{"id":1559,"date":"2021-03-25T13:09:06","date_gmt":"2021-03-25T04:09:06","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1559"},"modified":"2021-04-20T17:11:50","modified_gmt":"2021-04-20T08:11:50","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-42%e3%80%80th17%e5%88%86%e5%8c%96%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e8%bb%a2%e5%86%99%e5%9b%a0%e5%ad%906","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-42%e3%80%80th17%e5%88%86%e5%8c%96%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e8%bb%a2%e5%86%99%e5%9b%a0%e5%ad%906\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (42)\u3000Th17\u5206\u5316\u306b\u304a\u3051\u308b\u8ee2\u5199\u56e0\u5b50(6)\u3000\u30af\u30ea\u30b9\u30de\u30b9\u30d7\u30ec\u30bc\u30f3\u30c8"},"content":{"rendered":"<p><span style=\"color: #000080;\">\u56e0\u5b50\u5206\u6790\u3067\u81ea\u5206\u306b\u3068\u3063\u3066\u306f\u5c11\u3057\u5206\u304b\u308a\u3084\u3059\u3044\u89e3\u91c8\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u3082\u3061\u308d\u3093\u3053\u308c\u306f\u4e07\u80fd\u306e\u65b9\u6cd5\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7279\u306b\u6c17\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u306f\u3001\u4eca\u56de\u306e\u30c7\u30fc\u30bf\u306f\u3001\u4f8b\u3048\u3070Th0\u2192Th1day1\u2192Th1day3\u306e\u3088\u3046\u306b\u52d5\u3044\u3066\u3044\u304f\u3068\u601d\u308f\u308c\u308b\u306e\u3067\u3059\u304c\u3001\u3053\u306e\u6642\u9593\u7684\u306a\u95a2\u4fc2\u304c\u89e3\u6790\u306b\u53cd\u6620\u3055\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u3067\u3059\u3002\u3082\u3057Th1day1\u3068Th1day3\u306e\u30c7\u30fc\u30bf(\u304a\u3088\u3073Th2\u3084Th17\u3082\u305d\u3046\u3067\u3059\u304c)\u304c\u305d\u3063\u304f\u308a\u3072\u3063\u304f\u308a\u8fd4\u3063\u3066\u3044\u3066\u3082\u3001\u56e0\u5b50\u5206\u6790\u306e\u7d50\u679c\u306f\u5909\u308f\u308a\u307e\u305b\u3093\u3002\u3064\u307e\u308a\u6642\u9593\u7d4c\u904e\u3068\u3044\u3046\u60c5\u5831\u3092\u5206\u6790\u306b\u53d6\u308a\u5165\u308c\u3089\u308c\u3066\u3044\u306a\u3044\u306e\u3067\u3059\u3002\u3057\u304b\u3057\u3082\u3061\u308d\u3093\u6642\u7cfb\u5217\u3068\u3044\u3046\u306e\u306f\u751f\u7269\u306b\u3068\u3063\u3066\u5927\u4e8b\u306a\u3053\u3068\u3067\u3059\u3002\u300c\u8d64\u3061\u3083\u3093\u304c\u5b50\u4f9b\u306b\u306a\u3063\u3066\u5927\u4eba\u306b\u306a\u308b\u300d\u306e\u306f\u81ea\u7136\u306a\u3053\u3068\u3067\u3059\u304c\u3001\u300c\u8d64\u3061\u3083\u3093\u304c\u5b50\u4f9b\u306e\u6bb5\u968e\u3092\u98db\u3070\u3057\u3066\u5927\u4eba\u306b\u306a\u308a\u3001\u305d\u306e\u5f8c\u306b\u5b50\u4f9b\u306b\u306a\u308b\u300d\u306a\u3093\u3066\u3053\u3068\u306f\u3042\u308a\u3048\u307e\u305b\u3093\u3002\uff08\u5b50\u4f9b\u3063\u307d\u3044\u5927\u4eba\u3082\u3044\u307e\u3059\u304c\u3001\u305d\u308c\u306f\u5225\u306e\u8a71\u3067\u3059\u3002\uff09<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3000\u6642\u7cfb\u5217\u30c7\u30fc\u30bf\u3092\u3069\u3046\u3084\u3063\u3066\u8a55\u4fa1\u3059\u308b\u306e\u304b\u3068\u3044\u3046\u306e\u306f\u3001\u304d\u3063\u3068\u4eca\u306f\u8272\u3005\u306a\u65b9\u6cd5\u8ad6\u304c\u3042\u308b\u306e\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u79c1\u304c\u8abf\u3079\u3089\u308c\u3066\u3044\u306a\u3044\u3060\u3051\u3067\u3057\u3087\u3046\u3002\u305f\u3060\u3057\u898b\u3064\u3051\u3089\u308c\u305f\u3068\u3057\u3066\u3082\u3059\u3050\u306b\u5229\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308b\u304b\u3069\u3046\u304b\u304c\u554f\u984c\u306a\u306e\u3067\u3059\u304c\u30fb\u30fb\u30fb\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3000\u3044\u305a\u308c\u306b\u3057\u308dTh17\u7d30\u80de\u306e\u5206\u5316\u306b\u8ee2\u5199\u56e0\u5b50c-Maf\u304c\u91cd\u8981\u306a\u50cd\u304d\u3092\u3059\u308b\u3068\u3044\u3046\u6d41\u308c\u3067\u89e3\u6790\u3092\u9032\u3081\u3066\u3044\u305f\u306e\u3067\u3059\u304c\u30012008\u5e74\u306e\u30af\u30ea\u30b9\u30de\u30b9\u9803\u3001\u533b\u5c40\u3067\u6587\u732e\u691c\u7d22\u3092\u3057\u3066\u3044\u3066\u885d\u6483\u7684\u306a\u8ad6\u6587\u3092\u898b\u3064\u3051\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Bauquet et al., Nat Immunol 2008 \u3067\u3059\u3002\u3053\u306e\u8ad6\u6587\u3067ICOS\u3068\u3044\u3046\u5206\u5b50\u304b\u3089\u5165\u308b\u30b7\u30b0\u30ca\u30eb\u304cTh17\u7d30\u80de\u3068\u3001\u6ffe\u80de\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\uff08Tfh\u7d30\u80de)\u306bc-Maf\u3068IL-21\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u3001\u3068\u3044\u3046\u30bf\u30a4\u30c8\u30eb\u3067\u3059\u3002\u307e\u305f\u5148\u3092\u8d8a\u3055\u308c\u305f\u30fb\u30fb\u30fb\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3000\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u7d9a\u3051\u3089\u308c\u308b\u304b\u3069\u3046\u304b\u3001\u4fc4\u7136\u602a\u3057\u304f\u306a\u308a\u307e\u3057\u305f\u3002\u3084\u306f\u308a\u7814\u7a76\u306f\u300c\u65b0\u3057\u3044\u3053\u3068\u300d\u3092\u4f55\u304b\u63d0\u5531\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u304c\u5927\u4e8b\u3067\u3059\u3002\u300c\u4ee5\u524d\u4ed6\u306e\u4eba\u304c\u8a00\u3063\u305f\u3053\u3068\u3068\u540c\u3058\u30c7\u30fc\u30bf\u304c\u51fa\u307e\u3057\u305f\u300d\u3068\u3044\u3046\u306e\u3067\u306f\u91cd\u8981\u6027\u304c\u683c\u6bb5\u306b\u843d\u3061\u307e\u3059\u3002\u4e0b\u624b\u3092\u3059\u308b\u3068\u3069\u306e\u96d1\u8a8c\u3082\u53d6\u3063\u3066\u304f\u308c\u306a\u3044\u8ad6\u6587\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u79c1\u306b\u3068\u3063\u3066\u306f\u3068\u3093\u3067\u3082\u306a\u3044\u30af\u30ea\u30b9\u30de\u30b9\u30fb\u30d7\u30ec\u30bc\u30f3\u30c8\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3000Tfh\u7d30\u80de\u3068\u3044\u3046\u306e\u306fTh\u7d30\u80de\u306e\u4e00\u7a2e\u3067\u3059\u304c\u3001\u30ea\u30f3\u30d1\u7bc0\u306a\u3069\u306e\u4e8c\u6b21\u30ea\u30f3\u30d1\u7d44\u7e54\u3067B\u7d30\u80de\u304c\u30e1\u30e2\u30ea\u30fcB\u7d30\u80de\u3084\u5f62\u8cea\u7d30\u80de\u306b\u5206\u5316\u3059\u308b\u969b\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306eB\u7d30\u80de\u304c\u96c6\u307e\u3063\u3066\u3044\u308b\u90e8\u5206\u304c\u30ea\u30f3\u30d1\u6ffe\u80de\u3068\u547c\u3070\u308c\u3001\u3053\u3053\u306bTfh\u3084\u3001\u6ffe\u80de\u6a39\u72b6\u7d30\u80de\u3068\u547c\u3070\u308c\u308b\u7d30\u80de\u3082\u5b58\u5728\u3057\u307e\u3059\u3002\u3067\u3059\u304b\u3089Tfh\u306fTh\u7d30\u80de\u306e\u300c\u5b58\u5728\u3059\u308b\u5834\u6240\u300d\u3067\u5b9a\u7fa9\u3065\u3051\u3089\u308c\u3066\u304a\u308a\u3001Th1\/2\/17\u7d30\u80de\u3068\u306f\u5143\u3005\u306e\u5b9a\u7fa9\u304c\u9055\u3044\u307e\u3059\u3002\u3068\u3044\u3046\u308f\u3051\u3067\u3001Th1\u30bf\u30a4\u30d7\u306eThf\u7d30\u80de\u3084Th2\u30bf\u30a4\u30d7\u306eTfh\u7d30\u80de\u306a\u3069\u3082\u8003\u3048\u3089\u308c\u3001\u305d\u308c\u305e\u308cTfh1, Tfh2, Tfh17\u306a\u3069\u3068\u540d\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002\uff08\u3061\u3087\u3063\u3068\u7d30\u304b\u304f\u5206\u3051\u3059\u304e\u3068\u3044\u3046\u6c17\u3082\u3057\u307e\u3059\u3002\uff09<\/span><\/p>\n<p style=\"text-align: right;\"><strong>\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/strong><\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-41%e3%80%80th17%e5%88%86%e5%8c%96%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e8%bb%a2%e5%86%99%e5%9b%a0%e5%ad%905\/\"><span style=\"color: #333399;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (41)<\/span><\/a><span style=\"color: #0000ff;\"><strong><em>\u2190 Prev\u3000\u3000\u3000\u3000\u3000Next\u00a0\u2192<\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-43%e3%80%80th17%e5%88%86%e5%8c%96%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e8%bb%a2%e5%86%99%e5%9b%a0%e5%ad%907\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (43)<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u56e0\u5b50\u5206\u6790\u3067\u81ea\u5206\u306b\u3068\u3063\u3066\u306f\u5c11\u3057\u5206\u304b\u308a\u3084\u3059\u3044\u89e3\u91c8\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u3082\u3061\u308d\u3093\u3053\u308c\u306f\u4e07\u80fd\u306e\u65b9\u6cd5\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7279\u306b\u6c17\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u306f\u3001\u4eca\u56de\u306e\u30c7\u30fc\u30bf\u306f\u3001\u4f8b\u3048\u3070Th0\u2192Th1day1\u2192Th1day3\u306e\u3088\u3046\u306b\u52d5\u3044\u3066\u3044\u304f\u3068\u601d &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1559","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1559","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1559"}],"version-history":[{"count":4,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1559\/revisions"}],"predecessor-version":[{"id":1583,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1559\/revisions\/1583"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1559"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1559"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1559"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}