{"id":2413,"date":"2024-05-27T09:07:05","date_gmt":"2024-05-27T00:07:05","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=2413"},"modified":"2024-06-28T16:04:32","modified_gmt":"2024-06-28T07:04:32","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-88%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%8814%e3%80%80%e3%81%84","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-88%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%8814%e3%80%80%e3%81%84\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (88)\u3000Nfatc1 short form\u30d7\u30ed\u30b8\u30a7\u30af\u30c8(14)\u3000\u3044\u3088\u3044\u3088\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #000080;\">\u3088\u3046\u3084\u304f\u7814\u7a76\u306e\u76ee\u7684\u3060\u3063\u305f\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u3092\u5b9f\u884c\u3059\u308b\u6bb5\u968e\u307e\u3067\u3084\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u30b5\u30f3\u30d7\u30eb\u306fshort form\u7279\u7570\u7684KO\u30de\u30a6\u30b9\u7531\u6765\u306e\u5358\u7403\u7cfb\u7d30\u80de\u3092RANKL\u3067\u523a\u6fc0\u3057\u305f\u3082\u306e\/\u3057\u3066\u3044\u306a\u3044\u3082\u306e\u3001\u5bfe\u7167\u3068\u3057\u3066\u91ce\u751f\u578b(WT)\u30de\u30a6\u30b9\u7531\u6765\u306e\u5358\u7403\u7cfb\u3092RANKL\u3067\u523a\u6fc0\u3057\u305f\u3082\u306e\/\u3057\u3066\u3044\u306a\u3044\u3082\u306e\u3001\u306e\uff14\u7a2e\u985e\u306b\u306a\u308a\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #000080;\">Applied biosystems\u793e\u306eTAC\u3068\u3044\u3046\u30d5\u30ea\u30fc\u306e\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3067\uff14\u691c\u4f53\u3092\u6bd4\u8f03\u3057\u3066\u307f\u308b\u3068\u30fb\u30fb\u30fb\u307e\u305aWT\u306eRANKL-\u3068RANKL+\u3002\u3053\u308c\u306f\u5f53\u7136\u3001\u5f8c\u8005\u3067\u7834\u9aa8\u7d30\u80de\u306e\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308b\u5206\u5b50\u306e\u767a\u73fe\u304c\u5897\u3048\u3066\u3044\u308b\u306f\u305a\u3067\u3059\u3002\u6700\u3082\u5897\u3048\u3066\u3044\u305f\u306e\u304cAcp5\u3067\u30016800\u500d\u304f\u3089\u3044\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u9152\u77f3\u9178\u8010\u6027\u9178\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc(Tartrate-Resistant Acid Phosphatase, TRAP)\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u79c1\u9054\u306f\u901a\u5e38\u7834\u9aa8\u7d30\u80de\u3092TRAP\u67d3\u8272\u967d\u6027\u306e\u591a\u6838\u7d30\u80de\u3068\u3057\u3066\u8a8d\u8b58\u3057\u3066\u3044\u308b\u306e\u3067\u3053\u308c\u304c\u30c8\u30c3\u30d7\u306b\u6765\u308b\u306e\u306f\u7d0d\u5f97\u3067\u3059\u3002\uff13\u4f4d\u3068\uff14\u4f4d\u306bDcstamp (\u7d04740\u500d), Ocstamp\uff08osteoclast stimulatory transmembrane protein, \u7d04700\u500d\uff09\u304c\u30e9\u30f3\u30af\u30a4\u30f3\u3001\uff17\u4f4d\u306bOscar (osteoclast associated receptor, \u7d04180\u500d)\u304c\u5165\u3063\u3066\u3044\u307e\u3059\u300210\u4f4d\u4ee5\u964d\u308222\u756a\u306bCtsk (cathepsin K, 28\u500d)\u300132\u4f4d\u306bCalcr (calcitonin receptor, 25\u500d)\u306a\u3069\u3001\u6709\u540d\u306a\u7834\u9aa8\u7d30\u80de\u306e\u30de\u30fc\u30ab\u30fc\u306f\u8ed2\u4e26\u307f\u4e0a\u4f4d\u306b\u9854\u3092\u51fa\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u9020\u8840\u5e79\u7d30\u80de\u7531\u6765\u306e\u5358\u6838\u7403\u306f\u78ba\u304b\u306bRANKL\u306b\u5fdc\u7b54\u3057\u3066\u7834\u9aa8\u7d30\u80de\u306b\u5206\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3067\u304d\u307e\u3057\u305f\u3002\u6b21\u306bKO\u7d30\u80de\u306eRANKL-, RANKL+\u3092\u6bd4\u3079\u3066\u307f\u307e\u3059\u3002\u3053\u3053\u3067\u3082Acp5\u306f\u7d041600\u500d\u306b\u5897\u3048\u3066\u304a\u308a2\u4f4d\u3001Ocstamp, Dcstamp\u3082370\u500d\u3001360\u500d\u3067\uff13\u4f4d\u3068\uff14\u4f4d\u3001Ctsk\u304c110\u500d\u3067\uff17\u4f4d\u306b\u5165\u3063\u3066\u304a\u308a\u3001\u3053\u306eKO\u7d30\u80de\u306b\u3082RANKL\u306e\u30b7\u30b0\u30ca\u30eb\u306f\u3061\u3083\u3093\u3068\u5165\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3001\u300c\u7834\u9aa8\u7d30\u80de\u306e\u3088\u3046\u306a\u7d30\u80de\u300d\u306b\u306f\u306a\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u3067\u306fWT\u3068KO\u7d30\u80de\u306e\u9055\u3044\u306f\u3069\u3053\u306b\u3042\u308b\u3067\u3057\u3087\u3046\u304b\uff1f\u3044\u3088\u3044\u3088WT\u3068KO\u306eRANKL+\u540c\u58eb\u3092\u6bd4\u8f03\u3057\u3066\u307f\u307e\u3059\u3002\u4e00\u756a\u767a\u73fe\u306b\u5dee\u304c\u3042\u3063\u305f\u306e\u306fKO\u7d30\u80de\u30671\/330\u306b\u306a\u3063\u3066\u3044\u308bOscar\u3067\u3057\u305f\u300216\u4f4d\u306bCalcr\u304c\u5165\u3063\u3066\u3044\u307e\u3059(1\/21\u500d)\u3002Oscar\u304c\u30c8\u30c3\u30d7\u3068\u3044\u3046\u306e\u306f\u500b\u4eba\u7684\u306b\u306f\u611f\u6168\u6df1\u3044\u3082\u306e\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u3068\u3044\u3046\u306e\u306f\u533b\u79d1\u6b6f\u79d1\u6642\u4ee3\u306e2005\u5e74\u306bOscar\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u89e3\u6790\u3092\u3057\u3066\u3001Nfatc1\u306e\u5f37\u5236\u767a\u73fe\u306b\u5fdc\u7b54\u3059\u308b\u3053\u3068\u3092J Biol Chem\u8a8c\u306b\u5831\u544a\u3057\u3066\u3044\u305f\u304b\u3089\u3067\u3059\u3002\u3053\u306e\u6642\u306fNfatc1\u306e\u5f37\u5236\u767a\u73fe\u5b9f\u9a13\u3068\u3001\u305d\u308c\u306e\u9006\u306e\u5b9f\u9a13\u3068\u3057\u3066RNA interference (RNAi)\u3068\u3044\u3046\u624b\u6cd5\u3067Nfatc1\u306e\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u3066\u3044\u307e\u3057\u305f\u304c\u3001RNAi\u3060\u3068Nfatc1\u3092\u5b8c\u5168\u306b\u7121\u304f\u3059\u3053\u3068\u306f\u3067\u304d\u305a\u3001\u305b\u3044\u305c\u30441\/5\u304f\u3089\u3044\u306b\u3057\u304b\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u4eca\u56de\u306f\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u306a\u306e\u3067Nfatc1\u306eshort form\u306f0%\u3067\u3059\u3002\u7d0420\u5e74\u3092\u7d4c\u3066\u78ba\u8a8d\u5b9f\u9a13\u3092\u3084\u3063\u305f\u3053\u3068\u306b\u306a\u308a\u3001Oscar\u306e\u767a\u73fe\u306fNfatc1\u306e\u5185short form\u306b\u5f37\u304f\u4f9d\u5b58\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 12pt;\"><strong>\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 11pt; color: #000080;\"><a style=\"color: #000080;\" href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-87%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%8813%e3%80%80nfatc1\/\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (87)<\/a><\/span><span style=\"color: #0000ff;\"><strong><em><span style=\"font-size: 11pt;\"><span style=\"color: #000080;\">\u2190<\/span> Prev\u3000\u3000\u3000\u3000\u3000Next<\/span><\/em><\/strong><span style=\"font-size: 11pt;\">\u2192<a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-89%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%8815%e3%80%80nfatc1-short\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081(89)<\/span><\/a><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u3088\u3046\u3084\u304f\u7814\u7a76\u306e\u76ee\u7684\u3060\u3063\u305f\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u3092\u5b9f\u884c\u3059\u308b\u6bb5\u968e\u307e\u3067\u3084\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u30b5\u30f3\u30d7\u30eb\u306fshort form\u7279\u7570\u7684KO\u30de\u30a6\u30b9\u7531\u6765\u306e\u5358\u7403\u7cfb\u7d30\u80de\u3092RANKL\u3067\u523a\u6fc0\u3057\u305f\u3082\u306e\/\u3057\u3066\u3044\u306a\u3044\u3082\u306e\u3001\u5bfe\u7167\u3068\u3057\u3066\u91ce\u751f\u578b(WT)\u30de\u30a6\u30b9\u7531 &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2413","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2413","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=2413"}],"version-history":[{"count":4,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2413\/revisions"}],"predecessor-version":[{"id":2425,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2413\/revisions\/2425"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=2413"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=2413"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=2413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}