{"id":1083,"date":"2020-09-10T16:03:29","date_gmt":"2020-09-10T07:03:29","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1083"},"modified":"2020-09-10T16:03:29","modified_gmt":"2020-09-10T07:03:29","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-18%e3%80%80treg%e7%a0%94%e7%a9%b62cfse%e3%83%80%e3%82%a4%e3%83%aa%e3%83%a5%e3%83%bc%e3%82%b7%e3%83%a7","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-18%e3%80%80treg%e7%a0%94%e7%a9%b62cfse%e3%83%80%e3%82%a4%e3%83%aa%e3%83%a5%e3%83%bc%e3%82%b7%e3%83%a7\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (18)\u3000Treg\u7814\u7a76(2)CFSE\u30c0\u30a4\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3\u30a2\u30c3\u30bb\u30a4"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"font-size: 12pt; color: #000080;\">\u79c1\u304c\u30b5\u30a4\u30df\u30b8\u30f3\u30a2\u30c3\u30d7\u30c6\u30a4\u30af\u30a2\u30c3\u30bb\u30a4\u306e\u4ee3\u308f\u308a\u306b\u8a66\u3057\u3066\u307f\u305f\u304b\u3063\u305f\u5b9f\u9a13\u306f\u3001\u300cCFSE\u30c0\u30a4\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3\u30a2\u30c3\u30bb\u30a4\u300d\u3068\u3044\u3046\u3082\u306e\u3067\u3059\uff08\u5b9f\u9a13\u3057\u305f\u5f53\u6642\u306f\u305d\u3093\u306a\u540d\u524d\u306f\u3064\u3044\u3066\u3044\u306a\u304b\u3063\u305f\u3068\u601d\u3044\u307e\u3059\u304c\uff09\u3002\u30ea\u30f3\u30d1\u7403\u3092CFSE\u3068\u3044\u3046\u86cd\u5149\u7269\u8cea\u3067\u751f\u304d\u305f\u72b6\u614b\u3067\u67d3\u3081\u3066\u304a\u304f\u3068\u3001\u7d30\u80de\u304c\uff11\u56de\u5206\u88c2\u3059\u308b\u3068\u86cd\u5149\u7269\u8cea\u304c\u534a\u5206\u306b\u5206\u304b\u308c\u308b\u305f\u3081\u86cd\u5149\u5f37\u5ea6\u3082\u534a\u5206\u306b\u306a\u308a\u307e\u3059\u3002\uff12\u56de\u5206\u88c2\u3059\u308b\u30681\/4\u306b\u306a\u308b\u3001\u3068\u3044\u3046\u8a33\u3067\u3001\u5f90\u3005\u306b\u86cd\u5149\u5f37\u5ea6\u304c\u6e1b\u308a\u307e\u3059\u3002\u305d\u308c\u3092\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u6e2c\u5b9a\u3057\u3066\u3001\u5bfe\u6570\u30b0\u30e9\u30d5\u3067\u8868\u73fe\u3059\u308b\u3068\u7b49\u9593\u9694\u306b\u4e26\u3076\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/42a6f2ad809e835279bbb2eb28b640c5.jpg\" rel=\"lightbox[1083]\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1087\" src=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/42a6f2ad809e835279bbb2eb28b640c5.jpg\" alt=\"\" width=\"365\" height=\"148\" srcset=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/42a6f2ad809e835279bbb2eb28b640c5.jpg 365w, https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/42a6f2ad809e835279bbb2eb28b640c5-300x122.jpg 300w\" sizes=\"auto, (max-width: 365px) 100vw, 365px\" \/><\/a><\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u56f3\u306e\u3088\u3046\u306a\u611f\u3058\u3067\u3059\u3002\u70b9\u7dda\u306f\u523a\u6fc0\u7121\u3057\u3001\u5b9f\u7dda\u306f\u523a\u6fc0\u6709\u308a\u3067\u30d2\u30b9\u30c8\u30b0\u30e9\u30e0\u306b\u3057\u3066\u3042\u308a\u307e\u3059\uff08\u30d4\u30fc\u30af\u304c\u9ad8\u3044\u307b\u3069\u7d30\u80de\u6570\u304c\u591a\u3044\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\uff09\u3002\u5de6\u306b\u884c\u304f\u307b\u3069\u5206\u88c2\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002Treg\u3067\u306f\u306a\u3044\uff08\u901a\u5e38\u306e\uff09Th\u7d30\u80de\u306f\u3001\u523a\u6fc0\u3092\u3059\u308b\u3068\u3053\u306e\u30b0\u30e9\u30d5\u3067\u306f\uff14\u56de\u304f\u3089\u3044\u5206\u88c2\u3057\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u523a\u6fc0\u304c\u7121\u3044\u3068\u307b\u3068\u3093\u3069\u5206\u88c2\u3057\u307e\u305b\u3093\u3002CD25\u967d\u6027\u306eTreg\u7d30\u80de\u306f\u3001\u523a\u6fc0\u3092\u3057\u3066\u3082\u307b\u3068\u3093\u3069\u5de6\u5074\u306b\u30b7\u30d5\u30c8\u3057\u307e\u305b\u3093\uff08\u3061\u3087\u3063\u3068\u5206\u88c2\u3057\u3066\u3044\u308b\u3088\u3046\u306b\u3082\u898b\u3048\u308b\u306e\u3067\u3059\u304c\u3001Treg\u306e\u7d14\u5ea6\u306e\u554f\u984c\u304b\u3082\u3057\u308c\u307e\u305b\u3093\uff09\u3002\u7d20\u4eba\u30ec\u30d9\u30eb\u306e\u79c1\u304c\u3084\u3063\u3066\u3082\u3053\u308c\u304f\u3089\u3044\u306e\u30c7\u30fc\u30bf\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u306b\u6b63\u76f4\u611f\u52d5\u3057\u307e\u3057\u305f\u3002\u5927\u5b66\u9662\u751f\u306e\u6642\u3001\u3053\u306e\u65b9\u6cd5(Lyons et al., J Immunol Methods 1994)\u306b\u611f\u9298\u3092\u53d7\u3051\u3001\u3044\u3064\u304b\u3053\u306e\u65b9\u6cd5\u3092\u4f7f\u3063\u3066Treg\u306e\u89e3\u6790\u3092\u3084\u3063\u3066\u307f\u305f\u3044\u3068\u601d\u3063\u3066\u3044\u305f\u306e\u3067\u3059\u3002\u3061\u306a\u307f\u306bCFSE\u3092\u4f7f\u3063\u305fTreg\u7814\u7a76\u306f\u5f53\u6642\u307b\u3068\u3093\u3069\u898b\u304b\u3051\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u79c1\u304c\u4e00\u756a\u6700\u521d\u304b\u3069\u3046\u304b\u306f\u5206\u304b\u308a\u307e\u305b\u3093\u304c\u3001\u304b\u306a\u308a\u65e9\u3044\u65b9\u3060\u3063\u305f\u3068\u601d\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u7814\u7a76\u4eee\u8aac\u306f\u300cTreg\u304c\u6297\u539f\u63d0\u793a\u7d30\u80de(APC)\u306e\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u300d\u3067\u3059\u304c\u3001\u3069\u306e\u3088\u3046\u306b\u3059\u308c\u3070APC\u306e\u6a5f\u80fd\u3092\u8a55\u4fa1\u51fa\u6765\u308b\u3067\u3057\u3087\u3046\u304b\u3002APC\u304c\u7523\u751f\u3059\u308bIL-12\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u306b\u3057\u307e\u3057\u305f\u3002APC\uff08\u3053\u3053\u3067\u306fT\u7d30\u80de\u30fbB\u7d30\u80de\u306e\u3044\u306a\u3044SCID\u30de\u30a6\u30b9\u306e\u813e\u7d30\u80de\u3092\u4f7f\u3044\u307e\u3057\u305f\uff09\u3068T\u7d30\u80de\u3001\u305d\u3057\u3066\u305d\u306e\u4e21\u8005\u3092\u6a4b\u6e21\u3057\u3059\u308b\u6297CD3\u6297\u4f53\u3092\u8a66\u9a13\u7ba1\u5185\u3067\u5408\u308f\u305b\u308b\u3068\u3001\u57f9\u990a\u6db2\u4e2d\u306bIL-12\u304c\u51fa\u308b\u3068\u3044\u3046\u7cfb\u304c\u3042\u308b\u306e\u3067\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"color: #808080;\"><strong><span style=\"font-size: 12pt;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><span style=\"color: #000080;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/1069\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (17)<\/a>\u00a0<span style=\"color: #0000ff;\">\u00a0<strong><em>\u2190\u00a0Prev<\/em><\/strong><\/span><\/span><strong><em>\u3000\u3000\u3000<span style=\"color: #0000ff;\">Next \u2192\u3000<\/span><\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-19%e3%80%80treg%e7%a0%94%e7%a9%b63%e3%80%80%e3%83%8d%e3%82%ac%e3%83%86%e3%82%a3%e3%83%96%ef%bd%a5\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (19)<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u79c1\u304c\u30b5\u30a4\u30df\u30b8\u30f3\u30a2\u30c3\u30d7\u30c6\u30a4\u30af\u30a2\u30c3\u30bb\u30a4\u306e\u4ee3\u308f\u308a\u306b\u8a66\u3057\u3066\u307f\u305f\u304b\u3063\u305f\u5b9f\u9a13\u306f\u3001\u300cCFSE\u30c0\u30a4\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3\u30a2\u30c3\u30bb\u30a4\u300d\u3068\u3044\u3046\u3082\u306e\u3067\u3059\uff08\u5b9f\u9a13\u3057\u305f\u5f53\u6642\u306f\u305d\u3093\u306a\u540d\u524d\u306f\u3064\u3044\u3066\u3044\u306a\u304b\u3063\u305f\u3068\u601d\u3044\u307e\u3059\u304c\uff09\u3002\u30ea\u30f3\u30d1\u7403\u3092CFSE\u3068\u3044\u3046\u86cd\u5149\u7269\u8cea\u3067\u751f\u304d\u305f\u72b6 &#8230;","protected":false},"author":1,"featured_media":1087,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1083","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1083","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1083"}],"version-history":[{"count":0,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1083\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media\/1087"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1083"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1083"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1083"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}