{"id":2252,"date":"2023-07-18T17:21:47","date_gmt":"2023-07-18T08:21:47","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=2252"},"modified":"2023-08-18T17:29:43","modified_gmt":"2023-08-18T08:29:43","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-69%e3%80%80%e7%9a%ae%e8%86%9a%e7%ad%8b%e7%82%8e3","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-69%e3%80%80%e7%9a%ae%e8%86%9a%e7%ad%8b%e7%82%8e3\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (69)\u3000\u76ae\u819a\u7b4b\u708e(3)\u00a0"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\u305d\u308c\u306b\u3057\u3066\u3082\u3001\u305f\u3060\u540c\u3058\u30b0\u30eb\u30fc\u30d7\u306b\u5c5e\u3057\u3066\u3044\u308b\u3060\u3051\u3060\u3063\u305f\u79c1\u306b\u3082\u30c8\u30e9\u30a6\u30de\u3092\u6b8b\u3057\u305fIRF-2\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306e\u89e3\u6790\u304c\u3001\u305d\u306e\u7814\u7a76\u3092\u4e2d\u5fc3\u306b\u884c\u3063\u3066\u3044\u305fH\u7530\u3055\u3093\u306b\u3069\u308c\u307b\u3069\u306e\u30b9\u30c8\u30ec\u30b9\u3092\u3082\u305f\u3089\u3057\u305f\u304b\u306f\u60f3\u50cf\u3092\u7d76\u3057\u307e\u3059\u3002\u7d50\u5c40\u3053\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306f\u3001\u30d2\u30c8\u306e\u76ae\u819a\u708e\u3067\u3042\u308b\u4e7e\u766c\u3068\u306e\u985e\u4f3c\u3092\u63d0\u5531\u3059\u308b\u5f62\u30672000 \u5e74\u306bImmunity\u8a8c\u306b\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002H\u7530\u5148\u751f\u306f\u3053\u308c\u3067\u71c3\u3048\u5c3d\u304d\u305f\u30fb\u30fb\u30fb\u3068\u3044\u3046\u3053\u3068\u306f\u5168\u304f\u306a\u304f\u3001\u7d50\u5c40\u6240\u5c5e\u3057\u3066\u3044\u305f\u88fd\u85ac\u4f1a\u793e\u3092\u9000\u8077\u3057\u3066\u5927\u5b66\u306e\u7814\u7a76\u8005\u3068\u306a\u308a\u3001\u4eca\u306f\u540d\u53e4\u5c4b\u5e02\u7acb\u5927\u5b66\u306e\u6559\u6388\u3092\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u591a\u5206\u6700\u521d\u306f\u5e74\u53ce\u3082\u304b\u306a\u308a\u6e1b\u3063\u305f\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u60f3\u50cf\u3057\u307e\u3059\u304c\u3001\u7814\u7a76\u306e\u6301\u3064\u300c\u602a\u3057\u3044\u9b45\u529b\u300d\u306b\u6355\u307e\u3063\u3066\u3057\u307e\u3063\u305f\u597d\u4f8b\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u4eca\u3067\u3082\u3057\u3070\u3057\u3070H\u7530\u5148\u751f\u306b\u306f\u5b9f\u9a13\u306e\u30a2\u30c9\u30d0\u30a4\u30b9\u3092\u3044\u305f\u3060\u3044\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3055\u3066\u3001\u6297MDA5\u6297\u4f53\u967d\u6027\u76ae\u819a\u7b4b\u708e\u3067IFN-\u03b1\u3068IP-10\u304c\u9ad8\u5024\u306b\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u305f\u77ac\u9593\u306bIFN-\u03b1\u2192IP-10\u3068\u3044\u3046\u6d41\u308c\u3092\u601d\u3044\u51fa\u3057\u305f\u308f\u3051\u3067\u3059\u3002IRF-2KO\u30de\u30a6\u30b9\u306f\u300c\u4e7e\u766c\u300d\u306e\u30e2\u30c7\u30eb\u3068\u3057\u3066\u5831\u544a\u3057\u3066\u3044\u305f\u306e\u3067\u3059\u304c\u3001\u5b9f\u306f\u76ae\u819a\u7b4b\u708e\u306e\u30e2\u30c7\u30eb\u3060\u3063\u305f\u306e\u304b\u3082\u3057\u308c\u306a\u3044\u30fb\u30fb\u30fb\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u6700\u8fd1\u81a0\u539f\u75c5\u306e\u4ee3\u8868\u9078\u624b\u3067\u3042\u308b\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9(systemic lupus erythematosus, SLE)\u3067\u306fI\u578bIFN\u53d7\u5bb9\u4f53\u306b\u5bfe\u3059\u308b\u6297\u4f53\u304c\u6cbb\u7642\u85ac\u3068\u3057\u3066\u8a8d\u53ef\u3055\u308c\u307e\u3057\u305f\u3002SLE\u3067\u306fI\u578bIFN\u304c\u9ad8\u5024\u3067\u3042\u308b\u3053\u3068\u304c\u6614\u304b\u3089\u5831\u544a\u3055\u308c\u3066\u304d\u305f\u306e\u3067\u3059\u3002SLE\u306f\u201dtype I interferonopathy\u201d\u3067\u3042\u308b\u3068\u3044\u3046\u898b\u65b9\u304c\u3067\u304d\u307e\u3059\u3002\u3057\u304b\u3057\u3053\u306e\u76ae\u819a\u7b4b\u708e\u3067\u306fSLE\u306b\u6bd4\u3079\u3066\u3082IFN-\u03b1\u3068IP-10\u306f\u66f4\u306b\u9ad8\u3044\u30ec\u30d9\u30eb\u3067\u3057\u305f\u3002\u3080\u3057\u308d\u3053\u3063\u3061\u306e\u65b9\u304ctype I interferonopathy\u3068\u547c\u3076\u306e\u306b\u76f8\u5fdc\u3057\u3044\u306e\u3067\u306f\u306a\u3044\u304b\uff1f<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u5b9f\u969b\u3001\u3053\u306e\u76ae\u819a\u7b4b\u708e\u306b\u5bfe\u3057\u3066\u306f\u5f37\u529b\u306a\u6cbb\u7642\u3092\u3059\u308b\u3053\u3068\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u901f\u3084\u304b\u306b\u8840\u6e05IP-10\u306e\u30ec\u30d9\u30eb\u306f\u4e0b\u304c\u308a\u307e\u3059\u3057\u3001IFN-\u03b12\u306f\u6e2c\u5b9a\u9650\u754c\u4ee5\u4e0b\u306b\u306a\u308a\u307e\u3059\u3002\u3000\u3000<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">I\u578bIFN\u306e\u7523\u751f\u7d30\u80de\u3068\u3057\u3066\u306f\u5f62\u8cea\u7d30\u80de\u69d8\u6a39\u72b6\u7d30\u80de(plasmacytoid dendritic cells, pDCs)\u304c\u6709\u540d\u3067\u3059\uff08\u4ed6\u306e\u7d30\u80de\u3082\u7523\u751f\u3057\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\uff09\u304c\u3001IP-10\u306b\u3064\u3044\u3066\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u304b\u3002\u76ae\u819a\u7b4b\u708e\u306e\u76ae\u819a\u75c7\u72b6\u3001Gottron\u5fb4\u5019\u3068\u547c\u3070\u308c\u308b\u76ae\u75b9\u304c\u6709\u540d\u3067\u3042\u308a\u3001\u305d\u306e\u90e8\u5206\u3092\u751f\u691c\u3057\u305f\u30b5\u30f3\u30d7\u30eb\u3092\u5229\u7528\u3057\u3066IP-10\u3092\u86cd\u5149\u67d3\u8272\u3059\u308b\u3068\u3001\u5358\u7403\u7cfb\u306e\u30de\u30fc\u30ab\u30fc(CD68)\u3068\u91cd\u306a\u3063\u3066\u67d3\u307e\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u4e00\u65b9CD4\u3084CD8\uff08\u305d\u308c\u305e\u308c\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\u3001\u30ad\u30e9\u30fcT\u7d30\u80de\u306e\u6709\u540d\u306a\u30de\u30fc\u30ab\u30fc\uff09\u3068\u306f\u4e00\u7dd2\u306b\u67d3\u307e\u308a\u307e\u305b\u3093\uff08\u305d\u3082\u305d\u3082CD4\u967d\u6027\u7d30\u80de\u3001CD8\u967d\u6027\u7d30\u80de\u306f\u3053\u306e\u86cd\u5149\u67d3\u8272\u6a19\u672c\u306e\u4e2d\u306b\u307b\u3068\u3093\u3069\u898b\u5f53\u305f\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002IRF-2\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306e\u76ae\u819a\u3068\u306f\u304b\u306a\u308a\u69d8\u5b50\u304c\u7570\u306a\u308a\u307e\u3059\uff09\u3002\u3053\u306e\u7d50\u679c\u304b\u3089\u3001\u5358\u7403\/\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304cI\u578bIFN\u306e\u523a\u6fc0\u3092\u53d7\u3051\u3066IP-10\u3092\u7523\u751f\u3057\u3001\u8d70\u5316\u56e0\u5b50\u3067\u3042\u308bIP-10\u306b\u5bfe\u3057\u3066\u96c6\u307e\u3063\u3066\u304f\u308b\u514d\u75ab\u62c5\u5f53\u7d30\u80de\u306e\u4e3b\u4f53\u3082\u307e\u305f\u5358\u7403\u7cfb\u3067\u3042\u308b\u3001\u3068\u3044\u3046\u30b9\u30c8\u30fc\u30ea\u30fc\u304c\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u30d1\u30e9\u30af\u30e9\u30a4\u30f3\u3068\u547c\u3070\u308c\u308b\u3088\u3046\u306a\u5206\u6ccc\u5f62\u5f0f\u3068\u8003\u3048\u305f\u308f\u3051\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u305f\u3060\u3001\u6700\u521d\u306b\u6295\u7a3f\u3057\u305f\u96d1\u8a8c\u306e\u30ec\u30d3\u30e5\u30fc\u30a2\u30fc\u304b\u3089\u306f\u300cCD68, IP-10\u304c\u540c\u3058\u90e8\u5206\u3067\u67d3\u307e\u3063\u3066\u3044\u3066\u3082\u3001IP-10\u3092\u7523\u751f\u3057\u3066\u3044\u308b\u3068\u306f\u9650\u3089\u306a\u3044\u300d\u3068\u3044\u3046\u30b3\u30e1\u30f3\u30c8\u304c\u3064\u3044\u3066\u30ea\u30b8\u30a7\u30af\u30c8\u3092\u304f\u3089\u3063\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002\u307e\u3042\u78ba\u304b\u306b\u3001IP-10\u3092\u300c\u53d6\u308a\u8fbc\u3093\u3060\u300dCD68\u967d\u6027\u7d30\u80de\u3082\u540c\u3058\u3088\u3046\u306a\u5916\u898b\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u53b3\u3057\u3044\u30fb\u30fb\u30fb<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u305d\u306e\u30b3\u30e1\u30f3\u30c8\u3092\u53d7\u3051\u3066\u3001\u672b\u68a2\u8840\u304b\u3089\u5358\u7403\u3092\u53d6\u308a\u51fa\u3057\u3066\u8a66\u9a13\u7ba1\u5185\u3067I\u578bIFN\u523a\u6fc0\u3092\u884c\u3044\u3001\u7528\u91cf\u4f9d\u5b58\u6027\u306bIP-10\u304c\u57f9\u990a\u4e0a\u6e05\u4e2d\u306b\u7523\u751f\u3055\u308c\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u30c7\u30fc\u30bf\u3092\u3064\u3051\u3066\u5225\u306e\u96d1\u8a8c\u306b\u6295\u7a3f\u3057\u305f\u3089\u4eca\u5ea6\u306fOK\u304c\u51fa\u307e\u3057\u305f\u3002\u307e\u3042\u8f9b\u53e3\u306e\u30b3\u30e1\u30f3\u30c8\u3067\u3082\u3001\u305d\u308c\u306b\u5bfe\u5fdc\u3057\u3088\u3046\u3068\u3059\u308c\u3070\u8ad6\u6587\u306e\u5185\u5bb9\u306f\u901a\u5e38\u6539\u5584\u3059\u308b\u3082\u306e\u3067\u3059\u3002\uff08\u305f\u3060\u3001\u30ec\u30d3\u30e5\u30fc\u30a2\u30fc\u304b\u3089\u7121\u7406\u96e3\u984c\u3092\u3075\u3063\u304b\u3051\u3089\u308c\u3066\u5185\u5bb9\u304c\u60aa\u5316\u3059\u308b\u30b1\u30fc\u30b9\u3082\u3042\u308b\u6c17\u304c\u3057\u307e\u3059\u3002\u3042\u307e\u308a\u9177\u3044\u8981\u6c42\u3067\u3042\u308c\u3070\u53cd\u8ad6\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\uff09<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 12pt;\"><strong>\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-68%e3%80%80%e7%9a%ae%e8%86%9a%e7%ad%8b%e7%82%8e2\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (68)<\/span><\/a><span style=\"color: #0000ff;\"><strong><em>\u2190 Prev\u3000\u3000\u3000\u3000\u3000<span style=\"font-size: 11pt;\">Next \u2192<\/span><\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-70%e3%80%80%e7%9a%ae%e8%86%9a%e7%ad%8b%e7%82%8e4\/\"><span style=\"font-size: 11pt; color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (70)<\/span><\/a><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u305d\u308c\u306b\u3057\u3066\u3082\u3001\u305f\u3060\u540c\u3058\u30b0\u30eb\u30fc\u30d7\u306b\u5c5e\u3057\u3066\u3044\u308b\u3060\u3051\u3060\u3063\u305f\u79c1\u306b\u3082\u30c8\u30e9\u30a6\u30de\u3092\u6b8b\u3057\u305fIRF-2\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306e\u89e3\u6790\u304c\u3001\u305d\u306e\u7814\u7a76\u3092\u4e2d\u5fc3\u306b\u884c\u3063\u3066\u3044\u305fH\u7530\u3055\u3093\u306b\u3069\u308c\u307b\u3069\u306e\u30b9\u30c8\u30ec\u30b9\u3092\u3082\u305f\u3089\u3057\u305f\u304b\u306f\u60f3\u50cf\u3092\u7d76\u3057\u307e\u3059\u3002\u7d50\u5c40\u3053\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306f &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2252","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2252","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=2252"}],"version-history":[{"count":4,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2252\/revisions"}],"predecessor-version":[{"id":2270,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2252\/revisions\/2270"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=2252"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=2252"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=2252"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}