{"id":1060,"date":"2020-09-02T17:28:05","date_gmt":"2020-09-02T08:28:05","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1060"},"modified":"2020-09-02T17:28:05","modified_gmt":"2020-09-02T08:28:05","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-16%e3%80%80il-2%e3%83%91%e3%83%a9%e3%83%89%e3%82%af%e3%82%b92","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-16%e3%80%80il-2%e3%83%91%e3%83%a9%e3%83%89%e3%82%af%e3%82%b92\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (16)\u3000IL-2\u30d1\u30e9\u30c9\u30af\u30b9(2)"},"content":{"rendered":"<p><span style=\"color: #000080; font-size: 12pt;\">\u5b9f\u306f\u3053\u306eIL-2\u30d1\u30e9\u30c9\u30c3\u30af\u30b9\u306f\u5f53\u6642\u4eac\u90fd\u5927\u5b66\u306b\u3044\u3089\u3057\u305f\u5742\u53e3\u5fd7\u6587\u5148\u751f\u306b\u3088\u308a\u304d\u308c\u3044\u306b\u89e3\u6c7a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u5742\u53e3\u5148\u751f\u306f\u3001IL-2\u53d7\u5bb9\u4f53\u03b1\u9396(CD25)\u967d\u6027\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\u304c\u5236\u5fa1\u6027T\u7d30\u80de(regulatory T cell, Treg)\u3068\u3057\u3066\u3001\u514d\u75ab\u5fdc\u7b54\u3092\u8ca0\u306b\u5236\u5fa1\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u63d0\u5531\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u5f53\u6642\u306e\u5e38\u8b58\u3068\u306f\u304b\u3051\u96e2\u308c\u305f\u8aac\u3067\u3057\u305f\u3002\u524d\u56de\u3082\u66f8\u304d\u307e\u3057\u305f\u304c\u3001CD25\u967d\u6027T\u7d30\u80de\u306f\u6d3b\u6027\u5316T\u7d30\u80de\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u305f\u306e\u3067\u3059\u3002\u305d\u308c\u304c\u5168\u304f\u9006\u306e\u3001\u514d\u75ab\u3092\u6291\u5236\u3059\u308b\u50cd\u304d\u3092\u3059\u308b\u3068\u4e3b\u5f35\u3057\u305f\u308f\u3051\u3067\u3059\u304b\u3089\u3001\u305d\u3046\u7c21\u5358\u306b\u53d7\u3051\u5165\u308c\u3089\u308c\u305f\u3068\u306f\u601d\u3048\u307e\u305b\u3093\u3002\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u3053\u306eTreg\u306eCD25\u306f\u3001\u80f8\u817a\u304b\u3089\u51fa\u308b\u3068\u304d\u306b\u65e2\u306b\u967d\u6027\u3067\u3042\u308b\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3064\u307e\u308a\u80f8\u817a\u304b\u3089\u51fa\u308b\u3068\u304d\u306b\u3001\u5f93\u6765\u306e\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de(CD25\u9670\u6027CD4\u967d\u6027T\u7d30\u80de)\u3068\u306f\u5225\u306bTreg(CD25\u967d\u6027CD4\u967d\u6027T\u7d30\u80de)\u304c\u51fa\u3066\u304f\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u3082\u5e38\u8b58\u3068\u306f\u7570\u306a\u308a\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #000080; 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font-size: 12pt;\">\u66f4\u306b2003\u5e74\u306b\u5800\u660c\u5e73\u5148\u751f\u304c\u3001Treg\u306e\u5206\u5316\u306b\u5fc5\u9808\u306e\u8ee2\u5199\u56e0\u5b50\u3068\u3057\u3066FoxP3\u3092\u540c\u5b9a\u3057\u305f\u3053\u3068\u3067Treg\u306e\u5b58\u5728\u3092\u7591\u3046\u4eba\u306f\u3044\u306a\u304f\u306a\u3063\u305f\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u601d\u3044\u307e\u3059\u3002\u3053\u306e\u8ee2\u5199\u56e0\u5b50\u306b\u5909\u7570\u306e\u5165\u3063\u3066\u3044\u308b\u60a3\u8005\u306f\u5148\u5929\u6027\u306e\u708e\u75c7\u6027\u75be\u60a3(IPEX\u3068\u3044\u3046\u540d\u79f0\u3067\u547c\u3070\u308c\u3066\u3044\u307e\u3059)\u3092\u767a\u75c7\u3057\u307e\u3059\u304c\u3001\u305d\u308c\u306fFoxP3\u306e\u6a5f\u80fd\u7570\u5e38\u306e\u305f\u3081\u306bTreg\u304c\u3046\u307e\u304f\u5206\u5316\u51fa\u6765\u306a\u3044\u305f\u3081\u3068\u8003\u3048\u308b\u3068\u8aac\u660e\u304c\u3064\u3051\u3089\u308c\u308b\u306e\u3067\u3059\u3002\u81f4\u6b7b\u7684\u306a\u3001\u6df1\u523b\u306a\u75be\u60a3\u3067\u3059\u304c\u3001\u9aa8\u9ac4\u79fb\u690d\u304c\u3067\u304d\u308c\u3070\u6839\u6cbb\u3082\u671f\u5f85\u3067\u304d\u308b\u75be\u60a3\u3067\u3059\u3002\u9aa8\u9ac4\u79fb\u690d\u306b\u3088\u308a\u6b63\u5e38\u306aTreg\u304c\u4f5c\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u5800\u5148\u751f\u306e\u8ad6\u6587\u306fScience\u8a8c\u306b\u8f09\u308a\u307e\u3057\u305f\u304c\u3084\u306f\u308a\u8208\u596e\u3057\u3066\u8aad\u3093\u3060\u3053\u3068\u3092\u899a\u3048\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 12pt;\"><strong><span style=\"color: #808080;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-15%e3%80%80il-2%e3%83%91%e3%83%a9%e3%83%89%e3%82%af%e3%82%b91\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (15)<\/a>\u00a0\u00a0<span style=\"color: #0000ff;\"><strong><em>\u2190\u00a0Prev<\/em><\/strong><\/span><strong><em>\u3000\u3000\u3000<span style=\"color: #0000ff;\">Next \u2192<\/span><\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/event\/1069\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (17)<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u5b9f\u306f\u3053\u306eIL-2\u30d1\u30e9\u30c9\u30c3\u30af\u30b9\u306f\u5f53\u6642\u4eac\u90fd\u5927\u5b66\u306b\u3044\u3089\u3057\u305f\u5742\u53e3\u5fd7\u6587\u5148\u751f\u306b\u3088\u308a\u304d\u308c\u3044\u306b\u89e3\u6c7a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u5742\u53e3\u5148\u751f\u306f\u3001IL-2\u53d7\u5bb9\u4f53\u03b1\u9396(CD25)\u967d\u6027\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\u304c\u5236\u5fa1\u6027T\u7d30\u80de(regulatory T cell, Treg &#8230;","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1060","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1060","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1060"}],"version-history":[{"count":0,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1060\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1060"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1060"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1060"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}