{"id":2520,"date":"2025-04-08T15:20:37","date_gmt":"2025-04-08T06:20:37","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/?p=2520"},"modified":"2025-05-27T16:39:31","modified_gmt":"2025-05-27T07:39:31","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-94%e3%80%80%e9%96%a2%e7%af%80%e3%83%aa%e3%82%a6%e3%83%9e%e3%83%81%e3%81%a8sle4%e3%80%80%e9%96%a2%e7%af%80","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-94%e3%80%80%e9%96%a2%e7%af%80%e3%83%aa%e3%82%a6%e3%83%9e%e3%83%81%e3%81%a8sle4%e3%80%80%e9%96%a2%e7%af%80\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (94)\u3000\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3068SLE(4)\u3000\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3068IFN"},"content":{"rendered":"<p><span style=\"font-size: 16px; color: #000080;\">2022\u5e74\u306b\u79c1\u306b\u3068\u3063\u3066\u8208\u5473\u6df1\u3044\u8ad6\u6587\u304c2\u3064\u76f8\u6b21\u3044\u3067\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u4e00\u3064\u306f<\/span><\/p>\n<p><span style=\"font-size: 16px; color: #000080;\">Iwasaki et al., Dynamics of Type I and Type II Interferon Signature Determines Responsiveness to Anti-TNF Therapy in Rheumatoid Arthritis (Front Immunol. 2022)\u3067\u3059\u3002\u3053\u306e\u8ad6\u6587\u3067\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3092TNF\u963b\u5bb3\u85ac\u3067\u6cbb\u7642\u3059\u308b\u5834\u5408\u306b\u3069\u306e\u3088\u3046\u306a\u75c7\u4f8b\u3067\u7d99\u7d9a\u304c\u56f0\u96e3\u306b\u306a\u308b\u306e\u304b\uff08\u3064\u307e\u308a\u8ab0\u304cnon-responder\u306a\u306e\u304b\uff09\u3001\u3092\u69d8\u3005\u306a\u30b5\u30f3\u30d7\u30eb\u3092\u3092\u7db2\u7f85\u7684\u306b\u8abf\u3079\u308b\u3053\u3068\u3067\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306bI\u578b\u304a\u3088\u3073II\u578bIFN\u306e\u6a19\u7684\u5206\u5b50\u306e\u767a\u73fe\u306b\u6ce8\u76ee\u3057\u3066\u304a\u308a\u3001non-responder\u3067\u306f\u300c\u6cbb\u7642\u524d\u300d\u304b\u3089I\u578bIFN\u30b7\u30b0\u30ca\u30eb\u304c\u5f37\u304f\u5165\u3063\u3066\u3044\u308b\u3053\u3068\u3001\u307e\u305f\u6cbb\u7642\u306e\u300c\u904e\u7a0b\u300d\u3067II\u578bIFN\u30b7\u30b0\u30ca\u30eb\u304c\u3088\u308a\u5f37\u304f\u5165\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u308b\u3000\u3053\u3068\u3092\u898b\u51fa\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px; color: #000080;\">\u8ab0\u304cnon-responder\u3067\u3042\u308b\u304b\u3092\u4e88\u3081\u4e88\u60f3\u3067\u304d\u308c\u3070\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u306e\u4e88\u5f8c\u3092\u3088\u308a\u6539\u5584\u3067\u304d\u308b\u3067\u3057\u3087\u3046\u3057\u3001\u533b\u7642\u7d4c\u6e08\u7684\u306b\u3082\u5f53\u7136\u30e1\u30ea\u30c3\u30c8\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u6cbb\u7642\u524d\u306b\u4e88\u6e2c\u3059\u308b\u306e\u306f\u306a\u304b\u306a\u304b\u96e3\u3057\u305d\u3046\u3067\u3042\u308a\u3001\u300c\u9014\u4e2d\u7d4c\u904e\u300d\u306e\u30c7\u30fc\u30bf\u3082\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px; color: #000080;\">\u3000\u3082\u3046\u4e00\u3064\u306e\u8ad6\u6587\u306fSakashita et al., Serum level of IFN\u03b2 distinguishes early from late relapses after biologics withdrawal in rheumatoid arthritis (Sci Rep. 2022)\u3067\u3059\u3002\u3053\u308c\u306f\u5c11\u3057\u8996\u70b9\u304c\u7570\u306a\u3063\u3066\u304a\u308a\u3001\u751f\u7269\u88fd\u5264\u3067\u5bdb\u89e3\u306b\u5165\u3063\u305f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u3067\u751f\u7269\u88fd\u5264\u6295\u4e0e\u3092\u4e2d\u6b62\u3057\u307e\u3059\u3002\u305d\u306e\u5f8c\u7d4c\u6642\u7684\u306b\u8840\u6e05\u3092\u30b5\u30f3\u30d7\u30ea\u30f3\u30b0\u3057\u3001\u6db2\u6027\u56e0\u5b50\u3092\u5b9a\u91cf\u3057\u307e\u3059\u3002\u4e00\u90e8\u306e\u60a3\u8005\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u304c\u518d\u71c3\u3057\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u304c\u3001\u305d\u306e\u76f4\u524d\u306b\u5909\u52d5\u3057\u305f\u6db2\u6027\u56e0\u5b50\u306b\u6ce8\u76ee\u3059\u308b\u3001\u3068\u3044\u3046\u6226\u7565\u3067\u3059\u3002\u518d\u71c3\u306b\u5148\u99c6\u3051\u3066\u4f55\u304c\u5909\u5316\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u305d\u306e\u89e3\u6790\u3067\u62bd\u51fa\u3055\u308c\u305f\u6db2\u6027\u56e0\u5b50\u306fIFN-\u03b2\u3067\u3057\u305f\u3002\u5143\u3005\u8840\u6e05\u4e2d\u306eIFN-\u03b2\u306f\u306a\u304b\u306a\u304b\u5b9a\u91cf\u304c\u96e3\u3057\u3044\u30ec\u30d9\u30eb\u3057\u304b\u5b58\u5728\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u305d\u308c\u304c\u6e2c\u5b9a\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308b\u3068\u305d\u306e\u5f8c\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u304c\u518d\u71c3\u3059\u308b\u3001\u3068\u3044\u3046\u3053\u3068\u306a\u306e\u3067\u3059\u3002\u3064\u307e\u308a\u8840\u6e05IFN-\u03b2\u304c\u6e2c\u5b9a\u611f\u5ea6\u4ee5\u4e0b\u3067\u3042\u308b\u5185\u306f\u518d\u71c3\u306e\u30ea\u30b9\u30af\u306f\u4f4e\u3044\u3001\u3068\u3044\u3046\u3053\u3068\u3092\u4e3b\u5f35\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px; color: #000080;\">\u3000\u3053\u3053\u3067\u3001\u6700\u521d\u306e\u8ad6\u6587\u3067\u306fIFN-\u03b1, \u03b2\u305d\u306e\u3082\u306e\u3092\u6e2c\u5b9a\u3057\u305f\u308f\u3051\u3067\u306f\u306a\u3044\u3053\u3068\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\u3069\u3061\u3089\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3082\u540c\u3058\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u7d30\u80de\u5185\u306b\u30b7\u30b0\u30ca\u30eb\u3092\u5165\u308c\u3001I\u578bIFN\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u305d\u306e\u767a\u73fe\u306e\u7a0b\u5ea6\u3092\u6e2c\u5b9a\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u3001\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3057\u305f\u306e\u304cIFN-\u03b1\u306a\u306e\u304b\u3001IFN-\u03b2\u3067\u3042\u308b\u306e\u304b\u306f\u57fa\u672c\u7684\u306b\u533a\u5225\u304c\u3064\u304b\u306a\u3044\u304b\u3089\u3067\u3059\u3002\u5f8c\u8005\u306e\u8ad6\u6587\u3067\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u30ec\u30d9\u30eb\u3067\u5b9a\u91cf\u3057\u3066\u3044\u308b\u306e\u3067\u3001IFN-\u03b2\u3068\u4e3b\u5f35\u3057\u3066\u3044\u308b\u304b\u3089\u306b\u306fIFN-\u03b1\u3067\u306f\u306a\u3044\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u30c7\u30fc\u30bf\u3092\u898b\u3066\u79c1\u306f\u601d\u308f\u305a\u819d\u3092\u6253\u3061\u307e\u3057\u305f\uff08\u4eca\u306f\u305d\u3046\u3044\u3046\u4eba\u306f\u3044\u306a\u3044\uff1f\uff09\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><strong><span style=\"font-size: 16px;\">\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/span><\/strong><\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-93%e3%80%80%e9%96%a2%e7%af%80%e3%83%aa%e3%82%a6%e3%83%9e%e3%83%81%e3%81%a8sle3%e3%80%80irf%e5%86%8d\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (93)<\/span><\/a><span style=\"color: #0000ff;\"><strong><em>\u2190 Prev\u3000\u3000\u3000\u3000\u3000Next\u2192<\/em><\/strong><a href=\"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-95%e3%80%80%e9%96%a2%e7%af%80%e3%83%aa%e3%82%a6%e3%83%9e%e3%83%81%e3%81%a8sle5%e3%80%80%ce%b1%e3%81%8b\/\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081(95)<\/span><\/a><strong><em><span style=\"color: #ffffff;\">1<\/span><\/em><\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"2022\u5e74\u306b\u79c1\u306b\u3068\u3063\u3066\u8208\u5473\u6df1\u3044\u8ad6\u6587\u304c2\u3064\u76f8\u6b21\u3044\u3067\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u4e00\u3064\u306f Iwasaki et al., Dynamics of Type I and Type II Interferon Signature Determ &#8230;","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2520","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=2520"}],"version-history":[{"count":2,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2520\/revisions"}],"predecessor-version":[{"id":2531,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/2520\/revisions\/2531"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=2520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=2520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=2520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}