{"id":1117,"date":"2020-09-17T11:34:17","date_gmt":"2020-09-17T02:34:17","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1117"},"modified":"2020-09-17T11:34:17","modified_gmt":"2020-09-17T02:34:17","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-20%e3%80%80treg%e7%a0%94%e7%a9%b64%e3%80%80","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-20%e3%80%80treg%e7%a0%94%e7%a9%b64%e3%80%80\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (20)\u3000Treg\u7814\u7a76(4)\u3000"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\uff14\u3064\u524d(16)\u3067\u66f8\u3044\u305fIPEX\u3068\u3044\u3046\u708e\u75c7\u6027\u75be\u60a3\u306f\u3001\u30cd\u30ac\u30c6\u30a3\u30d6\u30fb\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u30b7\u30b9\u30c6\u30e0\u304c\u7834\u7dbb\u3057\u3066\u3044\u308b\u305f\u3081\u306b\u708e\u75c7\u304c\u7d42\u606f\u3057\u306a\u3044\u6df1\u523b\u306a\u75be\u60a3\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u30cd\u30ac\u30c6\u30a3\u30d6\uff65\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u30b7\u30b9\u30c6\u30e0\u306e\u9006\u306f\u30dd\u30b8\u30c6\u30a3\u30d6\u30fb\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u30b7\u30b9\u30c6\u30e0\u3067\u3059\u304c\u3001\u3053\u308c\u306f\u751f\u4f53\u304c\u4f55\u304b\u5909\u5316\u3092\u3059\u308b\u3068\u304d\u306b\u91cd\u8981\u3067\u3059\u3002Th\u7d30\u80de\u304cTh1\u7d30\u80de\u306b\u5206\u5316\u3059\u308b\u3068\u304d\u306a\u3069\u304c\u3053\u306e\u4f8b\u306b\u306a\u308a\u307e\u3059\u3002APC\u304cIL-12\u3092\u51fa\u3057\u3066Th\u7d30\u80de\u3092Th1\u7d30\u80de\u306b\u5206\u5316\u3055\u305b\u308b\u2192Th1\u7d30\u80de\u304cIFN-\u03b3\u3092\u7523\u751f\u3059\u308b\u2192IFN-\u03b3\u304cAPC\u3092\u6d3b\u6027\u5316\u3059\u308b\u2192\u30b9\u30bf\u30fc\u30c8\u306b\u623b\u308b<\/span><br \/>\n<span style=\"font-size: 12pt; color: #000080;\">\u3068\u3001\u30b0\u30eb\u30b0\u30eb\u56de\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u306d\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3069\u3061\u3089\u306e\u4ed5\u7d44\u307f\u3082\u5927\u4e8b\u3067\u3001\u524d\u8005\u3060\u3051\u3060\u3068\u751f\u4f53\u306f\u4f55\u306e\u5909\u5316\u3082\u8d77\u3053\u305b\u306a\u3044\u3002\u6210\u9577\u3082\u3067\u304d\u307e\u305b\u3093\u3057\u3001\u5206\u5316\u3082\u3067\u304d\u307e\u305b\u3093\u3002\u5f8c\u8005\u3060\u3051\u3060\u3068\u5909\u5316\u306b\u3069\u3093\u3069\u3093\u52a0\u901f\u304c\u3064\u3044\u3066\u3001\u30d6\u30ec\u30fc\u30ad\u304c\u3042\u308a\u307e\u305b\u3093\u304b\u3089\u3082\u3046\u53ce\u62fe\u304c\u3064\u304d\u307e\u305b\u3093\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">Treg\u306e\u5b9f\u9a13\u7d50\u679c\u306f\u8ad6\u6587\u306b\u307e\u3068\u3081\u3066\u3001BBRC\u3068\u3044\u3046\u901f\u5831\u8a8c\u306b\u51fa\u3057\u307e\u3057\u305f(Sato K et al., Biochem Biophys Res Commun. 2005)\u3002\u3082\u306f\u3084\u5927\u5b66\u9662\u751f\u3067\u306f\u306a\u3044\u306e\u3067\u300c\u8d64\u30da\u30f3\u6dfb\u524a\u300d\uff08\u2192(10)\u8ad6\u6587\u6307\u5c0e\uff09\u3092\u53d7\u3051\u308b\u3053\u3068\u3082\u3067\u304d\u305a\uff08\u610f\u5916\u3068\u7121\u7406\u306b\u304a\u9858\u3044\u3057\u305f\u3089\u6dfb\u524a\u3057\u3066\u3044\u305f\u3060\u3051\u305f\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\uff09\u3001\u4eca\u898b\u76f4\u3059\u3068\u672c\u5f53\u306b\u7a1a\u62d9\u306a\u8ad6\u6587\u3060\u306a\u3068\u601d\u3044\u307e\u3059\u3002\u3057\u304b\u3082\u3001\u6821\u6b63\u306e\u9023\u7d61\u304c\u30e1\u30fc\u30eb\u3067\u6765\u3066\u3044\u305f\u306f\u305a\u306a\u306e\u306b\u4f55\u6545\u304b\u898b\u9003\u3057\u3066\u3044\u3066\u3001\u6821\u6b63\u3057\u306a\u3044\u3046\u3061\u306b\u63b2\u8f09\u3055\u308c\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002\u898b\u305f\u3089\u4f55\u3068Fig\u306e\u756a\u53f7\u3092\u9593\u9055\u3048\u3066\u3044\u308b\u30fb\u30fb\u30fb\u3053\u3093\u306a\u3053\u3068\u3092\u3057\u3066\u3044\u305f\u3089\u30e9\u30dc\u306b\u3088\u3063\u3066\u306f\u6b7b\u7f6a\u3067\u3059\uff08\u3069\u3053\u306e\u30e9\u30dc\u3068\u306f\u8a00\u3044\u307e\u305b\u3093\uff09\u3002\u305f\u3060\u3001\u8208\u5473\u6df1\u3044\u5b9f\u969b\u306e\u73fe\u8c61\u306b\u3064\u3044\u3066\u3001\u601d\u8003\u5b9f\u9a13\u3067\u4eee\u8aac\u3092\u7acb\u3066\u3066\u3001\u305d\u308c\u3092\u691c\u8a3c\u3059\u308b\u3068\u3044\u3046\u30d7\u30ed\u30bb\u30b9\u306f\u672c\u5f53\u306b\u697d\u3057\u304f\u3001\u7d50\u679c\u3082\u304b\u306a\u308a\u4e88\u60f3\u901a\u308a\u3060\u3063\u305f\u306e\u3067\u3001\u4eca\u8003\u3048\u3066\u3082\u79c1\u306b\u3068\u3063\u3066\u306f\uff13\u672c\u306e\u6307\u306b\u5165\u308b\u8ad6\u6587\u3060\u3063\u305f\u3068\u601d\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">Treg\u306b\u3088\u308b\u514d\u75ab\u6291\u5236\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u305d\u306e\u5f8c\u3082\u8272\u3005\u306a\u3082\u306e\u304c\u63d0\u5531\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001Treg\u304cT\u7d30\u80de\u306e\u5468\u56f2\u306e\u4ee3\u8b1d\u74b0\u5883\u3092\u5909\u3048\u308b\u3068\u3044\u3046\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002\u69d8\u3005\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u8907\u5408\u7684\u306b\u4f5c\u7528\u3057\u3066Th\u306e\u6a5f\u80fd\u3092\u6291\u5236\u3059\u308b\u3001\u3068\u3044\u3046\u3088\u3046\u306a\u7406\u89e3\u306b\u306a\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 12pt; color: #808080;\"><strong>\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-19%e3%80%80treg%e7%a0%94%e7%a9%b63%e3%80%80%e3%83%8d%e3%82%ac%e3%83%86%e3%82%a3%e3%83%96%ef%bd%a5\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (19)<\/span><\/a> \u00a0<span style=\"color: #0000ff;\"><strong><em>\u2190\u00a0Prev<\/em><\/strong><\/span><strong><em>\u3000\u3000\u3000\u3000<span style=\"font-size: 11pt;\"><span style=\"color: #0000ff;\">Next \u2192<\/span>\u3000<\/span><\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-21%e3%80%80aire%e7%a0%94%e7%a9%b61%e3%80%80\"><span style=\"font-size: 11pt; color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (21)<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\uff14\u3064\u524d(16)\u3067\u66f8\u3044\u305fIPEX\u3068\u3044\u3046\u708e\u75c7\u6027\u75be\u60a3\u306f\u3001\u30cd\u30ac\u30c6\u30a3\u30d6\u30fb\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u30b7\u30b9\u30c6\u30e0\u304c\u7834\u7dbb\u3057\u3066\u3044\u308b\u305f\u3081\u306b\u708e\u75c7\u304c\u7d42\u606f\u3057\u306a\u3044\u6df1\u523b\u306a\u75be\u60a3\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002 \u30cd\u30ac\u30c6\u30a3\u30d6\uff65\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u30b7\u30b9\u30c6\u30e0\u306e\u9006\u306f\u30dd\u30b8\u30c6\u30a3\u30d6\u30fb\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af &#8230;","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1117","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1117","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1117"}],"version-history":[{"count":0,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1117\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1117"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1117"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1117"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}