{"id":860,"date":"2020-07-30T08:55:27","date_gmt":"2020-07-29T23:55:27","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=860"},"modified":"2020-07-30T08:55:27","modified_gmt":"2020-07-29T23:55:27","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-2%e3%80%80th1-th2%e3%83%91%e3%83%a9%e3%83%80%e3%82%a4%e3%83%a0","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-2%e3%80%80th1-th2%e3%83%91%e3%83%a9%e3%83%80%e3%82%a4%e3%83%a0\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (2)\u3000Th1\/Th2\u30d1\u30e9\u30c0\u30a4\u30e0"},"content":{"rendered":"<p><span style=\"color: #000080;\">\u514d\u75ab\u7d30\u80de\u306e\u6559\u80b2(selection)\u3068\u4e26\u3093\u3067\u3001\u3082\u3046\u4e00\u3064\u3068\u3066\u3082\u9762\u767d\u3044\u3068\u601d\u3063\u305f\u306e\u306f\u3001T\u7d30\u80de\u306e<br \/>\n\u30b5\u30d6\u30bb\u30c3\u30c8\u3068\u3044\u3046\u6982\u5ff5\u3067\u3059\u3002T\u7d30\u80de\u306f\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\uff08Th\u7d30\u80de\uff09\u3068\u3001\u7d30\u80de\u50b7\u5bb3\u6027T\u7d30\u80de(killer T cell, cytotoxic T cell, Tc\u7d30\u80de)\u306e\uff12\u7a2e\u985e\u306b\u5927\u5225\u3067\u304d\u307e\u3059\u3002\u4e21\u8005\u306e\u533a\u5225\u306f\u7d30\u80de\u8868\u9762\u306eCD4\u5206\u5b50\u3068CD8\u5206\u5b50\u306e\u6709\u7121\u3067\u3064\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002CD4\u5206\u5b50\u304c\u967d\u6027\u306a\u3089Th\u7d30\u80de\u3001CD8\u5206\u5b50\u304c\u967d\u6027\u306a\u3089Tc\u7d30\u80de\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u66f4\u306bTh\u7d30\u80de\u3082\uff12\u7a2e\u985e\u306b\u5206\u985e\u3067\u304d\u308b\u3053\u3068\u30921986\u5e74\u3001\u7c73\u56fdDNAX\u7814\u7a76\u6240\u306eMosmann\u3068\u3000Coffman\u304c\u5831\u544a\u3057\u307e\u3057\u305f\u3002\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3(interferon, IFN-)\u03b3\u3084IL-2\u3092\u4e3b\u306b\u7523\u751f\u3059\u308bTh1\u7d30\u80de\u3068\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3(interleukin, IL-)4, IL-5, IL-6\u306a\u3069\u3092\u7523\u751f\u3059\u308bTh2\u7d30\u80de\u3067\u3059\u3002Th1\u7d30\u80de\u304c\u7d30\u80de\u6027\u514d\u75ab\uff08\u3064\u307e\u308aTc\u7d30\u80de\u3084NK\u7d30\u80de\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306a\u3069\u306b\u3088\u3063\u3066\u611f\u67d3\u3057\u305f\u7d30\u80de\u3092\u6392\u9664\u3059\u308b\u4ed5\u7d44\u307f\uff09\u3001Th2\u7d30\u80de\u304c\u6db2\u6027\u514d\u75ab\uff08\u8840\u6e05\u306b\u542b\u307e\u308c\u308b\u6297\u4f53\u306b\u3088\u3063\u3066\u75c5\u539f\u4f53\u3092\u4e2d\u548c\u3059\u308b\u306a\u3069\u306e\u4ed5\u7d44\u307f\uff09\u3092\u5897\u5f37\u3059\u308b\u3068\u3044\u3046\u5f79\u5272\u5206\u62c5\u304c\u3042\u308b\u3068\u3044\u3046\u8aac\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u79c1\u304c\u8208\u5473\u6df1\u3044\u3068\u601d\u3063\u305f\u306e\u306f\u3001Th\u7d30\u80de\u306f\u80f8\u817a\u304b\u3089\u51fa\u3066\u304d\u305f\u3068\u304d\u306fTh1, Th2\u7d30\u80de\u3044\u305a\u308c\u306b\u3082\u306a\u308a\u3046\u308b\u3001\u30cb\u30e5\u30fc\u30c8\u30e9\u30eb\u306a\u5b58\u5728\u3060\u3068\u3044\u3046\u70b9\u3067\u3059\u3002Th1, Th2\u7d30\u80de\u3078\u306e\u5206\u5316\u3092\u6c7a\u5b9a\u3059\u308b\u306e\u306f\u305d\u306e\u7d30\u80de\u306e\u5468\u56f2\u306e\u74b0\u5883\u3067\u3059\u3002\u3082\u3063\u3068\u5177\u4f53\u7684\u306b\u8a00\u3048\u3070\u3001\u5468\u56f2\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u74b0\u5883\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306f\u7d30\u80de\u540c\u58eb\u306e\u60c5\u5831\u4f1d\u9054\u306b\u4f7f\u308f\u308c\u308b\u6db2\u6027\u56e0\u5b50\uff08\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u3067\u3042\u308a\u3001\u524d\u8ff0\u306eIFN-\u03b3, IL-2, IL-4, IL-5, IL-6\u306a\u3069\u306f\u3059\u3079\u3066\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\uff11\u7a2e\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">Th1\u7d30\u80de\u306e\u5206\u5316\u306b\u5fc5\u9808\u306a\u306e\u306fIL-12\u3068\u3044\u3046\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3001\u3053\u308c\u306f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306a\u3069\u306e\u7d30\u80de\u304c\u7523\u751f\u3057\u307e\u3059\u3002Th2\u7d30\u80de\u306e\u5834\u5408\u306fIL-4\u304c\u5206\u5316\u306b\u5fc5\u9808\u3067\u3059\u3002\u3053\u308c\u306fTh2\u7d30\u80de\u81ea\u8eab\u3082\u7523\u751f\u3057\u307e\u3059\u3057\u3001\u597d\u5869\u57fa\u7403\u3068\u3044\u3046\u7d30\u80de\u3082\u7523\u751f\u3057\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">Th\u7d30\u80de\u306f\u5fc5\u8981\u306b\u5fdc\u3058\u3066Th1, Th2\u7d30\u80de\u306e\u3069\u3061\u3089\u306b\u3082\u5909\u5316\u3059\u308b\u3001\u8ce2\u3044\u7d30\u80de\u306a\u306e\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">Th1\/Th2\u7d30\u80de\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u3001\u751f\u4f53\u306e\u514d\u75ab\u5fdc\u7b54\u306e\u6027\u8cea\u3092\u6c7a\u3081\u308b\u3068\u3044\u3046\u3053\u306e\u4eee\u8aac\u306f\u305d\u306e\u5f8c\u6570\u5341\u5e74\u9593\u3001\u514d\u75ab\u5b66\u306e\u4e16\u754c\u3092\u652f\u914d\u3059\u308b\u30d1\u30e9\u30c0\u30a4\u30e0\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-family: verdana, geneva, sans-serif; color: #808080;\"><strong>\u4f50\u85e4\u3000\u6d69\u4e8c\u90ce<\/strong><\/span><\/p>\n<p class=\"entryPostTitle entry-title\" style=\"text-align: right;\"><span style=\"font-size: 11pt;\"><span style=\"color: #0000ff;\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/851\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081<\/a><a style=\"color: #000080;\" href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/851\"> (1)<\/a><\/span> <strong><em><span style=\"color: #0000ff;\">\u2190<\/span><\/em><span style=\"color: #0000ff;\"><em> Prev\u3000\u3000<\/em>\u3000\u3000\u3000<em>Next<\/em> \u2192 <\/span><\/strong><\/span><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-3%e3%80%80%e5%a4%a7%e5%ad%a6%e9%99%a2%e9%80%b2%e5%ad%a6\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (3)<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u514d\u75ab\u7d30\u80de\u306e\u6559\u80b2(selection)\u3068\u4e26\u3093\u3067\u3001\u3082\u3046\u4e00\u3064\u3068\u3066\u3082\u9762\u767d\u3044\u3068\u601d\u3063\u305f\u306e\u306f\u3001T\u7d30\u80de\u306e \u30b5\u30d6\u30bb\u30c3\u30c8\u3068\u3044\u3046\u6982\u5ff5\u3067\u3059\u3002T\u7d30\u80de\u306f\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\uff08Th\u7d30\u80de\uff09\u3068\u3001\u7d30\u80de\u50b7\u5bb3\u6027T\u7d30\u80de(killer T cell, cytotoxic &#8230;","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-860","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/860","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=860"}],"version-history":[{"count":0,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/860\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=860"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=860"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=860"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}