{"id":1510,"date":"2026-08-05T18:31:17","date_gmt":"2026-08-05T09:31:17","guid":{"rendered":"https:\/\/www.jichi.ac.jp\/jmu-cgtr\/?p=1510"},"modified":"2026-08-05T18:46:47","modified_gmt":"2026-08-05T09:46:47","slug":"post-1510","status":"publish","type":"post","link":"https:\/\/www.jichi.ac.jp\/jmu-cgtr\/news\/post-1510\/","title":{"rendered":"\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u3092\u7528\u3044\u305f\u5869\u57fa\u7de8\u96c6\u306b\u3088\u308a\u8840\u53cb\u75c5B\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u5909\u7570\u3092\u30de\u30a6\u30b9\u3067\u4fee\u5fa9"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>\u2015 \u907a\u4f1d\u5b50\u88dc\u5145\u7642\u6cd5\u306b\u4ee3\u308f\u308b\u65b0\u305f\u306a\u6839\u6cbb\u7684\u30b2\u30ce\u30e0\u7de8\u96c6\u6cbb\u7642\u306e\u53ef\u80fd\u6027 \u2015<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3010\u7814\u7a76\u6210\u679c\u306e\u6982\u8981\u3011<\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u672c\u6210\u679c\u306f\u3001\u5f93\u6765\u306e\u907a\u4f1d\u5b50\u88dc\u5145\u7642\u6cd5\u3068\u306f\u7570\u306a\u308a\u3001\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u5b50\u5909\u7570\u305d\u306e\u3082\u306e\u3092\u4fee\u5fa9\u3059\u308b\u300c\u6839\u6cbb\u7684\u30b2\u30ce\u30e0\u7de8\u96c6\u6cbb\u7642\u300d\u306e\u53ef\u80fd\u6027\u3092\u793a\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u307e\u305f\u3001LNP\u3092\u7528\u3044\u305f\u975e\u30a6\u30a4\u30eb\u30b9\u6027\u9001\u9054\u6280\u8853\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u518d\u6295\u4e0e\u3084\u5c0f\u5150\u671f\u3078\u306e\u5fdc\u7528\u3082\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u4eca\u56de\u78ba\u7acb\u3057\u305f\u6280\u8853\u306f\u3001\u8840\u53cb\u75c5B\u306e\u307f\u306a\u3089\u305a\u3001\u3055\u307e\u3056\u307e\u306a\u5358\u4e00\u907a\u4f1d\u5b50\u75be\u60a3\u306b\u5bfe\u3059\u308b\u500b\u5225\u5316\u30b2\u30ce\u30e0\u7de8\u96c6\u533b\u7642\u306e\u5b9f\u73fe\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u306f\u81ea\u6cbb\u533b\u79d1\u5927\u5b66\u3092\u4ee4\u548c7\u5e74\u306b\u5352\u696d\u3057\u305f\u6c96\u7e04\u770c\u51fa\u8eab\u306e\u5ddd\u53e3\uff08\u80a5\u8c37\uff09\u3046\u3061\u306a\u3000\u5148\u751f\u304c\u7b46\u982d\u8457\u8005\u3067\u3042\u308a\u3001\u5f0a\u5b66\u306e\u30d5\u30ea\u30fc\u30b3\u30fc\u30b9\u30b9\u30c1\u30e5\u30fc\u30c7\u30f3\u30c8\u30c9\u30af\u30bf\u30fc\u5236\u5ea6\u30926\u5e74\u6b21\u306b\u5229\u7528\u3057\u3066\u884c\u3063\u305f\u7814\u7a76\u6210\u679c\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3010\u8ad6\u6587\u3011<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hiya-Kawaguchi U, Kashiwakura Y, Baatartsogt N, Lodoi K, Togashi T, Sato T, Tsuchida K, Batjargal K, Hayakawa M, Sato R, Sato Y, Ohmori T. Non-viral delivery of a base editor enables personalized correction of hemophilia B nonsense variants in a mouse model. Journal of Thrombosis and Haemostasis 2026 Jun 11:S1538-7836(26)00382-X [Epub ahead of print].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">doi: 10.1016\/j.jtha.2026.06.003.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3010\u7814\u7a76\u52a9\u6210\u3011<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u306f\u3001\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb\uff08AMED\uff09\u30a8\u30a4\u30ba\u5bfe\u7b56\u5b9f\u7528\u5316\u7814\u7a76\u4e8b\u696d\u300c\u8840\u53cb\u75c5\u304c\u62b1\u3048\u308b\u8ab2\u984c\u306e\u89e3\u6c7a\u3092\u76ee\u6307\u3057\u305f\u65b0\u898f\u6cbb\u7642\u6cd5\u30fb\u8a3a\u7642\u4f53\u5236\u306e\u5275\u51fa\u300d\uff08\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5927\u68ee \u53f8\uff09\u3001AMED\u518d\u751f\u30fb\u7d30\u80de\u533b\u7642\u30fb\u907a\u4f1d\u5b50\u6cbb\u7642\u5b9f\u73fe\u52a0\u901f\u5316\u30d7\u30ed\u30b0\u30e9\u30e0\uff08\u518d\u751f\u30fb\u7d30\u80de\u533b\u7642\u30fb\u907a\u4f1d\u5b50\u6cbb\u7642\u7814\u7a76\u958b\u767a\u8ab2\u984c[\u975e\u81e8\u5e8aPoC\u53d6\u5f97\u7814\u7a76\u8ab2\u984c]\uff09\u300c\u96e3\u6cbb\u6027\u809d\u75be\u60a3\u306b\u5bfe\u3059\u308b\u753b\u671f\u7684\u306a\u5c0f\u5150\u30b2\u30ce\u30e0\u7de8\u96c6\u6cbb\u7642\u306e\u5275\u51fa\u300d\uff08\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5927\u68ee\u3000\u53f8\uff09\u3001AMED\u518d\u751f\u30fb\u7d30\u80de\u533b\u7642\u30fb\u907a\u4f1d\u5b50\u6cbb\u7642\u5b9f\u73fe\u52a0\u901f\u5316\u30d7\u30ed\u30b0\u30e9\u30e0\uff08\u518d\u751f\u30fb\u7d30\u80de\u533b\u7642\u30fb\u907a\u4f1d\u5b50\u6cbb\u7642\u7814\u7a76\u4e2d\u6838\u62e0\u70b9\uff09\u300c\u6b21\u4e16\u4ee3\u533b\u7642\u3092\u76ee\u6307\u3057\u305f\u518d\u751f\u30fb\u7d30\u80de\u533b\u7642\u30fb\u907a\u4f1d\u5b50\u6cbb\u7642\u7814\u7a76\u958b\u767a\u62e0\u70b9\u300d\uff08\u7814\u7a76\u958b\u767a\u62c5\u5f53\u8005\uff1a\u5927\u68ee\u3000\u53f8\uff09\u3001\u79d1\u7814\u8cbb\uff08Japan Society for the Promotion of Science [JSPS] KAKENHI [JP23K27510]\uff09(\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5927\u68ee\u3000\u53f8)\u3001\u516c\u76ca\u8ca1\u56e3\u6cd5\u4eba\u3000\u5185\u85e4\u8a18\u5ff5\u79d1\u5b66\u632f\u8208\u8ca1\u56e3\uff08\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u5927\u68ee \u53f8\uff09\u3001\u306a\u3069\u306e\u652f\u63f4\u306b\u3088\u308a\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3010\u7528\u8a9e\u89e3\u8aac\u3011<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><sup>\uff0a1<\/sup>LNP\uff1a\u907a\u4f1d\u5b50\u6cbb\u7642\u3084\u30ef\u30af\u30c1\u30f3\u306b\u4f7f\u3046\u907a\u4f1d\u60c5\u5831\u3092\u4f53\u5185\u306e\u7d30\u80de\u3078\u5b89\u5168\u304b\u3064\u52b9\u7387\u3088\u304f\u5c4a\u3051\u308b\u305f\u3081\u306e\u3001\u8102\u8cea\u3067\u3067\u304d\u305f\u30ab\u30d7\u30bb\u30eb\u7528\u306e\u7269\u8cea\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><sup>\uff0a2<\/sup>\u5869\u57fa\u7de8\u96c6\uff1aDNA\u306e\u6587\u5b57\uff08\u5869\u57fa\uff09\u30921\u6587\u5b57\u3060\u3051\u6b63\u78ba\u306b\u66f8\u304d\u63db\u3048\u308b\u3053\u3068\u3067\u3001\u75c5\u6c17\u306e\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u5b50\u5909\u7570\u3092\u4fee\u5fa9\u3059\u308b\u65b0\u3057\u3044\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><sup>\uff0a3<\/sup>\u30ca\u30f3\u30bb\u30f3\u30b9\u5909\u7570\uff1a\u907a\u4f1d\u5b50\u306e\u9014\u4e2d\u306b\u300e\u7d42\u308f\u308a\u300f\u306e\u4fe1\u53f7\u304c\u751f\u3058\u3066\u3057\u307e\u3044\u3001\u672c\u6765\u5fc5\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6700\u5f8c\u307e\u3067\u4f5c\u308c\u306a\u304f\u306a\u308b\u5909\u7570\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><sup>\uff0a4<\/sup>AAV\u30d9\u30af\u30bf\u30fc\uff1a\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u3092\u4f53\u5185\u306e\u7d30\u80de\u3078\u904b\u3076\u305f\u3081\u306b\u5229\u7528\u3055\u308c\u308b\u3001\u75c5\u539f\u6027\u306e\u306a\u3044\u30a6\u30a4\u30eb\u30b9\u3092\u6539\u826f\u3057\u305f\u907a\u4f1d\u5b50\u306e\u904b\u3073\u5c4b\u3002\u69d8\u3005\u306a\u907a\u4f1d\u5b50\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3010\u554f\u3044\u5408\u308f\u305b\u5148\u3011<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a>\u3008\u7814\u7a76\u306b\u95a2\u3059\u308b\u554f\u5408\u305b\u3009<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u81ea\u6cbb\u533b\u79d1\u5927\u5b66 \u533b\u5b66\u90e8 \u751f\u5316\u5b66\u8b1b\u5ea7 \u75c5\u614b\u751f\u5316\u5b66\u90e8\u9580<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u51c6\u6559\u6388\u3000\u67cf\u5009\u3000\u88d5\u5fd7\uff08\u304b\u3057\u308f\u304f\u3089\u3000\u3086\u3046\u3058\uff09\u3001\u6559\u6388\u3000\u5927\u68ee \u53f8\uff08\u304a\u304a\u3082\u308a \u3064\u304b\u3055\uff09<a><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tel\uff1a0285-58-7324\u3000E-mail\uff1a<a href=\"mailto:ykashi@jichi.ac.jp\">ykashi@jichi.ac.jp<\/a>; 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