{"id":2314,"date":"2024-01-04T17:29:47","date_gmt":"2024-01-04T08:29:47","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=2314"},"modified":"2024-01-05T11:39:34","modified_gmt":"2024-01-05T02:39:34","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-75%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%881","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-75%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%881\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (75)\u3000Nfatc1 short form\u30d7\u30ed\u30b8\u30a7\u30af\u30c8(1)"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\u3053\u308c\u306f\u4ee5\u524d\u66f8\u3044\u305f\u3053\u3068\u306e\u7e70\u308a\u8fd4\u3057\u306b\u306a\u308b\u90e8\u5206\u304c\u591a\u3044\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u9ad8\u67f3\u5148\u751f\u304c\u7834\u9aa8\u7d30\u80de\u306e\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u306b\u57fa\u3065\u3044\u3066\u8ee2\u5199\u56e0\u5b50Nfatc1\u304c\u5206\u5316\u306e\u904e\u7a0b\u3067\u8457\u5897\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3001\u5831\u544a\u3057\u305f\u306e\u304c2002\u5e74\u306e\u3053\u3068\u3067\u3059(Takayanagi et al., Dev Cell)\u3002\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u306e\u5a01\u529b\u304c\u5f37\u304f\u5370\u8c61\u306b\u6b8b\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001Nfatc1\u306e\u5897\u3048\u65b9\u306e\u30ec\u30d9\u30eb\u304c\u51c4\u307e\u3058\u304f\u3001\u6570\u5341\u500d\uff08\u5b9f\u9a13\u306b\u3088\u3063\u3066\u306f\u6570\u767e\u500d\uff09\u3068\u3044\u3046\u5897\u3048\u65b9\u3067\u3057\u305f\u3002\u3053\u308c\u3060\u3051\u5897\u3048\u308b\u306e\u3060\u304b\u3089\u5f53\u7136\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u306f\u305a\u3001\u3068\u601d\u3046\u306e\u304c\u4eba\u60c5\uff08\uff1f\uff09\u3067\u3059\u3002\u3057\u304b\u3057Nfatc1\u306e\u30ce\u30c3\u30af\u30a2\u30a6\u30c8(KO)\u30de\u30a6\u30b9\u306f\u80ce\u6027\u81f4\u6b7b\u3067\u3042\u3063\u305f\u305f\u3081\u3001\u751f\u4f53\u30ec\u30d9\u30eb\u3067Nfatc1\u306e\u5fc5\u9808\u6027\u3092\u8a3c\u660e\u3059\u308b\u3053\u3068\u306f\u5bb9\u6613\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u79c1\u306e\u76df\u53cb\uff08\uff1d\u304f\u3055\u308c\u7e01\uff09\u3060\u3063\u305f\u671d\u9727\u5148\u751f\u304c\u305d\u306e\u58c1\u3092\u4e57\u308a\u8d8a\u3048\u308b\u3079\u304f\u3001\u9ad8\u67f3\u7814\uff08\u5f53\u6642\u533b\u79d1\u6b6f\u79d1\u5927\u5b66\uff09\u3067Nfatc1KO(-\/-)\u304a\u3088\u3073\u30d8\u30c6\u30ed(+\/-)\u30de\u30a6\u30b9\u306e\u9020\u8840\u5e79\u7d30\u80de\u3092\u3001\u7834\u9aa8\u7d30\u80de\u3092\u6301\u305f\u305a\u5927\u7406\u77f3\u9aa8\u75c5\u3092\u5448\u3059\u308bFos KO\u30de\u30a6\u30b9\u306b\u79fb\u5165\u3059\u308b\u3068\u3044\u3046\u5b9f\u9a13\u3067\u3001\u300cNfatc1<sup>+\/-<\/sup>\u7d30\u80de\u3092\u79fb\u5165\u3055\u308c\u305f\u30de\u30a6\u30b9\u306f\u7834\u9aa8\u7d30\u80de\u304c\u5206\u5316\u3057\u3066\u5927\u7406\u77f3\u9aa8\u75c5\u306b\u306a\u3089\u306a\u304f\u306a\u308b\uff08\u30ec\u30b9\u30ad\u30e5\u30fc\u3055\u308c\u308b\uff09\u304c\u3001Nfatc1<sup>-\/-<\/sup>\u7d30\u80de\u3092\u79fb\u5165\u3055\u308c\u305f\u30de\u30a6\u30b9\u306f\u7834\u9aa8\u7d30\u80de\u304c\u5206\u5316\u3067\u304d\u306a\u3044\u305f\u3081\u306b\u5927\u7406\u77f3\u9aa8\u75c5\u304c\u6cbb\u7652\u3057\u306a\u3044\uff08\u30ec\u30b9\u30ad\u30e5\u30fc\u3055\u308c\u306a\u3044\uff09\u300d\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f(J Exp Med 2005)\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3053\u306e\u6642\u3068\u3066\u3082\u9762\u767d\u3044\u73fe\u8c61\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002Nfatc1\u306f\u30bf\u30f3\u30d1\u30af\u30ec\u30d9\u30eb\u3067\u306f\u5c11\u306a\u304f\u3068\u3082\uff13\u3064\u306e\u9577\u3055\u306e\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u304c\u3042\u308a\u305d\u3046\u306a\u306e\u3067\u3059\u3002\u5927\u91cf\u306b\u8a98\u5c0e\u3055\u308c\u3066\u3044\u308bNfatc1\u306f\u4e00\u756a\u77ed\u3044\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u3067\u3057\u305f\u3002RANKL\u3067\u523a\u6fc0\u3055\u308c\u308b\u524d\u306f\u9577\u3044\u3082\u306e\u3068\u4e2d\u9593\u306e\u9577\u3055\u306e\u3082\u306e\u304c\u691c\u51fa\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306f\u5b9f\u306fT\u7d30\u80de\u3067\u3059\u3067\u306b\u898b\u3064\u304b\u3063\u3066\u3044\u305f\u73fe\u8c61\u3067\u30012005\u5e74\u306e\u8ad6\u6587\u306e\u5171\u8457\u8005\u3067\u3082\u3042\u308bEdgar Serfling\u535a\u58eb\u304c\u8a73\u7d30\u306b\u89e3\u6790\u3057\u3066\u3044\u307e\u3057\u305f(Chuvpilo et al., Immunity 2002)\u3002\u305d\u3082\u305d\u3082NFAT\u30d5\u30a1\u30df\u30ea\u30fc\u8ee2\u5199\u56e0\u5b50\u306fT\u7d30\u80de\u3067\u898b\u3064\u304b\u3063\u305f\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308a\u3001\u305d\u306e\u540d\u3082\u201dNuclear factor of activated T-cells\u201d\u3067\u3059\uff08\u76f4\u8a33\u3059\u308b\u3068\u300c\u6d3b\u6027\u5316T\u7d30\u80de\u306e\u6838\u5185\u56e0\u5b50\u300d\u304f\u3089\u3044\u306e\u610f\u5473\uff09\u3002\u305d\u3057\u3066\u3053\u306eNfatc1\u306b\u306f\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u304c\uff12\u3064\u3042\u308a\u3001\u3075\u3060\u3093\u306fP2\u3068\u3044\u3046\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u304c\u50cd\u3044\u3066\u3001\uff12\u756a\u76ee\u306eexon\u304b\u3089\u8ee2\u5199\u304c\u59cb\u307e\u308a\u3001\u4e0a\u8a18\u306e\u9577\u3044\u30bf\u30f3\u30d1\u30af\u3084\u4e2d\u9593\u306e\u9577\u3055\u306e\u30bf\u30f3\u30d1\u30af\u304c\u3067\u304d\u307e\u3059\u3002\u3057\u304b\u3057T\u7d30\u80de\u304c\u6d3b\u6027\u5316\u3057\u305f\u308a\u3001\u7834\u9aa8\u7d30\u80de\u524d\u99c6\u7d30\u80de\u304cRANKL\u306b\u3088\u308b\u523a\u6fc0\u3092\u53d7\u3051\u305f\u308a\u3059\u308b\u3068P1\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u304c\u6d3b\u6027\u5316\u3057\u3066\uff11\u756a\u76ee\u306eexon\u304b\u3089\u8ee2\u5199\u304c\u958b\u59cb\u3055\u308c\u307e\u3059\u3002\u3064\u307e\u308a\u540c\u3058Nfatc1\u3068\u8a00\u3063\u3066\u3082\u982d\u306e\u90e8\u5206\u306f\u7570\u306a\u308a\u307e\u3059\u3002\u305d\u308c\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u5c3b\u5c3e\u306e\u90e8\u5206\u3082\u5b9f\u306f\u77ed\u304f\u306a\u308a\u307e\u3059\u3002\u907a\u4f1d\u5b50\uff08DNA\uff09\u306f\u7d10\u306e\u3088\u3046\u306a\u69cb\u9020\u306e\u30a4\u30e1\u30fc\u30b8\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u5b9f\u969b\u306b\u306f\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306f\u5148\u982d\u90e8\u5206\u3060\u3051\u3067\u306f\u306a\u304f\u5c3b\u5c3e\u306e\u90e8\u5206\u306e\u8ee2\u5199\u3082\u5236\u5fa1\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002DNA\u306e\uff13\u6b21\u5143\u69cb\u9020\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u5f37\u304f\u793a\u5506\u3055\u308c\u307e\u3059\u3002\u3044\u305a\u308c\u306b\u3057\u308d\u305d\u306e\u7d50\u679c\u3001\u6700\u3082\u77ed\u3044Nfatc1\u306e\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u304c\u7523\u751f\u3055\u308c\u307e\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><strong><span style=\"font-size: 12pt;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><span style=\"color: #000080;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-74%e3%80%80%e7%a0%94%e7%a9%b6%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e9%9b%91%e6%84%9f3\/\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (74)<\/a><\/span><strong><em><span style=\"color: #0000ff;\">\u2190 Prev\u3000\u3000\u3000<\/span>\u3000\u3000<span style=\"color: #0000ff;\">Next \u2192<\/span><\/em><\/strong><span style=\"color: #0000ff;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-76%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%882\/\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081(76)<\/a><\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"\u3053\u308c\u306f\u4ee5\u524d\u66f8\u3044\u305f\u3053\u3068\u306e\u7e70\u308a\u8fd4\u3057\u306b\u306a\u308b\u90e8\u5206\u304c\u591a\u3044\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u9ad8\u67f3\u5148\u751f\u304c\u7834\u9aa8\u7d30\u80de\u306e\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u306b\u57fa\u3065\u3044\u3066\u8ee2\u5199\u56e0\u5b50Nfatc1\u304c\u5206\u5316\u306e\u904e\u7a0b\u3067\u8457\u5897\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3001\u5831\u544a\u3057\u305f\u306e\u304c2002\u5e74\u306e\u3053\u3068\u3067\u3059(Takayana &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2314","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2314","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=2314"}],"version-history":[{"count":4,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2314\/revisions"}],"predecessor-version":[{"id":2322,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2314\/revisions\/2322"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=2314"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=2314"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=2314"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}