{"id":2239,"date":"2023-06-30T11:33:06","date_gmt":"2023-06-30T02:33:06","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=2239"},"modified":"2023-07-18T17:23:45","modified_gmt":"2023-07-18T08:23:45","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-68%e3%80%80%e7%9a%ae%e8%86%9a%e7%ad%8b%e7%82%8e2","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-68%e3%80%80%e7%9a%ae%e8%86%9a%e7%ad%8b%e7%82%8e2\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (68)\u3000\u76ae\u819a\u7b4b\u708e(2)\u00a0"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\u307e\u305a\u306f\u3053\u306e\u75be\u60a3\u306b\u7279\u7570\u7684\u306a\u81ea\u5df1\u6297\u4f53\u306e\u767a\u898b\u3067\u3059\u3002\u6176\u5fdc\u5927\u5b66\u306e\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u3001140 kd\u306e\u5927\u304d\u3055\u306e\u6297\u539f\u3068\u53cd\u5fdc\u3059\u308b\u81ea\u5df1\u6297\u4f53\u304c\u60a3\u8005\u306e\u8840\u6e05\u4e2d\u306b\u5b58\u5728\u3059\u308b\u3001\u3068\u3044\u3046\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f(Sato S et al., Arthritis Rheum. 2005)\u3002\u3053\u308c\u306f\u6297CADM-140\u6297\u4f53\u3068\u540d\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u304cCADM\u306fclinically amyopathic DM \uff08\u81e8\u5e8a\u7684\u306b\u7b4b\u708e\u75c7\u72b6\u306e\u4e4f\u3057\u3044DM, 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I IFN\u7cfb\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u906e\u65ad\u3059\u308b\u3068\u76ae\u819a\u708e\u304c\u8d77\u304d\u306a\u304f\u306a\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u66f4\u306b\u708e\u75c7\u3092\u8d77\u3053\u3057\u3066\u3044\u308b\u76ae\u819a\u3067\u30b1\u30e2\u30ab\u30a4\u30f3IP-10\u304c\u8457\u660e\u306b\u9ad8\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u767a\u898b\u3057\u305f\u306e\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u3092\u89e3\u91c8\u3059\u308b\u305f\u3081\u306b\u6fc0\u3057\u3044\u9577\u6642\u9593\u306e\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\u304c\u7e70\u308a\u8fd4\u3055\u308c\u307e\u3057\u305f\uff08\u305d\u306e\u305f\u3081\u306b20\u5e74\u4ee5\u4e0a\u305f\u3063\u3066\u3082\u30c8\u30e9\u30a6\u30de\u3068\u3057\u3066\u8a18\u61b6\u306b\u523b\u307f\u8fbc\u307e\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u304c\uff09\u3002\u7d50\u8ad6\u3092\u7c21\u5358\u306b\u66f8\u304f\u3068IRF-2\u304ctype I IFN\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u666e\u6bb5\u306f\u8ca0\u306b\u5236\u5fa1\u3057\u3066\u304a\u308a\u3001\u305d\u308c\u304c\u6b20\u640d\u3057\u3066\u3044\u308b\u30de\u30a6\u30b9\u3067\u306f\u904e\u5270\u306btype I IFN\u30b7\u30b0\u30ca\u30eb\u304c\u5165\u308b\u3002\u305d\u308c\u304cIP-10\u306e\u904e\u5270\u7523\u751f\u306b\u3064\u306a\u304c\u308a\u3001\u5358\u6838\u7403\uff08\u4e3b\u3068\u3057\u3066CD8\u967d\u6027T\u7d30\u80de=\u30ad\u30e9\u30fcT\u7d30\u80de\uff09\u306e\u76ae\u819a\u6d78\u6f64\u3001\u76ae\u819a\u708e\u3092\u5f15\u304d\u8d77\u3053\u3059\u3001\u3068\u3044\u3046\u3082\u306e\u3067\u3057\u305f\u3002IP-10\u306f\u5143\u3005type II IFN\u3059\u306a\u308f\u3061IFN-\u03b3\u306e\u6a19\u7684\u5206\u5b50\u3068\u3057\u3066\u767a\u898b\u3055\u308c\u305f\u7d4c\u7def\u304c\u3042\u308b\u306e\u3067\u3059\u304c\u3001\u3042\u306e\u30a8\u30f3\u30c9\u30ec\u30b9\u306a\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\u3092\u7d4c\u9a13\u3057\u305f\u79c1\u306b\u3068\u3063\u3066\u306f\u3001IP-10\u306f\u65ad\u7136type I IFN\u306e\u6a19\u7684\u5206\u5b50\u306a\u306e\u3067\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 12pt;\"><strong>\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><span style=\"color: #0000ff;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-67%e3%80%80%e7%9a%ae%e8%86%9a%e7%ad%8b%e7%82%8e1\/\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (67)<\/a><\/span><strong><em><span style=\"color: #0000ff;\">\u2190 Prev\u3000\u3000\u3000\u3000\u3000Next \u2192<\/span><\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-69%e3%80%80%e7%9a%ae%e8%86%9a%e7%ad%8b%e7%82%8e3\/\"><span style=\"color: #0000ff;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (69)<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u307e\u305a\u306f\u3053\u306e\u75be\u60a3\u306b\u7279\u7570\u7684\u306a\u81ea\u5df1\u6297\u4f53\u306e\u767a\u898b\u3067\u3059\u3002\u6176\u5fdc\u5927\u5b66\u306e\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u3001140 kd\u306e\u5927\u304d\u3055\u306e\u6297\u539f\u3068\u53cd\u5fdc\u3059\u308b\u81ea\u5df1\u6297\u4f53\u304c\u60a3\u8005\u306e\u8840\u6e05\u4e2d\u306b\u5b58\u5728\u3059\u308b\u3001\u3068\u3044\u3046\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f(Sato S et al., Arthritis Rh 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