{"id":1106,"date":"2020-09-11T16:22:42","date_gmt":"2020-09-11T07:22:42","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1106"},"modified":"2020-09-11T16:22:42","modified_gmt":"2020-09-11T07:22:42","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-19%e3%80%80treg%e7%a0%94%e7%a9%b63%e3%80%80%e3%83%8d%e3%82%ac%e3%83%86%e3%82%a3%e3%83%96%ef%bd%a5","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-19%e3%80%80treg%e7%a0%94%e7%a9%b63%e3%80%80%e3%83%8d%e3%82%ac%e3%83%86%e3%82%a3%e3%83%96%ef%bd%a5\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (19)\u3000Treg\u7814\u7a76(3)\u3000\u30cd\u30ac\u30c6\u30a3\u30d6\uff65\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af"},"content":{"rendered":"<p><span style=\"color: #000080; font-size: 12pt;\">\u3053\u306eAPC + T cell + \u6297CD3\u6297\u4f53\u306e\u57f9\u990a\u7cfb\u3067\u3001T\u7d30\u80de\u304b\u3089\u51fa\u308bIL-2\u3068APC\u304b\u3089\u51fa\u308bIL-12\u3092\u6e2c\u5b9a\u3057\u305f\u3068\u3053\u308d\u3001T\u7d30\u80de\u3092Treg\u3060\u3051\u306b\u3059\u308b\u3068IL-2\u306f\u51fa\u305a\u3001Th\u7d30\u80de\u3060\u3051\u3060\u3068IL-2\u306f\u691c\u51fa\u3055\u308c\u3001Treg : Th = 1 : 1\u306b\u3059\u308b\u3068\u3061\u3087\u3046\u3069\u534a\u5206\uff08\u5e73\u5747\uff09\u306e\u91cf\u306b\u306a\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001\u305d\u306e\u6642\u306eIL-12\u7523\u751f\u3092\u898b\u308b\u3068\u3001Treg : Th = 1 : 1\u306e\u6642\u306eIL-12\u7523\u751f\u306fTh\u7d30\u80de\u3060\u3051\u306e\u5834\u5408\u306b\u6bd4\u3079\u3066\u6fc0\u6e1b\u3057\u3066\u304a\u308a\u3001\u5e73\u5747\u306b\u306f\u306a\u308a\u307e\u305b\u3093\u3002\u5f53\u521d\u306e\u300cTreg\u304cAPC\u306e\u6a5f\u80fd\u3092\u843d\u3068\u3057\u3066\u3044\u308b\u300d\u3068\u3044\u3046\u4eee\u8aac\u306b\u5408\u3046\u7d50\u679c\u3067\u3059\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/506bbfd3cfea957c418c318d9d17f0db.jpg\" rel=\"lightbox[1106]\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1107\" src=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/506bbfd3cfea957c418c318d9d17f0db.jpg\" alt=\"\" width=\"491\" height=\"177\" srcset=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/506bbfd3cfea957c418c318d9d17f0db.jpg 491w, https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/506bbfd3cfea957c418c318d9d17f0db-300x108.jpg 300w\" sizes=\"auto, (max-width: 491px) 100vw, 491px\" \/><\/a><\/p>\n<p><span style=\"color: #000080; font-size: 12pt;\">Th\u7d30\u80de\u306f\u6d3b\u6027\u5316\u3059\u308b\u3068CD40L\u3068\u3044\u3046\u5206\u5b50\u3092\u767a\u73fe\u3057\u3001\u305d\u308c\u304cAPC\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u3068\u3044\u3046\u6027\u8cea\u3092\u6301\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u304c\u3001Treg\u306f\u523a\u6fc0\u3057\u3066\u3082CD40L\u306e\u767a\u73fe\u304c\u4f4e\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u3053\u308c\u306f\u4ee5\u524d\u304b\u3089\u5206\u304b\u3063\u3066\u3044\u305f\u306e\u3067\u3059\u304c\u3001Treg\u306fCTLA4\u3068\u3044\u3046\u5206\u5b50\u3092\u767a\u73fe\u3057\u3066\u3044\u3066\u3001Th\u7d30\u80de\u3088\u308a\u3082APC\u3068\u7d50\u5408\uff08\u76f8\u4e92\u4f5c\u7528\uff09\u3057\u3084\u3059\u3044\u6027\u8cea\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #000080; font-size: 12pt;\">\u307e\u305f\u3001\u3053\u306eCFSE\u67d3\u8272\u306b\u3088\u308a\u3001\u300cTreg\u306f\u5358\u72ec\u3067\u306f\u307b\u3068\u3093\u3069\u5206\u88c2\u3057\u306a\u3044\u306e\u306b\u3001Th\u7d30\u80de\u304c\u3042\u308b\u3068\u7d50\u69cb\u5206\u88c2\u3059\u308b\u300d\u3053\u3068\u3082\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306fTh\u7d30\u80de\u304c\u7523\u751f\u3059\u308bIL-2\u306e\u305f\u3081\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002Treg\u81ea\u4f53\u306fIL-2\u3092\u7523\u751f\u3057\u306a\u3044\u306e\u3067\u3059\u304c\u3001\u4ed6\u4eba\uff08\u4eba\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\uff09\u306e\u7523\u751f\u3059\u308bIL-2\u306b\u983c\u3063\u3066\u5897\u6b96\u3059\u308b\u306e\u3067\u3059\u3002CD25\uff08\uff1dIL-2\u9ad8\u89aa\u548c\u6027\u53d7\u5bb9\u4f53\uff09\u3092\u767a\u73fe\u3057\u3066\u3044\u308b\u306e\u306f\u4f0a\u9054\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/3f455cbb9d15966646195c177661bd68.jpg\" rel=\"lightbox[1106]\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1108 alignleft\" src=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/3f455cbb9d15966646195c177661bd68.jpg\" alt=\"\" width=\"299\" height=\"251\" srcset=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/3f455cbb9d15966646195c177661bd68.jpg 365w, https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/3f455cbb9d15966646195c177661bd68-300x252.jpg 300w\" sizes=\"auto, (max-width: 299px) 100vw, 299px\" \/><\/a>\u6a2a\u7740\u306a\u751f\u304d\u65b9\u306e\u3088\u3046\u306b\u3082\u898b\u3048\u307e\u3059\u304c\u3001\u91cd\u306d\u91cd\u306d\u3001Treg\u306f\u4eba\u9593\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u300cAPC\u304cTh\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3057\u3066Th\u7d30\u80de\u304cIL-2\u3092\u7523\u751f\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u5897\u6b96\u3057\u305fTreg\u304cAPC\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b\u300d\u3053\u308c\u306f\u751f\u4f53\u306e\u6052\u5e38\u6027\u3092\u7dad\u6301\u3059\u308b\uff08=\u30db\u30e1\u30aa\u30b9\u30bf\u30b7\u30b9\uff09\u306e\u306b\u91cd\u8981\u306a\u30b7\u30b9\u30c6\u30e0\u306e\uff11\u3064\u3067\u3042\u308b\u3001\u300c\u30cd\u30ac\u30c6\u30a3\u30d6\uff65\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u30b7\u30b9\u30c6\u30e0\u300d\u306e\uff11\u4f8b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><strong><span style=\"font-size: 12pt; color: #808080;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-18%e3%80%80treg%e7%a0%94%e7%a9%b62cfse%e3%83%80%e3%82%a4%e3%83%aa%e3%83%a5%e3%83%bc%e3%82%b7%e3%83%a7\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (18)\u00a0<\/span><\/a>\u00a0<span style=\"color: #0000ff;\"><strong><em>\u2190\u00a0Prev<\/em><\/strong><\/span><\/span><strong><em>\u3000\u3000\u3000\u3000<span style=\"font-size: 11pt;\"><span style=\"color: #0000ff;\">Next \u2192<\/span>\u3000<\/span><\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-20%e3%80%80treg%e7%a0%94%e7%a9%b64%e3%80%80\"><span style=\"font-size: 11pt; color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (20)<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"\u3053\u306eAPC + T cell + \u6297CD3\u6297\u4f53\u306e\u57f9\u990a\u7cfb\u3067\u3001T\u7d30\u80de\u304b\u3089\u51fa\u308bIL-2\u3068APC\u304b\u3089\u51fa\u308bIL-12\u3092\u6e2c\u5b9a\u3057\u305f\u3068\u3053\u308d\u3001T\u7d30\u80de\u3092Treg\u3060\u3051\u306b\u3059\u308b\u3068IL-2\u306f\u51fa\u305a\u3001Th\u7d30\u80de\u3060\u3051\u3060\u3068IL-2\u306f\u691c\u51fa\u3055\u308c\u3001Treg : T &#8230;","protected":false},"author":1,"featured_media":1107,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1106","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1106","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1106"}],"version-history":[{"count":0,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1106\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media\/1107"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1106"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1106"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1106"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}