{"id":2267,"date":"2023-08-18T17:27:51","date_gmt":"2023-08-18T08:27:51","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=2267"},"modified":"2023-10-03T15:06:41","modified_gmt":"2023-10-03T06:06:41","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-70%e3%80%80%e7%9a%ae%e8%86%9a%e7%ad%8b%e7%82%8e4","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-70%e3%80%80%e7%9a%ae%e8%86%9a%e7%ad%8b%e7%82%8e4\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (70)\u3000\u76ae\u819a\u7b4b\u708e(4)\u00a0"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\u3055\u3066\u3001\u3053\u306eIP-10\u304c\u6297MDA5\u6297\u4f53\u967d\u6027\u76ae\u819a\u7b4b\u708e\u306e\u75c5\u52e2\u3092\u793a\u3059\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308a\u3048\u308b\u306e\u304b\uff1f\u305d\u3053\u306f\u4eca\u5f8c\u306e\u8ab2\u984c\u3067\u3059\u3002\u79c1\u305f\u3061\u304c\u4eca\u53c2\u8003\u306b\u3057\u3066\u3044\u308b\u691c\u67fb\u5024\u306f\u8840\u6e05\u30d5\u30a7\u30ea\u30c1\u30f3\u3067\u3059\u3002\u3053\u308c\u306f\u5f53\u9662\u3067\u306f\u305d\u306e\u65e5\u306e\u5185\u306b\u7d50\u679c\u304c\u51fa\u308b\u305f\u3081\u3001\u3068\u3066\u3082\u6709\u7528\u3067\u3059\u3002\u305f\u3060\u3001\u4e00\u90e8\u306e\u60a3\u8005\u3067\u306f\u9577\u671f\u9593\u306a\u304b\u306a\u304b\u5024\u304c\u4e0b\u304c\u3089\u305a\u3001\u3053\u308c\u3092\u6307\u6a19\u306b\u6cbb\u7642\u3092\u3057\u3066\u3044\u308b\u3068\u300c\u5f37\u3044\u6cbb\u7642\u3092\u3057\u3059\u304e(=overtreatment)\u300d\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3001\u3068\u3044\u3046\u61f8\u5ff5\u3092\u611f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3057\u305f\u3002IP-10\u306e\u7d4c\u904e\u3092\u898b\u308b\u3068\u3001\u3042\u307e\u308a\u306b\u3082\u901f\u3084\u304b\u306b\u4e0b\u304c\u3063\u3066\u3044\u308b\u306e\u3067\u3001\u3053\u308c\u3067\u6cb9\u65ad\u3059\u308b\u3068\u9006\u306b\u6cbb\u7642\u304c\u8db3\u308a\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u7d4c\u9a13\u306e\u84c4\u7a4d\u304c\u5fc5\u8981\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u30d5\u30a7\u30ea\u30c1\u30f3\u306b\u95a2\u3057\u3066\u306f\u3001\u4ee5\u524d\u8a71\u306b\u51fa\u3057\u305f\u6210\u4ebaStill\u75c5\u3067\u975e\u5e38\u306b\u9ad8\u5024\u306b\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u75be\u60a3\u3067\u306f\u8840\u6e05\u306eIL-18\u3082\u7570\u5e38\u9ad8\u5024\u306b\u306a\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001\u6297MDA5\u6297\u4f53\u967d\u6027\u76ae\u819a\u7b4b\u708e\u306e\u60a3\u8005\u3067\u3082\u30d5\u30a7\u30ea\u30c1\u30f3\u3001IL-18\u5171\u306b\u9ad8\u3044\u306e\u3067\u3059\u304c\u3001\u6210\u4ebaStill\u75c5\u307b\u3069\u306e\u6975\u7aef\u306a\u9ad8\u5024\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u306e\u8fba\u308a\u304c\u3069\u306e\u3088\u3046\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u306e\u304b\u3082\u5927\u5909\u8208\u5473\u6df1\u3044\u6240\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u4eca\u56de\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u643a\u308f\u308b\u524d\u306f\u6c17\u3065\u3044\u3066\u3044\u306a\u304b\u3063\u305f\u306e\u3067\u3059\u304c\u3001IP-10\u306f\u5b9f\u969b\u306bI\u578bIFN\u30b7\u30b0\u30ca\u30eb\u306e\u7a0b\u5ea6\u3092\u793a\u3059\u30de\u30fc\u30ab\u30fc\u306e\uff11\u3064\u3068\u3057\u3066\u8ad6\u6587\u3067\u3082\u4f7f\u308f\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u4f8b\u3048\u3070\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\u6cbb\u7642\u85ac\u30a2\u30cb\u30d5\u30ed\u30eb\u30de\u30d6\u306e\u52b9\u679c\u3092\u8abf\u3079\u308b\u969b\u306b\u3001IP-10\u306e\u30bf\u30f3\u30d1\u30af\u6fc3\u5ea6\u304c\uff29\u578bIFN\u306e\u4e0b\u6d41\u3067\u8a98\u5c0e\u3055\u308c\u308b\u5206\u5b50\uff08\u306e\uff11\u3064\uff09\u3068\u3057\u3066\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059(Smith et al., Sci Rep. 2020)\u3002\u3068\u3044\u3046\u308f\u3051\u3067\u3001II\u578bIFN(=IFN-\u03b3)\u2192IP-10\u7d4c\u8def\u3068\u540c\u69d8\u306b\u3001I\u578bIFN\u2192IP-10\u306e\u7d4c\u8def\u3082\u65e2\u306b\u78ba\u7acb\u3057\u3066\u3044\u305f\u8a33\u3067\u3059\u304c\u3001\u3053\u308c\u304c\u6297MDA5\u6297\u4f53\u967d\u6027\u76ae\u819a\u7b4b\u708e\u306e\u6210\u308a\u7acb\u3061\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\uff1f\u3068\u3044\u3046\u8003\u3048\u306f\u982d\u304b\u3089\u96e2\u308c\u307e\u305b\u3093\u3002\u305d\u3082\u305d\u3082\u3001\u6297MDA5\u6297\u4f53\u306e\u5bfe\u5fdc\u6297\u539f\u3067\u3042\u308bMDA5\u3068\u3044\u3046\u5206\u5b50\u306f\u300c\u7d30\u80de\u306b\u30a6\u30a4\u30eb\u30b9\u304c\u4fb5\u5165\u3057\u305f\u5834\u5408\u306b\u305d\u308c\u3092\u611f\u77e5\u3057\u3066\u3001\u7d30\u80de\u306bI\u578bIFN\u3092\u4f5c\u3089\u305b\u308b\u300d\u3068\u3044\u3046\u50cd\u304d\u3092\u6301\u3063\u305f\u5206\u5b50\u306a\u306e\u3067\u3059\u3002\u300cI\u578bIFN\u304c\u9ad8\u7523\u751f\u3055\u308c\u308b\u75be\u60a3\u306e\u81ea\u5df1\u6297\u539f\u304cI\u578bIFN\u7523\u751f\u306e\u5f15\u304d\u91d1\u3068\u306a\u308b\u5206\u5b50\u3067\u3042\u308b\u300d\u30fb\u30fb\u30fb\u3068\u3066\u3082\u5358\u306a\u308b\u5076\u7136\u306e\u4e00\u81f4\u3068\u306f\u601d\u3048\u307e\u305b\u3093\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3057\u304b\u3057\u95a2\u308f\u3063\u3066\u3044\u308b\u3068\u3057\u305f\u3089\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u3067\u3057\u3087\u3046\u304b\u3002\u4ee5\u524d\u4eac\u5927\u306e\u9ad8\u540d\u306a\u5148\u751f\u304c\u3053\u306e\u6297\u4f53\u306e\u3053\u3068\u3092\u30bb\u30df\u30ca\u30fc\u3067\u304a\u8a71\u3057\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u6297\u4f53\u81ea\u4f53\u304c\u6297MDA5\u6297\u4f53\u967d\u6027\u76ae\u819a\u7b4b\u708e\u3092\u60aa\u5316\u3055\u305b\u308b\u6a5f\u80fd\u3092\u6301\u3064\u3001\u3068\u306e\u3053\u3068\u3067\u3057\u305f\uff08\u3064\u307e\u308a\u5358\u306a\u308b\u75c5\u6c17\u306e\u300c\u7d50\u679c\u300d\u3067\u306f\u306a\u304f\u3001\u3053\u306e\u6297\u4f53\u81ea\u4f53\u304c\u75c5\u6c17\u306e\u300c\u539f\u56e0\u300d\u3068\u3082\u306a\u308b\u3001\u3068\u3044\u3046\u3053\u3068\uff09\u3002\u3057\u304b\u3057\u3001\u6297\u4f53\u304c\u7d30\u80de\u306e\u4e2d\u306b\u4fb5\u5165\u3057\u3066\u3001\u7d30\u80de\u306e\u4e2d\uff08\u7d30\u80de\u8cea\uff09\u306b\u3042\u308bMDA5\u3068\u7d50\u5408\u3059\u308b\u306a\u3069\u3068\u3044\u3046\u3053\u3068\u304c\u3042\u308b\u306e\u3060\u308d\u3046\u304b\uff1f\u3068\u5f53\u6642\u4e0d\u601d\u8b70\u306b\u601d\u3063\u305f\u3053\u3068\u3092\u899a\u3048\u3066\u3044\u307e\u3059\u3002\u6297\u4f53\u304c\u7d30\u80de\u306b\u53d6\u308a\u8fbc\u307e\u308c\u308b\u3053\u3068\u306f\u3042\u308b\u306e\u3067\u3059\u304c\u3001\u305d\u308c\u306f\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u3068\u3044\u3046\u5c0f\u80de\u306e\u5185\u90e8\u306b\u9589\u3058\u8fbc\u3081\u3089\u308c\u305f\u5f62\u3067\u53d6\u308a\u8fbc\u307e\u308c\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u7d30\u80de\u8cea\u5185\u306e\u30bf\u30f3\u30d1\u30af\uff08\u3053\u3053\u3067\u306fMDA5\uff09\u3068\u306f\u76f4\u63a5\u63a5\u89e6\u3057\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u305f\u3060\u3001\u5f37\u3044\u708e\u75c7\u306b\u3088\u3063\u3066\u7d30\u80de\u304c\u58ca\u6b7b\u306b\u9665\u3063\u305f\u3068\u304d\u3001\u7d30\u80de\u5185\u306eMDA5\u304c\u5916\u306b\u653e\u51fa\u3055\u308c\u308b\u3053\u3068\u306f\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002MDA5\u306fRNA\u306e\u30bb\u30f3\u30b5\u30fc\u3067\u3082\u3042\u308b\u305f\u3081MDA5\u3068RNA\u3068\u304c\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u304c\u81ea\u5df1\u6297\u4f53\u3068\u7d50\u5408\u3057\u3066\u3001\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u5185\u306b\u53d6\u308a\u8fbc\u307e\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u305d\u3046\u3067\u3059\u3002\u305d\u306e\u3088\u3046\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u30bf\u30f3\u30d1\u30af-RNA\u306e\u8907\u5408\u4f53\u304c\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u5185\u306eToll like receptor (TLR)\u3068\u7d50\u5408\u3059\u308c\u3070I\u578bIFN\u306e\u7523\u751f\u306f\u5f37\u304f\u523a\u6fc0\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 12pt;\"><strong>\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-69%e3%80%80%e7%9a%ae%e8%86%9a%e7%ad%8b%e7%82%8e3\/\"><span style=\"font-size: 11pt;\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (69<\/span><\/span><\/a><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-69%e3%80%80%e7%9a%ae%e8%86%9a%e7%ad%8b%e7%82%8e3\/\"><span style=\"color: #000080;\">)<\/span><\/a><strong><em><span style=\"color: #0000ff;\">\u2190 Prev\u3000\u3000\u3000\u3000\u3000<span style=\"font-size: 11pt;\">Next \u2192<\/span><\/span><\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-71%e3%80%80%e7%9a%ae%e8%86%9a%e7%ad%8b%e7%82%8e5\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (71)<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u3055\u3066\u3001\u3053\u306eIP-10\u304c\u6297MDA5\u6297\u4f53\u967d\u6027\u76ae\u819a\u7b4b\u708e\u306e\u75c5\u52e2\u3092\u793a\u3059\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308a\u3048\u308b\u306e\u304b\uff1f\u305d\u3053\u306f\u4eca\u5f8c\u306e\u8ab2\u984c\u3067\u3059\u3002\u79c1\u305f\u3061\u304c\u4eca\u53c2\u8003\u306b\u3057\u3066\u3044\u308b\u691c\u67fb\u5024\u306f\u8840\u6e05\u30d5\u30a7\u30ea\u30c1\u30f3\u3067\u3059\u3002\u3053\u308c\u306f\u5f53\u9662\u3067\u306f\u305d\u306e\u65e5\u306e\u5185\u306b\u7d50\u679c\u304c\u51fa\u308b\u305f\u3081\u3001\u3068\u3066\u3082\u6709\u7528\u3067\u3059\u3002\u305f\u3060 &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2267","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2267","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=2267"}],"version-history":[{"count":3,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2267\/revisions"}],"predecessor-version":[{"id":2288,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2267\/revisions\/2288"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=2267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=2267"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=2267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}