Japanese

Our Research

1. Deciphering Molecular Mechanisms of Cardiomyocyte Maturation

We aim to elucidate molecular mechanisms regulating cardiomyocyte maturation.
With an efficient, directed cardiac differentiation method, we are able to obtain cardiomyocytes from pluripotent stem cells. However, such cardiomyocytes were immature as fetal cardiomyocytes, which limits the potential of stem cell derived cardiomyocytes being a platform to study human heart diseases.
We will elucidate the molecular mechanisms and provide a platform to recaptulate human heart diseases in vitro.

2. Disease Modeling in vivo and in vitro

We are working on to model cardiac myopathy and malformation in vivo and/or in vitro.
In a collabolation with Drs. Koitabashi (Gunma U), Nishizono (Max Planck Florida), and other researchers of Jichi Medical Unviersity, we are generating animal models harvoring SNVs that found in congenital heart diseases and cardiac myopathy.
As a part of an AMED-sponsored project, we are establishing a number of patient-derived iPS cell lines for mitochondrial diseases and neural disorders in collabolation with Dr. Murayama (Chiba Children's Hospital) and our pediatrics department.
To analyze the physiological function of iPS cell-derived cardiomyocytes, we are developing new tools and techniques for sarcomere shortining with live-imaging, which may facilitate the cardiomyopathy study.
These studies will provide novel perspectives in heart diseases.

Members

Associate Professor
魚崎 英毅

Hideki Uosaki, MD., PhD

Associate Professor, PI

2004: M.D., Hokkaido University
2011: Ph.D, Kyoto University
In 2016, he joined to the division as a lecturer. In 2017, he was promoted to Associate Professor.

Junior faculty and Trainees

Assistant Professor
Tatsuya Anzai

Tatsuya Anzai, MD, PhD.

2012: M.D., Kanazawa University.
2022: Ph.D., Jichi Medical University
After residency at JICHI Medical University, he entered Ph.D. program at pediatrics department, JICHI Medical University in 2018.
He joined our lab to study VUS, related to congenital heart diseases, using mouse models and stem cell biology.
In 2022, he was awarded Ph.D. from JICHI Medical University and promoted to Assistant Professor of the pediatrics department, Jichi Meidlca University.
He contineus his gene thepary studies here as a part-time.

Postdoctoral Fellow
Takeshi Tokuyama

Takeshi Tokuyama, PhD

2017: Ph.D., Tokyo University of Pharmacy and Life Sciences.
After being a postdoc for Tokyo University of Pharmacy and Life Sciences and Johns Hopkins University, he joined as a postdoc in 2021.

Postdoctoral Fellow
Nawin Chanthra

Nawin Chanthra, MSc, PhD

Ph.D Student. He graduated from Chulalongkorn University, Thailand and joined our lab in 2016 as a Ph.D. student (JMU Special International Graduate Student Program). In 2020, Nawin was awarded a Ph.D.

Postdoctoral Fellow
Fuad Gandhi Torizal

Fuad Gandhi Torizal, DDs, PhD.

2010: D.Ds., Padjajaran University.
2013: M.Biotech., Gadjah Mada University.
2019: Ph.D., The University of Tokyo.
After being a postdoc at the University of Tokyo, he joined our lab as a postdoc in 2022.

Graduate Student
Razan

Razan Elfadil Ahmed Abbas, MD

2017: M.D., The University of Khartoum.
After one year of Internship at Ministry of Health Hospital in Sudan, she joined our lab as a research student in July, 2019 and continues as a graduate student from 2020

Laborantine

laborantine
石原 理恵

Rie Ishihara

Technical Staff

Alumni

Kumiko Iwabuchi, PhD
2020.10-2021.6: Postdoctoral Fellow
Current: Scientist of Synthego (CA, USA) and Visiting Researcher of our lab.
Nurmila Sari, PhD
2020.10-2021.3: Postdoctoral Fellow
2021.4-2021.10: Visiting Researcher of our lab,
current: RIKEN Postdoctoral Fellow (JSPS International Fellowship for Research in Japan; Standard Program)

Publication

Full Publication List

Preprints
2020
2019
2018
2017
2016
2015
ページのトップへ戻る