{"id":1435,"date":"2021-02-09T17:28:42","date_gmt":"2021-02-09T08:28:42","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1435"},"modified":"2021-03-25T17:29:56","modified_gmt":"2021-03-25T08:29:56","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-37%e3%80%80th17%e5%88%86%e5%8c%96%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e8%bb%a2%e5%86%99%e5%9b%a0%e5%ad%901","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-37%e3%80%80th17%e5%88%86%e5%8c%96%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e8%bb%a2%e5%86%99%e5%9b%a0%e5%ad%901\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (37)\u3000Th17\u5206\u5316\u306b\u304a\u3051\u308b\u8ee2\u5199\u56e0\u5b50(1)"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\u524d\u306b\u3082\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u7834\u9aa8\u7d30\u80de\u306e\u5206\u5316\u306e\u904e\u7a0b\u3067\u8ee2\u5199\u56e0\u5b50Nfatc1\u304c\u8457\u5897\u3059\u308b\u305f\u3081(Dev Cell 2002, Vol. 3, p889-)\u3001Nfatc1\u306f\u7834\u9aa8\u7d30\u80de\u5206\u5316\u306e\u300c\u30de\u30b9\u30bf\u30fc\u30ec\u30ae\u30e5\u30ec\u30fc\u30bf\u30fc\u300d\u3068\u8003\u3048\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002Th1, Th2\u7d30\u80de\u306b\u3064\u3044\u3066\u3082\u3001\u524d\u8005\u306a\u3089T-bet, \u5f8c\u8005\u3067\u306fGATA-3, c-Maf\u306e\u3088\u3046\u306a\u8ee2\u5199\u56e0\u5b50\u304c\u91cd\u8981\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u30011\u3064\u306e\u8ee2\u5199\u56e0\u5b50\u304c\u7d30\u80de\u306e\u5206\u5316\u3092\u5168\u3066\u898f\u5b9a\u3059\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u306e\u3067\u3001\u6700\u8fd1\u306f\u300c\u30de\u30b9\u30bf\u30fc\u30ec\u30ae\u30e5\u30ec\u30fc\u30bf\u30fc\u300d\u3068\u3044\u3046\u8a00\u8449\u306f\u3042\u307e\u308a\u4f7f\u308f\u308c\u306a\u304f\u306a\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">Th17\u7d30\u80de\u306b\u304a\u3044\u3066\u3082ROR\u03b3t\u3068\u3044\u3046\u8ee2\u5199\u56e0\u5b50\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u3059\u3067\u306b\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f(Cell 2006, Vol. 126, p1121-)\u3002\u3057\u304b\u3057\u4ed6\u306b\u3082\u3042\u308b\u3060\u308d\u3046\u3001\u3068\u3044\u3046\u5b89\u6613\u306a\u8003\u3048\u3067\u5b9f\u9a13\u3092\u59cb\u3081\u307e\u3057\u305f\u3002\u5358\u306b\u300c\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u300d\u304c\u3057\u305f\u304b\u3063\u305f\u3060\u3051\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">Th1, Th2, Th17\u7d30\u80de\u306e\u305d\u308c\u305e\u308c\u306e\u5206\u5316\u6761\u4ef6\u3067\u30de\u30a6\u30b9\u306e\u30ca\u30a4\u30fc\u30d6Th\u7d30\u80de\u3092\u57f9\u990a\u3057\u3001\u56de\u53ce\u3057\u305f\u7d30\u80de\u304b\u3089RNA\u3092\u56de\u53ce\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3053\u3053\u3067\u554f\u984c\u767a\u751f\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3053\u306e\u6642\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u306b\u7528\u3044\u305f\u306e\u306fAffymetrix\u793e\u306eGeneChip\u3068\u3044\u3046\u88fd\u54c1\u3067\u3057\u305f\u304c\u3001Dev Cell 2002\u306e\u9803\u3088\u308a\u306f\u53d7\u8a17\u89e3\u6790\u306e\u8cbb\u7528\u3082\u5927\u5206\u3053\u306a\u308c\u3066\u304d\u3066\u3044\u305f\u305f\u3081\u3001\u5916\u6ce8\u306b\u51fa\u3059\u65b9\u91dd\u3067\u3057\u305f\u3002\u3068\u3053\u308d\u304c\u3001\u305d\u306e\u4f1a\u793e\u304c\u89aa\u5207\u306a\u3053\u3068\u306bRNA\u306e\u7d14\u5ea6\u3092\u6e2c\u5b9a\u3057\u3066\u304f\u308c\u3066\u3001\u300c\u7d14\u5ea6\u304c\u8db3\u308a\u306a\u3044\u306e\u3067\u89e3\u6790\u3057\u306a\u3044\u65b9\u304c\u3088\u3044\u306e\u3067\u306f\u306a\u3044\u304b\u300d\u3068\u30a2\u30c9\u30d0\u30a4\u30b9\u3092\u304f\u308c\u305f\u306e\u3067\u3059\u3002\u78ba\u304b\u306b\u3001\u5927\u91d1\u3092\u6255\u3063\u3066\u5f97\u3089\u308c\u305f\u30c7\u30fc\u30bf\u304c\u4fe1\u7528\u3067\u304d\u306a\u3051\u308c\u3070\u3069\u3046\u3057\u3088\u3046\u3082\u3042\u308a\u307e\u305b\u3093\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u5f53\u6642\u79c1\u304c\u4f7f\u3063\u3066\u3044\u305f\u8a66\u85ac\u306f\u300c\u30bb\u30d1\u30be\u30fc\u30eb\u300d\u3068\u3044\u3046\u8a66\u85ac\u3068\u300cRNeasy\u300d\u3068\u3044\u3046\u30ad\u30c3\u30c8\u306e2\u7a2e\u985e\u3067\u3059\u3002\u5f8c\u8005\u306f\u30ab\u30e9\u30e0\u3092\u4f7f\u3063\u305f\u65b9\u6cd5\u3067\u3001\u304b\u306a\u308a\u5b9f\u9a13\u6642\u9593\u3092\u77ed\u7e2e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3068\u3053\u308d\u304c\u3069\u3061\u3089\u306e\u88fd\u54c1\u3092\u4f7f\u3063\u3066\u3082\u3001\u7d14\u5ea6\u304c\u30d1\u30b9\u3057\u307e\u305b\u3093\u3002\u672c\u6765\u306a\u3089\u3070\u3001\u5927\u5b66\u9662\u751f\u306e\u6642\u306b\u3084\u3063\u3066\u3044\u305f\u300c\u8d85\u9060\u5fc3\u300d\u3068\u3044\u3046\u6280\u8853\u3092\u4f7f\u3063\u3066RNA\u3092\u56de\u53ce\u3059\u308b\u3068\u7d14\u5ea6\u304c\u4e0a\u3052\u3089\u308c\u308b\u3088\u3046\u306b\u601d\u3044\u307e\u3059\u304c\u3001\u533b\u5c40\u306b\u306f\u8d85\u9060\u5fc3\u6a5f\u306f\u3042\u308a\u307e\u305b\u3093\u3057\u3001\u3057\u3070\u3089\u304f\u3084\u3063\u3066\u3044\u306a\u304b\u3063\u305f\u306e\u3067\u81ea\u4fe1\u304c\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\uff08\u30d0\u30e9\u30f3\u30b9\u3092\u3061\u3083\u3093\u3068\u53d6\u3089\u306a\u3044\u3068\u30ed\u30fc\u30bf\u30fc\u304c\u9060\u5fc3\u6a5f\u3092\u7a81\u304d\u7834\u3063\u3066\u5439\u3063\u98db\u3076\u3001\u3068\u3044\u3046\u90fd\u5e02\u4f1d\u8aac\uff1f\u304c\u3042\u308a\u307e\u3059\u3002\u5b89\u6613\u306b\u4f7f\u3048\u308b\u6a5f\u5668\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\uff09<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3053\u3053\u3067\u30011\u3064\u4e0a\u624b\u304f\u3044\u304f\u304b\u3082\u3057\u308c\u306a\u3044\u65b9\u6cd5\u3092\u8003\u3048\u307e\u3057\u305f\u3002\u300c\u30bb\u30d1\u30be\u30fc\u30eb\u300d\u3092\u4f7f\u3063\u3066\u3082\u300cRNeasy\u300d\u3092\u4f7f\u3063\u3066\u3082\u30c0\u30e1\u306a\u3089\u3001\u4e21\u65b9\u3092\u4f7f\u3063\u3066\u307f\u308c\u3070\u3088\u3044\u306e\u3067\u306f\u306a\u3044\u304b\uff1f\u3064\u307e\u308a\u30bb\u30d1\u30be\u30fc\u30eb\u3067\u7c97\u7cbe\u88fd\u3057\u305f\u30b5\u30f3\u30d7\u30eb\u3092\u3001\u30ab\u30e9\u30e0\u30ef\u30fc\u30af\u3067\u7cbe\u88fd\u3059\u308c\u3070\u3088\u3044\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u30a2\u30a4\u30c7\u30a2\u3067\u3059\u3002\u3053\u308c\u306f\u72d9\u3044\u901a\u308a\u4e0a\u624b\u304f\u3044\u304d\u307e\u3057\u305f\u3002\u3088\u3046\u3084\u304f\u53d7\u8a17\u5148\u306e\u4f1a\u793e\u306eOK\u304c\u51fa\u305f\u306e\u3067\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"color: #808080;\"><strong><span style=\"font-size: 12pt;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-36%e3%80%80%e3%81%9d%e3%81%97%e3%81%a6%e5%a4%a7%e5%ad%a6%e7%97%85%e9%99%a2%e3%81%b82\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (36)\u00a0<\/span><\/a>\u00a0<\/span><span style=\"color: #0000ff;\"><strong><em><span style=\"font-size: 11pt;\">\u2190 Prev\u3000\u3000\u3000\u3000\u3000Next\u00a0\u2192<\/span><\/em><\/strong><span style=\"font-size: 11pt;\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-38%e3%80%80th17%e5%88%86%e5%8c%96%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e8%bb%a2%e5%86%99%e5%9b%a0%e5%ad%902\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (38)<\/a><\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u524d\u306b\u3082\u66f8\u3044\u305f\u3088\u3046\u306b\u3001\u7834\u9aa8\u7d30\u80de\u306e\u5206\u5316\u306e\u904e\u7a0b\u3067\u8ee2\u5199\u56e0\u5b50Nfatc1\u304c\u8457\u5897\u3059\u308b\u305f\u3081(Dev Cell 2002, Vol. 3, p889-)\u3001Nfatc1\u306f\u7834\u9aa8\u7d30\u80de\u5206\u5316\u306e\u300c\u30de\u30b9\u30bf\u30fc\u30ec\u30ae\u30e5\u30ec\u30fc\u30bf\u30fc\u300d\u3068\u8003\u3048\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1435","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1435","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1435"}],"version-history":[{"count":1,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1435\/revisions"}],"predecessor-version":[{"id":1525,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1435\/revisions\/1525"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1435"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1435"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1435"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}