoto H: No evidence for patient-to-patient transmission of hepatitis C virus during upper gastrointestinal endoscopy: molecular studies on three acute hepatitis C patients. Dig Endosc 21:147-153, 2009

11. Davaalkham D, Enkhoyun T, Takahashi M, Nakamura Y, Okamoto H: Hepatitis A and E virus infections among children in Mongolia. Am J Trop Med Hyg 81:248-251, 2009.

12. Toda T, Mitsui T, Tsukamoto Y, Ebara T, Hirose A, Masuko K, Nagashima S, Takahashi M, Okamoto H: Molecular analysis of transmission of hepatitis C virus in a nurse who acquired acute hepatitis C after caring for a viremic patient with epistaxis. J Med Virol 81:1363-1370, 2009

13. Inoue J, Takahashi M, Mizuo H, Suzuki K, Aikawa T, Shimosegawa T, Okamoto H: Nucleotide substitutions of hepatitis E virus genomes associated with fulminant hepatitis and disease severity. Tohoku J Exp Med 218:279-284, 2009

14. Ichiyama K, Yamada K, Tanaka T, Nagashima S, Jirintai, Takahashi M, Okamoto H: Determination of the 5'-terminal sequence of subgenomic RNA of hepatitis E virus strains in cultured cells. Arch Virol 154:1945-1951, 2009
2008
1. Ennishi D, Terui Y, Yokoyama M, Mishima Y, Takahashi S, Takeuchi K, OKamoto H, Tanimoto M, Hatake K: Monitoring serum hepatitis C virus (HCV) RNA in patients with HCV-infected CD20-positive B-cell lymphoma undergoing rituximab combination chemotherapy. Am J Hematol 83(1):59-62, 2008

2. Ninomiya M, Takahashi M, Nishizawa T, Shimosegawa T, Okamoto H: Development of PCR asays with nested primers specific for differential detection of three human anelloviruses and early acquisition of dual or triple infection during infancy. J Clin Microbiol 46(2):507-514, 2008

3. Bando, M, Takahashi M, Ohno S, Hosono T, Hironaka M, Okamoto H, Sugiyama Y: Torque teno virus DNA titre elevated in idiopathic pulmonary fibrosis with primary lung cancer. Respirology 13(2):263-269, 2008.

4. Inoue J, Ueno Y, Kogure T, Nagasaki F, Kumura O, Obara N, Kido O, Nakagome Y, Kakazu E, Matsuda Y, Fukushima K, Segawa H, Nakajima I, Itoyama Y,Takahashi M, Okamoto H, Shimosegawa T: Analysis of the full-length genome of hepatitis B virus in the serum and cerebrospinal fluid of a patient with acute hepatitis B and transverse myelitis. J Clin Virol 41(4):301-304, 2008

5. Takahashi M, Hoshino Y, Tanaka T, Takahashi H, Nishizawa T, Okamoto H: Production of monoclonal antibodies against hepatitis E virus capsid protein and evaluation of their neuralizing activity in a cell culture system. Arch Virol 153(4):657-66, 2008

6. Takahashi M, Yamada K, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H: Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces. Arch Virol 153:1703-1713, 2008

7. Lorenzo FR, Tanaka T, Takahashi H, Ichiyama K, Hoshino Y, Yamada K, Inoue J, Takahashi M, Okamoto H: Mutational events during the primary propagation and consecutive passages of hepatitis E virus strain JE03-1760F in cell culture. Virus Res 137:86-96, 2008

2007
1. Endo K, Inoue J, Takahashi M, Mitsui T, Masuko K, Akahane Y, Okamoto H: Analysis of the full-length genome of a subgenotype IIIB hepatitis A virus isolate: primers for broadly reactive PCR and genotypic analysis. J Med Virol 79:8-17, 2007

2. Tsatsralt-Od B, Takahashi M, Endo K, Agimaa D, Buyankhuu O, Okamoto H: Comparison of hepatitis A and E virus infections among healthy children in Mongolia: evidence for infection with a subgenotype IA HAV in children. J Med Virol 79:18-25, 2007

3. Takikawa Y, Yasumi Y, Sato A, Endo R, Suzuki K, Mori Y, Akasaka H, Miura Y, Sawai T, Okamoto H: A case of acute hepatitis E associated with multidrug hypersensitivity and cytomegalovirus reactivation. Hepatol Res 37:158-165, 2007

4. Kumagai I, Abe K, Oikawa T, Sato A, Sato S, Endo R, Talikawa Y, Suzuki K, Masuda T, Sainokami S, Endo K, Takahashi M, Okamoto H: A male patient with severe acute hepatitis who was domestically infected with a genotype H hepatitis B virus in Iwate, Japan. J Gastroenterol 42(2):168-175, 2007

5. Tanaka T, Takahashi M, Kusano E, Okamoto H: Development and evaluation of an eficient cell-culture system for Hepatitis E virus. J Gen Virol 88:903-911, 2007

6. Davaalkham O, Ojima T, Uehara R, Watanabe M, Oki I, Endo K, Takahashi M, Okamoto H, Nakamura Y: Analysis of hepatitis B surface antigen mutations in Mongolia: molecular epidemiology and implications for mass vaccination. Arch Virol 152:575-584, 2007

7. Sainokami S, Abe K, Sato A, Endo R, Takikawa Y, Suzuki K, Okamoto H: Initial load of hepatitis B virus (HBV), its changing profile, and precore/core promoter mutations. correlate with the severity and outcome of acute HBV infection. J Gastroenterol 42(3):241-249, 2007

8. Lu L, Li C, Fu Y, Thaikrea L, Thongswat S, Maneekaru N, Apiharpiyakul C, Hotta H, Okamoto H, Netski D, Pybus OG, Murphy D, Hagedorn CH, Nelson KE: Complete genomes fo ehepatitis C virus subtypes 6f, 6i, 6j, and 6m: viral genetic diversity among Thai blood donors and infected spouses. J Gen Virol 8:1505-1518, 2007

9. Lu L, Li C, Fu Y, Gao F, Pybus OG, Abe K, Okamoto H, Hagedorn CH, Murphy D: Complete genomes of hepatitis C virus (HCV) subtypes 6c, 6l, 6o, 6p and 6q: completion of a full panel of genomes of HCV genotype 6. J Gen Virol 88:1519-1525, 2007.

10. Gotanda Y, Iwata A, Ohnuma H, Yoshikawa A, Mizoguchi H, Endo K, Takahahsi M, Okamoto H: Ongoing subclinical infection of hepatitis E virus among blood donors with an elevated alanine aminotransferase level in Japan. J Med Virol 79:734-742, 2007

11. Endo K, Takahashi M, Masuko K, Inoue K, Akahane Y, Okamoto H: Full-length sequences of subgenotype IIIA and IIIB hepatitis A virus isolates: characterization of genotype III HAV genomes. Virus Res 126:116-127, 2007

12. Ninomiya M, Nishizawa T, Takahashi M, Lorenzo FR, Shimosegawa T, Okamoto H: Identification and genomic characterization of a novel human torque teno virus of 3.2 kb. J Gen Virol 8:1939-1944, 2007

13. Tsatsralt-Od B, Takahashi M, Endo K, Agiimaa D, Buyankhuu O, Ninomiya M, Lorenzo FR, Okamoto H: Prevalence of hepatitis B, V, and delta virus infections among children in Mongolia: progress in childhood immunization. J Med Virol 79:1064-1074, 2007

14. Lorenzo FR, Tsatsralt-Od B, Ganbat S, Takahashi M, OKamoto H: Analysis of the full-length genome of hepatitis E virus isolates obtained from farm pigs in Mongolia. J Med Virol 79:1128-1137, 2007

15. Wibawa IDN, Suryadarma IGA, Mulyanto, Tsuda F, Matsumoto Y, Ninomiya M, Takahashi M, Okamoto H: Identification of genotype 4 hepatitis E virus strains from a patient with acute hepatitis E and farm pigs in Bali, Indonesia. J Med Virol 79:1138-1146, 2007

16. Okamoto H: Genetic variability and evolution of hepatitis E virus. Virus Res 127:216-228, 2007

17. Fukuda S, Ishikawa M, Ochiai N, Suzuki Y, Sunaga J, Shinohara N, Nozawa K, Tsuda F, Takahashi M, Okamoto H: Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991-2006. Arch Virol 152:1623-1635, 2007

18. Shrestha SM, Shrestha S, Shrestha A, Tsuda F, Endo K, Takahashi M, Okamoto H: High prevalence of hepatitis B virus infection and inferior vena cava obstruction among patients with liver cirrhosis or hepatocellular carcinoma in Nepal. J Gastroenterol Hepatol 22(11):1921-1928, 2007

19. Ninomiya M, Takahashi M, Shimosegawa T, Okamoto H: Analysis of the entire genomes of fifteen torque teno midi virus variants classifiable into a third group of genus Anellovirus. Arch Virol 152:1961-1975, 2007.

20. Takahashi M, Tanaka T, Azuma M, Kusano E, Aikawa T, Shibayama T, Yazaki Y, Mizuo H, Inoue J, Okamoto H: Prolonged fecal shedding of hepatitis E virus (HEV) during sporadic acute hepatitis E: evaluation of infectivity of HEV in fecal specimens in a cell culture system. J Clin Microbiol 45(11):3671-3679, 2007.

2006
1. Inoue J, Nishizawa T, Takahashi M, Aikawa T, Mizuo H, Suzuki K, Shimosegawa T, Okamoto H: Analysis of full-length genome of genotype 4 hepatitis E virus isolates from patients with fulminant or acute self-limited hepatitis E. J Med Virol 78:476-484, 2006

2. Tsatsralt-Od B, Takahashi M, Endo K, Buyankhuu O, Baatarkhuu O, Nishizawa T, Okamoto H: Infection with hepatitis A, B, C, and delta viruses among patients with acute hepatitis in Mongolia. J Med Virol 78:542-550, 2006

3. Inoue K, Ogawa O, Yamada M, Watanabe T, Okamoto H, Yoshiba M. Possible association of vigorous replication with the development of fulminant hepatitis. J Gastroenterol 41(4):383-387, 2006.

4. Mitsui T, Tsukamoto Y, Hirose A, Suzuki S, Yamazaki C, masuko K, Tsuda F, Endo K, Takahashi M, Okamoto H: Distinct changing profiles of hepatitis A and E virus infection among patients with acute hepatitis, patients on maintenance hemodialysis and healthy individuals in Japan. J Med Virol 78:1015-1024, 2006

5. Inoue J, Takahashi M, Ito K, Shimosegawa T, Okamoto H: Analysis of human and swine hepatitis E virus (HEV) isolates of genotype 3 in Japan that are only 81-83% similar to reported HEV isolates of the same genotype over the entire genome. J Gen Virol 87:2363-2369, 2006

6. Davaalkham D, Ojima T, Uehara R, Watanabe M, Oki I, Nymadawa P, Takahashi M, Okamoto H, Nakamura Y: Hepatitis delta virus infection in Mongolia: analyses of geographic distribution, risk factors and disease severity. Am J Trop Med Hyg 75:365-369, 2006

7. Inoue J, Takahahsi M, Yazaki Y, Tsuda F, Okamoto H.: Development and validation of an improved RT-PCR assay with nested universal primers for detection of hepatitis E virus strains with significant sequence divergence. J Virol Methods 137:325-333, 2006

2005
1. Takahashi M, Kusakai S, Mizuo H, Suzuki K, Fujimura K, Masuko K, Sugai Y, Aikawa T, Nishizawa T, Okamoto H: Simultaneous detection of immunoglobulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) is highly specific for diagnosis of acute HEV infection. J Clin Microbiol 43(1):49-56, 2005

2. Nakayama H, Sugai Y, Ikeya S, Inoue J, Nishizawa T, Okamoto H: Molecular investigation of interspousal transmission of hepatitis C virus in two Japanese patients who acquired acute hepatitis C after 40 or 42 years of marriage. J Med Virol 75:258-266, 2005

3. Ohnuma H, Yoshikawa A, Mizoguchi H, Okamoto H, the JRC NAT Screening Research Group: Characterization of genotype H hepatitis B virus strain identified for the first time from a Japanese blood donor by nucleic acid amplification test. J Gen Virol 86:595-599, 2005

4. Shibayama T, Masuda G, Ajisawa A, Hiruma K, Tsuda F, Nishizawa T, Takahashi M, Okamoto H: Characterization of seven genotypes (A to E, G and H) of hepatitis B virus recovered from Japanese patients infected with human immunodeficiency virus type 1. J Med Virol 76:24-32, 2005

5. Tokita H, Fukui H, Tanaka A, Kamitsukasa H, Yagura M, Harada H, Okamoto H: Risk factors for the development of hepatocellular carcinoma among patients with chronic hepatitis C who achieved a sustained virological response to interferon therapy. J Gastroenterol Hepatol 20:752-758, 2005

6. Nagasaki F, Ueno Y, Mano Y, Igarashi T, Yahagi K, Niitsuma H, Okamoto H, Shimosegawa T: A patient with clinical features of acute hepatitis E viral infection and autoimmune hepatitis. Tohoku J Exp Med 206:173-179, 2005

7. Ishii T, Ohto H, Takeuchi C, Ariga H, Hirai S, Ujiie N, Suzuki H, Okamoto H: Evolution in the hypervariable region of the hepatitis C virus in two infants infected by mother-to-infant transmission. Pediatr Int 47:278-285, 2005

8. Inoue J, Takahashi M, Nishizawa T, Narantuya L, Sakuma M, Kagawa Y, Shimosegawa T, Okamoto H: High prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia. J Med Virol 76:333-340, 2005

9. Mizuo H, Yazaki Y, Sugarawa K, Tsuda F, Takahashi M, Nishizawa T, Okamoto H: Possible risk factors for the transmission of hepatitis E virus and for the severe form of hepatitis E acquired locally in Hokkaido, Japan. J Med Virol 76:341-349, 2005

10. Takahashi M, Nishizawa T, Tanaka T, Tsatsralt-Od B, Inoue J, Okamoto H: Correlation between positivity for immunoglobulin A antibodies and viraemia of swine hepatitis E virus observed among farm pigs in Japan. J Gen Virol 86:1807-1813, 2005

11. Mitsui T, Tsukamoto Y, Suzuki S, Yamazaki C, Masuko K, Tsuda F, Takahashi M, Tsatsralt-Od B, Nishizawa T, Okamoto H: Serological and molecular studies on subclinical hepatitis E virus infection using periodic serum samples obtained from healthy individuals. J Med Virol 76:526-533, 2005

12. Nagasaki F, Ueno Y, Kanno N, Okamoto H, Shimosegawa T: A case of acute hepatitis with positive autoantibodies who actually had hepatitis E virus infection. Hepatol Res 32:134-137, 2005

13. Simmonds P, Bukh J, Combet C, Deleage G, Enomoto N, Feinstone S, Halfon P, Inchauspe G, Kuiken C, Maertens G, Mizokami M, Murphy DG, Okamoto H, Pawlotsky JM, Penin F, Sablon E, Shin-I T, Stuyver LJ, Thiel HJ, Viazov S, Weiner AJ, Widell A. Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Hepatology 42(4):962-973, 2005

14. Tsatsralt-Od B, Takahashi M, Nishizawa T, Endo K, Inoue J, Okamoto H: High prevalence of dual or triple infection of hepatitis B, C and delta viruses among patients with chronic liver disease in Mongolia. J Med Virol 77:491-499, 2005

15. Nishizawa T, Takahashi M, Endo K, Fujiwara S, Sakuma N, Kawazuma F, Sakamoto H, Sato Y, Bando M, Okamoto H: Analysis of the full-length genome of hepatitis E virus isolates obtained from wild boars in Japan. J Gen Virol 86:3321-3326, 2005

16. Tsatsralt-Od B, Takahashi M, Nishizawa T, Inoue J, Ulaankhuu D, Okamoto H: High prevalence of hepatitis B, C, and delta virus infections among blood donors in Mongolia. Arch Virol 150(12):2513-2528, 2005

2004
1. Shrestha SM, Shrestha S, Tsuda F, Nishizawa T, Takahashi M, Gotanda Y, Okamoto H: Genetic changes in hepatitis E virus of subtype 1a in patients with sporadic acute hepatitis E in Kathmandu, Nepal, from 1997 to 2002. J Gen Virol 85:97-104, 2004

2. Usui R, Kobayashi E, Takahashi M, Nishizawa T, Okamoto H: Presence of antibodies to hepatitis E virus in Japanese pet cats. Infection 32:57-58, 2004

3. Takahashi M, Nishizawa T, Gotanda Y, Tsuda F, Komatsu F, Kawabata T, Hasegawa K, Altankhuu M, Chimedregzen U, Narantuya L, Hoshino H, Hino K, Kagawa Y, Okamoto H: High prevalence of antibodies to hepatitis A and E viruses and viremia of hepatitis B, C, and D viruses among apparently healthy populations in Mongolia. Clin Diagn Lab Immunol 11(2):392-398, 2004

4. Yamamoto T, Suzuki H, Toyota T, Takahashi M, Okamoto H: Three male patients with sporadic acute hepatitis E in Sendai, Japan who were domestically infected with hepatitis E virus of genotype III or IV. J Gastroenterol 39(3):292-298, 2004

5. Wibawa IDN, Muljono DH, Mulyanto, Suryadarma IGA, Tsuda F, Takahashi M, Nishizawa T, Okamoto H: Prevalence of antibodies to hepatitis E virus among apparently healthy humans and pigs in Bali, Indonesia: identification of a pig infected with a genotype 4 hepatitis E virus. J Med Virol 73(1):38-44, 2004

6. Sainokami S, Abe K, Kumagai I, Miyasaka A, Endo R, Takikawa Y, Suzuki K, Mizuo H, Sugai Y, Akahane Y, Koizumi Y, Yajima Y, Okamoto H: Epidemiological and clinical study of sporadic acute hepatitis E caused by indigenous strains of hepatitis E virus in Japan compared with acute hepatitis A. J Gastroenterol 39:640-648, 2004

7. Fukuda S, Sunaga J, Saito N, Fujimura K, Itoh Y, Sasaki M, Tsuda F, Takahashi M, Okamoto H: Prevalence of antibodies to hepatitis E virus among Japanese blood donors: identification of three blood donors infected with a genotype 3 hepatitis E virus. J Med Virol 73:554-561, 2004

8. Koizumi Y, Isoda N, Sato Y, Iwaki T, Ono K, Ido K, Sugano K, Takahashi M, Nishizawa T, Okamoto H: Infection of a Japanese patient by genotype 4 hepatitis E virus while traveling in Vietnam. J Clin Microbiol 42(8):3883-3885, 2004

9. Sonoda H, Abe M, Sugimoto T, Sato Y, Bando M, Fukui E, Mizuo H, Takahashi M, Nishizawa T, Okamoto H: Prevalence of hepatitis E virus (HEV) infection in wild boars and deer and genetic identification of a genotype 3 HEV from a boar in Japan. J Clin Microbiol 42(11):5371-5374, 2004

10. Tanaka H, Yoshino H, Kobayashi E, Takahashi M, Okamoto H: Molecular investigation of hepatitis E virus infection in domestic and miniature pigs used for medical experiments. Xenotransplantation 11:503-510, 2004

11. Mitsui T, Tsukamoto Y, Yamazaki C, Masuko K, Tsuda F, Takahashi M, Nishizawa T, Okamoto H: Prevalence of hepatitis E virus infection among hemodialysis patients in Japan: evidence for infection with a genotype 3 HEV by blood transfusion. J Med Virol 74:563-572, 2004

2003
1. Shrestha SM, Shrestha S, Tsuda F, Nishizawa T, Gotanda Y, Takeda N, Okamoto H: Molecular investigation of hepatitis E virus infection in patients with acute hepatitis in Kathmandu, Nepal. J Med Virol 69:207-214, 2003

2. Tokita H, Harada H, Gotanda Y, Takahashi M, Nishizawa T, Okamoto H: Molecular and serological characterization of sporadic acute hepatitis E in a Japanese patient infected with a genotype III hepatitis E virus in 1993. J Gen Virol 84:421-427, 2003

3. Takahashi M, Nishizawa T, Okamoto H: Identification of a genotype III swine hepatitis E virus that was isolated from a Japanese pig born in 1990 and that is most closely related to Japanese isolates of human hepatitis E virus. J Clin Microbiol 41(3):1342-1343, 2003

4. Takahashi M, Nishizawa T, Miyajima H, Gotanda Y, Iita T, Tsuda F, Okamoto H: Swine hepatitis E virus strains in Japan form four phylogenetic clusters comparable with those of Japanese isolates of human hepatitis E virus. J Gen Virol 84(4):851-862, 2003

5. Nishizawa T, Takahashi M, Mizuo H, Miyajima H, Gotanda Y, Okamoto H: Characterization of Japanese swine and human hepatitis E virus isolates of genotype IV with 99% identity over the entire genome. J Gen Virol 84(5):1245-1251, 2003

6. Tokita H, Fukui H, Tanaka A, Kamitsukasa H, Yagura M, Harada H, Hebisawa A, Kurashima A, Okamoto H: Circulating KL-6 level at baseline is a predictive indicator for the occurrence of interstitial pneumonia during interferon treatment for chronic hepatitis C. Hepatol Res 26(2):91-97, 2003

7. Kuno A, Ido K, Isoda N, Satoh Y, Ono K, Satoh S, Inamori H, Sugano K, Kanai N, Nishizawa T, Okamoto H: Sporadic acute hepatitis E of a 47-year-old man whose pet cat was positive for antibody to hepatitis E virus. Hepatol Res 26(3):237-242, 2003

8. Yazaki Y, Mizuo H, Takahashi M, Nishizawa T, Sasaki N, Gotanda Y, Okamoto H: Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food. J Gen Virol 84(9):2351-2357, 2003

9. Nakamura M, Wang J, Murakami T, Ajiki T, Hakamata Y, kaneko T, Takahashi M, Okamoto H, Mayumi M, Kobayashi E: DNA immunization of the grafted liver by particle-mediated gene gun. Transplantation 76(9):1369-1375, 2003

10. Okamoto H, Takahashi M, Nishizawa T: Features of hepatitis E virus infection in Japan. Intern Med 42(11):1065-1071, 2003

11. Kato S, Okamoto H, Nishino Y, Oyake Y, Nakazato Y, Okuda M, Fujisawa T, Iinuma K, Blaser MJ: Helicobacter pylori and TT virus prevalence in Japanese children. J Gastroenterol 38:1126-1130, 2003

2002
1. Yokoyama H, Yasuda J, Okamoto H, Iwakura Y: Pathological changes of renal epithelial cells in mice transgenic for the TT virus ORF1 gene. J Gen Virol 83(1):141-150, 2002

2. Peng YH, Nishizawa T, Takahashi M, Ishikawa T, Yoshikawa A, Okamoto H: Analysis of the entire genomes of thirteen TT virus variants classifiable into the fourth and fifth genetic groups, isolated from viremic infants. Arch Virol 147(1): 21-41, 2002

3. Takahashi M, Asabe S, Gotanda Y, Kishimoto J, Tsuda F, Okamoto H: TT virus is distributed in various leukocyte subpopulations at distinct levels, with the highest viral load in granulocytes. Biochem Biophys Res Commun 290(1):242-248, 2002

4. Okamoto H, Takahashi M, Nishizawa T, Tawara A, Fukai K, Muramatsu U, Naito Y, Yoshikawa A: Genomic characterization of TT viruses (TTVs) in pigs,cats and dogs and their relatedness with species-specific TTVs in primates and tupaias. J Gen Virol 83(6):1291-1297, 2002

5. Tokita H, Murai S, Kamitsukasa H, Yagura M, Harada H, Takahashi M,Okamoto H: TT virus of certain genotypes may reduce the platelet count in patients who achieve a sustained virologic response to interferon treatment for chronic hepatitis C. Hepatol Res 23(2):105-114, 2002

6. Ohto H, Ujiie N, Takeuchi C, Sato A, Hayashi A, Ishiko H, Nishizawa T,Okamoto H, the Vertical Transmission of Hepatitis Viruses Collaborative Study Group: TT virus infection during childhood. Transfusion 42(7): 892-898, 2002

7. Takahashi M, Nishizawa T, Yoshikawa A, Sato S, Isoda N, Ido K, Sugano K, Okamoto H: Identification of two distinct genotypes of hepatitis E virus in a Japanese patient with acute hepatitis who had not traveled abroad. J Gen Virol 83(8):1931-1940, 2002

8. Tokita H, Murai S, Kamitsukasa H, Yagura M, Harada H, Takahashi M, Okamoto H: High TT virus load as an independent factor associated with the occurrence of hepatocellular carcinoma among patients with hepatitis C virus-related chronic liver disease. J Med Virol 67(4): 501-509, 2002

9. Akahane Y, Okada S, Sakamoto M, Wakamiya M, Kitamura T, Tawara A, Naitoh S, Tsuda F, Okamoto H: Persistence of hepatitis B viremia after recovery from acute hepatitis B: correlation between anti-HBc titer and HBV DNA in serum. Hepatol Res 24(1):8-17, 2002

10. Mizuo H, Suzuki K, Takikawa Y, Sugai Y, Tokita H, Akahane Y, Itoh K, Gotanda Y, Takahashi M, Nishizawa T, Okamoto H: Polyphyletic strains of hepatitis E virus are responsible for sporadic cases of acute hepatitis in Japan. J Clin Microbiol 40(9):3209-3218, 2002

11. Hiroishi K, Eguchi J, Ishii S, Okamoto H, Mitamura K, Imawari M: Differential effect of cytotoxic T lymphocyte variant epitopes on generation and cytotoxicity in chronic hepatitis C virus infection. Hepatol Res 24(2): 91-94, 2002

12. Al-Knawy B, Okamoto H, El-Mekki AA, Khalafalla ME, Wabel AA, Qazi F, Khan A, Shatoor A: Distribution of hepatitis C genotype and co-infection rate with hepatitis G in Saudi Arabia. Hepatol Res 24(2): 95-98, 2002

13. Aikawa T, Kojima M, Takahashi M, Nishizawa T, Okamoto H: Identification of indigenous hepatitis E virus from a Japanese patient who contracted sporadic acute hepatitis in 1982. J Infect Dis 186(10):1535-1536, 2002

14. Suzuki K, Aikawa T, Okamoto H: Fulminant hepatitis E in Japan. N Engl J Med 347(18):1456, 2002

15. Shrestha SM, Takeda N, Tsuda F, Okamoto H, Shrestha S, Shrestha VM: High prevalence of hepatitis B virus infection amongst Tibetans in Nepal. Trop Gastroenterol 23:63-65, 2002

2001
1. Tsuda F, Takahashi M, Nishizawa T, Akahane Y, Konishi K, Yoshizawa H, Okamoto H: IgM-class antibodies to TT virus (TTV) in patients with acute TTV infection. Hepatol Res 19:1-11, 2001

2. Tokita H, Murai S, Kamitsukasa H, Yagura M, Harada H, Tawara A, Takahashi M, Okamoto H: Influence of TT virus on the clinical course of alcoholic liver disease. Hepatol Res19:180-193, 2001

3. Tokita H, Murai S, Kamitsukasa H, Yagura M, Harada H, Hebisawa A, Takahashi M, Okamoto H: Influence of TT virus on the histopathological features of nonalcoholic fatty liver disease. Hepatol Res 19:197-211, 2001

4. Shibayama T, Masuda G, Ajisawa A, Takahashi M, Nishizawa T, Tsuda F, Okamoto H: Inverse relationship between the titre of TT virus DNA and the CD4 cell count in patients infected with HIV. AIDS 15(5):563-570, 2001

5. Tokita H, Murai S, Kamitsukasa H, Yagura M, Harada H, Takahashi M, Okamoto H: Influence of TT virus infection on the thrombocytopenia of patients with chronic liver disease. Hepatol Res 20(3):288-300, 2001

6. Yusufu Y, Mochida S, Matsui A, Okamoto H, Fujiwara K: TT virus infection in cases of fulminant hepatic failure-evaluation by clonality based on amino acid sequence of hypervariable regions. Hepatol Res 21:85-96, 2001

7. Muljono DH, Nishizawa T, Tsuda F, Takahashi M, Okamoto H: Molecular epidemiology of TT virus (TTV) and characterization of two novel TTV genotypes in Indonesia. Arch Virol 146(7):1249-1266, 2001

8. Okamoto H, Mayumi M: TT virus: virological and genomic characteristics and disease associations. J Gastroenterol 36(8):519-529, 2001

9. Okamoto H, Nishizawa T, Takahashi M, Tawara A, Peng Y, Kishimoto J, Wang Y: Genomic and evolutionary characterization of TT virus (TTV) in tupaias and comparison with species-specific TTVs in humans and non-human primates. J Gen Virol 82(9):2041-2050, 2001

10. Asabe S, Nishizawa T, Iwanari H, Okamoto H: Phosphorylation of serine-rich protein encoded by open reading frame 3 of the TT virus genome. Biochem Biophys Res Commun 286(2): 298-304, 2001

11. Okamoto H, Nishizawa T, Takahashi M, Asabe S, Tsuda F, Yoshikawa A: Heterogeneous distribution of TT virus of distinct genotypes in multiple tissues from infected humans. Virology 288(2):358-368, 2001

12. Okamoto H, Takahashi M, Nishizawa T, Fukai K, Muramatsu U, Yoshikawa A: Analysis of the complete genome of indigenous swine hepatitis E virus isolated in Japan. Biochem Biophys Res Commun 289(5):929-936, 2001

13. Bando M, Ohno S, Oshikawa K, Takahashi M, Okamoto H, Sugiyama Y: Infection of TT virus in patients with idiopathic pulmonary fibrosis. Respir Med 95(12):935-942, 2001

2000
1. Okamoto H, Fukuda M, Tawara A, Nishizawa T, Itoh Y, Hayasaka I, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M: Species-specific TT viruses and cross-species infection in nonhuman primates. J Virol 74(3): 1132-1139, 2000.

2. Okamoto H, Takahashi M, Nishizawa T, Tawara A, Sugai Y, Sai T, Tanaka T, Tsuda F: Replicative forms of TT virus DNA in bone marrow cells. Biochem Biophys Res Commun 270: 657-662, 2000.

3. Okamoto H, Ukita M, Nishizawa T, Kishimoto J, Hoshi Y, Mizuo H, Tanaka T, Miyakawa Y, Mayumi M: Circular double-stranded forms of TT virus DNA in the liver. J Virol 74(11): 5161-5167, 2000.

4. Okamoto H, Takahashi M, Kato N, Fukuda M, Tawara A, Fukuda S, Tanaka T, Miyakawa Y, Mayumi M: Sequestration of TT virus of restricted genotypes in peripheral blood mononuclear cells. J Virol 74(21):10236-10239, 2000.

5. Okamoto H, Nishizawa T, Tawara A, Peng Y, Takahashi M, Kishimoto J, Tanaka T, Miyakawa Y, Mayumi M: Species-specific TT viruses in humans and nonhuman primates and their phylogenetic relatedness. Virology 277: 368-378, 2000.

6. Okamoto H, Nishizawa T, Tawara A, Takahashi M, Kishimoto J, Sai T, Sugai Y: TT virus mRNAs detected in the bone marrow cells from an infected individual. Biochem Biophys Res Commun 279: 700-709, 2000.

7. Usuda S, Okamoto H, Tanaka T, Kidd-Ljunggren K, Holland PV, Miyakawa Y, Mayumi M: Differentiation of hepatitis B virus genotypes D and E by ELISA using monoclonal antibodies to epitopes on the preS2-region product. J Virol Methods 87:81-89, 2000.

8. Ohto H, Ujiie N, Sato A, Okamoto H, Mayumi M: Mother-to-infant transmission of GB virus type C/HGV. Transfusion 40:725-730, 2000.

9. Ukita M, Okamoto H, Nishizawa T, Tawara A, Takahashi M, Iizuka H, Miyakawa Y, Mayumi M: The entire nucleotide sequences of two distinct TT virus (TTV) isolates (TJN01 and TJN02) remotely related to the original TTV isolates. Arch Virol 145(8):1543-1559, 2000.

10. Tawara A, Akahane Y, Takahashi M, Nishizawa T, Ishikawa T, Okamoto H: Transmission of human TT virus of genotype 1a to chimpanzees with fecal supernatant or serum from patients with acute TTV infection. Biochem Biophys Res Commun 278: 470-476, 2000.

11. Itoh Y, Takahashi M, Fukuda M, Shibayama T, Ishikawa T, Tsuda F, Tanaka T, Nishizawa T, Okamoto H: Visualization of TT virus particles recovered from the sera and feces of infected humans. Biochem Biophys Res Commun 279: 718-724, 2000.

1999
1. Okamoto H, Kato N, Iizuka H, Tsuda F, Miyakawa Y, Mayumi M: Distinct genotypes of a nonenveloped DNA virus associated with posttransfusion non-A to G hepatitis (TT virus) in plasma and peripheral blood mononuclear cells. J Med Virol 57: 252-258, 1999

2. Okamoto H, Takahashi M, Nishizawa T, Ukita M, Fukuda M, Tsuda F, Miyakawa Y, Mayumi M: Marked genomic heterogeneity and frequent mixed infection of TT virus demonstrated by PCR with primers from coding and noncoding regions. Virology 259: 428-436, 1999.

3. Okamoto H, Nishizawa T, Ukita M, Takahashi M, Fukuda M, Iizuka H, Miyakawa Y, Mayumi M: The entire nucleotide sequence of a TT virus isolate from the United States (TUS01): comparison with reported isolates and phylogenetic analysis. Virology 259: 437-448, 1999.

4. Okamoto H, Nishizawa T, Ukita M: A novel unenveloped DNA virus (TT virus) associated with acute and chronic non-A to G hepatitis. Intervirology 42: 196-204,1999.

5. Usuda S, Okamoto H, Iwanari H, Baba K, Tsuda F, Miyakawa Y, Mayumi M: Serological detection of hepatitis B virus genotypes by ELISA with monoclonal antibodies to type-specific epitopes in the preS2-region product. J Virol Methods 80: 97-112,1999.

6. Koike K, Shimotohno K, Okada S, Okamoto H, Hayashi N, Ueda K, kaneko S, Koike K, Yokosuka O, Chiba T, Marusawa H, hino O, Utida T, Omata M, Juji T, Nojiri N, Takada K, Miyamura T, Osuga T, Ito Y: Survey of hepatitis B virus co-infection in hepatitis C virus-infected patients suffering from chronic hepatitis and hepatocellular carcinoma. Jpn J Cancer Res 90: 1270-1272, 1999

7. Hino K, Okuda M, Korenaga M, Murakami C, Okazaki M, Fujii K, Okita K, Tsuda F, Okamoto H, Mayumi M: Clinical evaluation of chronic liver diseases induced by different hepatitis C virus genotype in Japan, focused on the difference between genotypes III/2a and IV/2b. Hepatol Res 14: 204-211, 1999

8. Akbar N, Tsuda F, Basuki B, Okamoto H, Sulaiman HA, Noer HMS, Mayumi M.: The prevalence of GB virus C, risk factors and its relationship with other hepatitis viruses in general population of Jakarta, Indonesia. Hepatol Res 13: 193-204, 1999.

9. Ikeda H, Takasu M, Inoue K, Okamoto H, Miyakawa Y, Mayumi M: Infection with an unenveloped DNA virus (TTV) in patients with acute or chronic liver disease of unknown etiology and in those positive for hepatitis C virus RNA. J Hepatol 30: 205-212, 1999

10. Tsuda F, Okamoto H, Ukita M, Tanaka T, Akahane Y, Konishi K, Yoshizawa H, Miyakawa Y, Mayumi M: Determination of antibodies to TT virus (TTV) and application to blood donors and patients with post-transfusion non-A to G hepatitis in Japan. J Virol Methods 77: 199-206, 1999

11. Ukita M,Okamoto H, Kato N, Miyakawa Y, Mayumi M: Excretion into bile of a novel unenveloped DNA virus (TT virus) associated with acute and chronic non-A-G hepatitis. J Infect Dis 179(5): 1245-1248,1999.

12. Itoh K, Hirakawa K, Okamoto H, Ukita M, Tanaka H, Sawada N, Tsuda F, Miyakawa Y, Mayumi M: Infection by an unenveloped DNA virus associated with non-A to -G hepatitis in Japanese blood donors with or without elevated ALT levels. Transfusion 39:522-526, 1999.

13. Akahane Y, Sakamoto M, Miyazaki Y, Okada S, Inoue T, Ukita M, Okamoto H, Miyakawa Y, Mayumi M: Effect of interferon on a nonenveloped DNA virus (TT virus) associated with acute and chronic hepatitis of unknown etiology. J Med Virol 58: 196-200, 1999.

14. Nishizawa T, Okamoto H, Tsuda F, Aikawa T, Sugai Y, Konishi K, Akahane Y, Ukita M, Tanaka T, Miyakawa Y, Mayumi M: Quasispecies of TT virus (TTV) with sequence divergence in hypervariable regions of the capsid protein in chronic TTV infection. J Virol 73(11): 9604-9608, 1999.

15. Itoh K, Takahashi M, Ukita M, Nishizawa T, Okamoto H: Influence of primers on the detection of TT virus DNA by polymerase chain reaction. J Infect Dis 180: 1750-1751, 1999.

16. Ishikawa T, Hamano Y, Okamoto H: Frequent detection of TT virus in throat swabs of pediatric patients. Infection 27: 298, 1999.

1998
1. Okamoto H, Nishizawa T, Kato N, Ukita M, Ikeda H, Iizuka H, Miyakawa Y, Mayumi M: Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttransfusion hepatitis of unknown etiology. Hepatol Res 10: 1-16, 1998.

2. Okamoto H, Akahane Y, Ukita M, Fukuda M, Tsuda F, Miyakawa Y, Mayumi M: Fecal excretion of a nonenveloped DNA virus (TTV) associated with posttransfusion non-A-G hepatitis. J Med Virol 56: 128-132, 1998.

3. Inoue K, Yoshiba M, Sekiyama K, Okamoto H, Mayumi M: Clinical and molecular virological differences between fulminant hepatic failures following acute and chronic infection with hepatitis B virus. J Med Virol 55: 35-41,1998

4. Yamada K, Kotani M, Eguchi T, Kobayashi M, Yamazoe K, Yanagi R, Ichikawa S, Tsuda F, Okamoto H: Efficacy of hepatitis B vaccines with and without preS2-region product in Sumo wrestlers in Japan. Hepatol Res 12: 3-11, 1998

5. Usuda S, Okamoto H, Tsuda F, Tanaka T, Miyakawa Y,Mayumi M: An enzyme-linked immunosorbent assay with monoclonal antibodies for the determination of phosphorylated hepatitis B core protein (p21c) in serum. J Virol Methods 72: 95-103, 1998

6. Kanai K, Kako M, Kumada T, Tsubouchi H, Aikawa T, Kojima M, Harada H, Kawasaki T, Nakashima M, Okamoto H, Mishiro S: High-dose (9MU) long-term (60 weeks) alfa-interferon therapy for chronic hepatitis patients infected with HCV genotype 1b. Arch Virol 143: 1545-1554, 1998

7. Tokita H, Okamoto H, Iizuka H, Kishimoto J, Tsuda F, Miyakawa Y, Mayumi M: The entire nucleotide sequences of three hepatitis C virus isolates in genetic groups 7-9 and comparison with those in the other eight genetic groups. J Gen Virol 79: 1847-1857, 1998

8. Kayaba K, Igarashi M, Okamoto H, Tsuda F: Prevalence of anti-hepatitis C antibodies in a rural community without high mortality from liver disease in Niigata Prefecture. J Epidemiol 8(4): 250-255, 1998

9. Shrestha SM, Subedi NB, Shrestha S, Gaharjan KG, Tsuda F, Okamoto H: Epidemiology of hepatitis C virus infection in Nepal. Tropical Gastroenterol 19:102-104, 1998

10. Sawant P, Upadhyay AP, Levicnik-Stezinar S, Zali MR, Okamoto H: Genotypes of GB virus C and hepatitis C virus in hepatitis patients in India, Iran and Slovenia. Hepatol Res 10: 175-183, 1998

11. Akiyama H, Nakamura N, Tanikawa S, Sakamaki H, Onozawa Y, Shibayama T, Tanaka S, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M: Incidence and influence of GB virus C and hepatitis C virus infection in patients undergoing bone marrow transplantation. Bone Marrow Transplant 21: 1131-1135, 1998

12. Horiike N, Michitaka K, Okamoto H, Masumoto T, Ohno N, Nadano S, Yamashita Y, Hino T, Kanaoka M, Onji M: GB virus C/hepatitis G virus infection in autoimmune liver diseases. J Gastroenterol 33: 463-464, 1998

13. Toyoda H, Fukuda Y, Hayakawa T, Takamatsu J, Saito H, Okamoto H: GB virus C/hepatitis G virus isolates in Japanese haemophiliacs and their origins. Thromb Haemost 80: 242-245, 1998.

14. Woodfield D.G., Gane E, Okamoto H: Hepatitis TT virus is present in New Zealand. NZ Med J 111: 195-196, 1998.

15. Tanaka H, Okamoto H, Luengrojanakul P, Chainuvati T, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M: Infection with an unenveloped DNA virus(TTV) associated with posttransfusion non-A to G hepatitis in hepatitis patients and healthy blood donors in Thailand. J Med Virol 56: 234-238, 1998.

16. Fujiwara T, Iwata A, Iizuka H, Tanaka T, Okamoto H: Transfusion transmitted virus (letter). Lancet 352: 1310, 1998

17. Kanazawa K, Okamoto H: Hepatitis C virus infection in patients with urticaria. J Am Acad Dermatol 37:646, 1998

1997
1. Okamoto H, Miyakawa Y, Mayumi M: Molecular virology of hepatitis C virus. Viral Hepatitis Rev 3(1): 51-62,1997.

2. Okamoto H, Nakao H, Inoue T, Fukuda M, Kishimoto J, Iizuka H, Tsuda F, Miyakawa Y, Mayumi M: The entire nucleotide sequences of two GB virus C/hepatitis G virus isolates of distinct genotypes from Japan. J Gen Virol 78: 737-745,1997.

3. Miyakawa Y, Okamoto H, Mayumi M. The molecular basis of hepatitis B e antigen (HBeAg)-negative infections. J Viral Hepatitis 4(1): 1-8, 1997

4. Usuda S, Okamoto H, Ohnuma H, Tanaka T, Machida A, Miyakawa Y, Mayumi M: A monoclonal antibody against a hepatitis B e antigen epitope borne by six amino acids encoded by the precore region. J Virol Methods 68: 207-215, 1997

5. Kako M, Kanai K, Aikawa T, Iwabuchi S, Takehira Y, Kawasaki T, Tsubouchi H, Hino K, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M. Response to interferon-α2a in patients with e antigen-negative chronic hepatitis B. J Clin Gastroenterol 25(2): 440-445, 1997

6. Koyama T, Tsuda F, Ishikawa K, Oishi H, Tazawa M, Yoshizawa H, Sato S, Okamoto H. Antibodies to hepatitis C virus and elevated transaminase levels in a town of hyperendemicity in Iwate, Japan. J Gastroenterol Hepatol 12:67-72,1997

7. Hiroishi K, Kita H, Kojima M, Okamoto H, Moriyama T, Kaneko T, Ishikawa T, Ohnishi S, Aikawa T, Tanaka N, Yazaki Y, Mitamura K, Imawari M. Cytotoxic T lymphocyte response and viral load in hepatitis C virus infection. Hepatology 25(3):705-712,1997

8. Kondo M, Horie Y, Okano J, Kitamura A, Maeda N, Kawasaki H, Mishiro S, Yamamoto S, Itou T, Saeki S, Tanaka S, Okamoto H: High prevalence of hepatitis C virus infection in Japanese patients with porphyria cutanea tarda(letter). Hepatology 26(1): 246, 1997

9. Kaneko T, Moriyama T, Udaka K, Hiroishi K, Kita H, Okamoto H, Yagita H, Okumura K, Imawari M. Impaired induction of cytotoxic T lymphocytes by antagonism of a weak agonist borne by a variant hepatitis C virus epitope. Eur J Immunol 27: 1782-1787, 1997

10. Sasaki N, Matsui A, Momoi M, Tsuda F, Okamoto H: Loss of circulating hepatitis C virus in children who developed a persistent carrier state after mother-to-baby transmission. Pediatr Res 42(3): 263-267, 1997

11. Izumi T, sasaki R, Tsunoda S, Akutsu M, Okamoto H, Miura Y: B cell malignancy and hepatitis C virus infection. Leukemia 11(S3): 516-518, 1997

12. Kinoshita T, Miyake K, Nakao H, Tanaka T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M: Molecular investigation of GB virus C infection in hemophiliacs in Japan (concise commun). J Infect Dis 175: 454-457,1997

13. Shimizu M, Osada K, Okamoto H: Transmission of GB virus C by blood transfusions during heart surgery. Vox Sang 72: 76-78,1997

14. Sugai Y, Nakayama H, Fukuda M, Sawada N, Tanaka T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M: Infection with GB virus C in patients with chronic liver disease. J Med Virol 51: 175-181,1997

15. Wang Y, Chen HS, Fan MH, Liu HL, An P, Sawada N, Tanaka T, Tsuda F, Okamoto H: Infection with GB virus Cand hepatitis C virus in hemodialysis patients and blood donors in Beijing. J Med Virol 52: 26-30,1997

16. Chiyoda S, Inoue J, Okamoto H: Co-infection with GB virus C in an area of high endemicity for human T-lymphotropic virus type I in Japan. Infection 25(2):129-130,1997

17. Nagayama R, Miyake K, Okamoto H: Effect of interferon on GB virus C and hepatitis C virus in hepatitis patients with the co-infection. J Med Virol 52:156-160,1997

18. Yoshikawa A, Fukuda S, Itoh K, Kosaki N, Suzuki T, Hirakawa K, Nakao H, Inoue T, Fukuda M, Okamoto H: Infection with hepatitis G virus and its strain variant, the GB agent(GBV-C), among blood donors in Japan. Transfusion 37: 657-663,1997

19. Watanabe T, Ishiguro M, Kametani M, Sugai Y, Takakuwa K, Akahane Y, Masuko K, Shimizu M, Kojima M, Fujita K, Tsuda F, Okamoto H: GB virus C and hepatitis C virus infections in hemodialysis patients in eight Japanese centers. Nephron 76: 171-175,1997

20. Nakao H, Okamoto H, Fukuda M, Tsuda F, Mitsui T, Masuko K, Iizuka H, Miyakawa Y, Mayumi M: Mutation rate of GB virus C/hepatitis G virus over the entire genome and in subgenomic regions. Virology 233: 43-50, 1997

21. Shibayama T, Hayashi S, Saeki S, Tanaka T, Ohtake H, Tanaka S, Sawada N, Okamoto H: Infection with GB virus C in the patients with primary hepatocellular carcinoma in Japan. Hepatol Res 8: 37-43,1997

22. Shibayama T, Tanaka S, Ajisawa A, Masuda G, Okamoto H: Coinfection of GB virus C with HIV-1 in Japan. J Acquir Immune Defic Syndr Hum Retrovirol 15(4):319-320, 1997

23. Shrestha SM, Shrestha S, Tsuda F, Sawada N, Tanaka T, Okamoto H, Miyakawa Y, Mayumi M: Infection with GB virus C and hepatitis C virus in drug addicts, patients on maintenance hemodialysis, or with chronic liver disease in Nepal. J Med Virol 53: 157-161, 1997

24. Inoue T, Sakamoto M, Akahane Y, Okamoto H, Miyakawa Y, Mayumi M: Response to interferon of GB virus C and hepatitis C virus in patients with chronic hepatitis. Am J Gastroenterol 92(11): 1981-1985, 1997

25. Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Miyakawa Y, Mayumi M: A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem Biophys Res Commun 241: 92-97, 1997.

1996
1. Okamoto H, Kobata S, Tokita H, Inoue T, Woodfield G D, Holland P V, Al-Knawy B A, Uzunalimoglu O, Miyakawa Y, Mayumi M: A second-generation method of genotyping hepatitis C virus by the polymerase chain reaction with sense and antisense primers deduced from the core gene. J Virol Methods 57(1):31-45, 1996.

2. Kohno H, Inoue T, Tsuda F, Okamoto H, Akahane Y: Mutations in the envelope gene of hepatitis B virus variants co-occurring with antibody to surface antigen in sera from patients with chronic hepatitis B. J Gen Virol 77: 1825-1831,1996

3. Kanai K, Kako M, Aikawa T, Hino K, Tsubouchi H, Takehira Y, Iwabuchi S, Kawasaki T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M: Core promoter mutations of hepatitis B virus for the response to interferon in e antigen-positive chronic hepatitis B. Am J Gastroenterol 91(10): 2150-2156,1996

4. Moriyama K, Okamoto H, Tsuda F, Mayumi M: Reduced precore transcription and enhanced core-pregenome transcription of hepatitis B virus DNA after replacement of the precore-core promoter with sequences associated with e antigen-seronegative persistent infections. Virology 226(2): 269-280, 1996

5. Egawa K, Yukawa T, Arakawa S, Tanaka T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M: Hepatitis C virus antibody, viral RNA and genotypes in leprous patients in Japan. J Hepatol 24(4):397-402, 1996

6. Tokita H, Okamoto H, Iizuka H, Kishimoto J, Tsuda F, Lesmana L A, Miyakawa Y, Mayumi M: Hepatitis C virus variants from Jakarta, Indonesia classifiable into novel genotypes in the second (2e and 2f), tenth (10a) and eleventh (11a) genetic groups. J Gen Virol 77(2): 293-301, 1996

7. Akahane Y, Miyazaki Y, Naitoh S, Takeda K, Tsuda F, Okamoto H, Itoh K, Miyakawa Y, Mayumi M: Cold activation of complement for monitoring the response to interferon in patients with chronic hepatitis C. Am J Gastroenterol 91(2): 319-327, 1996

8. Mulyanto , Suwignyo S, Tsauri S, Itoh K, Mizui M, Tsuda F, Okamoto H, Yoshizawa H, Mishiro S: An easy dipstick assay for anti-core antibodies to screen blood donors for hepatitis C virus viremia. Vox Sang 70(4): 229-231, 1996

9. Itoh K, Tanaka H, Shiga J, Hirakawa K, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M: Cold activation of complement enhancing with the duration of storage in sera from blood donors with hepatitis C virus RNA. Int Hepatol Commun 5(2): 89-96, 1996

10. Fujimura Y, Ishimoto S, Shimoyama T, Narita N, Kuze Y, Yoshioka A, Fukui H, Tanaka T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M: Genotypes and multiple infections with hepatitis C virus in patients with haemophilia A in Japan. J Viral Hepatitis 3(2): 79-84, 1996

11. Kanazawa K, Yaoita H, Tsuda F, Okamoto H: Hepatitis C virus infection in patients with urticaria. J Am Acad Dermatol 35(2): 195-198, 1996

12. Kanazawa K, Aikawa T, Tsuda F, Okamoto H: Hepatitis C virus infection in patients with psoriasis [letter]. Arch Dermatol 132(11): 1391-1392, 1996

13. Nakao H, Okamoto H, Tokita H, Inoue T, Iizuka H, Pozzato G, Mishiro S: Full-length genomic sequence of a hepatitis C virus genotype 2c isolate (BEBE1) and the 2c-specific PCR primers. Arch Virol 141(3-4): 701-704, 1996

14. Holland PV, Barrera JM, Ercilla MG, Yoshida CFT, Wang Y, De Olim GAB, Betlach B, Kuramoto K, Okamoto H: Genotyping hepatitis C virus isolates from Spain, Brazil, China, and Macau by a simplified PCR method. J Clin Microbiol 34(10):2372- 2378, 1996.

15. Izumi T, Sasaki R, Miura Y, Okamoto H: Primary hepatosplenic lymphoma: association with hepatitis C virus infection [letter]. Blood 87(12): 5380-5381, 1996

16. Aikawa T, Kojima M, Onishi H, Tamura R, Fukuda S, Suzuki T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M: HLA DRB1 and DQB1 alleles and haplotypes influencing the progression of hepatitis C. J Med Virol 49(4): 274-278, 1996

17. Lvov D K, Samokhvalov E I, Tsuda F, Selivanov N A, Okamoto H, Stakhanova V M, Stakhgildyan I V, Doroshenko N V, Yashina T L, Kuzin S N, Suetina I A, Deryabin P G, Ruzaeva L A, Bezgodov V N, Firsova L A, Sorinson S N, Mishiro:. Prevalence of hepatitis C virus and distribution of its genotypes in Northern Eurasia. Arch Virol 141 (9): 1613-1622, 1996

18. Izumi T, Sasaki R, Miura Y, Okamoto H: B cell malignancy and hepatitis C virus infection [letter]. Leukemia Res 20(5):445, 1996

19. Izumi T, Sasaki R, Shimizu R, Miyazato A, Hoshino Y, Miura Y, Okamoto H: Hepatitis C virus infection in Waldenstrom's macroglobulinemia [letter]. Am J Hematol 52(3): 238-239, 1996

20. Lesmana L A, Sulaiman H A, Noer H M S, Tsuda F, Okamoto H: Hepatitis C virus genotypes and co-infection with GB virus C in patients with anti-HCV-positive chronic liver disease in Jakarta, Indonesia. Int Hepatol Commun 6(1):16-23, 1996

21. Aikawa T, Sugai Y, Okamoto H: Hepatitis G infection in drug abusers with chronic hepatitis C. N Engl J Med 334(3): 195-196,1996.

22. Mishiro S, Yoshiba M, Okamoto H: GBV-C in the aetiology of fulminant hepatitis. Lancet 347(8994): 120-121,1996

23. Masuko K, Mitsui T, Iwano K, Yamazaki C, Okuda K, Meguro T, Murayama N, Inoue T, Tsuda F. Okamoto H, Miyakawa Y, Mayumi M: Infection with hepatitis GB virus C in patients on maintenance hemodialysis. N Engl J Med 334(23): 1485-1490,1996

24. Egawa K, Yukawa T, Arakawa S, Nakao H, Inoue T, Tanaka T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M: Infection with GB virus C in leprous patients in Japan. J Med Virol 49:110-114,1996

25. Tsuda F, Hadiwandowo S, Sawada N, Fukuda M,Tanaka T, Okamoto H, Miyakawa Y, Mayumi M: Infection with GB virus C (GBV-C) in patients with chronic liver disease or on maintenance hemodialysis in Indonesia. J Med Virol 49: 248-252,1996

26. Nishiyama Y, Nakashima H, Hino K, Mori K, Ishikawa M, Okamoto H: Infection with hepatitis GB virus among Japanese hemophiliacs (letter). Transfusion 36(7): 669, 1996

27. Shimizu M, Osada K, Okamoto H: Transfusion-transmitted hepatitis G virus following open heart surgery. Transfusion 36(10): 937,1996

28. Masuko K, Okamoto H, Mayumi M: Hepatitis GB virus C. N Engl J Med 335: 1394,1996

29. Yui K, Ishiguro T, Okamoto H. Infection with GB virus C in female prisoners who were drug abusers in Japan (letter). Infection 24(5): 392,1996

30. Shrestha SM, Shrestha DM, Father TE, Gafney DM, Maharjan KG, Tsuda F, Okamoto H: Hepatitis B and C infection among drug abusers in Nepal. Trop Gastroenterol 17:212-213, 1996.

31. Tameda Y, Kosaka Y, Tagawa S, Takase K, Sawada N, Nakao H, Tsuda F, Tanaka T, Okamoto H, Miyakawa Y, Mayumi M: Infection with GB virus C (GBV-C) in patients with fulminant hepatitis. J Hepatol 25: 842-847, 1996

32. Sato K, Tanaka T, Okamoto H, Miyakawa Y, Mayumi M: Association of circulating hepatitis G virus with lipoproteins for a lack of binding with antibodies. Biochem Biophys Res Commun 229: 719-725, 1996

1995
1. Okamoto H, Crovatto M, Pozzato G, Feray C, Brechot C, Mishiro S: Molecular and clinical characteristics of the hepatitis C virus genotype '2c' found in Italians in Italy and France. Int Hepatol Commun 3(3):161-165, 1995.

2. Aikawa T, Kanai K, Kako M, Kawasaki T, Hino K, Iwabuchi S, Tsubouchi H, Takehira Y, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M: Interferon-α2a for chronic hepatitis B with e antigen or antibody: comparable antiviral effects on wild-type virus and precore mutant. J Viral Hepat 2:243-250, 1995.

3. Sato S, Suzuki K, Akahane Y, Akamatsu K, Akiyama K, Yunomura K, Tsuda F, Tanaka T, Okamoto H, Miyakawa Y, Mayumi M: Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis. Ann Intern Med 122(4):241-248, 1995.

4. Takahashi K, Kishimoto S, Ohori K, Yoshizawa H, Akahane Y, Okamoto H, Mishiro S: A unique set of mutations in the ' preX ' region of hepatitis B virus DNA frequently found in patients but not in asymptomatic carriers: implication for a novel variant. Int Hepatol Commun 3:131-138,1995

5. Tanaka S, Yoshiba M, Iino S, Fukuda M, Nakao H, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M: A common-source outbreak of fulminant hepatitis B in hemodialysis patients induced by precore mutant. Kidney Int 48: 1972-1978,1995

6. Akahane Y, Tsuda F, Okamoto H: Transmission of hepatitis C virus to spouses. Ann Intern Med 122(2): 154-155, 1995

7. Tsukamoto M, Miyazaki Y, Okamoto H, Akahane Y: Rebound of hepatitis C virus RNA in serum after withdrawal of interferon in patients with advanced liver disease. Int Hepatol Commun 3(1): 26-34, 1995

8. Kanazawa K, Yaoita H, Tsuda F, Murata K, Okamoto H: Association of prurigo with hepatitis C virus infection [letter]. Arch Dermatol 131(7): 852-853, 1995

9. Tokita H, Okamoto H, Luengrojanakul P, Vareesangthip K, Chainuvati T, Iizuka H, Tsuda F, Miyakawa Y, Mayumi M: Hepatitis C virus variants from Thailand classifiable into five novel genotypes in the sixth (6b), seventh (7c, 7d) and ninth (9b, 9c) major genetic groups. J Gen Virol 76(9): 2329-2335, 1995

10. Miyakawa Y, Okamoto H, Mayumi M: Classifying hepatitis C virus genotypes. Mol Med Today 1:20-25, 1995

11. Itoh K, Tanaka H, Shiga J, Hirakawa K, Tanaka T, Akahane Y, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M: Cold activation of complement as a marker of hepatitis C viremia in sera from blood donors. Transfus Sci 16(3): 283-289, 1995

12. Feray C, Gigou M, Samuel D, Paradis V, Mishiro S, Maertens G, Reynes M, Okamoto H, Bismuth H, Brechot C: Influence of the genotypes of hepatitis C virus on the severity of recurrent liver disease after liver transplantation. Gastroenterology 108(4): 1088-1096, 1995

13. Kita H, Hiroishi K, Moriyama T, Okamoto H, Kaneko T, Ohnishi S, Yazaki Y, Imawari M: A minimal and optimal cytotoxic T cell epitope within hepatitis C virus nucleoprotein. J Gen Virol 76(12): 3189-3193, 1995

14. Kanai K, Kako M, Aikawa T, Kumada T, Kawasaki T, Hatahara T, Oka Y, Mizokami M, Sakai T, Iwata K, Okamoto H, Mayumi M, Mishiro S: HCV RNA monitoring for tailored regimens of interferon therapy in hepatitis C. Biomed Pharmacother 49(2): 65-67, 1995

15. Kanai K, Kako M, Aikawa T, Kumada T, Kawasaki T, Hatahara T, Oka Y, Mizokami M, Sakai T, Iwata K, Okamoto H, Mayumi M: Clearance of serum hepatitis C virus RNA after interferon therapy in relation to virus genotype. Liver 15(4): 185-188, 1995

16. Kita H, Moriyama T, Kaneko T, Okamoto H, Hiroishi K, Ohnishi S, Imawari M: HLA B44-restricted cytotoxic T lymphocyte responses to the peptides of HCV nucleoprotein residues 81-100 in patients with chronic hepatitis C. J Gastroenterol 30: 809-812,1995

17. Yoshiba M, Okamoto H, Mishiro S: Detection of the GBV-C hepatitis virus genome in serum from patients with fulminant hepatitis of unknown aetiology. Lancet 346(8983): 1131-1132,1995

1994
1. Okamoto H, Tsuda F, Akahane Y, Sugai Y, Yoshiba M, Moriyama K, Tanaka T, Miyakawa Y, Mayumi M: Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J Virol 68(12):8102- 8110, 1994.

2. Okamoto H, Kojima M, Sakamoto M, Iizuka H, Hadiwandowo S, Suwignyo S, Miyakawa Y, Mayumi M: The entire nucleotide sequence and classification of a hepatitis C virus isolate of a novel genotype from an Indonesian patient with chronic liver disease. J Gen Virol 75(3): 629-635, 1994.

3. Okamoto H, Mishiro S: Genetic heterogeneity of hepatitis C virus. Intervirology 37 (2): 68-76, 1994.

4. Okamoto H, Mishiro S, Tokita H, Tsuda F, Miyakawa Y, Mayumi M: Superinfection of chimpanzees carrying hepatitis C virus of genotype II/1b with that of genotype III/2a or I/1a. Hepatology 20(5): 1131-1136, 1994.

5. Okamoto H: Serological markers for the diagnosis of hepatitis C virus infection. Asian Med J 37(3):154-164, 1994.

6. Yamamoto K, Horikita M, Tsuda F, Itoh K, Akahane Y, Yotsumoto S, Okamoto H, Miyakawa Y, Mayumi M: Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen. J Virol 68(4): 2671-2676, 1994

7. Machida A, Okamoto H, Tsuda F, Tanaka T, Domoto K, Mishiro S: Anti-preS2 neutralizes the hepatitis B virus variants with a vaccine-escape mutation at the amino acid position 126 or 145 within the S gene. Int Hepatol Commun 2: 186-189,1994

8. Suzuki H, Iino S, Shiraki K, Akahane Y, Okamoto H, Domoto K, Mishiro S: Safety and efficacy of a recombinant yeast-derived preS2+S-containing hepatitis B vaccine (TGP-943): phase 1,2 and 3 clinical testings. Vaccine 12(12): 1090-1096,1994

9. Horikita M, Itoh S, Yamamoto K, Shibayama T, Tsuda F, Okamoto H: Differences in the entire nucleotide sequence between hepatitis B virus genomes from carriers positive for antibody to hepatitis B e antigen with and without active disease. J Med Virol 44: 96-103,1994

10. Yoshiba M, Sekiyama K, Inoue K, Sugata F, Okamoto H: Genotype of hepatitis C virus in fulminant hepatitis C. Dig Dis Sci 39(1): 220-221, 1994

11. Hino K, Sainokami S, Shimoda K, Iino S, Wang Y, Okamoto H, Miyakawa Y, Mayumi M: Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C. J Med Virol 42(3): 299-305, 1994

12. Nagayama R, Miyake K, Tsuda F, Okamoto H: IgM antibody to a hepatitis C virus core peptide (CP14) for monitoring activity of liver disease in patients with acute or chronic hepatitis C. J Med Virol 42(3): 311-317, 1994

13. Ohto H, Terazawa S, Sasaki N, Sasaki N, Hino K, Ishiwata C, Kako M, Ujiie N, Endo C, Matsui A, Okamoto H, Mishiro S, the Vertical Transmission of Hepatitis C Virus Collaborative Study Group. Transmission of hepatitis C virus from mothers to infants. N Engl J Med 330(11): 744-750, 1994

14. Itoh K, Tanaka H, Shiga J, Hirakawa K, Akahane Y, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M: Hypocomplementemia associated with hepatitis C viremia in sera from voluntary blood donors. Am J Gastroenterol 89(11): 2019-2024, 1994

15. Shrestha SM, Tsuda F, Okamoto H, Tokita H, Horikita M, Tanaka T, Miyakawa Y, Mayumi M: Hepatitis B virus subtypes and hepatitis C virus genotypes in patients with chronic liver disease in Nepal. Hepatology 19(4): 805-809,1994

16. Hadiwandowo S, Tsuda F, Okamoto H, Tokita H, Wang Y, Tanaka T, Miyakawa Y, Mayumi M: Hepatitis B virus subtypes and hepatitis C virus genotypes in patients with chronic liver disease or on maintenance hemodialysis in Indonesia. J Med Virol 43 (2): 182-186, 1994

17. Nakata S, Song P, Duc D D, Quang N X, Murata K, Tsuda F, Okamoto H: Hepatitis C and B virus infections in populations at low or high risk in Ho Chi Minh and Hanoi, Vietnam. J Gastroenterol Hepatol 9(4): 416-419, 1994

18. Tokita H, Shrestha S M, Okamoto H, Sakamoto M, Horikita M, Iizuka H, Shrestha S, Miyakawa Y, Mayumi M: Hepatitis C virus variants from Nepal with novel genotypes and their classification into the third major group. J Gen Virol 75(4): 931-936, 1994.

19. Yunomura K, Sugaya H, Harada T, Tsuda F, Okamoto H: Type-specific antibodies to hepatitis C virus in patients with chronic hepatitis C for predicting response to interferon alfa. Int Hepatol Commun 2(4): 201-206, 1994

20. Akahane Y, Kojima M, Sugai Y, Sakamoto M, Miyazaki Y, Tanaka T, Tsuda F, Mishiro S, Okamoto H, Miyakawa Y, Mayumi M: Hepatitis C virus infection in spouses of patients with type C chronic liver disease. Ann Intern Med 120(9): 748-752, 1994.

21. Song P, Duc D D, Hien B, Nakata S, Chosa T, Watanabe J, Tsuda F, Murata K, Okamoto H: Markers of hepatitis C and B virus infections among blood donors in Ho Chi Minh City and Hanoi, Vietnam. Clin Diagn Lab Immunol 1(4): 413-418, 1994

22. Yamada G, Takahashi M, Miyamoto R, Tsuji T, Yoshizawa H, Okamoto H: Prediction of interferon effect in chronic hepatitis C by both quantification and genotyping of HCV-RNA. Dig Dis Sci 39(2):441, 1994

23. Takahashi M, Yamada G, Doi T, Takatani M, Kishi F, Miyamoto R, Yoshizawa H, Okamoto H, Tsuji T: Intrafamilial clustering of genotypes of hepatitis C virus RNA. Acta Med Okayama 48(6): 293-297, 1994

24. Woodfield DG, Harness M, Rix-Trott K, Tsuda F, Okamoto H, Mayumi M: Identification and genotyping of hepatitis C virus in injectable and oral drug users in New Zealand. Aust N Z J Med 24(1):47-50, 1994

25. Sakamoto M, Akahane Y, Tsuda F, Tanaka T, Woodfield DG, Okamoto H: Entire nucleotide sequence and characterization of a hepatitis C virus of genotype V/3a. J Gen Virol 75(7):1761-1768, 1994

26. Yoshiba M, Dehara K, Inoue K, Okamoto H, Mayumi M: Contribution of hepatitis C virus to non-A, non-B fulminant hepatitis in Japan. Hepatology 19(4): 829-835, 1994

27. Masuko K, Okuda K, Meguro T, Murayama N, Mitsui T, Ohmori T, Murata K, Tsuda F, Okamoto H: Hepatitis C virus antibodies, viral RNA and genotypes in sera from patients on maintenance haemodialysis. J Viral Hepat 1(1):65-71, 1994

28. Wang Y, Tao Q M, Zhao H Y, Tsuda F, Nagayama R, Yamamoto K, Tanaka T, Tokita H, Okamoto H, Miyakawa Y, Mayumi M: Hepatitis C virus RNA and antibodies among blood donors in Beijing. J Hepatol 21(4):634-640, 1994

29. Luengrojanakul P, Vareesangthip K, Chainuvati T, Murata K, Tsuda F, Tokita H, Okamoto H, Miyakawa Y, Mayumi M: Hepatitis C virus infection in patients with chronic liver disease or chronic renal failure and blood donors in Thailand. J Med Virol 44(3): 287-292, 1994

30. Tokita H, Okamoto H, Tsuda F, Song P, Nakata S, Chosa T, Iizuka H, Mishiro S, Miyakawa Y, Mayumi M: Hepatitis C virus variants from Vietnam are classifiable into the seventh, eighth, and ninth major genetic groups. Proc Natl Acad Sci USA 91( 23):11022-11026, 1994

31. Ohto H, Okamoto H, Mishiro S. Vertical transmission of hepatitis C virus - Reply (letter). N Engl J Med 331(6): 400, 1994

32. Kojima M, Osuga T, Tsuda F, Tanaka T, Okamoto H: Influence of antibodies to the hypervariable region of E2/NS1 glycoprotein on the selective replication of hepatitis C virus in chimpanzees. Virology 204(2): 665-672, 1994

33. Fukuda S, Suzuki T, Nagayama R, Tsuda F, Kojima M, Okamoto H, Tanaka T, Miyakawa Y, Mayumi M: Hepatitis C virus RNA in blood units with antibodies detectable by a second-generation passive hemagglutination assay, antibodies to synthetic core peptides or elevated transaminase levels. Transfus Sci 15(1):83-92, 1994

34. Ueno N, Sugaya H, Harada T, Tsuda F, Okamoto H: High rate of hepatitis C virus transmission to spouses from hepatitis patients with a history of transfusion. Int Hepatol Commun 2(5):250-256, 1994

35. Saitoh H, Naitoh S, Okamoto H, Akahane Y: Prompt decrease of circulating hepatitis C virus in patients with chronic hepatitis C after treatment with interferon. J Interferon Res 14: 239-244, 1994

1993
1. Okamoto H, Wang Y, Tanaka T, Machida A, Miyakawa Y, Mayumi M: Trans-complementation among naturally occurring deletion mutants of hepatitis B virus and integrated viral DNA for the production of viral particles with mutant genomes in hepatoma cell lines. J Gen Virol 74(3):407-414, 1993.

2. Okamoto H, Tokita H, Sakamoto M, Horikita M, Kojima M, Iizuka H, Mishiro S: Characterization of the genomic sequence of type V (or 3a) hepatitis C virus isolates and PCR primers for specific detection. J Gen Virol 74(11): 2385-2390, 1993.

3. Ohnuma H, Machida A, Okamoto H, Tsuda F, Sakamoto M, Tanaka T, Miyakawa Y, Mayumi M: Allelic subtypic determinants of hepatitis B surface antigen (i and t) that are distinct from d/y or w/r. J Virol 67(2): 927-932, 1993

4. Kondo Y, Tsukada K, Takeuchi T, Mitsui T, Iwano K, Masuko K, Itoh T, Tokita H, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M: High carrier rate after hepatitis B virus infection in the elderly. Hepatology 18(4): 768-774, 1993.

5. Yoshiba M, Sekiyama K, Iwabuchi S, Takatori M, Tanaka Y, Uchikoshi T, Okamoto H, Inoue K, Sugata F: Recurrent fulminant hepatic failure in an HB carrier after intensive chemotherapy. Dig Dis Sci 38(9): 1751-1755, 1993

6. Takahashi K, Kishimoto S, Ohori K, Yoshizawa H, Okamoto H, Miyakawa Y, Mayumi M: SDS-PAGE after micro-affinity adsorption for analysis of heterogeneous antigen polypeptides in individual sera. J Immunol Methods 157: 217-223, 1993

7. Taniguchi S, Okamoto H, Sakamoto M, Kojima M, Tsuda F, Tanaka T, Munekata E, Muchmore EE, Peterson DA, Mishiro S: A structurally flexible and antigenically variable N-terminal domain of the hepatitis C virus E2/NS1 protein: implication for an escape from antibody. Virology 195(1): 297-301, 1993

8. Wang Y, Okamoto H, Tsuda F, Nagayama R, Tao QM, Mishiro S: Prevalence, genotypes, and an isolate (HC-C2) of hepatitis C virus in Chinese patients with liver disease. J Med Virol 40(3): 254-260, 1993

9. Kinoshita T, Miyake K, Okamoto H, Mishiro S: Imported hepatitis C virus genotypes in Japanese hemophiliacs. J Infect Dis 168(1): 249-250, 1993

10. Sato K, Okamoto H, Aihara S, Hoshi Y, Tanaka T, Mishiro S: Demonstration of sugar moiety on the surface of hepatitis C virions recovered from the circulation of infected humans. Virology 196(1): 354-357, 1993

11. Watanabe J, Matsumoto C, Fujimura K, Shimada T, Yoshizawa H, Okamoto H, Iizuka H, Tango T, Ikeda H, Endo N, Mazda T, Nojiri T, Aoyama K, Kanemitsu K, Yamano H, Mizui M, Yokoishi F, Tokunaga K, Nishioka K:. Predictive value of screening tests for persistent hepatitis C virus infection evidenced by viraemia. Japanese experience. Vox Sang 65(3): 199-203, 1993

12. Yoshikawa A, Tanaka T, Hoshi Y, Kato N, Tachibana K, Iizuka H, Machida A, Okamoto H, Yamasaki M, Miyakawa Y, Mayumi M: Chimeric hepatitis B virus core particles with parts or copies of the hepatitis C virus core protein. J Virol 67(10): 6064-6070, 1993

13. Nagayama R, Tsuda F, Okamoto H, Wang Y, Mitsui T, Tanaka T, Miyakawa Y, Mayumi M: Genotype dependence of hepatitis C virus antibodies detectable by the first -generation enzyme-linked immunosorbent assay with C100-3 protein. J Clin Invest 92(3):1529-1533, 1993

1992
1. Okamoto H, Yano K, Nozaki Y, Matsui A, Miyazaki H, Yamamoto K, Tsuda F, Machida A, Mishiro S: Mutations within the S gene of hepatitis B virus transmitted from mothers to babies immunized with hepatitis B immune globulin and vaccine. Pediatr Res 32: 264-268, 1992.

2. Okamoto H, Sugiyama Y, Okada S, Kurai K, Akahane Y, Sugai Y, Tanaka T, Sato K, Tsuda F, Miyakawa Y, Mayumi M: Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources. J Gen Virol 73(3): 673-679, 1992.

3. Okamoto H, Tsuda F, Machida A, Munekata E, Akahane Y, Sugai Y, Mashiko K, Mitsui T, Tanaka T, Miyakawa Y, Mayumi M: Antibodies against synthetic oligopeptides deduced from the putative core gene for the diagnosis of hepatitis C virus infection. Hepatology 15(2): 180-186, 1992.

4. Okamoto H, Kurai K, Okada S, Yamamoto K, Iizuka H, Tanaka T, Fukuda S, Tsuda F, Mishiro S: Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes. Virology 188(1): 331-341, 1992.

5. Okamoto H, Kojima M, Okada S, Yoshizawa H, Iizuka H, Tanaka T, Muchmore EE, Peterson DA, Ito Y, Mishiro S: Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability. Virology 190(2): 894-899, 1992.

6. Okamoto H, Kanai N, Mishiro S: Full-length nucleotide sequence of a Japanese hepatitis C virus isolate (HC-J1) with high homology to USA isolates. Nucleic Acids Res 20 (23): 6410, 1992.

7. Iizuka H, Ohmura K, Ishijima A, Satoh K, Tanaka T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M: Correlation between anti-HBc titers and HBV DNA in blood units without detectable HBsAg. Vox Sang 63(2): 107-111, 1992

8. Kanagawa H, Takai E, Tsuda F, Machida A, Kojima M, Ishijima A, Tanaka T, Okamoto H, Miyakawa Y, Mayumi M: Hepatitis B surface antigen particles of subtypes adw and adr, and compound subtype (adwr) in symptom-free carriers in Japan. J Med Virol 37(4): 288-293, 1992

9. Yotsumoto S, Kojima M, Shoji I, Yamamoto K, Okamoto H, Mishiro S: Fulminant hepatitis related to transmission of hepatitis B variants with precore mutations between spouses. Hepatology 16(1): 31-35, 1992

10. Yoshiba M, Sekiyama K, Sugata F, Okamoto H, Yamamoto K, Yotsumoto S: Reactivation of precore mutant hepatitis B virus leading to fulminant hepatic failure following cytotoxic treatment. Dig Dis Sci 37(8): 1253-1259, 1992

11. Miyamoto H, Okamoto H, Sato K, Tanaka T, Mishiro S: Extraordinarily low density of hepatitis C virus estimated by sucrose density gradient centrifugation and the polymerase chain reaction. J Gen Virol 73(3): 715-718, 1992

12. Takahashi K, Okamoto H, Kishimoto S, Munekata E, Tachibana K, Akahane Y, Yoshizawa H, Mishiro S: Demonstration of a hepatitis C virus-specific antigen predicted from the putative core gene in the circulation of infected hosts. J Gen Virol 73(3):667-672, 1992

13. Yoshiba M, Sekiyama K, Sugata F, Kanamori H, Kodama F, Okamoto H: Activation of hepatitis C virus following immunosuppressive treatment (letter). Dig Dis Sci 37(3):478, 1992

14. Akahane Y, Aikawa T, Sugai Y, Tsuda F, Okamoto H , Mishiro S: Transmission of HCV between spouses. Lancet 339: 1059-1060, 1992

15. Wang Y, Okamoto H, Mishiro S: HCV genotypes in China (letter). Lancet 339:1168, 1992

16. Yoshikawa A, Takahashi K, Kishimoto S, Tsuda F, Akahane Y, Naito S, Tanaka T, Yoshizawa H, Yamasaki M, Okamoto H, Miyakawa Y, Mayumi M: Serodiagnosis of hepatitis C virus infection by ELISA for antibodies against the putative core protein (p20c) expressed in Escherichia coli. J Immunol Methods 148(1-2): 143-150, 1992

17. Kanai K, Kako M, Okamoto H: HCV genotypes in chronic hepatitis C and response to interferon. Lancet 339: 1543, 1992

18. Okada S, Akahane Y, Suzuki H, Okamoto H, Mishiro S:The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlates with responsiveness to interferon therapy in viremic patients. Hepatology 16(3):619-624, 1992

19. Takahashi K, Kishimoto S, Yoshizawa H, Okamoto H, Yoshikawa A, Mishiro S: p26 protein and 33-nm particle associated with nucleocapsid of hepatitis C virus recovered from the circulation of infected hosts. Virology 191(1): 431-434, 1992

20. Machida A, Ohnuma H, Tsuda F, Munekata E, Tanaka T, Akahane Y, Okamoto H, Mishiro S: Two distinct subtypes of hepatitis C virus defined by antibodies directed to the putative core protein. Hepatology 16(4): 886-891, 1992

21. Mitsui T, Iwano K, Masuko K, Yamazaki C, Okamoto H, Tsuda F, Tanaka T, Mishiro S: Hepatitis C virus infection in medical personnel after needlestick accident. Hepatology 16(5): 1109-1114, 1992

22. Yamada G, Takahashi M, Tsuji T, Yoshizawa H, Okamoto H: Quantitative HCV RNA and effect of interferon therapy in chronic hepatitis C. Dig Dis Sci 37(12):1926-1927, 1992

1991
1. Okamoto H, Okada S, Sugiyama Y, Kurai K, Iizuka H, Machida A, Miyakawa Y, Mayumi M: Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions. J Gen Virol 72(11): 2697-2704, 1991.

2. Kosaka Y, Takase K, Kojima M, Shimizu M, Inoue K, Yoshiba M, Tanaka S, Akahane Y, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M: Fulminant hepatitis B: induction by hepatitis B virus mutants defective in the precore region and incapable of encoding e antigen. Gastroenterology 100(4):1087-1094, 1991

3. Kojima M, Shimizu M, Tsuchimochi T, Koyasu M, Tanaka S, Iizuka H, Tanaka T, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M: Posttransfusion fulminant hepatitis B associated with precore-defective HBV mutants. Vox Sang 60(1):34-39, 1991

4. Terazawa S, Kojima M, Yamanaka T, Yotsumoto S, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M: Hepatitis B virus mutants with precore-region defects in two babies with fulminant hepatitis and their mothers positive for antibody to hepatitis B e antigen. Pediatr Res 29(1): 5-9, 1991

5. Sastrosoewignjo RI, Sandjaja B, Okamoto H: Molecular epidemiology of hepatitis B virus in Indonesia. J Gastroenterol Hepatol 6: 491-498, 1991

6. Miyakawa H, Kako M, Nagai K, Hino K, Iwabuchi S, Miyachi K, Okamoto H, Mayumi M:: HCV-RNA in type 2 autoimmune hepatitis. Am J Gastroenterol 86(11): 1688-1689,1991

7. Yoshiba M, Sekiyama K, Sugata F, Okamoto H:: Diagnosis of type C fulminant hepatitis by the detection of antibodies to the putative core proteins of hepatitis C virus. Gastroenterol Jpn 26(2): 234, 1991

8. Yoshiba M, Sekiyama K, Sugata F, Okamoto H, Mayumi M: Persistence of HCV replication in non-A, non-B fulminant viral hepatitis. Gastroenterol Jpn 26(2):235, 1991

9. Chen WR, Okamoto H, Tao QM: Similarity and diversity in sequence of HCV genome among Chinese, Japanese and American strains. Chin Med J 104(10):825-829, 1991

1990
1. Okamoto H, Yotsumoto S, Akahane Y, Yamanaka T, Miyazaki Y, Sugai Y, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M: Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol 64(3):1298-1303, 1990.

2. Okamoto H, Omi S, Wang Y, Imai M, Mayumi M: Trans-complementation of the C gene of human and the P gene of woodchuck hepadnaviruses. J Gen Virol 71(4):959-963, 1990

3. Okamoto H, Okada S, Sugiyama Y, Yotsumoto S, Tanaka T, Yoshizawa H, Tsuda F, Miyakawa Y, Mayumi M: The 5'-terminal sequence of the hepatitis C virus genome. Jpn J Exp Med 60(3): 167-177, 1990.

4. Okamoto H, Okada S, Sugiyama Y, Tanaka T, Sugai Y, Akahane Y, Machida A, Mishiro S, Yoshizawa H, Miyakawa Y, Mayumi M: Detection of hepatitis C virus RNA by a two- stage polymerase chain reaction with two pairs of primers deduced from the 5'-noncoding region. Jpn J Exp Med 60(4): 215-222, 1990.

5. Okamoto H, Munekata E, Tsuda F, Takahashi K, Yotsumoto S, Tanaka T, Tachibana K, Akahane Y, Sugai Y, Miyakawa Y, Mayumi M: Enzyme-linked immunosorbent assay for antibodies against the capsid protein of hepatitis C virus with a synthetic oligopeptide. Jpn J Exp Med 60(4):223-233, 1990.

6. Ohnuma H, Takai E, Machida A, Tsuda F, Okamoto H, Tanaka T, Naito M, Munekata E, Miki K, Miyakawa Y, Mayumi M: Synthetic oligopeptides bearing a common or subtypic determinant of hepatitis B surface antigen. J Immunol 145(7): 2265-2271, 1990

7. Yamanaka T, Akahane Y, Suzuki H, Okamoto H, Tsuda F, Miyakawa Y, Mayumi, M: Hepatitis B surface antigen particles with all four subtypic determinants: point mutations of hepatitis B virus DNA inducing phenotypic changes or double infection with viruses of different subtypes. Mol Immunol 27(5): 443-449, 1990

8. Yotsumoto S, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M: Subtyping hepatitis B virus DNA in free or integrated forms by amplification of the S-gene sequences by the polymerase chain reaction and single-track sequencing for adenine. J Virol Methods 28 (2): 107-116, 1990

9. Luengrojanakul P, Ohnuma H, Tachibana K, Usuda S, Okamoto H, Tanaka T, Tsuda F, Machida A, Mayumi M: Common and subtypic determinants of hepatitis B surface antigen particles: susceptibility to reduction and/or alkylation evaluated with monoclonal antibodies. Jpn J Exp Med 60(5): 253-261, 1990

10. Akahane Y, Yamanaka T, Suzuki H, Sugai Y, Tsuda F, Yotsumoto S, Omi S, Okamoto H, Miyakawa Y, Mayumi M: Chronic active hepatitis with hepatitis B virus DNA and antibody against e antigen in the serum. Disturbed synthesis and secretion of e antigen from hepatocytes due to a point mutation in the precore region. Gastroenterology 99 (4): 1113-1119, 1990

11. Omi S, Okamoto H, Tsuda F and Mayumi M: Defects in the precore region of hepatitis B virus DNA in a plasma pool from carriers seropositive for antibody against e antigen and with infectivity in chimpanzees. J Gastroenterol Hepatol 5(6):646-652, 1990.

12. Takeda K, Akahane Y, Suzuki H, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M: Defects in the precore region of the HBV genome in patients with chronic hepatitis B after sustained seroconversion from HBeAg to anti-HBe induced spontaneously or with interferon therapy. Hepatology 12(6):1284-1289, 1990

13. Kanai K, Iwata K, Nakao K, Kako M, Okamoto H: Suppression of hepatitis C virus RNA by interferon-α (letter). Lancet 336: 245, 1990

14. Mishiro S, Hoshi Y, Takeda K, Yoshikawa A, Gotanda T, Takahashi K, Akahane Y, Yoshizawa H, Okamoto H, Tsuda F, Peterson DA, Muchmore E: Non-A, non-B hepatitis specific antibodies directed at host-derived epitope: implication for an autoimmune process. Lancet 336:1400-1403, 1990

1989
1. Okamoto H, Omi S, Wang Y, Itoh Y, Tsuda F, Tanaka T, Akahane Y, Miyakawa Y, Mayumi M: The loss of subtypic determinants in alleles, d/y or w/r, on hepatitis B surface antigen. Mol Immunol 26(2):197-205, 1989.

2. Okamoto H, Yotsumoto S, Tsuda F, Machida A, Mayumi M: Quantitative and qualitative differences in serum HBV DNA between HBeAg positive carriers and those positive for anti-HBe. Jpn J Exp Med 59(6):259-262, 1989.

3. Tachibana K, Tanaka T, Usuda S, Okamoto H, Tsuda F, Akahane Y, Miyakawa Y, Mayumi M: Hepatitis B surface antigen with an excess or deficiency in subtypic determinants in sera from asymptomatic carriers in Japan. Viral Immunol 2(1):25-29, 1989

4. Sugai Y, Okamoto H: State of hepatitis B virus DNA in peripheral blood mononuclear cells from persistently infected individuals: correlation with e antigen and viral DNA in the serum as well as with the activity of liver disease. Tohoku J Exp Med 158: 73-84, 1989

1988
1. Okamoto H, Tsuda F, Sakugawa H, Sastrosoewignjo R I, Imai M, Miyakawa Y, Mayumi M: Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol 69(10):2575-2583, 1988.

2. Estacio R C, Chavez C C, Okamoto H, Lingao A L, Reyes M T, Domingo E, Mayumi M: Nucleotide sequence of a hepatitis B virus genome of subtype adw isolated from a Philippino: comparison with the reported three genomes of the same subtype. J Gastroenterol Hepatol 3(3): 215-222, 1988

1987
1. Okamoto H, Imai M, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M: Point mutation in the S gene of hepatitis B virus for a d/y or w/r subtypic change in two blood donors carrying a surface antigen of compound subtype adyr or adwr. J Virol 61(10):3030-3034, 1987.

2. Okamoto H, Imai M, Miyakawa Y, Mayumi M: Site-directed mutagenesis of hepatitis B surface antigen sequence at codon 160 from arginine to lysine for conversion of subtypic determinant from r to w. Biochem Biophys Res Commun 148(1):500-504, 1987.

3. Okamoto H, Imai M, Kametani M, Nakamura T, Mayumi M: Genomic heterogeneity of hepatitis B virus in a 54-year-old woman who contracted the infection through materno-fetal transmission. Jpn J Exp Med 57(4):231-236, 1987.

4. Okamoto H, Tsuda F, Mayumi M: Defective mutants of hepatitis B virus in the circulation of symptom-free carriers. Jpn J Exp Med 57(4):217-221, 1987.

5. Imai M, Hoshi Y, Okamoto H, Matsui T, Tsurimoto T, Matsubara K, Miyakawa Y, Mayumi M: Free and integrated forms of hepatitis B virus DNA in human hepatocellular carcinoma cells (PLC/342) propagated in nude mice. J Virol 61(11):3555-3560, 1987

6. Sastrosoewignjo RI, Omi S, Okamoto H, Mayumi M, Rustam M, Sujudi: The complete nucleotide sequence of HBV DNA clone of subtype adw (pMND122) from Menado in Sulawesi island, Indonesia. ICMR Ann 7: 51-60, 1987.

1986
1. Okamoto H, Imai M, Shimozaki M, Hoshi Y, Iizuka H, Gotanda T, Tsuda F, Miyakawa Y, Mayumi M: Nucleotide sequence of a cloned hepatitis B virus genome, subtype ayr: comparison with genomes of the other three subtypes. J Gen Virol 67:2305-2314,1986.

2. Okamoto H, Usuda S, Imai M, Tachibana K, Tanaka E, Kumakura T, Itabashi M, Takai E, Tsuda F, Nakamura T, Miyakawa Y, Mayumi M: Antibody to the receptor for polymerized human serum albumin in acute and persistent infection with hepatitis B virus. Hepatology 6:354-359, 1986.

3. Usuda S, Tsuda F, Gotanda T, Tachibana K, Nomura M, Okamoto H, Imai M, Nakamura T, Miyakawa Y, Mayumi M: A solid-phase enzyme immunoassay for the common and subtypic determinants of hepatitis B surface antigen with monoclonal antibodies. J Immunol Methods 87: 203-210,1986

4. Matsui T, Takano M, Miyamoto K, Itoh Y, Yoshizawa H, Koike M, Mochizuki T, Tanaka E, Okamoto H, Imai M, Mishiro S, Miyakawa Y, Mayumi M: Nude mice bearing human primary hepatocellular carcinoma that produces hepatitis B surface, core, and e antigens, as well as deoxyribonucleic acid polymerase. Gastroenterology 90(11):135-142,1986.

5. Tachibana K, Imai M, Okamoto H, Yoda K, Kadokura H, Katayama Y, Yamasaki M: Expression of the pre-S(2) gene of hepatitis B virus in Escherichia coli. Biotechnology Lett 8: 677-682,1986.

6. Sastrosoewignjo RI, Okamoto H, Mayumi M, Rustam M, Warsa UC, Sujudi: The complete nucleotide sequence of an HBV DNA clone of subtype adw (pPAD744) from Sumatra, Indonesia. ICMR Ann 6: 99-106, 1986.

1985
1. Okamoto H, Imai M, Usuda S, Tanaka E, Tachibana K, Mishiro S, Machida A, Nakamura T, Miyakawa Y, Mayumi M: Hemagglutination assay of polypeptide coded by the pre-S region of hepatitis B virus DNA with monoclonal antibody: correlation of pre-S polypeptide with the receptor for polymerized human serum albumin in serums containing hepatitis B antigens. J Immunol 134(2): 1212-1216,1985.

2. Sastrosoewignjo RI, Okamoto H, Mayumi M, Warsa UC, Sujudi: The complete nucleotide sequence of an HBV DNA clone of subtype adw (pRTB299) from Indonesia. ICMR Ann 5: 39-50, 1985.

3. Tanaka E, Imai M, Usuda S, Tachibana K, Okamoto H, Ohike Y, Nakamura T, Miyakawa Y, Mayumi M: A two-site sandwich radioimmunoassay of human gamma interferon with monoclonal antibodies. J Immunol Methods 77: 275-282, 1985.

1984
1. Tachibana K, Tanaka E, Usuda S, Okamoto H, Imai M, Nakamura T, Miyakawa Y, Mayumi M: A two-site sandwich radioimmunoassay of ß2-microglobulin with monoclonal antibodies. J Immunol Methods 75: 43-51, 1984.



トップボタン

自治医科大学ホームページに戻る