{"id":2157,"date":"2023-04-03T08:57:45","date_gmt":"2023-04-02T23:57:45","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=2157"},"modified":"2023-04-21T12:40:56","modified_gmt":"2023-04-21T03:40:56","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-63%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa9%e3%80%80%e3%83%97%e3%83%ad%e3%82%b8","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-63%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa9%e3%80%80%e3%83%97%e3%83%ad%e3%82%b8\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (63)\u3000\u7834\u9aa8\u7d30\u80de\u518d\u8a2a(9)\u3000\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306e\u88dc\u907a\u305d\u306e2"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\u305d\u306e\u8208\u5473\u6df1\u3044\u8ad6\u6587\u306e\u30bf\u30a4\u30c8\u30eb\u306f\u201dOsteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis\u201d\u3067\u3059\u3002\u3053\u306eTRANCE\u3068\u306f\u4f55\u304b\u3002\u3053\u308c\u306f\u7834\u9aa8\u7d30\u80de\u5206\u5316\u56e0\u5b50RANKL\u306e\u3053\u3068\u3067\u3059\u3002Choi\u535a\u58eb\u3089\u306f1997\u5e74\u306bTNF\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u4e00\u3064\u3068\u3057\u3066TARNCE\u3092\u767a\u8868\u3057\u3001\u7fcc\u5e74\u305d\u308c\u304c\u7834\u9aa8\u7d30\u80de\u5206\u5316\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f(Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL. Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T. Proc Natl Acad Sci U S A. 1998\u306a\u3069\u3002\u3053\u306e\u8ad6\u6587\u3067\u306fTRANCE\/RANKL\u3068TRANCE\u306e\u65b9\u304cRANKL\u306e\u524d\u306b\u8868\u8a18\u3055\u308c\u3066\u3044\u307e\u3059)\u3002\u305d\u306e\u5f8cRANKL\u3068\u3044\u3046\u8a00\u8449\u306e\u65b9\u304c\u5e83\u307e\u3063\u305f\u306e\u3067\u3059\u304c\u3001Choi\u535a\u58eb\u306fTRANCE\u3068\u3044\u3046\u540d\u79f0\u306b\u3053\u3060\u308f\u308a\u304c\u5f37\u304b\u3063\u305f\u306e\u3067\u3057\u3087\u3046\u3002\u30d7\u30e9\u30a4\u30c9\u304c\u57a3\u9593\u898b\u3048\u307e\u3059\u3002\u30fb\u30fb\u30fb\u305f\u3060\u6700\u8fd1\u306e\u8ad6\u6587\u3067\u306fChoi\u535a\u58eb\u3082RANKL\u3092\u4f7f\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u9591\u8a71\u4f11\u984c\u3001\u3053\u306e2005\u5e74\u306e\u8ad6\u6587\u3067\u306f\u3001TNF\u3068IL-1\u03b2\u306e\u7d44\u307f\u5408\u308f\u305b\u3084TNF\u3068TGF\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u3082\u7834\u9aa8\u7d30\u80de\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u4e3b\u5f35\u3057\u3066\u3044\u307e\u3059\u3002\u3061\u3083\u3093\u3068TRANCE\u3084RANK\u306e\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u7d30\u80de\u3092\u7528\u3044\u305f\u89e3\u6790\u3067\u3001\u5fae\u91cf\u306aRANKL\u306e\u5f71\u97ff\u3092\u5426\u5b9a\u3067\u304d\u308b\u3088\u3046\u306b\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3064\u307e\u308a\u3001TNF\u306a\u3069\u306e\uff08\u708e\u75c7\u6027\uff09\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u3063\u3066<u>RANKL\u975e\u4f9d\u5b58\u6027\u306b\u7834\u9aa8\u7d30\u80de\u304c\u5206\u5316\u3057\u3046\u308b\u3068\u3044\u3046\u30a2\u30a4\u30c7\u30a2\uff08\u5831\u544a\uff09<\/u>\u306f\u7d50\u69cb\u524d\u304b\u3089\u3042\u3063\u305f\u306e\u3067\u3059\u3002\u6211\u3005\u306e\u5831\u544a\u306f\u305d\u306e\u7cfb\u8b5c\u306b\u9023\u306a\u308b\u3082\u306e\u306e\u4e00\u3064\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u304a\u3044\u3066\u3001TNF\u5358\u72ec\u306e\u963b\u5bb3\u3067\u306f\u5341\u5206\u306a\u9aa8\u7834\u58ca\u306e\u6291\u5236\u306b\u3064\u306a\u304c\u3089\u306a\u3044\u3053\u3068\u304c\u3042\u308b\u306e\u306f\u3001<u>TNF\u306b\u306f\u4f9d\u5b58\u3057\u3066\u3044\u306a\u3044\u7834\u9aa8\u7d30\u80de\u8a98\u5c0e\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u7d44\u307f\u5408\u308f\u305b<\/u>\u3082\u5b58\u5728\u3059\u308b\u304b\u3089\u3001\u306a\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u305d\u308c\u304c\u73fe\u6642\u70b9\u3067\u306e\u79c1\u306e\u89e3\u91c8\u3067\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><strong><span style=\"font-size: 12pt;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-62%e3%80%80-%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa-8%e3%80%80-%e3%83%97%e3%83%ad%e3%82%b8\/\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (62)<\/a><span style=\"color: #0000ff;\"><strong><em>\u2190 Prev\u3000\u3000\u3000\u3000\u3000Next \u2192<\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-64%e3%80%80%e7%a0%b4%e9%aa%a8%e7%b4%b0%e8%83%9e%e5%86%8d%e8%a8%aa10%e3%80%80-%e9%80%86%e5%95%8f%e9%a1%8c\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (64)<\/span><\/a><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u305d\u306e\u8208\u5473\u6df1\u3044\u8ad6\u6587\u306e\u30bf\u30a4\u30c8\u30eb\u306f\u201dOsteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis\u201d\u3067\u3059\u3002\u3053\u306eTRANCE\u3068\u306f\u4f55\u304b\u3002\u3053\u308c\u306f\u7834\u9aa8\u7d30\u80de\u5206\u5316\u56e0 &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2157","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2157","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=2157"}],"version-history":[{"count":3,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2157\/revisions"}],"predecessor-version":[{"id":2190,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2157\/revisions\/2190"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=2157"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=2157"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=2157"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}