{"id":1625,"date":"2021-05-14T17:01:40","date_gmt":"2021-05-14T08:01:40","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1625"},"modified":"2022-09-09T11:01:31","modified_gmt":"2022-09-09T02:01:31","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-44%e3%80%80th17%e5%88%86%e5%8c%96%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e8%bb%a2%e5%86%99%e5%9b%a0%e5%ad%908","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-44%e3%80%80th17%e5%88%86%e5%8c%96%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e8%bb%a2%e5%86%99%e5%9b%a0%e5%ad%908\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (44)\u3000Th17\u5206\u5316\u306b\u304a\u3051\u308b\u8ee2\u5199\u56e0\u5b50(8)\u3000 c-Maf\u306e\u591a\u5f69\u306a\u5f79\u5272"},"content":{"rendered":"<p><span style=\"color: #000080; font-size: 12pt;\">c-Maf\u2192IL-23\u53d7\u5bb9\u4f53\u3000\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u6790\u3057\u3066\u3001\u8ad6\u6587\u3092Journal of Biological Chemistry\u8a8c\u306b\u300c\u306d\u3058\u3053\u307f\u300d\u307e\u3057\u305f(Sato K et al., 2011)\u3002\u3053\u308c\u306f\u53e4\u3044\u6b74\u53f2\u3092\u6301\u3064\u7531\u7dd2\u6b63\u3057\u3044\u96d1\u8a8c\u3067\u3059\u3002\u304c\u3001\u6700\u8fd1\u6a29\u5a01\u304c\u843d\u3061\u3066\u3044\u3066\u3057\u3087\u307c\u3044\u8ad6\u6587\u3067\u3082\u901a\u3057\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u5642\u3082\u3042\u308a\u307e\u3059\u3002\u78ba\u304b\u306b\u305d\u3046\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u79c1\u306f\u304d\u3063\u3061\u308a\u30ea\u30b8\u30a7\u30af\u30c8\u3055\u308c\u305f\u3053\u3068\u3082\u3042\u308a\u307e\u3059\uff08\u81ea\u6162\u3059\u308b\u3088\u3046\u306a\u3053\u3068\u3067\u306f\u306a\u3044\uff09\u3002\u3053\u306e\u3068\u304d\u306e\u8ad6\u6587\u306b\u306f\u3001c-Maf\u3092\u5f37\u5236\u767a\u73fe\u3057\u305f\u30de\u30a6\u30b9\u306e\u672b\u68a2\u8840\u306eT\u7d30\u80de\u306f\u3001\u305d\u306e\u307b\u3068\u3093\u3069\u304c\u30e1\u30e2\u30ea\u30fc\u7d30\u80de\uff08\u30ca\u30a4\u30fc\u30d6\u7d30\u80de\u3067\u306f\u306a\u304f\uff09\u306e\u8868\u73fe\u578b\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3092\uff11\u3064\u306e\u8b0e\u3068\u3057\u3066\u8a18\u8ff0\u3057\u307e\u3057\u305f\u3002c-Maf\u306e\u50cd\u304d\u306b\u306f\u307e\u3060\u307e\u3060\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u3042\u308a\u305d\u3046\u3067\u3059\u3002\u3000\u3000<\/span><\/p>\n<p><span style=\"color: #000080; font-size: 12pt;\">Th17, Tfh\u7d30\u80de\u306f\u3069\u3061\u3089\u3082IL-21\u3092\u7523\u751f\u3057\u307e\u3059\u304c\u3001c-Maf\u304c\u76f4\u63a5IL-21\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306b\u4f5c\u7528\u3057\u3066IL-21\u7523\u751f\u3092\u5236\u5fa1\u3059\u308b\u3068\u3044\u3046\u5831\u544a\u3082\u51fa\u3066\u3044\u307e\u3059(Hiramatsu et al., J Leukoc Biol. 2010)\u3002\u307e\u305f\u3001\u8fd1\u5e74\u7279\u306b\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u767a\u75c7\u306b\u95a2\u4fc2\u3059\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u300c\u672b\u68a2\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de(peripheral helper T cell, Tph\u7d30\u80de\u2026\u305a\u3044\u3076\u3093\u5730\u5473\u306a\u540d\u524d\u3092\u3064\u3051\u305f\u3082\u306e\u3067\u3059\u3002Rao et al., Nature 2017)\u3082\u3084\u306f\u308ac-Maf\u3092\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7d30\u80de\u3082IL-21\u3092\u767a\u73fe\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u305d\u306e\u70b9\u3067Th17, Tfh\u3068\u5171\u901a\u3057\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u305d\u3046\u3044\u3046\u308f\u3051\u3067\u3001\u4eca\u3067\u3082c-Maf\u306f\u5927\u5909\u9b45\u529b\u7684\u306a\u8ee2\u5199\u56e0\u5b50\u3060\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000080; font-size: 12pt;\">\u3000\u3055\u3066\u3001\u57fc\u7389\u533b\u5927\u306b\u7570\u52d5\u3057\u305f\u6642\u306e\uff11\u3064\u306e\u8ab2\u984c\u306f\u3001\u300c\u5b9f\u969b\u306e\u75be\u60a3\u306b\u304a\u3051\u308bTh1\/Th2\/Th17\u5fdc\u7b54\u3092\u8abf\u3079\u308b\u300d\u3053\u3068\u3067\u3057\u305f\u3002\u4f55\u3057\u308d\u305d\u308c\u307e\u3067\u306eTh1, Th2\u3057\u304b\u5b58\u5728\u3057\u306a\u3044\u4e16\u754c\u3067\u306f\u3001\u708e\u75c7\u6027\u75be\u60a3\u306f\uff12\u7a2e\u985e\u306b\u3057\u304b\u5206\u985e\u3067\u304d\u307e\u305b\u3093\u3002\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306fTh1\u75be\u60a3\u3001\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\u306fTh2\u75be\u60a3\u3001\u3068\u3044\u3063\u305f\u5177\u5408\u3067\u3059\u3002\u307e\u3042\u3053\u3046\u3044\u3046\u4e8c\u5206\u6cd5\u3082\u306e\u3069\u304b\u3067\u826f\u3044\u3088\u3046\u306b\u601d\u3044\u307e\u3059\u3002\u304c\u3001\u6d41\u77f3\u306b\u5358\u7d14\u3059\u304e\u308b\u611f\u3058\u306f\u62ed\u3048\u307e\u305b\u3093\u3002\u4f55\u3088\u308a\u3001\u5b9f\u969b\u306b\u81ea\u5206\u306e\u624b\u3067\u5b9a\u91cf\u3057\u3066\u307f\u306a\u3044\u3068\u7d0d\u5f97\u3067\u304d\u307e\u305b\u3093\u3002<\/span><\/p>\n<p><span style=\"color: #000080; font-size: 12pt;\">\u3000\u3057\u304b\u3057\u3001\u3044\u3056Th1\/Th2\/Th17\u5fdc\u7b54\u3092\u5b9a\u91cf\u3057\u3066\u307f\u3088\u3046\u3068\u3059\u308b\u3068\u3001\u305d\u308c\u307b\u3069\u7c21\u5358\u3067\u306f\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u306b\u3059\u3050\u306b\u6c17\u3065\u304b\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 12pt;\"><strong>\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-43%e3%80%80th17%e5%88%86%e5%8c%96%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e8%bb%a2%e5%86%99%e5%9b%a0%e5%ad%907\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (43)<\/span><\/a><strong><em><span style=\"color: #0000ff;\">\u2190 Prev\u3000\u3000\u3000\u3000\u3000Next \u2192<\/span><\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-45%e3%80%80%e3%83%92%e3%83%88%e3%81%aeth1-2-17%e5%bf%9c%e7%ad%94-1-%e9%9b%a3%e3%81%97%e3%81%84%ef%bc%81\/\"><span style=\"color: #0000ff;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (45)<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"c-Maf\u2192IL-23\u53d7\u5bb9\u4f53\u3000\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u6790\u3057\u3066\u3001\u8ad6\u6587\u3092Journal of Biological Chemistry\u8a8c\u306b\u300c\u306d\u3058\u3053\u307f\u300d\u307e\u3057\u305f(Sato K et al., 2011)\u3002\u3053\u308c\u306f\u53e4\u3044\u6b74\u53f2\u3092\u6301\u3064\u7531\u7dd2\u6b63\u3057\u3044\u96d1 &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1625","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1625","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1625"}],"version-history":[{"count":6,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1625\/revisions"}],"predecessor-version":[{"id":2020,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1625\/revisions\/2020"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1625"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1625"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1625"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}