{"id":996,"date":"2024-10-23T08:30:04","date_gmt":"2024-10-22T23:30:04","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/bioconvergence\/?p=996"},"modified":"2025-12-08T05:34:02","modified_gmt":"2025-12-07T20:34:02","slug":"inflammatoryremodeling_jp","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/bioconvergence\/inflammatoryremodeling_jp\/","title":{"rendered":"\u708e\u75c7\u3092\u4ecb\u3057\u305f\u7d44\u7e54\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u6a5f\u69cb"},"content":{"rendered":"<p>\u5fc3\u81d3\u75c5\u3084\u6162\u6027\u814e\u81d3\u75c5\u306e\u7d44\u7e54\u306b\u306f\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306a\u3069\u306e\u708e\u75c7\u7d30\u80de\u304c\u96c6\u7a4d\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u708e\u75c7\u7d30\u80de\u306f\u3001\u3053\u308c\u307e\u3067\u7d30\u83cc\u611f\u67d3\u3084\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306a\u3069\u3001\u611f\u67d3\u5fdc\u7b54\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3067\u306f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304c\u611f\u67d3\u75c7\u3067\u306f\u306a\u3044\u5fc3\u4e0d\u5168\u3084\u6162\u6027\u814e\u81d3\u75c5\u306e\u7d44\u7e54\u306b\u306a\u305c\u96c6\u7a4d\u3059\u308b\u306e\u304b\u3001\u307e\u305f\u3053\u308c\u3089\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306f\u75c5\u614b\u3067\u3069\u306e\u3088\u3046\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u306e\u304b\u306f\u3053\u308c\u307e\u3067\u5927\u304d\u306a\u7591\u554f\u3068\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002<br \/>\n\u8fd1\u5e74\u306e\u7814\u7a76\u304b\u3089\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306f\u5747\u4e00\u306a\u7d30\u80de\u96c6\u56e3\u3067\u306f\u306a\u304f\u3001\u69d8\u3005\u306a\u4e9c\u96c6\u56e3\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u5224\u3063\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u708e\u75c7\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3067\u3042\u308b\u4e00\u9178\u5316\u7a92\u7d20(Nitric oxide, NO)\u3092\u7523\u751f\u3059\u308b\u708e\u75c7\u60f9\u8d77\u578b(M1)\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001NO\u7523\u751f\u3092\u6291\u5236\u3059\u308b\u708e\u75c7\u6291\u5236\u578b(M2)\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306a\u3069\u306e\u5206\u985e\u304c\u826f\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u79c1\u9054\u306f\u3053\u308c\u307e\u3067\u4f4e\u9178\u7d20\u74b0\u5883\u3067\u6d3b\u6027\u5316\u3055\u308c\u308b\u8ee2\u5199\u56e0\u5b50Hypoxia inducible factor-\u03b1(HIF-\u03b1)\u306b\u7740\u76ee\u3057\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u6d3b\u6027\u5316\u306e\u5206\u5b50\u6a5f\u69cb\u89e3\u660e\u306b\u53d6\u308a\u7d44\u3093\u3067\u304d\u307e\u3057\u305f\u3002HIF-\u03b1\u306b\u306f\u4e3b\u306b3\u3064\u306e\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u7279\u306bHIF-1\u03b1\u3001HIF-2\u03b1\u306b\u3064\u304d\u8a73\u7d30\u306a\u89e3\u6790\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u79c1\u9054\u306fHIF-1\u03b1\u304cM1\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3001HIF-2\u03b1\u304cM2\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u767a\u73fe\u3057\u3001\u305d\u308c\u305e\u308cNO\u7523\u751f\u3092\u5897\u52a0\u30fb\u6e1b\u5c11\u3055\u305b\u308b\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u4e8b\uff08HIF\u30b9\u30a4\u30c3\u30c1\u30f3\u30b0\uff09\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\uff08<a href=\"http:\/\/genesdev.cshlp.org\/content\/24\/5\/491\">Gene Dev 2010;24:491<\/a>, <a href=\"https:\/\/www.pnas.org\/content\/110\/43\/17570\">PNAS 2013;110:17570<\/a>\uff09\u3002<br \/>\nHIF-1\u03b1\u30b7\u30b0\u30ca\u30eb\u306f\u307e\u305f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u547c\u5438\u3092\u6291\u5236\u3057\u3001\u5acc\u6c17\u7684\u89e3\u7cd6\u3078\u3068\u7d30\u80de\u5185\u4ee3\u8b1d\u3092\u30b7\u30d5\u30c8\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u708e\u75c7\u5c40\u6240\u3078\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u96c6\u7a4d\u3092\u4fc3\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/ncomms11635\">Nature Commun 2016;7:11635<\/a>\uff09\u3002\u3053\u308c\u3089\u5fc3\u81d3\u306b\u96c6\u7a4d\u3059\u308b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u4e00\u3064\u3067\u3042\u308b\u30aa\u30f3\u30b3\u30b9\u30bf\u30c1\u30f3M\u3092\u5206\u6ccc\u3059\u308b\u3053\u3068\u3067\u3001\u5fc3\u81d3\u306e\u904e\u5270\u306a\u7dda\u7dad\u5316\u3092\u9632\u3050\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u5224\u3063\u3066\u304d\u307e\u3057\u305f\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-10859-w\">Nature Comm 2019;10:2824<\/a>\uff09\u3002\u5f15\u304d\u7d9a\u304d\u75c5\u614b\u306b\u304a\u3051\u308b\u708e\u75c7\u7d30\u80de\u306e\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u5fc3\u81d3\u75c5\u3084\u6162\u6027\u814e\u81d3\u75c5\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u3078\u3068\u7e4b\u3052\u308b\u3079\u304f\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5fc3\u81d3\u75c5\u3084\u6162\u6027\u814e\u81d3\u75c5\u306e\u7d44\u7e54\u306b\u306f\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306a\u3069\u306e\u708e\u75c7\u7d30\u80de\u304c\u96c6\u7a4d\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u708e\u75c7\u7d30\u80de\u306f\u3001\u3053\u308c\u307e\u3067\u7d30\u83cc\u611f\u67d3\u3084\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306a\u3069\u3001\u611f\u67d3\u5fdc\u7b54\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3067\u306f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304c\u611f\u67d3\u75c7 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[15],"tags":[],"class_list":["post-996","post","type-post","status-publish","format-standard","hentry","category-research-jp"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/posts\/996","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/comments?post=996"}],"version-history":[{"count":5,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/posts\/996\/revisions"}],"predecessor-version":[{"id":1335,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/posts\/996\/revisions\/1335"}],"wp:attachment":[{"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/media?parent=996"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/categories?post=996"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jichi.ac.jp\/bioconvergence\/wp-json\/wp\/v2\/tags?post=996"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}