{"id":1283,"date":"2020-11-24T11:47:16","date_gmt":"2020-11-24T02:47:16","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1283"},"modified":"2020-11-24T11:47:16","modified_gmt":"2020-11-24T02:47:16","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-29%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b65%e3%80%80%e3%80%80%e7%a0%b4%e9%aa%a8","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-29%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b65%e3%80%80%e3%80%80%e7%a0%b4%e9%aa%a8\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (29)\u3000\u7834\u9aa8\u7d30\u80de\u7814\u7a76(5)\u3000\u3000\u7834\u9aa8\u7d30\u80de\u5206\u5316\u306e\u30d1\u30e9\u30c9\u30af\u30b9"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1(RA)\u304cTh1\u5bc4\u308a\u306e\u75be\u60a3\u3067\u3042\u308b\u3068\u3044\u3046\u306e\u306f\u3001RA\u754c\u306e\u5927\u5fa1\u6240\u3067\u3042\u308bSmolen\u5148\u751f\u304c\u63d0\u5531\u3057\u305f\u304b\u3089\u5e83\u304f\u4fe1\u3058\u3089\u308c\u3066\u3044\u305f\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u60f3\u50cf\u3057\u3066\u3044\u307e\u3059(Smolen et al., Scand J Rheumatol. 1996\u306a\u3069)\u3002<br \/>\n<\/span><span style=\"font-size: 12pt; color: #000080;\">RA\u3067\u306f\u95a2\u7bc0\u8fd1\u508d\u306e\u9aa8\u304c\u7834\u9aa8\u7d30\u80de\u306b\u3088\u308a\u7834\u58ca\u3055\u308c\u307e\u3059\u3057\u3001<u>\u7834\u9aa8\u7d30\u80de\u5206\u5316\u56e0\u5b50\u306e\u6b63\u4f53\u304c\u3001\u5143\u3005T\u7d30\u80de\u304c\u7523\u751f\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u3057\u3066\u767a\u898b\u3055\u308c\u305fRANKL\u305d\u306e\u3082\u306e\u3067\u3042\u3063\u305f\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001Th1\u7d30\u80de\u304cRANKL\u3092\u767a\u73fe\u3057\u3066\u7834\u9aa8\u7d30\u80de\u3092\u8a98\u5c0e\u3057\u3001\u95a2\u7bc0\u306e\u7834\u58ca\u3092\u3082\u305f\u3089\u3059\u3001\u3068\u3044\u3046\u8003\u3048\u65b9<\/u>\u306f\u3068\u3066\u3082\u81ea\u7136\u306a\u3082\u306e\u306b\u601d\u3048\u307e\u3059\u3002<br \/>\n<\/span><span style=\"font-size: 12pt; color: #000080;\">\u3057\u304b\u3057\u3001IFN-\u03b3\u304c\u7834\u9aa8\u7d30\u80de\u5206\u5316\u3092\u5f37\u529b\u306b\u963b\u5bb3\u3059\u308b\u3068\u3044\u3046\u767a\u898b\u306f\u3001\u4e0a\u8a18\u306e\u4eee\u8aac\u306b\u7591\u554f\u3092\u6295\u3052\u304b\u3051\u308b\u3082\u306e\u3067\u3057\u305f\u3002\u3068\u3044\u3046\u306e\u306fTh1\u7d30\u80de\u306e\u7523\u751f\u3059\u308b\u4ee3\u8868\u7684\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304cIFN-\u03b3\u3060\u304b\u3089\u3067\u3059\u3002RA\u304c\u672c\u5f53\u306bTh1-type disease\u3067\u3042\u308c\u3070\u7834\u9aa8\u7d30\u80de\u306f\u5206\u5316\u3067\u304d\u305a\u3001\u9aa8\u7834\u58ca\u3082\u8d77\u304d\u306a\u3044\u306f\u305a\u3060\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3082\u3046\u4e00\u3064\u4e0d\u601d\u8b70\u306a\u3053\u3068\u3068\u3057\u3066\u3001RA\u306e\u52d5\u7269\u5b9f\u9a13\u30e2\u30c7\u30eb\u3068\u3057\u3066\u5e83\u304f\u5229\u7528\u3055\u308c\u3066\u3044\u308b\u5b9f\u9a13\u7cfb\u306b\u30b3\u30e9\u30fc\u30b2\u30f3\u95a2\u7bc0\u708e\uff08CIA, \u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u514d\u75ab\u3057\u3066\u95a2\u7bc0\u708e\u3092\u60f9\u8d77\u3059\u308b\uff09\u304c\u3042\u308b\u306e\u3067\u3059\u304c\u3001IFN-\u03b3\u306e\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3084IFN-\u03b3\u53d7\u5bb9\u4f53\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306bCIA\u3092\u8a98\u5c0e\u3059\u308b\u3068\u3001\u95a2\u7bc0\u708e\u306f\u8efd\u304f\u306a\u308b\u3069\u3053\u308d\u304b\u3001\u3080\u3057\u308d\u91cd\u75c7\u5316\u3059\u308b\u3068\u3044\u3046\u8ad6\u6587\u304c\u6b21\u3005\u306b\u51fa\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u306f<u>IFN-\u03b3\u30b7\u30b0\u30ca\u30eb\u304c\u3001\u95a2\u7bc0\u708e\u3092\u60aa\u304f\u3059\u308b\u3088\u308a\u3080\u3057\u308d\u9632\u5fa1\u7684\u306b\u4f5c\u7528\u3057\u3066\u3044\u308b\u3053\u3068<\/u>\u3092\u793a\u5506\u3057\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3053\u308c\u306f\u4eee\u8aac\u306e\u3069\u3053\u304b\u306b\u304a\u304b\u3057\u3044\u6240\u304c\u3042\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3001\u3068\u601d\u3044\u307e\u3057\u305f\u3002IL-2\u30d1\u30e9\u30c9\u30af\u30b9\u3092\u521d\u3081\u3066\u77e5\u3063\u305f\u6642\u3068\u540c\u3058\u3088\u3046\u306a\u30bd\u30ef\u30bd\u30ef\u3057\u305f\u6c17\u6301\u3061\u306b\u306a\u308a\u307e\u3057\u305f\u3002Th1\u3084Th2\u7d30\u80de\u306f\u8a66\u9a13\u7ba1\u5185\u3067\u5206\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3057\u3001\u5236\u5fa1\u6027T\u7d30\u80de(Treg)\u306f\u78c1\u6c17\u30d3\u30fc\u30ba\u3092\u5229\u7528\u3057\u3066\u96c6\u3081\u3066\u304f\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u7834\u9aa8\u7d30\u80de\u306e\u5206\u5316\u7cfb\u306b\u3053\u308c\u3089\u306eT\u7d30\u80de\u3092\u52a0\u3048\u308b\u3053\u3068\u306f\u3055\u307b\u3069\u96e3\u3057\u3044\u3053\u3068\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u305d\u3046\u3044\u3046\u308f\u3051\u3067\u3001\u3053\u308c\u304cTH\u7814\u306b\u53c2\u52a0\u3057\u305f\u6642\u306b\u771f\u3063\u5148\u306b\u53d6\u308a\u7d44\u3093\u3060\u7814\u7a76\u306e\u4e00\u3064\u3067\u3059\u3002<br \/>\n\u7d50\u679c\u306f\u304b\u306a\u308a\u306f\u3063\u304d\u308a\u3057\u3066\u3044\u307e\u3057\u305f\u3002<br \/>\n<\/span><span style=\"font-size: 12pt; color: #000080;\">\u30fbTh1, Th2\u7d30\u80de\u306f\u7834\u9aa8\u7d30\u80de\u5206\u5316\u3092\u5f37\u304f\u6291\u5236\u3057\u307e\u3057\u305f\u3002<br \/>\n<\/span><span style=\"font-size: 12pt; color: #000080;\">\u30fbTreg\u7d30\u80de\u306f\u7834\u9aa8\u7d30\u80de\u5206\u5316\u306b\u307b\u3068\u3093\u3069\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><strong><span style=\"font-size: 12pt;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-28-%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b64%e3%82%82%e3%81%86%ef%bc%91%e3%81%a4%e3%81%ae\"><span style=\"font-size: 11pt; color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (28) <\/span><\/a><strong><em><span style=\"color: #0000ff;\"><span style=\"font-size: 11pt;\">\u2190 Prev\u3000\u3000\u3000\u3000\u3000<\/span><\/span><\/em><\/strong><span style=\"font-size: 11pt;\"><span style=\"color: #0000ff;\"><em><strong>Next\u00a0\u2192<\/strong><\/em><\/span><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-30%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b66%e3%80%80%e3%83%91%e3%83%a9%e3%83%89\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (30)<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1(RA)\u304cTh1\u5bc4\u308a\u306e\u75be\u60a3\u3067\u3042\u308b\u3068\u3044\u3046\u306e\u306f\u3001RA\u754c\u306e\u5927\u5fa1\u6240\u3067\u3042\u308bSmolen\u5148\u751f\u304c\u63d0\u5531\u3057\u305f\u304b\u3089\u5e83\u304f\u4fe1\u3058\u3089\u308c\u3066\u3044\u305f\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u60f3\u50cf\u3057\u3066\u3044\u307e\u3059(Smolen et al., Scand J Rheumatol. &#8230;","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1283","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1283","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1283"}],"version-history":[{"count":0,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1283\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1283"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1283"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1283"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}