{"id":1293,"date":"2020-12-01T10:11:13","date_gmt":"2020-12-01T01:11:13","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1293"},"modified":"2020-12-01T10:11:13","modified_gmt":"2020-12-01T01:11:13","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-30%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b66%e3%80%80%e3%83%91%e3%83%a9%e3%83%89","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-30%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b66%e3%80%80%e3%83%91%e3%83%a9%e3%83%89\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (30)\u3000\u7834\u9aa8\u7d30\u80de\u7814\u7a76(6)\u3000\u30d1\u30e9\u30c9\u30af\u30b9\u89e3\u6d88\u306e\u9375"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">Th1, Th2, Treg\u3044\u305a\u308c\u3082\u7834\u9aa8\u7d30\u80de\u5206\u5316\u3092\u4fc3\u9032\u3057\u306a\u3044\u3068\u3044\u3046\u306e\u306f\u3001\u307e\u3042\u305d\u308c\u307b\u3069\u9a5a\u304f\u3079\u304d\u3053\u3068\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u7834\u9aa8\u7d30\u80de\u306e\u5206\u5316\u7cfb\u306f\u5e83\u304f\u5229\u7528\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u305d\u3053\u306b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u6dfb\u52a0\u3059\u308b\u306e\u306f\u5bb9\u6613\u3067\u3059\u3002\u591a\u304f\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u7834\u9aa8\u7d30\u80de\u5206\u5316\u3092\u963b\u5bb3\u3059\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u96c6\u7a4d\u3057\u3064\u3064\u3042\u308a\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3000\u3057\u304b\u3057\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1(RA)\u304cT\u7d30\u80de\u6a5f\u80fd\u306e\u963b\u5bb3\u85ac\u3067\u6539\u5584\u3059\u308b\u75be\u60a3\u3067\u3042\u308a\u3001\u304b\u3064\u9aa8\u7834\u58ca\u304c\u554f\u984c\u306b\u306a\u308b\u75be\u60a3\u3067\u3042\u308b\u3001\u3068\u3044\u30462\u3064\u306e\u4e8b\u5b9f\u306f\u3069\u306e\u3088\u3046\u306b\u3059\u308c\u3070\u6574\u5408\u6027\u304c\u53d6\u308c\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u30001\u3064\u306e\u4eee\u8aac\u3068\u3057\u3066\u3001Th1, Th2, Treg\u306e\u3044\u305a\u308c\u3067\u3082\u7121\u3044\u3088\u3046\u306aT\u7d30\u80de\u304c\u5b58\u5728\u3057\u3066\u3001\u305d\u308c\u304c\u7834\u9aa8\u7d30\u80de\u5206\u5316\u3092\u4fc3\u9032\u3059\u308b\u3001\u3068\u8003\u3048\u308c\u3070\u77db\u76fe\u306f\u8d77\u304d\u306a\u3044\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u305d\u308c\u306f30\u5e74\u8fd1\u304f\u514d\u75ab\u5b66\u306e\u4e16\u754c\u306b\u541b\u81e8\u3057\u3066\u304d\u305fTh1\/Th2\u30d1\u30e9\u30c0\u30a4\u30e0\u306b\u771f\u3063\u5411\u304b\u3089\u9006\u3089\u3046\u3088\u3046\u306a\u8003\u3048\u65b9\u3067\u3059\uff08<a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-2%e3%80%80th1-th2%e3%83%91%e3%83%a9%e3%83%80%e3%82%a4%e3%83%a0\">\u3053\u3068\u306f\u3058\u3081(2)<\/a>\u53c2\u7167\uff09\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3000\u3057\u304b\u3057\u3001\u305d\u3046\u8003\u3048\u306a\u3051\u308c\u3070\u8a71\u304c\u9032\u307f\u307e\u305b\u3093\u3002\u305d\u3057\u3066\u3001\u591a\u304f\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u7834\u9aa8\u7d30\u80de\u5206\u5316\u3092\u963b\u5bb3\u3059\u308b\u4e2d\u3067\u30011\u3064\u4f8b\u5916\u7684\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u308c\u304cIL-17\u3067\u3059\u3002\u5f53\u6642\u5973\u5b50\u533b\u5927\u306b\u304a\u3089\u308c\u305f\u5c0f\u7af9\u5148\u751f\u3089\u304c\u3001RA\u60a3\u8005\u306e\u95a2\u7bc0\u6ed1\u6db2\u306b\u5b58\u5728\u3059\u308bIL-17\u304c\u7834\u9aa8\u7d30\u80de\u5206\u5316\u3092\u4fc3\u9032\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u30921999\u5e74\u306b\u5831\u544a\u3057\u3066\u3044\u305f\u306e\u3067\u3059(Kotake et al., J Clin Invest.)\u3002\u3053\u308c\u306b\u6ce8\u76ee\u3057\u306a\u3044\u624b\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u305d\u3057\u3066\u95a2\u9023\u8ad6\u6587\u3092\u63a2\u3057\u3066\u3044\u308b\u6642\u306b\u3001\u9a5a\u304f\u3088\u3046\u306a\u8ad6\u6587\u304c\u898b\u3064\u304b\u308a\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 Aggarwal et al., J Biol Chem. 2003\u304c\u305d\u308c9\u3067\u3059\u3002\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3IL-23\u304c\u7279\u5b9a\u306eT\u7d30\u80de\u306b\u4f5c\u7528\u3057\u3066\u3001IL-17\u7523\u751f\u3092\u8a98\u5c0e\u3059\u308b\u3068\u3044\u3046\u3082\u306e\u3067\u3057\u305f\u3002Th1\u5206\u5316\u306b\u5fc5\u9808\u306eIL-12\u306f\u3080\u3057\u308dIL-17\u7523\u751f\u3092\u6291\u5236\u3059\u308b\u3068\u306e\u3053\u3068\u3067\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3000\u306a\u305c\u9a5a\u3044\u305f\u306e\u304b\u3001\u305d\u308c\u306fIL-23\u3092\u767a\u898b\u3057\u305f2000\u5e74\u306e\u8ad6\u6587\u304c\u3001\u79c1\u304c\u5927\u5b66\u9662\u751f\u306e\u6642\u306b\u30b8\u30e3\u30fc\u30ca\u30eb\u30bb\u30df\u30ca\u30fc\u3067\u7d39\u4ecb\u3057\u305f\uff08\u305d\u3057\u3066\u6012\u3089\u308c\u305f\uff09\u8ad6\u6587\u305d\u306e\u3082\u306e\u3060\u3063\u305f\u304b\u3089\u3067\u3059\uff08<a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-14%e3%80%80%e3%82%b8%e3%83%a3%e3%83%bc%e3%83%8a%e3%83%ab%e3%82%bb%e3%83%9f%e3%83%8a%e3%83%bc\">\u3053\u3068\u306f\u3058\u3081(14)<\/a>\uff09\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">IL-12\u306b\u3088\u304f\u4f3c\u305f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3001\u3067\u3082\u5c11\u3057\u5f79\u5272\u304c\u9055\u3044\u305d\u3046\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3001\u305d\u308c\u304cIFN-\u03b3\u3067\u306f\u306a\u304f\u3001IL-17\u306e\u8a98\u5c0e\u306b\u91cd\u8981\u30fb\u30fb\u30fb\u79c1\u306f\u904b\u547d\u8ad6\u8005\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u305d\u306e\u6642\u3061\u3087\u3063\u3068\u904b\u547d\u7684\u306a\u3082\u306e\u3092\u611f\u3058\u305f\u306e\u306f\u4e8b\u5b9f\u3067\u3059\u3002IL-12\u304cTh1\u7d30\u80de\u3092\u5206\u5316\u3055\u305b\u3066IFN-\u03b3\u3092\u7523\u751f\u3055\u305b\u308b\u3088\u3046\u306b\u306a\u308b\u306e\u3060\u3063\u305f\u3089\u3001IL-23\u304c\u300c\u65b0\u3057\u3044Th\u30b5\u30d6\u30bb\u30c3\u30c8\u300d\u3092\u5206\u5316\u3055\u305b\u3066IL-17\u3092\u7523\u751f\u3055\u305b\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u30fb\u30fb\u30fb\uff1f\u3000\u3000\u3053\u308c\u306f\u8a66\u3057\u3066\u307f\u308b\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><strong><span style=\"font-size: 12pt;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-29%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b65%e3%80%80%e3%80%80%e7%a0%b4%e9%aa%a8\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (29)<\/span><\/a> <strong><em><span style=\"color: #0000ff;\"><strong>\u2190 Prev\u3000\u3000\u3000\u3000\u3000<\/strong><\/span><span style=\"color: #0000ff;\">Next \u2192<\/span><\/em><\/strong><span style=\"color: #000080;\">\u00a0<a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-31%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b67%e3%80%80-thoc%e7%99%ba%e8%a6%8b%ef%bc%81\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (31)<\/a><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"Th1, Th2, Treg\u3044\u305a\u308c\u3082\u7834\u9aa8\u7d30\u80de\u5206\u5316\u3092\u4fc3\u9032\u3057\u306a\u3044\u3068\u3044\u3046\u306e\u306f\u3001\u307e\u3042\u305d\u308c\u307b\u3069\u9a5a\u304f\u3079\u304d\u3053\u3068\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u7834\u9aa8\u7d30\u80de\u306e\u5206\u5316\u7cfb\u306f\u5e83\u304f\u5229\u7528\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u305d\u3053\u306b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u6dfb\u52a0\u3059\u308b\u306e\u306f\u5bb9\u6613\u3067\u3059\u3002\u591a\u304f\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3 &#8230;","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1293","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1293","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1293"}],"version-history":[{"count":0,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1293\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1293"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1293"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}