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color: #000080;\">NK\u7d30\u80de\u306bIL-18\u3092\u3075\u308a\u304b\u3051\u308b\u3068\u78ba\u304b\u306bIFN-\u03b3\u304cmRNA\u30ec\u30d9\u30eb\u306710\u500d\u4ee5\u4e0a\u306b\u5897\u3048\u308b\u306e\u3067\u3059\u304c\u3001\u305d\u3053\u306bIL-6\u3092\u52a0\u3048\u3066\u3082\u4e0a\u4e57\u305b\u52b9\u679c\u304c\u5168\u304f\u898b\u3089\u308c\u306a\u3044\u306e\u3067\u3059\u3002\u3068\u3053\u308d\u304c\u3001IL-18\u306bIL-10\u3092\u52a0\u3048\u308b\u3068\u660e\u3089\u304b\u306b\u76f8\u4e57\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u305d\u308c\u3060\u3051\u3067\u306f\u306a\u304f\u3001NK\u7d30\u80de\u306e\u57f9\u990a\u4e0a\u6e05\u4e2d\u306eIFN-\u03b3\u3092\u5b9a\u91cf\u3059\u308b\u3068\u3001IL-18\u3068IL-10\u3092\u5171\u306b\u52a0\u3048\u305f\u5834\u5408\u3067\u3057\u304b\u30bf\u30f3\u30d1\u30af\u30ec\u30d9\u30eb\u306eIFN-\u03b3\u306f\u691c\u51fa\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-2012 alignleft\" src=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u308154\u3000\u56f3.jpg\" alt=\"\" width=\"873\" height=\"398\" srcset=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u308154\u3000\u56f3.jpg 873w, https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u308154\u3000\u56f3-300x137.jpg 300w, https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u308154\u3000\u56f3-768x350.jpg 768w\" sizes=\"auto, (max-width: 873px) 100vw, 873px\" \/><\/span><\/p>\n<p><span style=\"font-size: 12pt; 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Immunol. 2018)\u3002\u4eca\u56de\u60a3\u8005\u7531\u6765\u306eNK\u7d30\u80de\u3092\u8abf\u3079\u305f\u8a33\u3067\u306f\u306a\u3044\u306e\u3067\u78ba\u5b9a\u7684\u306a\u3053\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\u304c\u3001IL-10\u3068\u3044\u3046\u6297\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u4ee3\u8868\u683c\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u56e0\u5b50\u304c\u72b6\u6cc1\u306b\u3088\u3063\u3066\u306fIFN-\u03b3\u3084TRAIL\u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3057\u3066\u708e\u75c7\u3092\u60f9\u8d77\u3059\u308b\u3068\u3044\u3046\u9006\uff08\uff1d\u50ac\u708e\u75c7\u6027\uff09\u306e\u5f79\u5272\u3092\u679c\u305f\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3060\u3068\u3044\u3046\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u305f\u3060\u3057\u3001IFN-\u03b3\u3067\u523a\u6fc0\u3057\u305f\u5358\u7403\u304b\u3089\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u306fIL-10\u306b\u3088\u3063\u3066\u660e\u3089\u304b\u306b\u6291\u5236\u3055\u308c\u308b\u306e\u3067\u3001\u7d30\u80de\u7a2e\u306b\u3088\u308b\u9055\u3044\u306f\u975e\u5e38\u306b\u5927\u304d\u3044\u3088\u3046\u3067\u3059\u3002\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u6027\u8cea\u3082\u3001\u30d2\u30c8\u500b\u4eba\u3068\u540c\u3058\u3088\u3046\u306b\u5358\u7d14\u306b\u5584\u60aa\u4e8c\u5206\u3067\u304d\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3053\u3068\u3092\u5b9f\u611f\u3057\u307e\u3057\u305f(Aizaki et al., Clin Exp Rheumatol. 2021)\u3002AOSD\u306b\u3064\u3044\u3066\u306f\u3001\u5206\u304b\u3063\u305f\u3053\u3068\u3088\u308a\u3082\u5897\u3048\u305f\u8b0e\u306e\u65b9\u304c\u591a\u3044\u3068\u3044\u3046\uff08\u3088\u304f\u3042\u308b\u30d1\u30bf\u30fc\u30f3\u3067\u3059\u304c\uff09\u7d50\u679c\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u65e5\u672c\u3067\u3082AOSD\u306b\u5bfe\u3057\u3066IL-1\u963b\u5bb3\u85ac\u304c\u4f7f\u3048\u308b\u3088\u3046\u306b\u306a\u308b\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u4f7f\u7528\u7d4c\u9a13\u304b\u3089\u307e\u305f\u65b0\u3057\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304f\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><strong><span style=\"font-size: 12pt;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-53%e3%80%80%e3%83%92%e3%83%88%e3%82%b5%e3%82%a4%e3%83%88%e3%82%ab%e3%82%a4%e3%83%b3%e3%80%804-%e3%80%8c\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (53)<\/span><\/a><strong><em><span style=\"color: #0000ff;\">\u2190 Prev\u3000\u3000\u3000\u3000\u3000Next\u00a0<\/span><\/em><\/strong><span style=\"color: #000080;\"><span style=\"color: #0000ff;\">\u2192<\/span><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-55%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa1%e3%80%80-%e6%8c%af%e3%82%8a%e5%87%ba\/\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (55)<\/a><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"NK\u7d30\u80de\u306bIL-18\u3092\u3075\u308a\u304b\u3051\u308b\u3068\u78ba\u304b\u306bIFN-\u03b3\u304cmRNA\u30ec\u30d9\u30eb\u306710\u500d\u4ee5\u4e0a\u306b\u5897\u3048\u308b\u306e\u3067\u3059\u304c\u3001\u305d\u3053\u306bIL-6\u3092\u52a0\u3048\u3066\u3082\u4e0a\u4e57\u305b\u52b9\u679c\u304c\u5168\u304f\u898b\u3089\u308c\u306a\u3044\u306e\u3067\u3059\u3002\u3068\u3053\u308d\u304c\u3001IL-18\u306bIL-10\u3092\u52a0\u3048\u308b\u3068\u660e\u3089\u304b\u306b\u76f8\u4e57\u52b9\u679c\u304c\u8a8d\u3081\u3089 &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2010","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2010","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=2010"}],"version-history":[{"count":8,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2010\/revisions"}],"predecessor-version":[{"id":2062,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2010\/revisions\/2062"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=2010"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=2010"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=2010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}