{"id":2080,"date":"2022-12-16T11:45:34","date_gmt":"2022-12-16T02:45:34","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=2080"},"modified":"2023-01-27T16:00:34","modified_gmt":"2023-01-27T07:00:34","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-56%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa%e3%80%802-tnf%e3%81%a8rankl","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-56%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa%e3%80%802-tnf%e3%81%a8rankl\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (56)\u3000\u7834\u9aa8\u7d30\u80de\u518d\u8a2a(2)\u3000 TNF\u3068RANKL"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1(rheumatoid arthritis, RA)\u306e\u9aa8\u7834\u58ca\u306b\u3064\u3044\u3066\u3001\u5927\u304d\u306a\u885d\u6483\u3092\u53d7\u3051\u305f\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002TEMPO\u30b9\u30bf\u30c7\u30a3\u3068\u3044\u3046\u6cbb\u9a13\u7d50\u679c\u306e\u5831\u544a\u3067\u3001\u3053\u308c\u306fRA\u60a3\u8005\u306bTNF\u963b\u5bb3\u85ac\u3067\u3042\u308b\u30a8\u30bf\u30cd\u30eb\u30bb\u30d7\u30c8\u3092\u6295\u4e0e\u3059\u308b\u3068\u3001\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8(MTX)\u6295\u4e0e\u306b\u6bd4\u3079\u3066\u9aa8\u7834\u58ca\u306e\u9032\u884c\u304c\u6291\u5236\u3055\u308c\u308b\u3068\u3044\u3046\u5185\u5bb9\u3067\u3057\u305f(Arthritis and Rheumatol. 2006)\u3002\u66f4\u306b\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u30a8\u30bf\u30cd\u30eb\u30bb\u30d7\u30c8\u3068MTX\u3092\u4f75\u7528\u3059\u308b\u3068\u3001\u9aa8\u7834\u58ca\u306f\u307b\u3068\u3093\u3069\u9032\u884c\u3057\u306a\u3044\u3068\u3044\u3046\u7d50\u679c\u3067\u3059\u3002\u307e\u3042\u4f75\u7528\u3057\u305f\u5834\u5408\u3067\u3082\u4e00\u90e8\u306e\u60a3\u8005\u306b\u3064\u3044\u3066\u306f\u9aa8\u7834\u58ca\u306f\u9032\u884c\u3057\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304c\u3001\u300c\u5e73\u5747\u3059\u308b\u3068\u9032\u884c\u3057\u3066\u3044\u306a\u3044\u300d\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u305d\u308c\u306f\u3068\u308a\u3082\u306a\u304a\u3055\u305a\u300c\u4e00\u90e8\u306e\u60a3\u8005\u306b\u3064\u3044\u3066\u306f\u9006\u306b\u9aa8\u7834\u58ca\u304c\u6539\u5584\u3057\u3066\u3044\u308b\u300d\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3053\u306e\u7d50\u679c1\u3064\u3092\u3068\u3063\u3066\u3082\u3001TNF\u304cRA\u306e\u9aa8\u7834\u58ca\u306b\u5927\u304d\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u660e\u3089\u304b\u3067\u3059\u3002TNF\u306fRANKL\u3068\u540c\u3058\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308a\u3001\u540c\u3058\u3088\u3046\u306b3\u91cf\u4f53\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002\u7d50\u6676\u69cb\u9020\u89e3\u6790\u306e\u7d50\u679c\u3092\u898b\u3066\u3082\u74dc\u4e8c\u3064\u3067\u3059\u3002\u3060\u304b\u3089TNF\u304cRANKL\u3068\u540c\u3058\u3088\u3046\u306b\u7834\u9aa8\u7d30\u80de\u306e\u5206\u5316\u3092\u4fc3\u9032\u3057\u3066\u3082\u4e0d\u601d\u8b70\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u5b9f\u969b\u306b\u306f\u3001RANKL<u>\u306e\u4ee3\u308f\u308a\u306b<\/u>TNF\u3092\u4f7f\u3063\u3066\u3082\u8a66\u9a13\u7ba1\u5185\u3067\u7834\u9aa8\u7d30\u80de\u3092\u5206\u5316\u3055\u305b\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3059\u3002\u305d\u3053\u3067TNF\u306fRANKL\u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\u3001\u300c\u9593\u63a5\u7684\u306b\u300d\u7834\u9aa8\u7d30\u80de\u3092\u8a98\u5c0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u305f\u306e\u3067\u3059\u3002\u3053\u308c\u306b\u95a2\u3057\u30662000\u5e74\u306bTeitelbaum\u306e\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u51fa\u305f\u8ad6\u6587\u306f\u5927\u5909\u9762\u767d\u3044\u5185\u5bb9\u3067\u3057\u305f(Lam et al., J Clin Invest. 2000)\u3002\u3053\u308c\u306f\u3001\u300cTNF\u304c\u3042\u308b\u3068\u3054\u304f\u5c11\u91cf\u306eRANKL\u3067\u3082\u7834\u9aa8\u7d30\u80de\u5206\u5316\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u300d\u3068\u3044\u3046\u3082\u306e\u3067\u3057\u305f\u3002\u306a\u308b\u307b\u3069\u30fc\u3001\u3044\u304b\u306b\u3082\u3042\u308a\u305d\u3046\u306a\u3053\u3068\u3060\u3001\u3068\u601d\u3063\u305f\u306e\u3092\u899a\u3048\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\uff01\u81ea\u5206\u3067\u8a66\u3057\u3066\u307f\u308b\u3068\u3001\u3042\u307e\u308a\u305d\u3046\u306f\u306a\u3089\u306a\u3044\u306e\u3067\u3059\u3002TNF\u3092\u52a0\u3048\u3066\u3084\u308b\u3068RANKL\u306b\u3088\u308b\u7834\u9aa8\u7d30\u80de\u5206\u5316\u304c\u5374\u3063\u3066\u963b\u5bb3\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306a\u7d50\u679c\u3067\u3059\u3002\u4e0d\u601d\u8b70\u306b\u601d\u3063\u3066\u8272\u3005\u8a66\u3057\u3066\u307f\u308b\u3068\u3001RANKL\u3092\u52a0\u3048\u3066\u300c1\u65e5\u5f8c\u306b\u300dTNF\u3092\u8ffd\u52a0\u3057\u3066\u3084\u308b\u3068\u7834\u9aa8\u7d30\u80de\u5206\u5316\u304c\u4ea2\u9032\u3059\u308b\u3068\u3044\u3046\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u7834\u9aa8\u7d30\u80de\u306e\u524d\u99c6\u7d30\u80de\u304c\u6700\u521d\u306bTNF\u306b\u51fa\u4f1a\u3063\u3066\u3057\u307e\u3046\u3068\u7834\u9aa8\u7d30\u80de\u306b\u306a\u308a\u306b\u304f\u304f\u306a\u308b\u5370\u8c61\u3067\u3059\u3002\u3053\u308c\u306f\u5f8c\u306bOchi et al., Proc Natl Acad Sci USA. 2007\u306b\u3064\u306a\u304c\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u305d\u308c\u3067\u306fRA\u60a3\u8005\u306e\u95a2\u7bc0\u3067\u306f\u3001(1)\u307e\u305a\u6700\u521d\u306b\u524d\u99c6\u7d30\u80de\u304cRANKL\u306e\u523a\u6fc0\u3092\u53d7\u3051\u3000(2)\u6b21\u306bTNF\u306e\u523a\u6fc0\u3082\u52a0\u308f\u308b\u3000\u3068\u3044\u3046\u3088\u3046\u306a\u3053\u3068\u304c\u6301\u7d9a\u7684\u306b\u8d77\u304d\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3000\u305d\u3046\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3053\u308c\u306f\u660e\u3089\u304b\u306b\u3061\u3087\u3063\u3068\u8907\u96d1\u306a\u904e\u7a0b\u306b\u306a\u308a\u307e\u3059\u3002TNF\u306e\uff08\u7834\u9aa8\u7d30\u80de\u5206\u5316\u306b\u304a\u3051\u308b\uff09\u5f79\u5272\u306f\u4ed6\u306b\u3042\u308b\u306e\u3067\u306f\u306a\u3044\u304b\uff1f\u3068\u3044\u3046\u6c17\u304c\u3057\u3066\u304d\u307e\u3057\u305f\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 12pt;\"><strong>\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"color: #000080;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-55%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa1%e3%80%80-%e6%8c%af%e3%82%8a%e5%87%ba\/\"><span style=\"font-size: 11pt;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (55)<\/span><\/a><\/span><strong style=\"font-size: 14.08px;\"><em style=\"font-size: 14.08px;\"><span style=\"font-size: 11pt;\"><span style=\"color: #000080;\">\u2190<\/span> <span style=\"color: #0000ff;\">Prev\u3000\u3000\u3000\u3000\u3000<strong><em>Next\u00a0\u2192<\/em><\/strong><\/span><\/span><\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-57%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa3%e3%80%80-%e5%a6%84%e6%83%b3%e3%81%af\/\"><span style=\"font-size: 11pt; color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (57)<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1(rheumatoid arthritis, RA)\u306e\u9aa8\u7834\u58ca\u306b\u3064\u3044\u3066\u3001\u5927\u304d\u306a\u885d\u6483\u3092\u53d7\u3051\u305f\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002TEMPO\u30b9\u30bf\u30c7\u30a3\u3068\u3044\u3046\u6cbb\u9a13\u7d50\u679c\u306e\u5831\u544a\u3067\u3001\u3053\u308c\u306fRA\u60a3\u8005\u306bTNF\u963b\u5bb3\u85ac\u3067\u3042\u308b\u30a8\u30bf\u30cd\u30eb\u30bb\u30d7\u30c8\u3092\u6295\u4e0e\u3059\u308b\u3068\u3001 &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2080","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2080","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=2080"}],"version-history":[{"count":5,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2080\/revisions"}],"predecessor-version":[{"id":2092,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2080\/revisions\/2092"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=2080"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=2080"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=2080"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}