{"id":1311,"date":"2020-12-14T17:06:54","date_gmt":"2020-12-14T08:06:54","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1311"},"modified":"2021-03-25T17:29:57","modified_gmt":"2021-03-25T08:29:57","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-32%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b68%e3%80%80th17%e7%b4%b0%e8%83%9e","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-32%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b68%e3%80%80th17%e7%b4%b0%e8%83%9e\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (32)\u3000\u7834\u9aa8\u7d30\u80de\u7814\u7a76(8)\u3000Th17\u7d30\u80de\u73fe\u308b\u30fb\u305d\u3057\u3066\u6025\u5c55\u958b"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">2005\u5e74\u306bNature Immunology\u8a8c\u306b\u9023\u5831\u3067\u65b0\u3057\u3044Th\u30b5\u30d6\u30bb\u30c3\u30c8\u3068\u3057\u3066\u3001IL-17\u3092\u7523\u751f\u3059\u308bTh\u7d30\u80de\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u7d30\u80de\u306fTh17\u7d30\u80de\u3068\u540d\u4ed8\u3051\u3089\u308c\u3001\u5206\u5316\u306e\u65b9\u6cd5\u306f\u79c1\u305f\u3061\u304c\u7528\u3044\u305f\u65b9\u6cd5\u3068\u307b\u3068\u3093\u3069\u540c\u3058\u3067\u3057\u305f\u3002\u5148\u3092\u8d8a\u3055\u308c\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002<br \/>\n<\/span><span style=\"font-size: 12pt; color: #000080;\">\u3000\u3053\u308c\u3089\u306e\u8ad6\u6587\u81ea\u4f53\u306b\u306f\u9a5a\u304d\u306f\u7121\u304f\u3001\u3084\u306f\u308a\u4f3c\u305f\u3088\u3046\u306a\u3053\u3068\u3092\u8003\u3048\u308b\u4eba\u306f\u3044\u308b\u3093\u3060\u306a\u3042\u3068\u3044\u3046\u611f\u6168\u306e\u3088\u3046\u306a\u3082\u306e\u3092\u611f\u3058\u305f\u3053\u3068\u3092\u899a\u3048\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u3068\u3001\u5206\u5316\u306e\u3055\u305b\u65b9\u304c\u672c\u5f53\u306b\u305d\u3063\u304f\u308a\u3067\u3042\u308b\u3053\u3068\u306b\u306f\u9a5a\u304d\u307e\u3057\u305f\u3002<br \/>\n<\/span><span style=\"font-size: 12pt; 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color: #000080;\">\u3000TGF-\u03b2\u306f\u5236\u5fa1\u6027T\u7d30\u80de(Treg)\u3092\u8a66\u9a13\u7ba1\u5185\u3067\u5206\u5316\u3055\u305b\u308b\u3068\u304d\u306b\u6dfb\u52a0\u3057\u307e\u3059\u3002\u5742\u53e3\u5148\u751f\u304c\u898b\u3064\u3051\u3089\u308c\u305fTreg\u306f\u80f8\u817a\u306b\u304a\u3044\u3066\u3059\u3067\u306bTreg\u306b\u904b\u547d\u3065\u3051\u3089\u308c\u3066\u3044\u305f\u7d30\u80de\u3067\u3059\u304c\u3001\u305d\u3046\u3067\u306a\u3044Th\u7d30\u80de\u3082\u3001\u8a66\u9a13\u7ba1\u5185\u3067TGF-\u03b2\u3092\u52a0\u3048\u3066\u5206\u5316\u3055\u305b\u308b\u3068Treg\u7d30\u80de\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3088\u3046\u306b\u306a\u308a\u3001inducible Treg (iTreg)\u306a\u3069\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3064\u307e\u308aIL-6\u306e\u6709\u308a\u7121\u3057\u3067\u708e\u75c7\u6027\u306eTh17\u7d30\u80de\u306b\u306a\u3063\u305f\u308a\u3001\u708e\u75c7\u3092\u93ae\u9759\u3055\u305b\u308bTreg\u7d30\u80de\u306b\u306a\u3063\u305f\u308a\u3059\u308b\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3000\u3058\u3083\u3042IL-23\u306e\u7acb\u5834\u306f\u3069\u3046\u306a\u3093\u3060\u3001\u3068\u3044\u3046\u70b9\u306b\u3064\u3044\u3066\u306f\u3001Th17\u7d30\u80de\u306e\u5206\u5316\u3068\u3044\u3046\u3088\u308a\u3001Th17\u7d30\u80de\u306e\u5897\u6b96\u3084\u6d3b\u6027\u5316\u306b\u91cd\u8981\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u3044\u3046\u4f4d\u7f6e\u3065\u3051\u306b\u306a\u3063\u3066\u3044\u304d\u307e\u3057\u305f\u3002<br \/>\n<\/span><span style=\"font-size: 12pt; color: #000080;\">\u3000\u3068\u3044\u3046\u306e\u306f\u3001\u80f8\u817a\u304b\u3089\u51fa\u305f\u3070\u304b\u308a\u3067\u6297\u539f\u306b\u51fa\u4f1a\u3063\u3066\u3044\u306a\u3044\u3088\u3046\u306a\u300c\u30ca\u30a4\u30fc\u30d6Th\u7d30\u80de\u300d\u306fIL-23\u306e\u53d7\u5bb9\u4f53\u3092\u6301\u3063\u3066\u3044\u306a\u3044\u3088\u3046\u306a\u306e\u3067\u3059\u3002\u5206\u5316\u56e0\u5b50\u3060\u3068\u601d\u3063\u3066\u3044\u305f\u79c1\u306f\u9593\u9055\u3063\u3066\u3044\u305f\u3053\u3068\u306b\u306a\u308a\u307e\u3059\uff08\u305d\u3057\u3066\u305d\u308c\u306f2005\u5e74\u306eNature Immunology\u8a8c\u306b\u51fa\u3057\u305f\u4eba\u305f\u3061\u3082\u540c\u69d8\u3067\u3059\uff09\u3002<br \/>\n<\/span><span style=\"font-size: 12pt; color: #000080;\">\u79c1\u500b\u4eba\u3068\u3057\u3066\u306f\u3001IL-12\u3068IL-23\u3092\u3042\u304f\u307e\u3067\u4e26\u5217\u306e\u95a2\u4fc2(IL-12\u2192Th1, IL-23\u2192Th17)\u3068\u6349\u3048\u3066\u3044\u305f\u3053\u3068\u304c\u539f\u56e0\u3060\u3063\u305f\u3068\u601d\u3044\u307e\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 12pt;\"><strong><span style=\"color: #808080;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-31%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b67%e3%80%80-thoc%e7%99%ba%e8%a6%8b%ef%bc%81\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (31)<\/a>\u00a0\u00a0<strong><em><span style=\"color: #0000ff;\">\u2190 Prev\u3000\u3000\u3000\u3000\u3000Next \u2192<\/span><\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-33%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e7%a0%94%e7%a9%b69%e3%80%80%e5%b9%bb%e3%81%aetho\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (33)<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"2005\u5e74\u306bNature Immunology\u8a8c\u306b\u9023\u5831\u3067\u65b0\u3057\u3044Th\u30b5\u30d6\u30bb\u30c3\u30c8\u3068\u3057\u3066\u3001IL-17\u3092\u7523\u751f\u3059\u308bTh\u7d30\u80de\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u7d30\u80de\u306fTh17\u7d30\u80de\u3068\u540d\u4ed8\u3051\u3089\u308c\u3001\u5206\u5316\u306e\u65b9\u6cd5\u306f\u79c1\u305f\u3061\u304c\u7528\u3044\u305f\u65b9\u6cd5\u3068\u307b\u3068\u3093\u3069\u540c\u3058\u3067\u3057\u305f\u3002\u5148 &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1311","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1311"}],"version-history":[{"count":1,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1311\/revisions"}],"predecessor-version":[{"id":1536,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1311\/revisions\/1536"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}