{"id":1168,"date":"2020-10-14T11:22:44","date_gmt":"2020-10-14T02:22:44","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1168"},"modified":"2020-10-14T11:22:44","modified_gmt":"2020-10-14T02:22:44","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-24%e3%80%80aire%e7%a0%94%e7%a9%b64%e3%80%80%e3%82%a4%e3%83%b3%e3%83%91%e3%82%af%e3%83%88%e3%81%ae","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-24%e3%80%80aire%e7%a0%94%e7%a9%b64%e3%80%80%e3%82%a4%e3%83%b3%e3%83%91%e3%82%af%e3%83%88%e3%81%ae\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (24)\u3000Aire\u7814\u7a76(4)\u3000\u30a4\u30f3\u30d1\u30af\u30c8\u306e\u3042\u308b\u8ad6\u6587"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\u201cProjection of an Immunological Self Shadow Within the Thymus by the Aire Protein\u201d<br \/>\n<\/span><span style=\"font-size: 12pt; color: #000080;\">\u3068\u3044\u3046\u30bf\u30a4\u30c8\u30eb\u306e\u3053\u306e\u8ad6\u6587\u306f2002\u5e74\u306bScience\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n<\/span><span style=\"font-size: 12pt; color: #000080;\">\u307e\u305a\u30bf\u30a4\u30c8\u30eb\u304c\u683c\u597d\u826f\u3044\u3067\u3059\u306d\u3002\u76f4\u8a33\u3059\u308b\u3068\u300cAire\u30bf\u30f3\u30d1\u30af\u306b\u3088\u308a\u80f8\u817a\u306e\u4e2d\u306b\u514d\u75ab\u5b66\u7684\u306a\u81ea\u5df1\u304c\u6295\u5f71\u3055\u308c\u308b\u300d\u3068\u3067\u3082\u306a\u308a\u307e\u3059\u304b\u3002Shadow\u3068\u304bprojection\u306a\u3069\u3068\u3044\u3046\u8a00\u8449\u306f\u751f\u7269\u306e\u8ad6\u6587\u3067\u306f\u3042\u307e\u308a\u898b\u306a\u3044\u8a00\u8449\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3053\u3068\u306f\u3058\u3081(1)\u3067\u8ff0\u3079\u305f\u3088\u3046\u306b\u3001T\u7d30\u80de\u306f\u81ea\u8eab(self)\u3092\u653b\u6483\u3057\u306a\u3044\u3088\u3046\u306b\u80f8\u817a\u3067\u6559\u80b2\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u3002self\u3092\u653b\u6483\u3059\u308b\u3088\u3046\u306a\u7d30\u80de\u306f\u3053\u306e\u6559\u80b2\u306e\u904e\u7a0b\u3067\u6392\u9664\u3055\u308c\u307e\u3059\u3002\u81ea\u5df1\u306e\u30bf\u30f3\u30d1\u30af\u3092\u653b\u6483\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306b\u306f\u3001T\u7d30\u80de\u306b\u81ea\u5df1\u30bf\u30f3\u30d1\u30af\u3092\u5b9f\u969b\u306b\u4f5c\u3063\u3066\uff62\u898b\u305b\u308b\uff63\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u306b\u80f8\u817a\u306e\u7d30\u80de\u306f\u81ea\u5df1\u306e\u30bf\u30f3\u30d1\u30af\u3092\u5168\u7a2e\u985e\u4f5c\u308b\u80fd\u529b\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u305f\u3068\u3048\u3070\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u3088\u3046\u306b\u3001\u901a\u5e38\u81b5\u81d3\u3067\u3057\u304b\u4f5c\u3089\u308c\u306a\u3044\u3088\u3046\u306a\u30bf\u30f3\u30d1\u30af\u306b\u3064\u3044\u3066\u3082\u3001\u6559\u80b2\u306e\u305f\u3081\u306b\u306f\u80f8\u817a\u3067\uff08\u5c11\u91cf\u3067\u826f\u3044\u306e\u3067\u3057\u3087\u3046\u304c\uff09\u4f5c\u3089\u308c\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u3046\u3067\u306a\u3044\u3068\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u975e\u81ea\u5df1\u3068\u8a8d\u8b58\u3059\u308b\u3088\u3046\u306aT\u7d30\u80de\u304c\u6392\u9664\u3055\u308c\u305a\u306b\u672b\u68a2\u306b\u51fa\u3066\u304d\u3066\u3057\u307e\u3044\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u50cd\u304d\u3092\u963b\u5bb3\u3059\u308b\u3088\u3046\u306a\u514d\u75ab\u5fdc\u7b54\u304c\u8d77\u304d\u304b\u306d\u307e\u305b\u3093\u3002\u5177\u4f53\u7684\u306b\u306fT\u7d30\u80de\u3068B\u7d30\u80de\u304c\u5354\u529b\u3057\u5408\u3063\u3066\u3001\u300c\u6297\u30a4\u30f3\u30b9\u30ea\u30f3\u6297\u4f53\u300d\u304c\u3067\u304d\u3066\u3057\u307e\u3046\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u305d\u3046\u306a\u3063\u305f\u3089\u7cd6\u5c3f\u75c5\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3053\u306e\u8ad6\u6587\u306e\u7b46\u8005\u3089\u306f\u3001Aire\u306b\u3088\u3063\u3066\u591a\u69d8\u306a\u30bf\u30f3\u30d1\u30af\uff08\u306e\u4e00\u90e8\uff09\u304c\u80f8\u817a\u3067\u4f5c\u3089\u308c\u308b\u3001\u3068\u3044\u3046\u3053\u3068\u3092\u4e3b\u5f35\u3057\u305f\u306e\u3067\u3059\u3002\u514d\u75ab\u5b66\u306e\u91cd\u8981\u306a\u4eee\u8aac\u306b\u5207\u308a\u8fbc\u3080\u3088\u3046\u306a\u8ad6\u6587\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3057\u304b\u3057\u3001\u6b63\u76f4\u306a\u3053\u3068\u3092\u8a00\u3046\u3068\u5f53\u6642\u3053\u306e\u8ad6\u6587\u3092\u898b\u305f\u3068\u304d\u306b\u3001(16)\u3067\u66f8\u3044\u305f\u3088\u3046\u306a\uff62\u30a8\u30a6\u30ec\u30ab\uff01\uff63\u3068\u3044\u3046\u6c17\u306b\u306f\u306a\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002APECED\u306f\u907a\u4f1d\u6027\u75be\u60a3\u3067\u3042\u308b\u308f\u3051\u3067\u3059\u304c\u3001\u540c\u3058\u5bb6\u7cfb\u306e\u60a3\u8005\u3055\u3093\u3067\u3082\u304b\u306a\u308a\u75c7\u72b6\u306f\u9055\u3046\u3088\u3046\u3067\u3059\u3002\u307e\u305f\u767a\u75c7\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3082\u69d8\u3005\u306a\u3088\u3046\u3067\u3059\u3002\u3053\u306e\u8ad6\u6587\u306e\u3088\u3046\u306a\u672c\u8cea\u7684\u306a\u90e8\u5206\u306b\u554f\u984c\u304c\u8d77\u304d\u308b\u306e\u3067\u3042\u308c\u3070\u3001\u3082\u3063\u3068\u5e7c\u5c11\u671f\u304b\u3089\u3001\u3082\u3063\u3068\u5f37\u3044\u75c7\u72b6\u304c\u51fa\u308b\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b?\u3000\u5b9f\u969b\u3001Treg\u306e\u6a5f\u80fd\u7570\u5e38\u3067\u3042\u308bIPEX\u306e\u5834\u5408\u306f\u5e7c\u5c11\u6642\u304b\u3089\u5f37\u3044\u75c7\u72b6\u304c\u51fa\u308b\u3088\u3046\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u30b9\u30c8\u30fc\u30ea\u30fc\u3068\u3057\u3066\u306f\u6d3e\u624b\u3067\u9762\u767d\u3044\u306e\u3067\u3059\u304c\u3001\u3053\u306e\u9803\u306b\u306a\u308b\u3068\u79c1\u3082\u30b9\u30ec\u3066\u304d\u3066\u304a\u308a\u3001\u8aad\u3093\u3060\u8ad6\u6587\u3092\u3059\u3050\u306b\u306f\u4fe1\u3058\u306a\u3044\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u81ea\u5206\u3067\u78ba\u8a8d\u3057\u305f\u3053\u3068\u3057\u304b\u672c\u5f53\u306b\u306f\u4fe1\u3058\u3089\u308c\u306a\u304f\u306a\u3063\u3066\u3044\u305f\u306e\u3067\u3059\u3002\u305d\u3057\u3066\u3082\u3046\uff11\u3064\u3001\u91cd\u8981\u306a\u3053\u3068\u306b\u6c17\u3065\u3044\u3066\u3044\u307e\u3057\u305f\u3002<br \/>\n<\/span><span style=\"font-size: 12pt; color: #000080;\">\u305d\u308c\u306f\u81ea\u5206\u304c\u307e\u3060\u3001\u300c\u57fa\u790e\u7684\u306a\u7814\u7a76\u3092\u6e80\u8db3\u3059\u308b\u307b\u3069\u3084\u308a\u8db3\u308a\u3066\u3044\u306a\u3044\u300d\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"color: #808080; font-size: 12pt;\"><strong>\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-23-aire%e7%a0%94%e7%a9%b63-%e6%9c%ac%e5%bd%93%e3%81%af%e3%82%84%e3%82%8a%e3%81%9f%e3%81%8b%e3%81%a3\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (23)<\/a> <\/span><span style=\"color: #0000ff;\"><span style=\"font-size: 11pt;\"><strong><em>\u2190\u00a0Prev\u3000\u3000\u3000\u3000\u3000<\/em><\/strong><\/span><strong><em>Next \u2192<\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-25%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b61%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (25)<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u201cProjection of an Immunological Self Shadow Within the Thymus by the Aire Protein\u201d \u3068\u3044\u3046\u30bf\u30a4\u30c8\u30eb\u306e\u3053\u306e\u8ad6\u6587\u306f2002\u5e74\u306bScience\u8a8c &#8230;","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1168","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1168","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1168"}],"version-history":[{"count":0,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1168\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1168"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1168"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1168"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}