{"id":2500,"date":"2025-01-10T18:04:19","date_gmt":"2025-01-10T09:04:19","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/?p=2500"},"modified":"2026-06-16T09:28:56","modified_gmt":"2026-06-16T00:28:56","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-93%e3%80%80%e9%96%a2%e7%af%80%e3%83%aa%e3%82%a6%e3%83%9e%e3%83%81%e3%81%a8sle3%e3%80%80irf%e5%86%8d","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-93%e3%80%80%e9%96%a2%e7%af%80%e3%83%aa%e3%82%a6%e3%83%9e%e3%83%81%e3%81%a8sle3%e3%80%80irf%e5%86%8d\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (93)\u3000\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3068SLE(3)\u3000IRF\u518d\u767b\u5834"},"content":{"rendered":"<p><span style=\"font-size: 16px; color: #000080;\">2005\u5e74\u306bSLE\u3068IRF5\u907a\u4f1d\u5b50\u306e\u4e00\u5869\u57fa\u591a\u578b(SNP)\u3068\u304c\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f(Sigurdsson\u3089)\u3002\u3053\u308c\u306f\u5317\u6b27\u304b\u3089\u306e\u5831\u544a\u3060\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u305d\u306e\u5f8c\u4ed6\u306e\u5730\u57df\u304b\u3089\u3082\u540c\u69d8\u306e\u95a2\u9023\u304c\u5831\u544a\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px; color: #000080;\">IRF\u306finterferon regulatory factor\u3067\u3042\u308a\u3001\u8ee2\u5199\u56e0\u5b50\u30d5\u30a1\u30df\u30ea\u30fc\u3092\u5f62\u6210\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u591a\u304f\u306f(1) IFN\u30b7\u30b0\u30ca\u30eb\u306b\u95a2\u4e0e\u3059\u308b\u56e0\u5b50\u3000(2) IFN\u3067\u8a98\u5c0e\u3055\u308c\u308b\u6a19\u7684\u907a\u4f1d\u5b50 (3) IFN\u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u56e0\u5b50\u3000\u3067\u3042\u308a\u305d\u308c\u3089\u306e\u5f79\u5272\u304c\u91cd\u8907\u3057\u3066\u3044\u308b\u5206\u5b50\u3082\u3042\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066I\u578bIFN\u306e\u95a2\u4e0e\u304c\u5f37\u3044\u75be\u60a3\u3067\u3042\u308bSLE\u3067IRF-5\u306e\u6a5f\u80fd\u7570\u5e38\u304c\u3042\u308b\uff08\u304b\u3082\u3057\u308c\u306a\u3044\uff09\u3068\u3044\u3046\u306e\u306f\u7d0d\u5f97\u3057\u3084\u3059\u3044\u4eee\u8aac\u3067\u3059\u3002\u524d\u306b\u3082\u66f8\u3044\u305f\u3068\u601d\u3044\u307e\u3059\u304c\u79c1\u306fIRF-1, IRF-2\u3092\u540c\u5b9a\u3057\u305f\u30e9\u30dc\u3067\u5927\u5b66\u9662\u751f\u6d3b\u3092\u9001\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u5f53\u6642\u306fIRF-1, IRF-2, IRF-3, IRF-7, IRF-9\u304c\u89e3\u6790\u306e\u4e2d\u5fc3\u3067\u3001IRF-7\u4ee5\u5916\u306e\u30ce\u30c3\u30af\u30a2\u30a6\u30c8(KO)\u30de\u30a6\u30b9\u306f\u3059\u3067\u306b\u5b58\u5728\u3057\u3001\u61f8\u547d\u306bIRF-7\u306eKO\u30de\u30a6\u30b9\u304c\u4f5c\u3089\u308c\u3066\u3044\u308b\u6700\u4e2d\u3067\u3057\u305f\u3002IRF-3\u3068IRF-7\u3068\u304cI\u578bIFN\u306e\u7523\u751f\u306b\u7279\u306b\u91cd\u8981\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u5b9f\u969b\u65b0\u305f\u306b\u4f5c\u3089\u308c\u305fIRF-7KO\u30de\u30a6\u30b9\u3068IRF-3KO\u30de\u30a6\u30b9\u3092\u4ea4\u914d\u3057\u3001\u4e21\u6b20\u640d\u7d30\u80de\u306f\u523a\u6fc0\u3092\u3057\u3066\u3082I\u578bIFN\u7523\u751f\u304c\u8d77\u304d\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\uff08\u65b0\u305f\u306b\u4f5c\u3089\u308c\u305f\u3001\u3068\u66f8\u304d\u307e\u3057\u305f\u304c\u305d\u3053\u306b\u306f\u8840\u3068\u6d99\u306e\u7269\u8a9e\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u79c1\u306f\u9593\u8fd1\u3067\u305d\u308c\u3092\u898b\u3066\u6050\u308c\u304a\u306e\u306e\u3044\u3066\u3044\u305f\u3060\u3051\u3067\u3059\u304c\u30fb\u30fb\u30fb\uff09<\/span><\/p>\n<p><span style=\"font-size: 16px; color: #000080;\">\u305d\u306e\u7d50\u679c\u3092\u8e0f\u307e\u3048\u308b\u3068SLE\u306e\u611f\u53d7\u6027\u56e0\u5b50\u306bIRF-5\u304c\u3042\u3063\u3066\u3082\u304a\u304b\u3057\u304f\u306f\u306a\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u305cIRF-3\u30847\u3067\u306f\u306a\u3044\u306e\u3060\u308d\u3046\uff1f\u3068\u3061\u3087\u3063\u3068\u4e0d\u601d\u8b70\u306b\u306f\u611f\u3058\u3066\u3044\u307e\u3057\u305f\u3002\uff08IRF-5\u3068SLE\u3068\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u306f\u305d\u306e\u5f8c\u6a2a\u6d5c\u5e02\u5927\u304b\u3089\u8a73\u7d30\u306a\u89e3\u6790\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a(Ban et al., Nat Commun. 2021\u306a\u3069), IRF-5\u304cSLE\u306e\u6709\u529b\u306a\u6cbb\u7642\u6a19\u7684\u3067\u3042\u308b\u3053\u3068\u3001IRF-5\u304c\u3084\u306f\u308aI\u578bIFN\u306e\u7523\u751f\u306b\u3082\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3000\u306a\u3069\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\uff09<\/span><\/p>\n<p><span style=\"font-size: 16px; color: #000080;\">\u3000\u3057\u304b\u3057\u79c1\u304c\u3088\u308a\u9a5a\u3044\u305f\u306e\u306f\u3001IRF-5\u3068\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3068\u306e\u95a2\u9023\u3082\u5831\u544a\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3053\u3068\u3067\u3059\u3002\u524d\u56de\u66f8\u3044\u305f\u3088\u3046\u306bSLE\u3068\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3068\u304c\u5bfe\u7acb\u3059\u308b\u3088\u3046\u306a\u75be\u60a3\u3067\u3042\u308c\u3070\u3053\u306e\u3088\u3046\u306a\u3053\u3068\u306f\u8aac\u660e\u3057\u306b\u304f\u3044\u3068\u601d\u308f\u308c\u307e\u3059\u3002\uff08\u540c\u4e00\u306eSNP\u304cSLE\u306e\u611f\u53d7\u6027\u306f\u5897\u3059\u304c\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u306f\u9006\u306b\u7f79\u308a\u306b\u304f\u304f\u3059\u308b\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308c\u3070\u5bfe\u7acb\u4eee\u8aac\u3067\u3082\u826f\u3055\u305d\u3046\u3067\u3059\u304c\u3001\u3069\u3046\u3084\u3089\u305d\u3046\u3067\u306f\u306a\u3055\u305d\u3046\u3067\u3059\u3002\uff09<\/span><\/p>\n<p><span style=\"font-size: 16px; color: #000080;\">\u3000\u4e21\u8005\u304c\u53cd\u5bfe\u65b9\u5411\u3092\u5411\u3044\u3066\u3044\u308b\u75be\u60a3\u3067\u3042\u308b\u3001\u3068\u3044\u3046\u5358\u7d14\u306a\u4eee\u8aac\u306f\u6210\u7acb\u3057\u305d\u3046\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u5c11\u306a\u304f\u3068\u3082\u4e00\u90e8\u5206\u306b\u304a\u3044\u3066\u306f\u540c\u3058\u65b9\u5411\u3092\u898b\u3066\u3044\u308b\uff08=\u5171\u901a\u70b9\u306e\u3042\u308b\uff09\u75be\u60a3\u3068\u8003\u3048\u305f\u307b\u3046\u304c\u3088\u3044\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 16px;\"><strong>\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"color: #0000ff; font-size: 14px;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-92%e3%80%80%e9%96%a2%e7%af%80%e3%83%aa%e3%82%a6%e3%83%9e%e3%83%81%e3%81%a8sle2%e3%80%80%e5%af%be%e7%ab%8b\/\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (92)<\/a><strong><em>\u2190 Prev\u3000\u3000\u3000\u3000\u3000Next\u2192<\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-94%e3%80%80%e9%96%a2%e7%af%80%e3%83%aa%e3%82%a6%e3%83%9e%e3%83%81%e3%81%a8sle4%e3%80%80%e9%96%a2%e7%af%80\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081(94)<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"2005\u5e74\u306bSLE\u3068IRF5\u907a\u4f1d\u5b50\u306e\u4e00\u5869\u57fa\u591a\u578b(SNP)\u3068\u304c\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f(Sigurdsson\u3089)\u3002\u3053\u308c\u306f\u5317\u6b27\u304b\u3089\u306e\u5831\u544a\u3060\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u305d\u306e\u5f8c\u4ed6\u306e\u5730\u57df\u304b\u3089\u3082\u540c\u69d8\u306e\u95a2\u9023\u304c\u5831\u544a\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002 IRF &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2500","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2500","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=2500"}],"version-history":[{"count":4,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2500\/revisions"}],"predecessor-version":[{"id":2607,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2500\/revisions\/2607"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=2500"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=2500"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=2500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}