{"id":1238,"date":"2020-10-28T11:41:44","date_gmt":"2020-10-28T02:41:44","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1238"},"modified":"2020-10-28T11:41:44","modified_gmt":"2020-10-28T02:41:44","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-26-%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b62-%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-26-%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b62-%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (26) \u7834\u9aa8\u7d30\u80de\u7814\u7a76(2) \u7834\u9aa8\u7d30\u80de\u7814\u7a76\u306e\u52a0\u901f"},"content":{"rendered":"<p><span style=\"color: #000080; font-size: 12pt;\">\u7834\u9aa8\u7d30\u80de\u306f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u7cfb\u306e\u7d30\u80de\u306a\u306e\u3067\u3001\u9aa8\u9ac4\u7d30\u80de\u3084\u813e\u7d30\u80de\u306b\u524d\u99c6\u7d30\u80de\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u7834\u9aa8\u7d30\u80de\u5206\u5316\u3092\uff62\u52a9\u3051\u308b\uff63\u50cd\u304d\u3092\u3059\u308b\u7d30\u80de\u3082\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u308c\u304c\u9aa8\u9ac4\u306b\u5b58\u5728\u3059\u308b\u30b9\u30c8\u30ed\u30fc\u30de\u7d30\u80de\u3084\u3001\u9aa8\u5f62\u6210\u306b\u91cd\u8981\u306a\u9aa8\u82bd\u7d30\u80de\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #000080; font-size: 12pt;\">\u30de\u30a6\u30b9\u306e\u9aa8\u82bd\u7d30\u80de\u3068\u3001\u813e\u7d30\u80de\u3084\u9aa8\u9ac4\u7d30\u80de\u3092\u4e00\u7dd2\u306b\u57f9\u990a\uff08\u5171\u5b58\u57f9\u990a\uff09\u3057\u3001\u305d\u3053\u306b\u30d3\u30bf\u30df\u30f3D\u306a\u3069\u3092\u6dfb\u52a0\u3059\u308b\u3068\u3001\u591a\u6838\u306e\u5de8\u5927\u7d30\u80de\u304c\u8a66\u9a13\u7ba1\u5185\u3067\u3082\u89b3\u5bdf\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\uff08\u305f\u3068\u3048\u3070Takahashi N, Akatsu T, Udagawa N, et al. : Endocrinology, 123 : 2600-2602, 1988\uff09\u3002\u305d\u306e\u7d30\u80de\u306f\u9152\u77f3\u9178\u62b5\u6297\u6027\u9178\u6027\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\uff08Tartrate- Resistant Acid. Phosphatase\uff1bTRAP\uff09\u967d\u6027\u3067\u3042\u308a\u3001\u3053\u306eTRAP\u306f\u7834\u9aa8\u7d30\u80de\u306e\u91cd\u8981\u306a\u30de\u30fc\u30ab\u30fc\u306e\uff11\u3064\u3067\u3059\u3002\u66f4\u306b\u8a66\u9a13\u7ba1\u5185\u3067\u9aa8\u57fa\u8cea\u3092\u5438\u53ce\u3059\u308b\u80fd\u529b\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3059(= pit formation assay)\u3002<\/span><\/p>\n<p><span style=\"color: #000080; font-size: 12pt;\">\u3000\u3053\u3046\u3044\u3046\u57f9\u990a\u7cfb\u3092\u4e00\u304b\u3089\u7acb\u3061\u4e0a\u3052\u308b\u3053\u3068\u304c\u3069\u308c\u307b\u3069\u5927\u5909\u306a\u3053\u3068\u304b\u3002\u6dfb\u52a0\u3059\u308b\u8a66\u85ac\u3060\u3063\u3066\u7121\u6570\u306b\u8003\u3048\u3089\u308c\u308b\u308f\u3051\u3067\u3059\u3057\u3001\u305d\u306e\u6fc3\u5ea6\u3060\u3063\u3066\u7121\u9650\u306b\u5909\u3048\u3089\u308c\u307e\u3059\u3002\u6c17\u304c\u9060\u304f\u306a\u308b\u3088\u3046\u306a\u7814\u7a76\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #000080; font-size: 12pt;\">\u3000\u305d\u3046\u3044\u3046\u8a33\u3067\u3001\u30b9\u30c8\u30ed\u30fc\u30de\u7d30\u80de\u3084\u9aa8\u82bd\u7d30\u80de\u306f\u3001\u7834\u9aa8\u7d30\u80de\u306e\u5206\u5316\u306b\u5fc5\u8981\u306a\u56e0\u5b50\u3092\u7523\u751f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002\u3053\u306e\uff62\u7834\u9aa8\u7d30\u80de\u5206\u5316\u56e0\u5b50(osteoclast differentiation factor, ODF)\uff63\u306e\u6b63\u4f53\u3092\u660e\u3089\u304b\u306b\u3059\u3079\u304f\u3001\u56fd\u969b\u7684\u306a\u6fc0\u3057\u3044\u7af6\u4e89\u304c\u59cb\u307e\u308a\u307e\u3057\u305f\u3002\u5f53\u7136\u305d\u306e\u56e0\u5b50\u306f\u9aa8\u7c97\u9b06\u75c7\u306e\u3088\u3046\u306a\u75be\u60a3\u306e\u6a19\u7684\u5206\u5b50\u306b\u306a\u308a\u3048\u308b\u3068\u3044\u3046\u3053\u3068\u3082\u3042\u308a\u5275\u85ac\u4e0a\u306e\u4fa1\u5024\u3082\u9ad8\u3044\u308f\u3051\u3067\u3059\u3002\u305d\u306e\u56e0\u5b50\u306e\uff11\u3064\u306fM-CSF\u3068\u3044\u3046\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308a\u3001\u3053\u308c\u306f\u5358\u7403\u7cfb\u306e\u7d30\u80de\u306e\u751f\u5b58\uff65\u5206\u5316\u306b\u5fc5\u8981\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306a\u306e\u3067\u3001\u540c\u69d8\u306e\u6027\u8cea\u3092\u6301\u3064\u7834\u9aa8\u7d30\u80de\u5206\u5316\u306b\u5fc5\u8981\u306a\u306e\u306f\u3055\u307b\u3069\u610f\u5916\u306a\u3053\u3068\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3082\u3046\uff11\u3064\u306e\u56e0\u5b50\u304cODF\u306e\u672c\u614b\u3068\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u304c\u30011998\u5e74\u9803\u306b\u76f8\u6b21\u3044\u3067\u540c\u5b9a\u3055\u308c\u3001\u540c\u4e00\u5206\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u305d\u308c\u306f1997\u5e74\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u305f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3RANKL\u3060\u3063\u305f\u306e\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #000080; font-size: 12pt;\">\u3000\u3053\u306e\uff12\u3064\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u5206\u304b\u3063\u305f\u3053\u3068\u3067\u3001\u7834\u9aa8\u7d30\u80de\u306e\u7814\u7a76\u306f\u52a0\u901f\u3057\u307e\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"color: #808080; font-size: 12pt;\"><strong>\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-25%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b61%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (25)<\/a>\u00a0\u00a0<span style=\"color: #0000ff;\"><strong><em>\u2190 Prev\u3000\u3000\u3000\u3000\u3000Next \u2192<\/em><\/strong><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-27%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b63%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (27)<\/a><\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u7834\u9aa8\u7d30\u80de\u306f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u7cfb\u306e\u7d30\u80de\u306a\u306e\u3067\u3001\u9aa8\u9ac4\u7d30\u80de\u3084\u813e\u7d30\u80de\u306b\u524d\u99c6\u7d30\u80de\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u7834\u9aa8\u7d30\u80de\u5206\u5316\u3092\uff62\u52a9\u3051\u308b\uff63\u50cd\u304d\u3092\u3059\u308b\u7d30\u80de\u3082\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u308c\u304c\u9aa8\u9ac4\u306b\u5b58\u5728\u3059\u308b\u30b9\u30c8\u30ed\u30fc\u30de\u7d30\u80de\u3084\u3001\u9aa8\u5f62\u6210\u306b\u91cd\u8981\u306a\u9aa8\u82bd\u7d30\u80de &#8230;","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1238","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1238","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1238"}],"version-history":[{"count":0,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1238\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1238"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1238"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1238"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}