{"id":1720,"date":"2021-06-25T17:14:10","date_gmt":"2021-06-25T08:14:10","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1720"},"modified":"2022-09-09T11:02:25","modified_gmt":"2022-09-09T02:02:25","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-47%e3%80%80-%e3%83%92%e3%83%88%e3%81%aeth1-2-17%e5%bf%9c%e7%ad%94%e3%80%803-%e6%84%8f%e5%a4%96%e3%81%99","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-47%e3%80%80-%e3%83%92%e3%83%88%e3%81%aeth1-2-17%e5%bf%9c%e7%ad%94%e3%80%803-%e6%84%8f%e5%a4%96%e3%81%99\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (47)\u3000 \u30d2\u30c8\u306eTh1\/2\/17\u5fdc\u7b54(3)\u3000 \u610f\u5916\u3059\u304e\u308b\u7d50\u679c"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\u8a66\u9a13\u7ba1\u5185\u3067\u523a\u6fc0\u3057\u305f\u5358\u6838\u7403\u306e\u57f9\u990a\u4e0a\u6e05\u304b\u3089\u306f\u3001IFN-\u03b3(Th1\u5fdc\u7b54)\u3001IL-4(Th2\u5fdc\u7b54)\u3001IL-17\uff08Th17\u5fdc\u7b54\uff09\u3044\u305a\u308c\u3082\u5341\u5206\u306b\u6e2c\u5b9a\u3067\u304d\u307e\u3059\u3002\uff08\u307e\u3042\u4ee5\u524d\u3082\u66f8\u304d\u307e\u3057\u305f\u304c\u3001\u305f\u3068\u3048\u3070IFN-\u03b3\u306fCD8\u967d\u6027T\u7d30\u80de\u306e\u65b9\u304c\u3088\u308a\u591a\u304f\u51fa\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u306f\u3042\u308a\u307e\u3059\u3002\uff09<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3000\u3053\u306e\u65b9\u6cd5\u3092\u7528\u3044\u3066\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u306e\u751f\u7269\u88fd\u5264\u6295\u4e0e\u524d\u5f8c\u306e\u30b5\u30f3\u30d7\u30eb\u3092\u6bd4\u8f03\u3059\u308b\u3053\u3068\u3092\u8a08\u753b\u3057\u307e\u3057\u305f\u3002\u751f\u7269\u88fd\u5264\uff08\u3053\u306e\u6642\u306fTNF\u963b\u5bb3\u85ac\uff09\u3092\u6295\u4e0e\u3059\u308b\u3068\u307b\u3068\u3093\u3069\u306e\u75c7\u4f8b\u3067\u708e\u75c7\u306f\u4f4e\u4e0b\u3057\u3001DAS28\u306e\u3088\u3046\u306a\u75c5\u52e2\u3092\u628a\u63e1\u3059\u308b\u305f\u3081\u306ecomposite score\u3082\u4f4e\u4e0b\u3057\u307e\u3059\u3002\u3053\u306e\u72b6\u6cc1\u3067\u30b5\u30f3\u30d7\u30eb\u3092\u6bd4\u8f03\u3059\u308c\u3070\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u306b\u306f\u5dee\u304c\u51fa\u308b\u3060\u308d\u3046\u3068\u4e88\u60f3\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u304c\u5f53\u6642\u4e88\u60f3\u3057\u3066\u3044\u305f\u3088\u3046\u306b\u672c\u5f53\u306bTh17\u578b\u306e\u75be\u60a3\u3067\u3042\u308c\u3070\u3001\u6cbb\u7642\u304c\u594f\u529f\u3057\u305f\u5834\u5408\u306bIL-17\u7523\u751f\u304c\u4f4e\u4e0b\u3057\u3066\u304f\u308b\u3060\u308d\u3046\u3068\u3044\u3046\u306e\u304c\u4f5c\u696d\u4eee\u8aac\u3067\u3059\u3002\u3082\u3061\u308d\u3093\u3001\u305d\u308c\u307b\u3069\u6cbb\u7642\u306b\u7279\u7570\u6027\u304c\u306a\u304f\u3001\u300c\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c3\u7a2e\u985e\u3068\u3082\u6cbb\u7642\u5f8c\u306b\u4f4e\u4e0b\u3059\u308b\u300d\u3068\u3044\u3046\u53ef\u80fd\u6027\u3082\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u304c\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3000\u502b\u7406\u59d4\u54e1\u4f1a\u306b\u8a08\u753b\u3092\u901a\u3057\u3066\u3001\u3044\u3056\u691c\u4f53\u3092\u96c6\u3081\u59cb\u3081\u308b\u3068\u3001\u7279\u5fb4\u7684\u306a\u30d1\u30bf\u30fc\u30f3\u304c\u898b\u3048\u3066\u304d\u307e\u3057\u305f\u3002IFN-\u03b3, IL-4, IL-17\u306e\u3044\u305a\u308c\u3082\u3001\u7523\u751f\u91cf\u306f\u300c\u6cbb\u7642\u5f8c\u306b\u5897\u3048\u308b\u300d\u50be\u5411\u304c\u3042\u3063\u305f\u306e\u3067\u3059\u3002\u7d71\u8a08\u5b66\u7684\u306b\u3082\u6709\u610f\u5dee\u304c\u3064\u304f\u30ec\u30d9\u30eb\u3067\u3059\u3002\u3053\u308c\u306f\u5168\u7136\u4e88\u60f3\u3057\u3066\u3044\u306a\u3044\u7d50\u679c\u3067\u3057\u305f\u3002\u3068\u8a00\u3046\u3088\u308a\u3001\u6b63\u53cd\u5bfe\u3067\u3057\u305f\u3002\u3069\u3046\u89e3\u91c8\u3057\u305f\u3089\u826f\u3044\u306e\u304b\u3001\u982d\u3092\u62b1\u3048\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u5076\u7136\u3001\u6cbb\u7642\u52b9\u679c\u306e\u4f4e\u3044\u60a3\u8005\u3070\u304b\u308a\u96c6\u307e\u3063\u305f\u306e\u3067\u3057\u3087\u3046\u304b\u3002\u3057\u304b\u3057DAS28\u3082\u3001\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308bCRP\u3082\u6709\u610f\u306b\u4e0b\u304c\u3063\u3066\u3044\u307e\u3059\u3002\u6cbb\u7642\u306f\u52b9\u3044\u3066\u3044\u308b\u306f\u305a\u3067\u3059\u3002\u305d\u3053\u3067\u540c\u3058\u57f9\u990a\u4e0a\u6e05\u3092\u4f7f\u3063\u3066IL-6\u3092\u6e2c\u5b9a\u3057\u3066\u307f\u308b\u3068\u3001\u6709\u610f\u5dee\u306e\u51fa\u308b\u30ec\u30d9\u30eb\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u5e73\u5747\u5024\u306f\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3082\u307e\u305f\u4e0d\u601d\u8b70\u306a\u3053\u3068\u3067\u3057\u305f\u3002\u3068\u3044\u3046\u306e\u306f\u3001CRP\u306e\u8a98\u5c0e\u306b\u306fIL-6\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304a\u308a\u3001CRP\u306fIL-6\u306e\u5024\u3092\u53cd\u6620\u3059\u308bsurrogate marker\uff08\u4ee3\u66ff\u30de\u30fc\u30ab\u30fc\u3001\u4ee3\u7528\u30de\u30fc\u30ab\u30fc\uff09\u3068\u8003\u3048\u3089\u308c\u308b\u304b\u3089\u3067\u3059\u3002\u3064\u307e\u308a\u3001\u751f\u4f53\u5185\u3067\u306fIL-6\u306f\u6e1b\u5c11\u3057\u3066\u3044\u308b\u306f\u305a\u3067\u3059\u3002\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u3053\u306e\u5b9f\u9a13\u65b9\u6cd5\u81ea\u4f53\u306b\u5927\u304d\u306a\u554f\u984c\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3000\u305d\u3082\u305d\u3082\u3001\u6cbb\u7642\u524d\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u91cf\u3092\u898b\u308b\u3068\u3001\u5065\u5e38\u4eba\uff08\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\uff09\u306e\u305d\u308c\u3068\u6bd4\u3079\u3066\u4f4e\u3044\u5024\u3067\u3057\u305f\u3002\u8a66\u9a13\u7ba1\u5185\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u91cf\u304c\u5897\u3048\u308b\u3001\u3068\u3044\u3046\u306e\u306f\u78ba\u304b\u306a\u306e\u3067\u3059\u304c\u3001\u3080\u3057\u308d\u300c\u6b63\u5e38\u306b\u8fd1\u304f\u306a\u3063\u3066\u3044\u308b\u300d\u3068\u89e3\u91c8\u3057\u305f\u65b9\u304c\u3088\u3044\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><strong><span style=\"font-size: 12pt;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-46%e3%80%80%e3%83%92%e3%83%88%e3%81%aeth1-2-17%e5%bf%9c%e7%ad%94%e3%80%802-%e3%83%95%e3%83%ad%e3%83%bc\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (46)<\/span><\/a><strong><em><span style=\"color: #0000ff;\">\u2190 Prev\u3000\u3000\u3000\u3000\u3000Next \u2192<\/span><\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-48%e3%80%80%e3%83%92%e3%83%88%e3%81%aeth1-2-17%e5%bf%9c%e7%ad%94%e3%80%804-%e6%84%8f%e5%a4%96%e3%81%99\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (48)<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u8a66\u9a13\u7ba1\u5185\u3067\u523a\u6fc0\u3057\u305f\u5358\u6838\u7403\u306e\u57f9\u990a\u4e0a\u6e05\u304b\u3089\u306f\u3001IFN-\u03b3(Th1\u5fdc\u7b54)\u3001IL-4(Th2\u5fdc\u7b54)\u3001IL-17\uff08Th17\u5fdc\u7b54\uff09\u3044\u305a\u308c\u3082\u5341\u5206\u306b\u6e2c\u5b9a\u3067\u304d\u307e\u3059\u3002\uff08\u307e\u3042\u4ee5\u524d\u3082\u66f8\u304d\u307e\u3057\u305f\u304c\u3001\u305f\u3068\u3048\u3070IFN-\u03b3\u306fCD8\u967d\u6027T\u7d30\u80de\u306e\u65b9\u304c\u3088\u308a\u591a &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1720","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1720","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1720"}],"version-history":[{"count":4,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1720\/revisions"}],"predecessor-version":[{"id":2022,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1720\/revisions\/2022"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1720"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1720"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}