{"id":2053,"date":"2022-11-07T16:21:54","date_gmt":"2022-11-07T07:21:54","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=2053"},"modified":"2022-12-16T11:46:53","modified_gmt":"2022-12-16T02:46:53","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-55%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa1%e3%80%80-%e6%8c%af%e3%82%8a%e5%87%ba","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-55%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa1%e3%80%80-%e6%8c%af%e3%82%8a%e5%87%ba\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (55)\u3000\u7834\u9aa8\u7d30\u80de\u518d\u8a2a(1)\u3000 \u632f\u308a\u51fa\u3057\u306b\u623b\u308b"},"content":{"rendered":"<p><span style=\"color: #000080; font-size: 12pt;\">\u30d2\u30c8\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30fb\u30b1\u30e2\u30ab\u30a4\u30f3\u306e\u8a71\u306f\u524d\u56de\u307e\u3067\u3067\u4e00\u6bb5\u843d\u3068\u3057\u3066\u3001\u7834\u9aa8\u7d30\u80de\u306e\u8a71\u306b\u623b\u308a\u307e\u3059\u3002\u533b\u79d1\u6b6f\u79d1\u6642\u4ee3(2006\u5e74)\u306bTh17\u7d30\u80de\u304c\u7834\u9aa8\u7d30\u80de\u5206\u5316\u3092\u4fc3\u9032\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u5831\u544a\u3057\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306fIL-17\u304c\u9aa8\u82bd\u7d30\u80de\u306b\u4f5c\u7528\u3057\u3066\u3001\u7834\u9aa8\u7d30\u80de\u5206\u5316\u56e0\u5b50(RANKL)\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3060\u3068\u8003\u3048\u3066\u3044\u307e\u3057\u305f\u3002\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u3001\u9aa8\u7834\u58ca\u304c\u8d77\u304d\u3066\u3044\u308b\u95a2\u7bc0\u5c40\u6240\u3067\u306f\u3001\u9aa8\u82bd\u7d30\u80de\u306e\u4ee3\u308f\u308a\u306b\u6ed1\u819c\u7dda\u7dad\u82bd\u7d30\u80de\u304c\u305d\u306e\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u4e88\u60f3\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u6ed1\u819c\u7dda\u7dad\u82bd\u7d30\u80de\u306f\u30d7\u30ec\u30fc\u30c8\u5185\u3067\u57f9\u990a\u3067\u304d\u308b\u306e\u3067\u3001\u305d\u3053\u306bIL-17\u3092\u52a0\u3048\u3066\u3084\u308c\u3070RANKL\u306e\u8a98\u5c0e\u304c\u89b3\u5bdf\u3055\u308c\u308b\u306f\u305a\u3067\u3059\u3002\u305d\u306e\u5b9f\u9a13\u306f\u57fc\u7389\u533b\u5927\u306b\u3044\u308b\u6642\u306b\u884c\u3044\u307e\u3057\u305f\u3002IL-17\u3092\u3075\u308a\u304b\u3051\u305f\u30b5\u30f3\u30d7\u30eb\u3068\u3075\u308a\u304b\u3051\u3066\u3044\u306a\u3044\u30b5\u30f3\u30d7\u30eb\u3092\u56de\u53ce\u3057\u3066RNA\u3092\u62bd\u51fa\u3057\u3001\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u3092\u884c\u3046\u3060\u3051\u306e\u7c21\u5358\u306a\u5b9f\u9a13\u3067\u3059\u3002\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u3082\u5b9f\u7528\u5316\u3055\u308c\u305f\u76f4\u5f8c\u306b\u6bd4\u3079\u308b\u3068\u8cbb\u7528\u304c\u76f8\u5f53\u4e0b\u304c\u308a\u3001\u624b\u304c\u51fa\u3057\u3084\u3059\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3092\u898b\u308b\u3068\u30fb\u30fb\u30fb\u4f55\u3068\u3001RANKL\u306emRNA\u30ec\u30d9\u30eb\u306e\u767a\u73fe\u306f\u201dabsent\u201d\u3068\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002IL-17\u306e\u6709\u7121\u306b\u95a2\u308f\u3089\u305a\u3001\u3067\u3059\uff08\u56f3\uff09\u3002<br \/>\n<\/span><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-2054 alignleft\" src=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u308155\u3000\u56f3-300x173.png\" alt=\"\" width=\"300\" height=\"173\" srcset=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u308155\u3000\u56f3-300x173.png 300w, https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u308155\u3000\u56f3-768x443.png 768w, https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u308155\u3000\u56f3.png 790w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><span style=\"color: #000080; font-size: 12pt;\">Affymetrix\u793e\u306eGeneChip\u306f\u72ec\u7279\u306e\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3067mRNA\u304c\u767a\u73fe\u3057\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u3092\u7d71\u8a08\u7684\u306b\u5224\u65ad\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u76ae\u8089\u306a\u3053\u3068\u306b\u3001RANKL\u306e\u56ee\u53d7\u5bb9\u4f53\u3067\u3042\u308aRANKL\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u906e\u65ad\u3059\u308b\u5206\u5b50\u306eOPG\u306f\u201dpresent\u201d\u3068\u8a55\u4fa1\u3055\u308c\u3001\u3057\u304b\u3082IL-17\u3067\u8a98\u5c0e\u3055\u308c\u308b\u3088\u3046\u3067\u3057\u305f\u3002RANKL\u3068OPG\u306fGeneChip\u4e0a\u306b\u305d\u308c\u305e\u308c2\u3064\u305a\u3064\u30d7\u30ed\u30fc\u30d6\u304c\u4e57\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3001\u3069\u3061\u3089\u3082\u540c\u3058\u3088\u3046\u306a\u30d1\u30bf\u30fc\u30f3\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3082\u3084\u81ea\u5206\u306e\u4eee\u8aac\u3092\u5426\u5b9a\u3059\u308b\u7fbd\u76ee\u306b\u306a\u3063\u305f\u3088\u3046\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #000080; font-size: 12pt;\">\u4ed6\u306b\u3082\u8272\u3005\u306a\u30b1\u30e2\u30ab\u30a4\u30f3\u3001\u7279\u306b\u597d\u4e2d\u7403\u306e\u904a\u8d70\u306b\u95a2\u308f\u308b\u30b1\u30e2\u30ab\u30a4\u30f3\u3084\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308bIL-6\u306f\u304b\u306a\u308a\u8a98\u5c0e\u3055\u308c\u3066\u3044\u307e\u3057\u305f\uff08\u8868\uff09\u3002\u57f9\u990a\u4e0a\u6e05\u3092\u7528\u3044\u3066ELISA\u306b\u3088\u308a\u5b9a\u91cf\u3092\u884c\u3046\u3068\u3084\u306f\u308a\u305d\u308c\u3089\u306e\u30b1\u30e2\u30ab\u30a4\u30f3\u3084IL-6\u306f\u30bf\u30f3\u30d1\u30af\u30ec\u30d9\u30eb\u3067\u5897\u3048\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3067\u304d\u307e\u3057\u305f(Ota M et al., J Bone Miner Metab. 2015)\u3002Th17\u7d30\u80de\u306f\u597d\u4e2d\u7403\u5fdc\u7b54\u306b\u91cd\u8981\u306aT\u7d30\u80de\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u3053\u306e\u7d50\u679c\u306f\u59a5\u5f53\u306a\u3082\u306e\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u305d\u3046\u3059\u308b\u3068Th17\u7d30\u80de\u304c\u7834\u9aa8\u7d30\u80de\u5206\u5316\u3092\u4fc3\u9032\u3059\u308b\u3068\u3044\u3046\u73fe\u8c61\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f\u632f\u308a\u51fa\u3057\u306b\u623b\u3063\u305f\u683c\u597d\u3067\u3059\u3002<br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2055\" src=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u308155\u3000\u8868-293x300.png\" alt=\"\" width=\"466\" height=\"477\" srcset=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u308155\u3000\u8868-293x300.png 293w, https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u308155\u3000\u8868-768x787.png 768w, https:\/\/www.jichi.ac.jp\/alle\/cms\/wp-content\/uploads\/\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u308155\u3000\u8868.png 886w\" sizes=\"auto, (max-width: 466px) 100vw, 466px\" \/><br \/>\n<\/span><\/p>\n<p style=\"text-align: right;\"><strong><span style=\"font-size: 12pt;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-54%e3%80%80%e3%83%92%e3%83%88%e3%82%b5%e3%82%a4%e3%83%88%e3%82%ab%e3%82%a4%e3%83%b34-%e3%80%80%e8%ac%8e\/\"><span style=\"font-size: 11pt; color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (54)<\/span><\/a><strong><em><span style=\"font-size: 11pt;\"><span style=\"color: #0000ff;\">\u2190 Prev\u3000<\/span><\/span>\u3000\u3000\u3000<span style=\"color: #0000ff;\">Next\u00a0\u2192<\/span><\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-56%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa%e3%80%802-tnf%e3%81%a8rankl\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (56)<\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"\u30d2\u30c8\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30fb\u30b1\u30e2\u30ab\u30a4\u30f3\u306e\u8a71\u306f\u524d\u56de\u307e\u3067\u3067\u4e00\u6bb5\u843d\u3068\u3057\u3066\u3001\u7834\u9aa8\u7d30\u80de\u306e\u8a71\u306b\u623b\u308a\u307e\u3059\u3002\u533b\u79d1\u6b6f\u79d1\u6642\u4ee3(2006\u5e74)\u306bTh17\u7d30\u80de\u304c\u7834\u9aa8\u7d30\u80de\u5206\u5316\u3092\u4fc3\u9032\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u5831\u544a\u3057\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306fIL-17\u304c\u9aa8\u82bd\u7d30\u80de\u306b\u4f5c\u7528\u3057\u3066\u3001\u7834\u9aa8\u7d30 &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2053","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2053","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=2053"}],"version-history":[{"count":6,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2053\/revisions"}],"predecessor-version":[{"id":2084,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2053\/revisions\/2084"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=2053"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=2053"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=2053"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}