{"id":1759,"date":"2021-08-11T11:38:51","date_gmt":"2021-08-11T02:38:51","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=1759"},"modified":"2022-09-09T11:02:59","modified_gmt":"2022-09-09T02:02:59","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-49%e3%80%80%e3%83%92%e3%83%88%e3%81%aeth1-2-17%e5%bf%9c%e7%ad%94%e3%80%805-%e6%84%8f%e5%a4%96%e3%81%99","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-49%e3%80%80%e3%83%92%e3%83%88%e3%81%aeth1-2-17%e5%bf%9c%e7%ad%94%e3%80%805-%e6%84%8f%e5%a4%96%e3%81%99\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (49)\u3000\u30d2\u30c8\u306eTh1\/2\/17\u5fdc\u7b54(5)\u3000 \u610f\u5916\u3059\u304e\u308b\u7d50\u679c\u306e\u89e3\u91c8-2"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\u30a4\u30f3\u30d5\u30ea\u30ad\u30b7\u30de\u30d6\u6295\u4e0e\u5f8c\u306e\u672b\u68a2\u8840\u5358\u6838\u7403\u304b\u3089\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u306e\u65b9\u304c\u6295\u4e0e\u524d\u3088\u308a\u3082\u9ad8\u304f\u306a\u308b\u3068\u3044\u3046\u306e\u306f\u610f\u5916\u3067\u3057\u305f\u304c\u3001\u3080\u3057\u308d\u300c\u30a4\u30f3\u30d5\u30ea\u30ad\u30b7\u30de\u30d6\u6295\u4e0e\u524d\u306e\u7523\u751f\u304c\u5065\u5e38\u4eba\u3088\u308a\u4f4e\u304f\u3001\u305d\u308c\u304c\u6cbb\u7642\u5f8c\u306b\u5065\u5e38\u4eba\u306b\u8fd1\u3065\u3044\u305f\u300d\u3088\u3046\u306b\u898b\u3048\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u6cbb\u7642\u524d\u306e\u672b\u68a2\u8840\u5358\u6838\u7403\u306e\u5fdc\u7b54\u6027\u304c\u843d\u3061\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u5c40\u6240\uff08\u3053\u3053\u3067\u306f\u95a2\u7bc0\uff09\u306e\u708e\u75c7\u304c\u8d77\u304d\u3066\u3044\u308b\u305f\u3081\u306b\u3001\u904e\u5270\u306a\u708e\u75c7\u5fdc\u7b54\u3092\u6291\u3048\u3088\u3046\u3068\u3059\u308b\u30cd\u30ac\u30c6\u30a3\u30d6\u30fb\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u304c\u5168\u4f53\u7684\u306b\uff08\u975e\u7279\u7570\u7684\u306b\uff09\u304b\u304b\u3063\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u307e\u3057\u305f\uff08\u4ee5\u524d\u5236\u5fa1\u6027T\u7d30\u80de\u3067\u5b9f\u9a13\u3057\u305f\u3068\u304d\u306b\u305d\u3046\u3057\u305f\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u304c\u91cd\u8981\u3060\u308d\u3046\u3068\u8003\u5bdf\u3057\u305f\u3053\u3068\u3082\u5f71\u97ff\u3057\u3066\u3044\u307e\u3059\u3002Sato et al., Biochem Biophys Res commun. 2005\uff09\u3002\u305d\u306e\u30cd\u30ac\u30c6\u30a3\u30d6\u30fb\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u306e\u6307\u6a19\u3068\u3057\u3066\u3001\u8840\u6f3f\u4e2d\u306e\u30a2\u30eb\u30ae\u30ca\u30fc\u30bc\u3068\u3044\u3046\u9175\u7d20\u306e\u6d3b\u6027\u3092\u8abf\u3079\u3066\u307f\u3088\u3046\u3068\u8003\u3048\u307e\u3057\u305f\u3002\u30a2\u30eb\u30ae\u30ca\u30fc\u30bc\u304c\u6cbb\u7642\u524d\u5f8c\u3067\u300c\u4e0b\u304c\u3063\u3066\u3044\u308b\u7fa4\u300d\u3068\u3001\u300c\u4e0a\u304c\u3063\u3066\u3044\u308b\u7fa4\u300d\u306b\u5206\u3051\u3066\u6bd4\u3079\u308b\u3068\u3001\u524d\u8005\u3067\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u304c\u4e0a\u6607\u3057\u3066\u304a\u308a\u3001\u5f8c\u8005\u3067\u306f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u4e0a\u6607\u304c\u898b\u3089\u308c\u306a\u304f\uff08\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u306f\u306a\u304f\uff09\u306a\u308a\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3084\u306f\u308a\u30cd\u30ac\u30c6\u30a3\u30d6\u30fb\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u304c\u3042\u308a\u305d\u3046\u306a\u7d50\u679c\u3067\u3059\u3002\u8fd1\u5e74\u3001\u514d\u75ab\u5b66\u306b\u69d8\u3005\u306a\u4ee3\u8b1d\u306e\u7814\u7a76\u304c\u5c0e\u5165\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u3046\u3057\u305f\u30a2\u30eb\u30ae\u30ca\u30fc\u30bc\u6d3b\u6027\u89e3\u6790\u306a\u3069\u3082\u4ee3\u8b1d\u514d\u75ab\u5b66\u7814\u7a76\u306e\u4e00\u74b0\u3068\u8a00\u3048\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u305d\u306e\u5f8c\u305d\u306e\u5206\u91ce\u306b\u306f\u624b\u3092\u3064\u3051\u3066\u3044\u307e\u305b\u3093\u3002\u79c1\u306b\u3068\u3063\u3066\u3053\u3053\u306f\u672a\u958b\u306e\u5206\u91ce\u3068\u3057\u3066\u6b8b\u3063\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3000\u3053\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u3064\u3044\u3066\u306f\u3001\u300c\u672b\u68a2\u8840\u5358\u6838\u7403\u304b\u3089\u306f\u6cbb\u7642\u5f8c\u306b\u7523\u751f\u304c\u5897\u3048\u308b\u304c\u3001\u8840\u6e05\u4e2d\u3067\u6cbb\u7642\u5f8c\u306b\u4f4e\u4e0b\u3057\u3001\u66f4\u306b\u8840\u6e05\u4e2d\u3067\u6e2c\u5b9a\u53ef\u80fd\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u300d\u3092\u63a2\u3057\u3001\u8840\u6e05IL-21\u304c\u30ae\u30ea\u30ae\u30ea\u6e2c\u5b9a\u3067\u304d\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u306e\u3067\u305d\u306e\u7d50\u679c\u3092\u3064\u3051\u3066\u30a2\u30b8\u30a2\u30ea\u30a6\u30de\u30c1\u5b66\u4f1a\u8a8c\u306b\u4f55\u3068\u304b\u300c\u306d\u3058\u8fbc\u307f\u300d\u307e\u3057\u305f(Miyoshi et al., Int J Rheum Dis. 2018)\u3002\u3053\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u901a\u3058\u3066\u3001\u6e2c\u5b9a\u306e\u305f\u3081\u306b\u8272\u3005\u5de5\u592b\u3059\u308b\u3053\u3068\u306e\u5371\u967a\u6027\u3092\u5b66\u3073\u307e\u3057\u305f\u3002\u5371\u967a\u6027\u306f\u5927\u3052\u3055\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u8840\u7403\u3092\u523a\u6fc0\u3059\u308b\u306a\u3069\u306e\u64cd\u4f5c\u306e\u305f\u3081\u306b\u3001\u7d50\u679c\u306b\u610f\u5916\u306a\u5f71\u97ff\u304c\u51fa\u308b\u3053\u3068\u3082\u3042\u308b\u306e\u3067\u3059\u3002\u3067\u304d\u308c\u3070\u30b5\u30f3\u30d7\u30eb\u3092\u3001\u306a\u308b\u3079\u304f\u624b\u3092\u52a0\u3048\u305a\u306b\u6e2c\u5b9a\u3059\u308b\u65b9\u304c\u7d20\u76f4\u306a\u7d50\u679c\u304c\u51fa\u305b\u305d\u3046\u3067\u3059\u3002(45)\u3067\u8ff0\u3079\u305f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u6b4c\uff08\uff1f\uff09\u306b\u5bc4\u305b\u3066\u8a00\u3048\u3070\u3001\u2463\u6e2c\u308c\u306a\u3044\u306a\u3089\u3000\u6e2c\u308c\u308b\u3082\u306e\u3092\u898b\u3064\u3051\u3088\u3046\u3000\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002\u3067\u306f\u6e2c\u5b9a\u3067\u304d\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u306f\u3069\u306e\u3088\u3046\u306a\u3082\u306e\u3067\u3057\u3087\u3046\u304b\u3002IL-21\u3082\u3001\u591a\u304f\u306e\u8840\u6e05\u30b5\u30f3\u30d7\u30eb\u3067\u691c\u51fa\u9650\u754c\u4ee5\u4e0b\u3067\u3057\u305f\u3002\u691c\u51fa\u611f\u5ea6\u30ae\u30ea\u30ae\u30ea\u3060\u3068\u3001\u6e2c\u5b9a\u8aa4\u5dee\u3082\uff08\u76f8\u5bfe\u7684\u306b\uff09\u5927\u304d\u304f\u306a\u3089\u3056\u308b\u3092\u3048\u307e\u305b\u3093\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><strong><span style=\"font-size: 12pt;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-48%e3%80%80%e3%83%92%e3%83%88%e3%81%aeth1-2-17%e5%bf%9c%e7%ad%94%e3%80%804-%e6%84%8f%e5%a4%96%e3%81%99\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (48)<\/span><\/a><strong><em><span style=\"color: #0000ff;\">\u2190 Prev\u3000\u3000\u3000\u3000\u3000<\/span><span style=\"color: #0000ff;\">Next \u2192<\/span><\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-50%e3%80%80%e3%83%92%e3%83%88%e3%82%b5%e3%82%a4%e3%83%88%e3%82%ab%e3%82%a4%e3%83%b3%e3%80%801-%e6%b8%ac\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (50)<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u30a4\u30f3\u30d5\u30ea\u30ad\u30b7\u30de\u30d6\u6295\u4e0e\u5f8c\u306e\u672b\u68a2\u8840\u5358\u6838\u7403\u304b\u3089\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u306e\u65b9\u304c\u6295\u4e0e\u524d\u3088\u308a\u3082\u9ad8\u304f\u306a\u308b\u3068\u3044\u3046\u306e\u306f\u610f\u5916\u3067\u3057\u305f\u304c\u3001\u3080\u3057\u308d\u300c\u30a4\u30f3\u30d5\u30ea\u30ad\u30b7\u30de\u30d6\u6295\u4e0e\u524d\u306e\u7523\u751f\u304c\u5065\u5e38\u4eba\u3088\u308a\u4f4e\u304f\u3001\u305d\u308c\u304c\u6cbb\u7642\u5f8c\u306b\u5065\u5e38\u4eba\u306b\u8fd1\u3065\u3044\u305f\u300d\u3088\u3046\u306b\u898b\u3048\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001 &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1759","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=1759"}],"version-history":[{"count":5,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1759\/revisions"}],"predecessor-version":[{"id":2024,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/1759\/revisions\/2024"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=1759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=1759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=1759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}