Introduction

医局員紹介

教授ご挨拶

糖尿病センター

合同カンファランス

研究業績

• ＞2023年　原著論文

  1) GR-KLF15 pathway controls hepatic lipogenesis during fasting.

  Takeuchi Y, Murayama Y, Aita Y, Mehrazad Saber Z, Karkoutly S, Tao D, Katabami K, Ye C, Shikama A, Masuda Y, Izumida Y, Miyamoto T, Matsuzaka T, Kawakami Y, Shimano H, Yahagi N.

  FEBS J 291:259-271, 2024.

   

  2) New balance capability index as a screening tool for mild cognitive impairment.

  Suzuki Y, Tsubaki T, Nakaya K, Kondo G, Takeuchi Y, Aita Y, Murayama Y, Shikama A, Masuda Y, Suzuki H, Kawakami Y, Shimano H, Arai T, Hada Y, Yahagi N.

  BMC Geriatr 23:74, 2023.

   

   

  3) A novel missense MEN1 mutation in a sporadic case of multiple endocrine neoplasia type 1 complicated with papillary thyroid carcinoma.

  Shibuya K, Ebihara K, Takahashi M, Kurashina T, Nagashima S, Okada K, Ishibashi S.

  JMA J 6:216-219, 2023.

   

  4) A case of vasoactive intestinal peptide-secreting tumor (VIPoma) arising from MEN1 inactivation which recurred 15 years after the initial resection.

  Sakurai M, Wakabayashi T, Kondo Y, Ikeda E, Watanabe K, Takei A, Okazaki H, Okada K, Ebihara K, Kakiuchi N, Ogawa S, Fukushima N, Ishibashi S.

  Endocr J 70:573-579, 2023.

   

  5) Serum 25-hydroxycholesterol levels are increased in patients with coronavirus disease 2019.

  Asano T, Wakabayashi T, Kondo Y, Okada K, Yamamuro D, Koga Y, Oka K, Sakurai M, Sawayama N, Takahashi M, Okazaki H, Ebihara K, Minami K, Morisawa Y, Hatakeyama S, Matsumura M, Ishibashi S.

  J Clin Lipidol 17:78-86, 2023.

   

   

• ＞2022年以前　原著論文

  2022年以前の代表的論文

   

  1) Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.

  Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Pall D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators.

  N Engl J Med 387:1923-1934, 2022.

   

  2) Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice.

  Takahashi M, Yamamuro D, Wakabayashi T, Takei A, Takei S, Nagashima S, Okazaki H, Ebihara K, Yagyu H, Takayanagi Y, Onaka T, Goldberg IJ, Ishibashi S.

  J Biol Chem 298:102322, 2022.

   

  3) AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4.

  Shibuya K, Ebihara K, Ebihara C, Sawayama N, Isoda M, Yamamuro D, Takahashi M, Nagashima S, Ishibashi S.

  J Biol Chem 298:101936, 2022.

   

  4) FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin.

  Takeuchi Y, Yahagi N, Aita Y, Mehrazad Saber Z, Ho MH, Huyan Y, Murayama Y, Shikama A, Masuda Y, Izumida Y, Miyamoto T, Matsuzaka T, Kawakami Y, Shimano H.

  iScience 24:103446, 2021.

   

  5) Genome-wide screening of upstream transcription factors using an expression library.

  Yahagi N, Takeuchi Y.

  F1000Research 10:51, 2021.

   

  6) Leptin sensitizing effect of 1,3-butanediol and its potential mechanism.

  Isoda M, Ebihara K, Sawayama N, Murakami A, Ebihara C, Shibuya K, Takei A, Takei S, Wakabayashi T, Yamamuro D, Takahashi M, Nagashima S, Ishibashi S.

  Sci Rep 11:17691, 2021.

   

  7) Myeloid HMG-CoA reductase determines adipose tissue inflammation, insulin resistance, and hepatic steatosis in diet-induced obese mice.

  Takei A, Nagashima S, Takei S, Yamamuro D, Murakami A, Wakabayashi T, Isoda M, Yamazaki H, Ebihara C, Takahashi M, Ebihara K, Ishibashi S.

  Diabetes 69:158-164, 2020.

   

  8) β-cell-specific deletion of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme a) reductase causes overt diabetes due to reduction of β-cell mass and impaired insulin secretion.

  Takei S, Nagashima S, Takei A, Yamamuro D, Wakabayashi T, Murakami A, Isoda M, Yamazaki H, Ebihara C, Takahashi M, Ebihara K, Dezaki K, Takayanagi Y, Onaka T, Fujiwara K, Yashiro T, Ishibashi S.

  Diabetes 69:2352-2363, 2020.

   

  9) Critical role of SREBP-1c large-VLDL pathway in environment-induced hypertriglyceridemia of Apo AV deficiency.

  Takanashi M, Kimura T, Li C, Tanaka M, Matsuhashi A, Yoshida H, Noda A, Xu P, Takase S, Okazaki S, Iizuka Y, Kumagai H, Ikeda Y, Gotoda T, Takahashi M, Yagyu H, Ishibashi S, Yamauchi T, Kadowaki T, Liang G, Okazaki H.

  Arterioscler Thromb Vasc Biol 39:373-386, 2019.

   

  10) Cost-effectiveness of a new opportunistic screening strategy for walk-in fingertip HbA1c testing at community pharmacies in Japan.

  Shono A, Kondo M, Hoshi S, Okubo R, Yahagi N.

  Diabetes Care 41:1218-1226, 2018.

   

  11) KLF15 enables rapid switching between lipogenesis and gluconeogenesis during fasting.

  Takeuchi Y, Yahagi N, Aita Y, Murayama Y, Sawada Y, Piao X, Toya N, Oya Y, Shikama A, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Yamamoto T, Sekiya M, Matsuzaka T, Nakagawa Y, Urayama O, Kawakami Y, Iizuka Y, Gotoda T, Itaka K, Kataoka K, Nagai R, Kadowaki T, Yamada N, Lu Y, Jain MK, Shimano H.

  Cell Rep 16:2373-86, 2016.

   

  12) Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis.

  Ebihara C, Ebihara K, Aizawa-Abe M, Mashimo T, Tomita T, Zhao M, Gumbilai V, Kusakabe T, Yamamoto Y, Aotani D, Yamamoto-Kataoka S, Sakai T, Hosoda K, Serikawa T, Nakao K.

  Hum Mol Genet 2015 24:4238-49, 2015.

   

  13) Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization.

  Izumida Y, Yahagi N, Takeuchi Y, Nishi M, Shikama A, Takarada A, Masuda Y, Kubota M, Matsuzaka T, Nakagawa Y, Iizuka Y, Itaka K, Kataoka K, Shioda S, Niijima A, Yamada T, Katagiri H, Nagai R, Yamada N, Kadowaki T, Shimano H.

  Nat Commun 4:2316, 2013.