{"id":1123,"date":"2020-09-23T17:33:18","date_gmt":"2020-09-23T08:33:18","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1123"},"modified":"2020-09-23T17:33:18","modified_gmt":"2020-09-23T08:33:18","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-21%e3%80%80aire%e7%a0%94%e7%a9%b61%e3%80%80","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-21%e3%80%80aire%e7%a0%94%e7%a9%b61%e3%80%80\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (21)\u3000Aire\u7814\u7a76(1)\u3000"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">Treg\u306e\u5b9f\u9a13\u3092\u3057\u3066\u3044\u305f\u9803\u306b\u3001\u3082\u3046\u4e00\u3064\u53d6\u308a\u7d44\u3093\u3060\u8ab2\u984c\u304c\u3042\u308a\u307e\u3057\u305f\u3002Aire\u3068\u3044\u3046\u5206\u5b50\u306e\u6a5f\u80fd\u89e3\u6790\u3067\u3059\u3002\u3053\u308c\u306b\u6ce8\u76ee\u3057\u305f\u304d\u3063\u304b\u3051\u306f\u672c\u5f53\u306b\u5076\u7136\u3067\u3001\u5c0f\u5150\u79d1\u533b\u306e\u59bb\u304c\u5927\u5b66\u9662\u751f\u3068\u3057\u3066\u305d\u306e\u5206\u5b50\u306e\u6a5f\u80fd\u3092\u89e3\u6790\u3057\u3066\u3044\u305f\u304b\u3089\u3067\u3059\u3002Aire\u306f\u8ee2\u5199\u56e0\u5b50\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u300c\u81ea\u5df1\u514d\u75ab\u6027\u591a\u817a\u6027\u5185\u5206\u6ccc\u4e0d\u5168\u75c7\u30fb\u30ab\u30f3\u30b8\u30c0\u75c7\u30fb\u5916\u80da\u8449\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED))\u3068\u3044\u3046\u3001\u65e5\u672c\u8a9e\u306b\u3057\u3066\u3082\u82f1\u8a9e\u306b\u3057\u3066\u3082\u9577\u3044\u540d\u524d\u306e\u75be\u60a3\u3092\u6765\u3059\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3064\u307e\u308aAPCED\u3068\u3044\u3046\u75be\u60a3\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u304cAire\u3060\u3063\u305f\u3001\u3068\u3044\u3046\u8a33\u3067\u3059\u3002\u3057\u304b\u3057\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3088\u304f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3000\u3061\u306a\u307f\u306b\u3001\u5f53\u6642\uff11\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u306e\u5909\u7570\u304c\u539f\u56e0\u3067\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3092\u6765\u3059\u306e\u306f\u3001FoxP3-IPEX, Aire-APECED\u306e\uff12\u3064\u306e\u7d44\u307f\u5408\u308f\u305b\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5076\u7136\u306b\u3082\u305d\u306e\u4e21\u65b9\u306e\u7814\u7a76\u306b\u307b\u307c\u540c\u6642\u306b\u53d6\u308a\u7d44\u3093\u3060\u308f\u3051\u3067\u3059\u304c\u3001\u307e\u3042\u7121\u8b00\u306a\u8a66\u307f\u3067\u3082\u3042\u308a\u307e\u3057\u305f\u3002\u79c1\u306fAire\u304c\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308c\u3070\u3001\u305d\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u3092\u77e5\u308a\u305f\u3044\u3068\u8003\u3048\u307e\u3057\u305f\u3002\u305d\u3053\u3067Aire\u907a\u4f1d\u5b50\u3092\u57f9\u990a\u7d30\u80de\u306b\u5f37\u5236\u767a\u73fe\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u3069\u306e\u3088\u3046\u306a\u5206\u5b50\u304c\u8a98\u5c0e\u3055\u308c\u308b\u306e\u304b\u3092\u898b\u3066\u307f\u3088\u3046\u3068\u601d\u3044\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3057\u304b\u3057\u5019\u88dc\u306b\u306a\u308b\u5206\u5b50\u304c\u305d\u3082\u305d\u3082\u5206\u304b\u3089\u306a\u3044\u306e\u306b\u3001\u3069\u3046\u3084\u3063\u3066\u89e3\u6790\u3059\u308c\u3070\u3088\u3044\u3067\u3057\u3087\u3046\u304b\uff1f<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u4eca\u3067\u3042\u308c\u3070\u8ff7\u308f\u305a\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u3092\u884c\u3063\u3066\u3001Aire\u306e\u5f37\u5236\u767a\u73fe\u306e\u6709\u7121\u3067\u767a\u73fe\u91cf\u306e\u5909\u5316\u3059\u308bmRNA\u3092\u7db2\u7f85\u7684\u306b\u5b9a\u91cf\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u3059\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u5f53\u6642\u3082\u3001GeneChip\u3068\u3044\u3046\u624b\u6cd5\u304c\u5b9f\u7528\u5316\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u304b\u306a\u308a\u8cbb\u7528\u306e\u304b\u304b\u308b\u5b9f\u9a13\u3067\u3001\u3068\u3066\u3082\u624b\u304c\u51fa\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u76ee\u3092\u3064\u3051\u305f\u306e\u306fRNase protection assay\u3068\u3044\u3046\u624b\u6cd5\u3067\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 12pt;\"><strong><span style=\"color: #808080;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-20%e3%80%80treg%e7%a0%94%e7%a9%b64%e3%80%80\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (20)<\/span><\/a>\u00a0\u00a0<span style=\"color: #0000ff;\"><strong><em>\u2190\u00a0Prev<\/em><\/strong><\/span><\/span><strong><em>\u3000\u3000\u3000\u3000<span style=\"font-size: 11pt;\"><span style=\"color: #0000ff;\">Next \u2192\u3000<\/span><\/span><\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-22%e3%80%80aire%e7%a0%94%e7%a9%b62%e3%80%80-rnase-protection-assayrpa\"><span style=\"font-size: 11pt; color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (22)<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Treg\u306e\u5b9f\u9a13\u3092\u3057\u3066\u3044\u305f\u9803\u306b\u3001\u3082\u3046\u4e00\u3064\u53d6\u308a\u7d44\u3093\u3060\u8ab2\u984c\u304c\u3042\u308a\u307e\u3057\u305f\u3002Aire\u3068\u3044\u3046\u5206\u5b50\u306e\u6a5f\u80fd\u89e3\u6790\u3067\u3059\u3002\u3053\u308c\u306b\u6ce8\u76ee\u3057\u305f\u304d\u3063\u304b\u3051\u306f\u672c\u5f53\u306b\u5076\u7136\u3067\u3001\u5c0f\u5150\u79d1\u533b\u306e\u59bb\u304c\u5927\u5b66\u9662\u751f\u3068\u3057\u3066\u305d\u306e\u5206\u5b50\u306e\u6a5f\u80fd\u3092\u89e3\u6790\u3057\u3066\u3044\u305f\u304b\u3089\u3067\u3059\u3002Aire\u306f\u8ee2\u5199\u56e0 &#8230;","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1123","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1123","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1123"}],"version-history":[{"count":0,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1123\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1123"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1123"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1123"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}