{"id":2358,"date":"2024-03-15T12:25:26","date_gmt":"2024-03-15T03:25:26","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=2358"},"modified":"2024-03-15T18:24:26","modified_gmt":"2024-03-15T09:24:26","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-83%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%889%e3%80%80%ef%bc%88","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-83%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%889%e3%80%80%ef%bc%88\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (83)\u3000Nfatc1 short form\u30d7\u30ed\u30b8\u30a7\u30af\u30c8(9)\u3000\uff08\u518d\u5ea6\uff09\u89e3\u6790\u958b\u59cb"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\u65b0\u3057\u3044\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\uff08\u30d8\u30c6\u30ed\uff09\u3068\u91ce\u751f\u578b(wild type, WT)\u306e\u30de\u30a6\u30b9\u3092\u4ea4\u914d\u3059\u308b\u3068\u3001\u4ed4\u306f1:1\u306e\u5272\u5408\u3067WT\u3068\u30d8\u30c6\u30ed\u30de\u30a6\u30b9\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u60f3\u5b9a\u901a\u308a\u3067\u3059\u3002\u305d\u3057\u3066\u30d8\u30c6\u30ed\u30de\u30a6\u30b9\u540c\u58eb\u3092\u4ea4\u914d\u3059\u308b\u3068\u305d\u306e\u4ed4\u306f\u30fb\u30fb\u30fb1:2\u3067WT\u3068\u30d8\u30c6\u30ed\u30de\u30a6\u30b9\u3067\u3059\u3002\u3053\u308c\u306f\u30fb\u30fb\u30fb\u524d\u56de\u306e\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3068\u660e\u3089\u304b\u306b\u7570\u306a\u308a\u307e\u3059\u3002\u30ce\u30c3\u30af\u30a2\u30a6\u30c8(KO)\u30de\u30a6\u30b9\u304c\u80ce\u6027\u81f4\u6b7b\u3067\u3042\u308b\u3053\u3068\u304c\u5f37\u304f\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; 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color: #000080;\">\u901a\u5e38\u306e\u5b9f\u9a13\u306f\u3053\u3046\u3067\u3059\u3002(1)\u809d\u81d3\u306e\u7d30\u80de\u3092M-CSF\u306e\u5b58\u5728\u5316\u3067\u57f9\u990a\u3059\u308b-&gt;(2)\u3059\u308b\u3068\u5358\u7403\u7cfb\u306e\u7d30\u80de\u3060\u3051\u304c\u751f\u304d\u6b8b\u308b-&gt;(3)\u305d\u3053\u306bM-CSF+RANKL\u3092\u52a0\u3048\u308b\u3068TRAP\u967d\u6027\u7834\u9aa8\u7d30\u80de\u304c\u5206\u5316\u3059\u308b\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">(2)\u306e\u30b9\u30c6\u30c3\u30d7\u304c\u4e0a\u624b\u304f\u884c\u3063\u3066\u3044\u306a\u3044\u3088\u3046\u3067\u3001\u30b9\u30c6\u30c3\u30d7(3)\u306e\u691c\u8a3c\u304c\u3067\u304d\u3066\u3044\u307e\u305b\u3093\u3002\u809d\u81d3\u306b\u5358\u7403\u7cfb\u306e\u300c\u524d\u99c6\u7d30\u80de\u300d\u304c\u5b58\u5728\u3057\u3066\u3044\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u306f\u305f\u3068\u56f0\u308a\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">T\u7d30\u80de\u3084B\u7d30\u80de\u3067\u3042\u308c\u3070\u3053\u306e\u3088\u3046\u306a\u5834\u5408\u306e\u89e3\u6c7a\u7b56\u306f\u3001KO\u80ce\u4ed4\u7531\u6765\u306e\u9020\u8840\u5e79\u7d30\u80de\u3092Rag2KO\u306a\u3069\u306eT, B\u7d30\u80de\u306e\u3044\u306a\u3044\u30de\u30a6\u30b9\u306b\u79fb\u690d\u3059\u308b\u3068\u3044\u3046\u3084\u308a\u65b9\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u79c1\u81ea\u8eab\u6614c-Maf KO\u30de\u30a6\u30b9\u306e\u89e3\u6790\u306a\u3069\u3067\u3084\u3063\u305f\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><strong><span style=\"font-size: 12pt;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-82%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%888%e3%80%80%e8%b3%aa\/\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (82)<\/a><\/span><strong><em><span style=\"color: #0000ff;\">\u2190 Prev\u3000\u3000\u3000\u3000\u3000<\/span><\/em><\/strong><span style=\"font-size: 11pt;\"><em><strong><span style=\"color: #0000ff;\">Next \u2192<\/span><\/strong><\/em><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-84%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%8810%e3%80%80%e8%87%b4\/\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081(84)<\/a><\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u65b0\u3057\u3044\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\uff08\u30d8\u30c6\u30ed\uff09\u3068\u91ce\u751f\u578b(wild type, WT)\u306e\u30de\u30a6\u30b9\u3092\u4ea4\u914d\u3059\u308b\u3068\u3001\u4ed4\u306f1:1\u306e\u5272\u5408\u3067WT\u3068\u30d8\u30c6\u30ed\u30de\u30a6\u30b9\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u60f3\u5b9a\u901a\u308a\u3067\u3059\u3002\u305d\u3057\u3066\u30d8\u30c6\u30ed\u30de\u30a6\u30b9\u540c\u58eb\u3092\u4ea4\u914d\u3059\u308b\u3068\u305d\u306e\u4ed4\u306f\u30fb\u30fb\u30fb1:2\u3067W &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2358","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=2358"}],"version-history":[{"count":4,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2358\/revisions"}],"predecessor-version":[{"id":2367,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2358\/revisions\/2367"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=2358"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=2358"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=2358"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}