{"id":865,"date":"2020-07-31T09:00:11","date_gmt":"2020-07-31T00:00:11","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/alle\/cms\/?p=865"},"modified":"2020-07-31T09:00:11","modified_gmt":"2020-07-31T00:00:11","slug":"%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-3%e3%80%80%e5%a4%a7%e5%ad%a6%e9%99%a2%e9%80%b2%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/alle\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-3%e3%80%80%e5%a4%a7%e5%ad%a6%e9%99%a2%e9%80%b2%e5%ad%a6\/","title":{"rendered":"\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (3)\u3000\u5927\u5b66\u9662\u9032\u5b66"},"content":{"rendered":"<p><span style=\"color: #003366;\">\u5927\u5b66\u75c5\u9662\u3067\uff11\u5e74\u3001\u864e\u306e\u9580\u75c5\u9662\u3067\uff12\u5e74\u7814\u4fee\u306e\u5f8c\u306b\u514d\u75ab\u5b66\u306e\u5927\u5b66\u9662\u306b\u9032\u5b66\u3057\u307e\u3057\u305f\u3002<br \/>\n\u5e73\u621010\u5e74\u306e\u3053\u3068\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #003366;\">\u305d\u3053\u3067\u306f\u6b63\u306b\u8208\u5473\u306e\u3042\u3063\u305fTh1\/Th2\u5206\u5316\u306e\u7814\u7a76\u304c\u9032\u884c\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u5927\u5b66\u9662\u306e\u5148\u8f29<br \/>\n\u3067\u3042\u308bS\u85e4\u5065O\u5148\u751f\u306e\u30c6\u30fc\u30de\u3067\u3059\u3002\u7e01\u3042\u3063\u3066\u3068\u3044\u3046\u3079\u304d\u304b\u3001\u4eca\u306e\u533b\u5c40\u3067\u3082\u5927\u5909\u304a\u4e16\u8a71\u306b\u306a\u3063\u3066\u3044\u308b\u5148\u751f\u3067\u3059\u3002\u305d\u3082\u305d\u3082\u3053\u306e\u4f0f\u305b\u5b57\u306b\u610f\u5473\u304c\u3042\u308b\u306e\u304b\u3069\u3046\u304b\uff65\uff65\uff65<\/span><\/p>\n<p><span style=\"color: #003366;\">\u514d\u75ab\u5b66\u6559\u5ba4\u306e\u6559\u6388\u306f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u3057\u305fTT\u5148\u751f\uff08\u3053\u306e\u30a4\u30cb\u30b7\u30e3\u30eb\u3082\u610f\u5473\u304c\u3042\u308b\u3068\u306f\u601d\u3048\u307e\u305b\u3093\u304c\uff09\u3067\u3042\u308a\u3001IFN-\u03b2\u306e\u907a\u4f1d\u5b50\u914d\u5217\u3092\u6c7a\u5b9a\u3057\u307e\u3057\u305f\u3002<br \/>\n\u305d\u308c\u306b\u7559\u307e\u3089\u305a\u3001IFN-\u03b2\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u3092\u63a2\u3057\u3066IRF (interferon regulatory factor)-1, IRF-2\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u5f8cIRF\u30d5\u30a1\u30df\u30ea\u30fc\u306fIRF-9\u307e\u3067\u5bb6\u65cf\u304c\u5897\u3048\u307e\u3057\u305f\u3002IFN-\u03b2\u306e\u5236\u5fa1\u3092\u5b9f\u969b\u306b\u3057\u3066\u3044\u308b\u306e\u306f\u5b9f\u306fIRF-3\u3068IRF-7\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3082TT\u7814\u304b\u3089\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u304c\u305d\u308c\u306f\u5f8c\u306e\u8a71\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #003366;\">IRF-1\u306f\u591a\u5f69\u306a\u6a5f\u80fd\u3092\u6301\u3063\u3066\u304a\u308a\u3001IRF-1\u306e\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306e\u8868\u73fe\u578b\u306e\uff11\u3064\u306bTh1\u5206\u5316\u306e\u969c\u5bb3\u304c\u3042\u308a\u307e\u3057\u305f\u3002Th1\/Th2\u30d0\u30e9\u30f3\u30b9\u304cTh2\u306b\u504f\u3063\u3066\u304a\u308a\u3001\u3042\u307e\u308aIFN-\u03b3\u304c\u7523\u751f\u3055\u308c\u305a\u3001\u9006\u306bIL-4\u306e\u7523\u751f\u304c\u5f37\u3044\u306e\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #003366;\">\u7814\u7a76\u306e\u7d50\u679c\u3001S\u85e4\u5148\u751f\u9054\u306f\u3001Th1\u5206\u5316\u306b\u5fc5\u9808\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308bIL-12\u304cIRF-1\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3067\u306f\u7523\u751f\u3055\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u3064\u307e\u308aIRF-1\u306fIL-12\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u3060\u3063\u305f\u306e\u3067\u3059(Immunity 1997, 6: 673-679)\u3002\u7d20\u6674\u3089\u3057\u3044\u7814\u7a76\u3067\u3001\u3068\u3066\u3082\u7fa8\u307e\u3057\u304f\u601d\u3063\u305f\u3053\u3068\u3092\u899a\u3048\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u79c1\u81ea\u8eab\u304cTh1\/Th2\u5206\u5316\u306e\u5b9f\u9a13\u3092\u3059\u308b\u3053\u3068\u306b\u306a\u3063\u305f\u306e\u306f\u304b\u306a\u308a\u5f8c\u306e\u8a71\u3067\u3059\u3002\u79c1\u306f\u8208\u5473\u3092\u6301\u3063\u3066\u3044\u305fT\u7d30\u80de\u3067\u306f\u306a\u304f\u3001NK\uff08\u30ca\u30c1\u30e5\u30e9\u30eb\u30ad\u30e9\u30fc\uff09\u7d30\u80de\u7814\u7a76\u306b\u624b\u3092\u67d3\u3081\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"color: #808080; font-family: verdana, geneva, sans-serif; font-size: 11pt;\"><strong>\u4f50<\/strong><strong>\u85e4\u3000\u6d69\u4e8c\u90ce<\/strong><\/span><\/p>\n<p class=\"entryPostTitle entry-title\" style=\"text-align: right;\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-2%e3%80%80th1-th2%e3%83%91%e3%83%a9%e3%83%80%e3%82%a4%e3%83%a0\"><span style=\"font-size: 11pt;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (2)<\/span><\/a><\/span><span style=\"font-size: 11pt;\"><span style=\"color: #0000ff;\">\u00a0<strong><span style=\"color: #0000ff;\">\u2190<\/span><span style=\"color: #0000ff;\"><em> Prev\u3000\u3000<\/em>\u3000\u3000\u3000<em>Next<\/em> \u2192\u00a0<\/span><\/strong><\/span><a href=\"https:\/\/www.jichi.ac.jp\/alle\/cms\/%e6%95%99%e6%8e%88%e3%81%b6%e3%82%8d%e3%81%90%ef%bc%88%e8%b6%85%e4%b8%8d%e5%ae%9a%e6%9c%9f%e6%8e%b2%e8%bc%89%ef%bc%89\/%e7%a7%81%e7%9a%84%e5%85%8d%e7%96%ab%e5%ad%a6%e3%81%93%e3%81%a8%e3%81%af%e3%81%98%e3%82%81-4%e3%80%80nk%e7%b4%b0%e8%83%9e\"><span style=\"color: #000080;\">\u79c1\u7684\u514d\u75ab\u5b66\u3053\u3068\u306f\u3058\u3081 (4)<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u5927\u5b66\u75c5\u9662\u3067\uff11\u5e74\u3001\u864e\u306e\u9580\u75c5\u9662\u3067\uff12\u5e74\u7814\u4fee\u306e\u5f8c\u306b\u514d\u75ab\u5b66\u306e\u5927\u5b66\u9662\u306b\u9032\u5b66\u3057\u307e\u3057\u305f\u3002 \u5e73\u621010\u5e74\u306e\u3053\u3068\u3067\u3059\u3002 \u305d\u3053\u3067\u306f\u6b63\u306b\u8208\u5473\u306e\u3042\u3063\u305fTh1\/Th2\u5206\u5316\u306e\u7814\u7a76\u304c\u9032\u884c\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u5927\u5b66\u9662\u306e\u5148\u8f29 \u3067\u3042\u308bS\u85e4\u5065O\u5148\u751f\u306e\u30c6\u30fc\u30de\u3067\u3059\u3002\u7e01\u3042\u3063\u3066 &#8230;","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-865","post","type-post","status-publish","format-standard","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/comments?post=865"}],"version-history":[{"count":0,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/posts\/865\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/media?parent=865"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/categories?post=865"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/alle\/wp-json\/wp\/v2\/tags?post=865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}