{"id":2404,"date":"2024-05-13T16:30:08","date_gmt":"2024-05-13T07:30:08","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=2404"},"modified":"2024-05-27T09:08:22","modified_gmt":"2024-05-27T00:08:22","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-87%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%8813%e3%80%80nfatc1","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-87%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%8813%e3%80%80nfatc1\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (87)\u3000Nfatc1 short form\u30d7\u30ed\u30b8\u30a7\u30af\u30c8(13)\u3000Nfatc1\u8a98\u5c0e\u306e\u30d6\u30ec\u30fc\u30ad\u5f79\u5019\u88dc"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\u533b\u5c40\u306b\u306f\u96d1\u8a8c\u306e\u898b\u672c\u8a8c\u304c\u5c4a\u304f\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3042\u308b\u65e5\u4f55\u6c17\u306a\u304f\u300c\u708e\u75c7\u3068\u514d\u75ab\u300d\u8a8c(2020\u5e74\uff19\u6708\u53f7)\u3092\u3081\u304f\u3063\u3066\u3044\u305f\u3068\u3053\u308d\u3001\u300c\u30c0\u30a6\u30f3\u75c7\u56e0\u5b50DSCR-1\u3068\u75c5\u7684\u8840\u7ba1\u65b0\u751f\u300d\u3068\u3044\u3046\u30bf\u30a4\u30c8\u30eb\u306e\u7dcf\u8aac\u304c\u76ee\u306b\u6b62\u307e\u308a\u307e\u3057\u305f\u3002\u7834\u9aa8\u7d30\u80de\u3068\u306f\u4e00\u898b\u306a\u3093\u306e\u95a2\u4fc2\u3082\u306a\u3044\u306e\u3067\u3059\u304c\u3001NFAT\u7d4c\u8def\u3068\u3044\u3046\u30ad\u30fc\u30ef\u30fc\u30c9\u304c\u66f8\u3044\u3066\u3042\u3063\u305f\u306e\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3092\u523a\u6fc0\u3059\u308bVEGF\u3092\u6dfb\u52a0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\uff11\u6642\u9593\u4ee5\u5185\u306b\u8a98\u5c0e\u3055\u308c\u308b\u907a\u4f1d\u5b50\u306f\u307b\u3068\u3093\u3069\u304cNFAT\u306e\u6d3b\u6027\u5316\u306b\u4f34\u3046\u3082\u306e\u3060\u305d\u3046\u3067\u3059\u3002\u305d\u3057\u3066\uff11\u6642\u9593\u304b\u3089\uff14\u6642\u9593\u306b\u304b\u3051\u3066\u6700\u3082NFAT\u4f9d\u5b58\u7684\u306b\u8a98\u5c0e\u3055\u308c\u308b\u306e\u304cDSCR-1\u3067\u3042\u308a\u3001\u3053\u306e\u5206\u5b50\u306e\u30c9\u30e1\u30a4\u30f3\u306f\u5f37\u3044\u300c\u30ab\u30eb\u30b7\u30cb\u30e5\u30fc\u30ea\u30f3\u8131\u30ea\u30f3\u9178\u5316\u9175\u7d20\u963b\u5bb3\u6d3b\u6027\u300d\u3092\u6709\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u306e\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u30ab\u30eb\u30b7\u30cb\u30e5\u30fc\u30ea\u30f3(CN)\u306f\u30ab\u30eb\u30b7\u30a6\u30e0(Ca)\u4f9d\u5b58\u6027\u306b\u50cd\u304f\u8131\u30ea\u30f3\u9178\u5316\u9175\u7d20\u3067\u3001NFAT\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u306f\u7d30\u80de\u8cea\u3067CN\u306b\u3088\u308a\u8131\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b\u3068\u6d3b\u6027\u5316\u3057\u3066\u6838\u306b\u79fb\u884c\u3057\u3001\u8ee2\u5199\u56e0\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002\u5b9f\u969bCN\u963b\u5bb3\u85ac\u3067\u3042\u308b\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3A\u3084\u30bf\u30af\u30ed\u30ea\u30e0\u30b9\u306fNFAT\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u514d\u75ab\u6291\u5236\u85ac\u3068\u3057\u3066\u50cd\u304f\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u81e8\u5e8a\u5fdc\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3053\u306eDSCR-1\u306fNFAT\u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\u3001NFAT\u306e\u6a5f\u80fd\u3092\u6291\u5236\u3059\u308b\u5206\u5b50\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3044\u304b\u306b\u3082\u79c1\u304c\u63a2\u3057\u6c42\u3081\u3066\u304d\u305f\u30d6\u30ec\u30fc\u30ad\u5f79\u3068\u3057\u3066\u30d4\u30c3\u30bf\u30ea\u3067\u3059\u3002\u4f55\u3068\u3001\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u306a\u3069\u3084\u308b\u524d\u306b\u3082\u3046\u7b54\u3048\u304c\u51fa\u3066\u3057\u307e\u3063\u305f\u30fb\u30fb\u30fb\uff08\u306e\u304b\uff1f\uff09<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">\u3057\u304b\u3057\u9a5a\u304d\u306f\u305d\u308c\u3060\u3051\u306b\u7559\u307e\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u66f4\u306b\u8aad\u307f\u9032\u3081\u308b\u3068\u3001\u3053\u306eDSCR-1\u306f\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u304c\uff12\u3064\u3042\u308a\u3001\u300c\u5148\u982d\u306b\u76f8\u5f53\u3059\u308b\u30a8\u30af\u30bd\u30f3\u304c\u7570\u306a\u308b\u3053\u3068\u3067\u9577\u3044\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0(DSCR-1L)\u3068\u77ed\u3044\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0(DSCR-1s)\u304c\u5b58\u5728\u3059\u308b\u300d\u305d\u3046\u306a\u306e\u3067\u3059\u3002\u5185\u76ae\u7d30\u80de\u3067VEGF\u523a\u6fc0\u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\u308b\u306e\u306fDSCR-1s\u306e\u65b9\u3060\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u306fRANKL\u523a\u6fc0\u306b\u3088\u3063\u3066short form\u304c\u7279\u7570\u7684\u306b\u8a98\u5c0e\u3055\u308c\u308bNfatc1\u3068\u305d\u3063\u304f\u308a\u3067\u3059\u3002\u79c1\u306f\u6065\u305a\u304b\u3057\u306a\u304c\u3089\u3053\u306e\u3088\u3046\u306a\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u306e\u4f5c\u3089\u308c\u65b9\u3092\u3001\u305d\u308c\u307e\u3067Nfatc1\u4ee5\u5916\u306b\u77e5\u3089\u306a\u304b\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u7d50\u69cb\u3053\u306e\u30d1\u30bf\u30fc\u30f3\u3067\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u304c\u3067\u304d\u308b\u30b1\u30fc\u30b9\u306f\u591a\u3044\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u30d2\u30c8\u306e\u907a\u4f1d\u5b50\u306e\u6570\u306f\uff12\u4e07\u304f\u3089\u3044\u3068\u8a00\u308f\u308c\u307e\u3059\u3002\u610f\u5916\u306b\u5c11\u306a\u304f\u611f\u3058\u3089\u308c\u307e\u3059\u304c\u3001\u3053\u306e\u3088\u3046\u306b\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u3092\u6301\u3064\u907a\u4f1d\u5b50\u3082\u3042\u308a\u307e\u3059\u3057\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u306a\u3044\u300c\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u300d\u3082\u8a08\u7b97\u306b\u3044\u308c\u308b\u3068\u7d30\u80de\u3092\u5f62\u4f5c\u308b\u5206\u5b50\u306e\u8907\u96d1\u6027\u306f\u683c\u6bb5\u306b\u4e0a\u304c\u308b\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><strong><span style=\"font-size: 12pt;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-86%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%8812%e3%80%80%e9%80%a0\/\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (86)<\/a><\/span><strong><em><span style=\"color: #0000ff;\">\u2190 Prev\u3000\u3000\u3000\u3000\u3000Next<\/span><\/em><\/strong><span style=\"color: #0000ff;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-88%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%8814%e3%80%80%e3%81%84\/\">\u2192\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081(88)\u3000<\/a><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u533b\u5c40\u306b\u306f\u96d1\u8a8c\u306e\u898b\u672c\u8a8c\u304c\u5c4a\u304f\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3042\u308b\u65e5\u4f55\u6c17\u306a\u304f\u300c\u708e\u75c7\u3068\u514d\u75ab\u300d\u8a8c(2020\u5e74\uff19\u6708\u53f7)\u3092\u3081\u304f\u3063\u3066\u3044\u305f\u3068\u3053\u308d\u3001\u300c\u30c0\u30a6\u30f3\u75c7\u56e0\u5b50DSCR-1\u3068\u75c5\u7684\u8840\u7ba1\u65b0\u751f\u300d\u3068\u3044\u3046\u30bf\u30a4\u30c8\u30eb\u306e\u7dcf\u8aac\u304c\u76ee\u306b\u6b62\u307e\u308a\u307e\u3057\u305f\u3002\u7834\u9aa8\u7d30\u80de\u3068\u306f\u4e00\u898b\u306a\u3093\u306e\u95a2 &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2404","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2404","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=2404"}],"version-history":[{"count":2,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2404\/revisions"}],"predecessor-version":[{"id":2415,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2404\/revisions\/2415"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=2404"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=2404"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=2404"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}