{"id":331,"date":"2021-07-07T10:42:00","date_gmt":"2021-07-07T01:42:00","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wordpress\/?p=331"},"modified":"2025-12-07T21:27:09","modified_gmt":"2025-12-07T12:27:09","slug":"oxygenparadox_jp","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/bioconvergence\/oxygenparadox_jp\/","title":{"rendered":"\u7d44\u7e54\u9593\u8cea\u6a5f\u80fd\u3092\u5236\u5fa1\u3059\u308b\u9178\u7d20\u30b7\u30b0\u30ca\u30eb"},"content":{"rendered":"<p>\u9178\u7d20\u306f\u5730\u7403\u4e0a\u306e\u751f\u547d\u4f53\u306b\u5fc5\u9808\u306e\u5206\u5b50\u3067\u3042\u308a\u3001\u9178\u7d20\u306e\u6b20\u4e4f\u306f\u751f\u547d\u7dad\u6301\u306b\u304a\u3051\u308b\u8105\u5a01\u3068\u306a\u308a\u307e\u3059\u3002\u9178\u7d20\u304c\u6e1b\u5c11\u3057\u305f\u4f4e\u9178\u7d20\u74b0\u5883\u306b\u304a\u3044\u3066\u306f\u3001\u7d30\u80de\u306f\u4f4e\u9178\u7d20\u8a98\u5c0e\u56e0\u5b50(HIF)\u3092\u5373\u5ea7\u306b\u84c4\u7a4d\u3055\u305b\u3001\u305d\u306e\u8ee2\u5199\u6d3b\u6027\u306b\u3088\u308a\u3001\u7d30\u80de\u304c\u88ab\u308b\u4f4e\u9178\u7d20\u30b9\u30c8\u30ec\u30b9\u3092\u56de\u907f\u3059\u308b\u305f\u3081\u306e\u907a\u4f1d\u5b50\u8abf\u7bc0\u3092\u50cd\u304b\u305b\u307e\u3059\u3002\u305d\u306e\u4f4e\u9178\u7d20\u7d30\u80de\u5fdc\u7b54\u6a5f\u69cb\u306b\u9b45\u4e86\u3055\u308c\u3001\u6211\u3005\u306f\u300115\u5e74\u7a0b\u524d\u304b\u3089\u3001HIF\u306e\u6d3b\u6027\u5316\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6280\u8853\u306e\u958b\u767a\u3092\u9032\u3081\u3066\u304d\u307e\u3057\u305f(<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0015736\">PLoS ONE 2011;5:e15736<\/a>, <a href=\"https:\/\/www.nature.com\/articles\/srep34311\">Sci Rep 2016;6:34311<\/a>)\u30022019\u5e74\u306e\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u304c\u300c\u4f4e\u9178\u7d20\u5fdc\u7b54\u306e\u4ed5\u7d44\u307f\u306e\u767a\u898b\u300d\u306b\u95a2\u3059\u308b\u7814\u7a76\u6210\u679c\u306b\u8d08\u3089\u308c\u305f\u3053\u3068\u304c\u793a\u3059\u3088\u3046\u306b\u3001HIF\u3092\u4ecb\u3057\u305f\u4f4e\u9178\u7d20\u5fdc\u7b54\u306f\u3053\u306e20\u5e74\u7a0b\u306e\u9593\u306b\u5927\u304d\u306a\u9032\u5c55\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u8fd1\u5e74\u3001HIF\u975e\u4f9d\u5b58\u7684\u306a\u9178\u7d20\u5fdc\u7b54\u6a5f\u69cb\u3084\u3001\u751f\u4f53\u7d44\u7e54\u306b\u304a\u3044\u3066\u306f\u4f4e\u9178\u7d20\u74b0\u5883\u3092\u7d44\u7e54\u6052\u5e38\u6027\u306e\u8abf\u6574\u3084\u7d30\u80de\u6a5f\u80fd\u306e\u6d3b\u6027\u5316\u306b\u5fc5\u8981\u3068\u3059\u308b\u3001\u4f4e\u9178\u7d20=\u30b9\u30c8\u30ec\u30b9\u3068\u3044\u3046\u6982\u5ff5\u3092\u8986\u3059\u9178\u7d20\u30b7\u30b0\u30ca\u30eb\u306e\u91cd\u8981\u6027(\u9178\u7d20\u30d1\u30e9\u30c9\u30c3\u30af\u30b9)\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u4e00\u898b\u3059\u308b\u3068\u7d30\u80de\u306b\u3068\u3063\u3066\u4e0d\u5229\u306a\u4f4e\u9178\u7d20\u74b0\u5883\u306b\u304a\u3044\u3066\u3082\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u306f\u751f\u5b58\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308a\u3001\u3080\u3057\u308d\u7a4d\u6975\u7684\u306b\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u5fc3\u7dda\u7dad\u5316\u3092\u6297\u9032\u3059\u308b\u3053\u3068\u3092\u6211\u3005\u306f\u5831\u544a\u3057\u3066\u304d\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.atsjournals.org\/doi\/full\/10.1165\/rcmb.2016-0186OC\">AJRCMB 2018;58:216<\/a>, <a href=\"https:\/\/www.jstage.jst.go.jp\/article\/ihj\/60\/4\/60_18-710\/_article\/-char\/ja\/\">Int Heart J 2019;60:958<\/a>\uff09\u3002\u5225\u306e\u4f8b\u3068\u3057\u3066\u3001\u7d44\u7e54\u306e\u708e\u75c7\u306e\u7d42\u606f\u306b\u5fc5\u8981\u306a\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6b7b\u7d30\u80de\u8caa\u98df\u904e\u7a0b\u304c\u4f4e\u9178\u7d20\u74b0\u5883\u3067\u6d3b\u6027\u5316\u3055\u308c\u308b\u3053\u3068\u3082\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u96fb\u5b50\u4f1d\u9054\u7cfb\u3068\u89e3\u7cd6\u7cfb\u306b\u3088\u3063\u3066\u62c5\u308f\u308c\u308b\u7d30\u80de\u5185\u306e\u30a8\u30cd\u30eb\u30ae\u30fc(ATP)\u7523\u751f\u6a5f\u69cb\u3060\u3051\u304b\u3089\u306f\u8aac\u660e\u3067\u304d\u306a\u3044\u3053\u308c\u3089\u306e\u73fe\u8c61\u306b\u3064\u3044\u3066\u3001\u30e6\u30cb\u30fc\u30af\u306a\u751f\u4f53\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6280\u8853\u3084\u907a\u4f1d\u5b66\u7684\u52d5\u7269\u30e2\u30c7\u30eb\u3092\u99c6\u4f7f\u3057\u3066\u3001\u591a\u89d2\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u8a66\u307f\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u9178\u7d20\u7814\u7a76\u306e\u65b0\u3057\u3044\u65b9\u5411\u6027\u3092\u63a2\u7d22\u3059\u308b\u8a66\u307f\u3068\u3057\u3066\u3001<a href=\"https:\/\/www.jichi.ac.jp\/bioconvergence\/oxygenb\/\">\u5b66\u8853\u5909\u9769\u9818\u57df(B) \u751f\u4f53\u9178\u7d20\u52d5\u529b\u5b66<\/a> \u3092\u63a8\u9032\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u9178\u7d20\u306f\u5730\u7403\u4e0a\u306e\u751f\u547d\u4f53\u306b\u5fc5\u9808\u306e\u5206\u5b50\u3067\u3042\u308a\u3001\u9178\u7d20\u306e\u6b20\u4e4f\u306f\u751f\u547d\u7dad\u6301\u306b\u304a\u3051\u308b\u8105\u5a01\u3068\u306a\u308a\u307e\u3059\u3002\u9178\u7d20\u304c\u6e1b\u5c11\u3057\u305f\u4f4e\u9178\u7d20\u74b0\u5883\u306b\u304a\u3044\u3066\u306f\u3001\u7d30\u80de\u306f\u4f4e\u9178\u7d20\u8a98\u5c0e\u56e0\u5b50(HIF)\u3092\u5373\u5ea7\u306b\u84c4\u7a4d\u3055\u305b\u3001\u305d\u306e\u8ee2\u5199\u6d3b\u6027\u306b\u3088\u308a\u3001\u7d30\u80de\u304c\u88ab\u308b\u4f4e\u9178\u7d20\u30b9\u30c8\u30ec\u30b9\u3092\u56de\u907f\u3059 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1307,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[15,57],"tags":[],"class_list":["post-331","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-jp","category-oxygensignaling-jp"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/posts\/331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/comments?post=331"}],"version-history":[{"count":13,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/posts\/331\/revisions"}],"predecessor-version":[{"id":1323,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/posts\/331\/revisions\/1323"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/media\/1307"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/media?parent=331"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/categories?post=331"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/tags?post=331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}