{"id":385,"date":"2021-07-10T21:21:47","date_gmt":"2021-07-10T12:21:47","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wordpress\/?p=385"},"modified":"2025-12-08T05:39:32","modified_gmt":"2025-12-07T20:39:32","slug":"cellcellcommunication","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/bioconvergence\/en\/cellcellcommunication\/","title":{"rendered":"Interpretation and manipulation of tissue celltope"},"content":{"rendered":"<p>Biotopes serve as comfortable habitats for the coexistence of multiple organisms in nature. Similarly, cells within living tissues actively establish a more comfortable environment for themselves, we termed it as a \u201ccelltope\u201d. Disruption of this environment can lead to disease; however, by manipulating disease-specific celltopes, therapeutic strategies to reverse or halt disease progression can be feasible. We have been working on developing a comprehensive and deep analytical approach to understand tissue celltopes, especially focusing on cell-cell interactions (<a href=\"https:\/\/www.nature.com\/articles\/s41467-023-43855-2\">Nat Commun 2023; 14: 8031<\/a>). This opto-intereactmics technique is achieved by unique synthetic biomolecules for integrating optical cell labeling technologies with single cell omics. We are striving further refinement of interpretation strategies of tissue celltopes. We&#8217;re also developing unique technologies to manipulate celltopes for disease-specific therapeutic strategies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Biotopes serve as comfortable habitats for the coexistence of multiple organisms in nature. Similarly, cells w [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1309,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17,78],"tags":[],"class_list":["post-385","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-en","category-celltope-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/posts\/385","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/comments?post=385"}],"version-history":[{"count":12,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/posts\/385\/revisions"}],"predecessor-version":[{"id":1339,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/posts\/385\/revisions\/1339"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/media\/1309"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/media?parent=385"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/categories?post=385"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/tags?post=385"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}