{"id":2419,"date":"2024-06-28T16:01:53","date_gmt":"2024-06-28T07:01:53","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=2419"},"modified":"2024-11-01T12:21:09","modified_gmt":"2024-11-01T03:21:09","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-89%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%8815%e3%80%80nfatc1-short","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-89%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%8815%e3%80%80nfatc1-short\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (89)\u3000Nfatc1 short form\u30d7\u30ed\u30b8\u30a7\u30af\u30c8(15)\u3000Nfatc1 short form\u306e\u6b20\u640d\u3067\u7834\u9aa8\u7d30\u80de\u304c\u878d\u5408\u3057\u306a\u3044\u7406\u7531"},"content":{"rendered":"<p><span style=\"font-size: 12pt; color: #333399;\">Nfatc1\u81ea\u4f53\u306e\u767a\u73fe\u91cf\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u304b\u3002WT\u3067\u306fRANKL\u523a\u6fc0\u306b\u3088\u3063\u3066\u7d0413\u500d\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f(short+middle+long)\/(middle+long)\u306b\u76f8\u5f53\u3059\u308b\u3053\u3068\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\u3053\u306eGeneChip\u3067\u306f\u3053\u308c\u3089\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u533a\u5225\u3057\u3066\u3044\u306a\u3044\u306e\u3067\u3059\u3002KO\u306e\u5834\u5408\u3001RANKL\u523a\u6fc0\u30672.6\u500d\u3068\u3044\u3046\u7d50\u679c\u3067\u3057\u305f\u3002Short form\u306fKO\u7d30\u80de\u3067\u3082mRNA\u30ec\u30d9\u30eb\u3067\u306f\u8a98\u5c0e\u3055\u308c\u307e\u3059\u3002\u3061\u3083\u3093\u3068\u3057\u305f\u30bf\u30f3\u30d1\u30af\u306b\u306a\u3089\u306a\u3044\u3060\u3051\u3067\u3059\u3002<u>WT\u3068KO\u3068\u3067Nfatc1\u306e\u8a98\u5c0e\u306b\u5dee\u304c\u3042\u308b\u306e\u306f\u3001Nfatc1 short form\u306e\u8a98\u5c0e\u304cNfatc1 short form\u81ea\u4f53\u306b\u3088\u3063\u3066\u4e3b\u306b\u62c5\u308f\u308c\u3066\u3044\u308b\u3053\u3068\u3001middle\u3084long form\u304c\u5b58\u5728\u3057\u3066\u3082short form\u306e\u8a98\u5c0e\u306b\u306f\u4e0d\u5341\u5206\u3067\u3042\u308b\u3053\u3068\uff08\uff1d\u30dd\u30b8\u30c6\u30a3\u30d6\u30fb\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u30eb\u30fc\u30d7\u304c\u56de\u3089\u306a\u3044\u3053\u3068\uff09\u3092\u793a\u5506\u3057\u307e\u3059<\/u>\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #333399;\">\u3055\u3066\u3001Nfatc1 short form\u306eKO\u7d30\u80de\u3067\u7834\u9aa8\u7d30\u80de\u304c\u591a\u6838\u306b\u306a\u3089\u306a\u304b\u3063\u305f\u306e\u306f\u3069\u3046\u3057\u3066\u3067\u3057\u3087\u3046\u304b\u3002Oscar\u306fKO\u3057\u3066\u3082\u591a\u6838\u306b\u306f\u306a\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u3053\u308c\u3067\u306f\u8aac\u660e\u3067\u304d\u306a\u3044\u3067\u3057\u3087\u3046\u3002KO\u7d30\u80de\u3067\u767a\u73fe\u306e\u843d\u3061\u3066\u3044\u308b\u4ed6\u306e\u5206\u5b50\u3092\u898b\u3066\u307f\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #333399;\">\uff14\u756a\u76ee\u306b\u304a\u3061\u3066\u3044\u308bAblim1 (actin-binding LIM protein 1, 1\/60\u500d), 8\u756a\u76ee\u306eMyo1d (myosin ID , 1\/35\u500d)\u3042\u305f\u308a\u306f\u7d30\u80de\u9aa8\u683c\u306b\u95a2\u9023\u3059\u308b\u306e\u3067\u904b\u52d5\u304c\u6bd4\u8f03\u7684\u6fc0\u3057\u304f\u3001\u3057\u304b\u3082\u7652\u5408\u3059\u308b\u7834\u9aa8\u7d30\u80de\u5206\u5316\u306b\u91cd\u8981\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u300222\u4f4d\u300134\u4f4d\u306b\u30e9\u30f3\u30af\u30a4\u30f3\u3057\u3066\u3044\u308bItga2 (integrin aloha 2, 1\/15\u500d), Itgb3 (integrin beta 3, 1\/10\u500d)\u306f\u63a5\u7740\u5206\u5b50\u30a4\u30f3\u30c6\u30b0\u30ea\u30f3\u306e\u69cb\u6210\u8981\u7d20\u306a\u306e\u3067\u3053\u308c\u3082\u95a2\u4fc2\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #333399;\">6\u4f4d\u306eMst1r(macrophage stimulating 1 receptor (c-met-related tyrosine kinase), 1\/40\u500d)\u3082\u3053\u306e\u30ea\u30ac\u30f3\u30c9\u3067\u3042\u308bmacrophage-stimulating protein (MSP)\u304b\u3089\u30b7\u30b0\u30ca\u30eb\u304c\u5165\u308b\u3068\u7834\u9aa8\u7d30\u80de\u306e\u6d3b\u6027\u5316\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #333399;\">\u3053\u308c\u3089\u306e\u5206\u5b50\u304cNfatc1 short form\u306e\u8ee2\u5199\u6a19\u7684\u3067\u3042\u308a\u3001\u305d\u308c\u3089\u306e\u767a\u73fe\u304c\u843d\u3061\u3066\u3044\u308b\u3053\u3068\u3067\u3061\u3083\u3093\u3068\u3057\u305f\u7834\u9aa8\u7d30\u80de\u304c\u5206\u5316\u3067\u304d\u306a\u3044\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u60f3\u50cf\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; color: #333399;\">\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u3092\u3059\u308b\u524d\u306b\u898b\u3064\u3051\u305f\u30cd\u30ac\u30c6\u30a3\u30d6\u30fb\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u5206\u5b50\u306e\u5019\u88dc\u3067\u3042\u308bDSCR-1\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u304b\u3002\u3053\u308c\u306fRcan1\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306b\u30b3\u30fc\u30c9\u3055\u308c\u308b\u30bf\u30f3\u30d1\u30af\u3067\u3059\u304c\u3001Rcan1\u306e\u767a\u73fe\u306fWT\u3067\u306fRANKL\u523a\u6fc0\u306710.5\u500d\u304f\u3089\u3044\u306b\u5897\u3048\u3066\u3044\u307e\u3059\u3002KO\u3067\u306f\u5897\u52a0\u306f2.6\u500d\u3067\u3042\u308a\u3001WT\u3068KO\u306e\u9593\u3067\u6bd4\u3079\u308b\u30686.5\u500d\u306e\u5dee\u304c\u3042\u308a\u307e\u3059\u3002\u3084\u306f\u308aNfatc1 short form\u2192Rcan1\u2192NFAT\u30b7\u30b0\u30ca\u30eb\u306e\u6291\u5236\u3000\u3068\u3044\u3046\u7d4c\u8def\u306f\u3042\u308a\u305d\u3046\u3067\u3059\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"color: #808080;\"><strong>\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-88%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%8814%e3%80%80%e3%81%84\/\"><span style=\"font-size: 11pt; color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (88)<\/span><\/a><span style=\"color: #0000ff;\"><strong><em><span style=\"font-size: 11pt;\"><span style=\"color: #000080;\">\u2190<\/span> Prev\u3000\u3000\u3000\u3000\u3000Next\u2192<\/span><\/em><\/strong><span style=\"font-size: 11pt;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-90%e3%80%80nfatc1-short-form%e3%83%97%e3%83%ad%e3%82%b8%e3%82%a7%e3%82%af%e3%83%8816%e3%80%80%e6%80%92\/\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081(90)<\/a><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"Nfatc1\u81ea\u4f53\u306e\u767a\u73fe\u91cf\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u304b\u3002WT\u3067\u306fRANKL\u523a\u6fc0\u306b\u3088\u3063\u3066\u7d0413\u500d\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f(short+middle+long)\/(middle+long)\u306b\u76f8\u5f53\u3059\u308b\u3053\u3068\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\u3053\u306eGeneChip &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2419","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2419","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=2419"}],"version-history":[{"count":4,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2419\/revisions"}],"predecessor-version":[{"id":2467,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2419\/revisions\/2467"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=2419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=2419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=2419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}