{"id":2089,"date":"2022-12-27T14:10:32","date_gmt":"2022-12-27T05:10:32","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=2089"},"modified":"2023-01-17T16:10:09","modified_gmt":"2023-01-17T07:10:09","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-57%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa3%e3%80%80-%e5%a6%84%e6%83%b3%e3%81%af","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-57%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa3%e3%80%80-%e5%a6%84%e6%83%b3%e3%81%af\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (57)\u3000\u7834\u9aa8\u7d30\u80de\u518d\u8a2a(3)\u3000 \u5984\u60f3\u306f\u81a8\u3089\u3093\u3060\u304c"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">TNF\u306e\uff08\u7834\u9aa8\u7d30\u80de\u5206\u5316\u306b\u304a\u3051\u308b\uff09\u5f79\u5272\u3001\u305d\u308c\u306fRANKL\u306e\u767a\u73fe\u3092\u4fc3\u3057\u305f\u308a\u3001RANKL\u306e\u50cd\u304d\u3092\u52a9\u3051\u305f\u308a\u3059\u308b\u3053\u3068\u3067\u306f\u306a\u304f\u3001\u3082\u3063\u3068\u7a4d\u6975\u7684\u306bRANKL\u975e\u4f9d\u5b58\u7684\u306b\u7834\u9aa8\u7d30\u80de\u5206\u5316\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3001\u3068\u3044\u3046\u8003\u3048\u306b\u81f3\u308a\u307e\u3057\u305f\u3002\u524d\u56de\u8a00\u53ca\u3057\u305fTEMPO\u30b9\u30bf\u30c7\u30a3\u306e\u3001TNF\u963b\u5bb3\u306b\u3088\u308b\u9aa8\u7834\u58ca\u6291\u5236\u52b9\u679c\u306f\u885d\u6483\u7684\u306a\u3082\u306e\u3067\u3057\u305f\u3057\u3001\u305d\u308c\u306b\u6bd4\u3079\u308b\u3068RANKL\u963b\u5bb3\u306b\u3088\u308b\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u52b9\u679c\u306f\u304b\u306a\u308a\u63a7\u3048\u3081\u306a\u3082\u306e\u306b\u601d\u3048\u307e\u3057\u305f\uff08\u6297RANKL\u6297\u4f53\u306f\u4e16\u754c\u4e2d\u3067\u9aa8\u7c97\u9b06\u75c7\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u6d3b\u8e8d\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u65e5\u672c\u3067\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u88dc\u52a9\u7684\u306a\u6cbb\u7642\u85ac\u3068\u3057\u3066\u3082\u9069\u5fdc\u304c\u3042\u308a\u307e\u3059\uff09\u3002\u3082\u3061\u308d\u3093\u300cRANKL\u7121\u304f\u3057\u3066\u9aa8\u7834\u58ca\u7121\u3057\u300d\u3068\u3044\u3046\u5f37\u529b\u306a\u30d1\u30e9\u30c0\u30a4\u30e0\u304c\u3042\u308a\u307e\u3059\u306e\u3067\u3001\u3053\u3046\u3044\u3046\u4eee\u8aac\u306f\u901a\u5e38\u3001\u5984\u60f3\u3068\u3057\u3066\u5207\u308a\u6368\u3066\u308b\u3079\u304d\u306a\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u6368\u3066\u308b\u306b\u3057\u3066\u306fTNF\u3068RANKL\u3068\u306f\u4f3c\u3059\u304e\u3066\u3044\u308b\u3088\u3046\u306b\u601d\u3048\u307e\u3057\u305f\u3002\u3000<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3000TNF\u306b\u3042\u3068\u4f55\u3089\u304b\u306e\u8981\u7d20\u3092\u8db3\u3057\u3066\u3084\u308c\u3070\u3001RANKL\u3068\u540c\u3058\u3088\u3046\u306a\u7834\u9aa8\u7d30\u80de\u5206\u5316\u6a5f\u80fd\u304c\u518d\u69cb\u6210\u3067\u304d\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u30fb\u30fb\u30fb\u3002\u5b9f\u306f1\u3064\u3001\u3068\u3063\u3066\u304a\u304d\u306e\u30a2\u30a4\u30c7\u30a2\u304c\u3042\u308a\u307e\u3057\u305f\u3002RANKL\u306e\u53d7\u5bb9\u4f53\u306fRANK\u3067\u3059\uff08\u3068\u3044\u3046\u3088\u308a\u3001RANK\u306e\u30ea\u30ac\u30f3\u30c9\u304cRANK ligand = RANKL\uff09\u3002RANK\u306freceptor activator of NF\u03baB\u306e\u7565\u3067\u3001\u8ee2\u5199\u56e0\u5b50NF\u03baB\u3092\u6d3b\u6027\u5316\u3059\u308b\u53d7\u5bb9\u4f53\u3068\u3044\u3046\u307b\u3069\u306e\u610f\u5473\u3067\u3059\u3002NF\u03baB\u306f\u708e\u75c7\u306b\u95a2\u308f\u308b\u8272\u3005\u306a\u5206\u5b50\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u91cd\u8981\u306a\u8ee2\u5199\u56e0\u5b50\u306a\u306e\u3067\u3059\u304c\u3001\u5b9f\u969b\u306f\u3044\u304f\u3064\u304b\u7a2e\u985e\u304c\u3042\u308a\u3001\u53e4\u5178\u7684\u7d4c\u8def\u3068\u975e\u53e4\u5178\u7684\u7d4c\u8def\u3068\u3067\u306f\u6700\u7d42\u7684\u306b\u6d3b\u6027\u5316\u3055\u308c\u308b\u8ee2\u5199\u56e0\u5b50(= NF\u03baB)\u306e\u7a2e\u985e\u304c\u9055\u3044\u307e\u3059\u3002\u524d\u8005\u3067\u306f\u4e3b\u306bRelA\u3068p50\u306e\u30d8\u30c6\u30ed\u30c0\u30a4\u30de\u30fc\u3001\u5f8c\u8005\u3067\u306fRelB\u3068p52\u306e\u30d8\u30c6\u30ed\u30c0\u30a4\u30de\u30fc\u304cNF\u03baB\u3068\u3057\u3066\u8ee2\u5199\u306b\u50cd\u304d\u307e\u3059\u3002\u300cRANKL\u523a\u6fc0\u3067\u306f\u975e\u53e4\u5178\u7684\u7d4c\u8def\u304c\u512a\u52e2\u3067\u3042\u308b\u300d\u3068\u3044\u3046\u8a71\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u79c1\u304c\u8003\u3048\u305f\u306e\u306f\u3001TNF\u523a\u6fc0\u3067(RANKL\u306b\u6bd4\u3079\u3066)\u975e\u53e4\u5178\u7684\u7d4c\u8def\u306e\u6d3b\u6027\u304c\u8db3\u308a\u306a\u3044\u306e\u3067\u3042\u308c\u3070\u3001\u4f55\u3089\u304b\u306e\u65b9\u6cd5\u3092\u8db3\u3057\u3066\u975e\u53e4\u5178\u7684\u7d4c\u8def\u306e\u523a\u6fc0\u3092\u88dc\u3063\u3066\u3084\u308c\u3070RANKL\u3068\u540c\u69d8\u306e\u50cd\u304d\u306b\u306a\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3001\u3068\u3044\u3046\u4eee\u8aac\u3067\u3059\u3002\u5358\u7403\u7cfb\u7d30\u80de\u306eCD40\u3068\u3044\u3046\u53d7\u5bb9\u4f53\u306b\u523a\u6fc0\u3092\u5165\u308c\u308c\u3070NF\u03baB\u306e\u975e\u53e4\u5178\u7684\u7d4c\u8def\u304c\u6d3b\u6027\u5316\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u306a\u306e\u3067\u3001<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">RANKL \u2251 TNF + CD40\u523a\u6fc0<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u306b\u306a\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u8003\u3048\u3067\u3059\u3002\u7d20\u4eba\u306a\u306e\u3067\u6016\u3044\u3082\u306e\u306f\u4f55\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u65e9\u901f\u6fc3\u5ea6\u3092\u5909\u3048\u3066\u7834\u9aa8\u7d30\u80de\u524d\u99c6\u7d30\u80de\u3092TNF\u3068\u6297CD40\u6297\u4f53\u3068\u3067\u523a\u6fc0\u3059\u308b\u5b9f\u9a13\u3092\u3084\u3063\u3066\u307f\u307e\u3057\u305f\u3002\u7d50\u679c\u306f\u30fb\u30fb\u30fbTRAP\u67d3\u8272\u967d\u6027\u306e\u591a\u6838\u7d30\u80de\u306f\u898b\u4e8b\u306b\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u3053\u304b\u3089\u6570\u5e74\u3001\u3053\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306f\u4f11\u7720\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><strong><span style=\"font-size: 12pt;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-56%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa%e3%80%802-tnf%e3%81%a8rankl\/\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (56)<\/a><span style=\"color: #0000ff;\"><strong><em>\u2190 Prev\u3000\u3000\u3000\u3000\u3000<\/em><\/strong><strong><em>Next\u00a0\u2192<\/em><\/strong><\/span><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=2097&amp;preview=true\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (58)<\/span><\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"TNF\u306e\uff08\u7834\u9aa8\u7d30\u80de\u5206\u5316\u306b\u304a\u3051\u308b\uff09\u5f79\u5272\u3001\u305d\u308c\u306fRANKL\u306e\u767a\u73fe\u3092\u4fc3\u3057\u305f\u308a\u3001RANKL\u306e\u50cd\u304d\u3092\u52a9\u3051\u305f\u308a\u3059\u308b\u3053\u3068\u3067\u306f\u306a\u304f\u3001\u3082\u3063\u3068\u7a4d\u6975\u7684\u306bRANKL\u975e\u4f9d\u5b58\u7684\u306b\u7834\u9aa8\u7d30\u80de\u5206\u5316\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3001\u3068\u3044\u3046\u8003\u3048\u306b\u81f3\u308a\u307e\u3057\u305f\u3002\u524d\u56de\u8a00 &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2089","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=2089"}],"version-history":[{"count":4,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2089\/revisions"}],"predecessor-version":[{"id":2100,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2089\/revisions\/2100"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=2089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=2089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=2089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}