これまでの発表論文

Amano Y, Matsubara D, Kihara A, Nishino H, Mori Y, Niki T. Expression and localisation of methylthioadenosine phosphorylase (MTAP) in oral squamous cell carcinoma and their significance in epithelial-to-mesenchymal transition. Pathology. 2022;54:294-301.

Kawazu M, Ueno T, Saeki K, Sax N, Togashi Y, Kaneseki T, Chida K, Kishigami F, Sato K, Kojima S, Otsuka M, Kawazoe A, Nishinakamura H, Maeda Y, Yamamoto Y, Yamashita K, Inoue S, Tanegashima T, Matsubara D, Tane K, Tanaka Y, Iinuma H, Hashiguchi Y, Hazama S, Khor SS, Tokunaga K, Tsuboi M, Niki T, Eto M, Shitara K, Torigoe T, Ishihara S, Aburatani H, Haeno H, Nishikawa H, Mano H. HLA Class I analysis provides insight into the genetic and epigenetic background of immune evasion in colorectal cancer with high microsatellite instability. Gastroenterology. 2022;162:799-812.

Amano Y, Kihara A, Hasegawa M, Miura T, Matsubara D, Fukushima N, Nishino H, Mori Y, Niki T. Clinicopathological and Prognostic Significance of Stromal Patterns in Oral Squamous Cell Carcinoma. Front Med (Lausanne). 2022 Apr 15;9:859144. doi: 10.3389/fmed.2022.859144. eCollection 2022.

Kihara A, Amano Y, Fukushima N, Fujiwara H, Niki T. ZEB1 expression is frequently detected in undifferentiated and dedifferentiated carcinomas, but is not specific among endometrial carcinomas. Histopathology. 2022 Jul;81(1):108-118. doi: 10.1111/his.14671.

Hirai S, Idogawa M, Sumi T, Yamaguchi M, Niki T, Sakuma Y. Dual inhibition of BCL2L1 and MCL1 is highly effective against RET fusion-positive or MET exon 14 skipping mutation-positive lung adenocarcinoma cells. Biochem Biophys Res Commun. 2022, 630:24-29. doi: 10.1016/j.bbrc.2022.09.039. Epub 2022 Sep 14.

Matsubara D, Yoshimoto T, Akolekar N, Totsuka T, Amano Y, Kihara A, Miura T, Isagawa Y, Sakuma Y, Ishikawa S, Ushiku T, Fukayama M, Niki T. Genetic and phenotypic determinants of morphologies in 3D cultures and xenografts of lung tumor cell lines. Cancer Sci. 2022 Dec 19. doi: 10.1111/cas.15702.

Kamei J, Yokoyama H, Niki T, Suda R, Sugihara T, Fujisaki A, Ando S, Iwami D, Fujimura T. Complete response to pembrolizumab for metastatic urothelial carcinoma in the renal pelvis of allograft kidney. IJU Case Rep. 2022 Mar 25;5(3):199-202. doi: 10.1002/iju5.12438. eCollection 2022 May. PMID: 35509786

Hyuga T, Nakamura S, Tanabe K, Kubo T, Niijima H, Kawahara Y, Nakata W, Furukawa R, Sakaguchi M, Shimada A, Matsuki M, Niki T, Kamiyama Y, Moriya K, Nakai H. A pediatric case of inverted papilloma in the bladder detected by screening ultrasonography based on findings from a school medical checkup J Pediatric Surg Case Rep, 2022, DOI 10.1016/j.epsc.2022.102472

Funaki T, Ito T, Tanei ZI, Goto A, Niki T, Matsubara D, Murakami Y. CADM1 promotes malignant features of small-cell lung cancer by recruiting 4.1R to the plasma membrane. Biochem Biophys Res Commun. 2021;534:172-178.

Amano Y, Tsuji K, Kihara A, Matsubara D, Fukushima N, Nishino H, Niki T. Solitary adrenal metastasis from salivary duct carcinoma of the parotid gland successfully treated by surgery: A case report. Medicine. 2021.100(2):e24011.

Sakuma Y, Hirai S, Sumi T, Tada M, Kojima T, Niki T, Yamaguchi M. MCL1 inhibition enhances the efficacy of docetaxel against airway-derived squamous cell carcinoma cells. Exp Cell Res. 2021 Sep 15;406(2):112763.

Kihara A, Iizuka T, Endo S, Horie K, Kanda H, Niki T. Ovarian clear cell carcinoma with an immature teratoma component showing ARID1A deficiency and an identical PIK3CA mutation. J Obstet Gynaecol Res. 2021 Jun 9. doi: 10.1111/jog.14864

Kihara A, Amano Y, Matsubara D, Fukushima N, Fujiwara H, Niki T. Infrequent loss of SMARCA4, SMARCA2, and SMARCB1 expression in uterine mesenchymal tumors. Hum Pathol. 2021;116:12-21.

Kihara A, Amano Y, Matsubara D, Fukushima N, Fujiwara H, Niki T. BRG1, INI1, and ARID1B deficiency in endometrial carcinoma: A clinicopathological and immunohistochemical analysis of a large series from a single institution. Am J Surg Pathol 2020 44(12):1712-1724.

Matsubara D, Yoshimoto T, Soda M, Amano Y, Kihara A, Funaki T, Ito T, Sakuma Y, Shibano T, Endo S, Hagiwara K, Ishikawa S, Fukayama M, Murakami Y, Mano H, Niki T. Reciprocal expression of TFF-1 (trefoil factor-1) and TTF-1 (thyroid transcription factor-1) in lung adenocarcinomas. Canser Sci, 2020 111:2183-2195.

Hirai S, Tada M, Yamaguchi M, Niki T, Sakuma Y. EGFR-independent EGFR-mutant lung adenocarcinoma cells depend on Bcl-xL and MCL1 for survival. Biochem Biophys Res Commun. 2020; 526: 417-423.

Nakaya T, Kamiya K, Nakaya M, Tsuji K, Niki T, Ohtsuki M, Tanaka A. Myofibroblast phagocytic cutaneous mucinosis: phagocytosis of mucinous substances by myofibroblasts in a distinctive cutaneous mucinosis: A case report. Medicine (Baltimore). 2020 Jul 17;99(29):e20867.

Amano Y, Sakaguchi-Tamba M, Sasaki Y, Oshiro H, Fukushima N, Fujita T, Masuda S, Niki T. Adenomyoepithelioma with HER2-FISH-confirmed DCIS component: a case report and review of the literature. Medicine. 2020.99(42):e22665.

Kihara A, Amano Y, Matsubara D, Fukushima N, Fujiwara H, Niki T. BRG1, INI1, and ARID1B Deficiency in Endometrial Carcinoma: A Clinicopathologic and Immunohistochemical Analysis of a Large Series From a Single Institution. Am J Surg Pathol. 2020; 44:1712-1724.

Yoshimoto T, Matsubara D, Soda M, Ueno T, Amano Y, Kihara A, Sakatani T, Nakano T, Shibano T, Endo S, Hagiwara K, Fukayama M, Denda-Nagai K, Irimura T, Mano H, Niki T. MUC21 is a Key Molecule Involved in the Incohesive Growth Pattern in Lung Adenocarcinoma. Canser Sci, 2019 110:3006-3011

Kihara A, Amano Y, Yoshimoto T, Matsubara D, Fukushima N, Fujiwara H, Niki T. Stromal p16 expression helps distinguish atypical polypoid adenomyoma from myoinvasive endometrioid carcinoma of the uterus. Am J Surg Pathol, 2019 43:1526-1535

Ito T, Nakamura A, Tanaka I, Tsuboi Y, Morikawa T, Nakajima J, Takai D, Fukayama M, Sekido Y, Niki T, Matsubara D, Murakami Y. CADM1 associates with Hippo pathway core kinases; membranous co-expression of CADM1 & LATS2 in lung tumors predicts good prognosis. Canser Sci, 2019 110:2284-2295

Hirosawa T, Morimoto N, Miura K, Ono K, Watanabe S, Fujieda T, Murayama K, Takaoka Y, Nomoto H, Tsukui M, Isoda N, Niki T, Tokushige K, Yamamoto H. The successful treatment of hepatocellular carcinoma arising from congenital hepatic fibrosis using radiofrequency ablation under laparoscopy. Clin J Gastroenterol. 2019 Jan 7. doi: 10.1007/s12328-018-00932-0.

Takigami A, Yamasawa H, Kurosaki A, Sakamoto N, Onuki T, Mato N, Tetsuka K, Endo S, Niki T, Bando M, Hagiwara K. Pazopanib Confers a Progression-free Survival in a Patient with Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Lung. Intern Med. 2019 Jan 10. doi: 10.2169/internalmedicine.1549-18.

Komatsubara T, Oshiro H, Sakuma Y, Sata N, Niki T, Fukushima N. Overexpression of matriptase in tumor stroma is a poor prognostic indicator of extrahepatic bile duct cancer. Pathol Int. 2019;69:86-93.

Kaneko Y, Saito S, Takahashi K, Kanamaru R, Hosoya Y, Yamaguchi H, Kitayama J, Niki T, Lefor AK, Sata N. Neuroendocrine carcinoma of the esophagus with an adenocarcinoma component. Clin J Gastroenterol. 2019 May 27. doi: 10.1007/s12328-019-00995-7.

Nakaya T, Sogabe M, Yamamoto SI, Tsuji K, Nakaya M, Niki T, Endo S, Tanaka A. Pancreatic carcinoma metastasis to a lung carcinoma lesion and pulmonary fibrotic regions, overtaking the stromal microenvironment: A case report. Medicine (Baltimore). 2019 Jun;98(24):e15888.

Tada M, Sumi T, Tanaka Y, Hirai S, Yamaguchi M, Miyajima M, Niki T, Takahashi H, Watanabe A, Sakuma Y.MCL1 inhibition enhances the therapeutic effect of MEK inhibitors KRAS mutant lung adenocarcinoma cells. Lung Cancer. 2019 Jul;133:88-95. doi:10.1016/j.lungcan.2019.05.014.

Fujimoto Y, Takahashi H, Horie K, Nakaya T, Niki T, Fujiwara H, Matsubara S. Rapid Growth of Pelvic Cyst during Pregnancy: A Case Report. Case Rep Obstet Gynecol. 2019 May 13;2019:3120921. doi: 10.1155/2019/3120921. eCollection 2019.

Morita K, Mito K, Niki T, Fukushima N. Is an atypical flat lesion (AFL) a precursor lesion of the pancreatic ductal adenocarcinoma in human? Pathol Int. 2018 Apr 17. doi: 10.1111/pin.12670.

Sumi T, Hirai S, Yamaguchi M, Tanaka Y, Tada M, Yamada G, Hasegawa T, Miyagi Y, Niki T, Watanabe A, Takahashi H, Sakuma Y. Survivin knockdown induces senescence in TTF‑1-expressing, KRAS-mutant lung adenocarcinomas. Int J Oncol. 2018;53:33-46．doi: 10.3892/ijo.2018.4365.

Sumi T, Hirai S, Yamaguchi M, Tanaka Y, Tada M, Niki T, Takahashi H, Sakuma Y. Trametinib downregulates survivin expression in RB1-positive KRAS-mutant lung adenocarcinoma cells. Biochem Biophys Res Commun 2018 501(1):253-258

Kunita A, Morita S, Irisa TU, Goto A, Niki T, Takai D, Nakajima J, Fukayama M. MicroRNA-21 in cancer-associated fibroblasts supports lung adenocarcinoma progression. Sci Rep. 2018;8(1):8838. doi: 10.1038/s41598-018-27128-3.

Takaoka Y, Morimoto N, Miura K, Nomoto H, Murayama K, Hirosawa T, Watanabe S, Fujieda T, Ttsukui M, Kawata H, Niki T, Isoda N, Iijima M, Yamamoto H. A successful treatment for hepatocellular carcinoma with Osler-Rendu-Weber disease using radiofrequency ablation under laparoscopy. Clin J Gastroenterol. 2018 Jun 16. doi: 10.1007/s12328-018-0877-x.

Morita K, Oshiro H, Mito K, Mieno MN, Tamba-Sakaguchi M, Niki T, Miki A, Koizumi M, Sakuma Y, Komatsubara T, Sata N, Fukushima N. Prognostic significance of the degree of lymphatic vessel invasion in locally advanced, surgically resectable pancreatic head cancer: A single center experience. Medicine (Baltimore). 2018 Dec;97(49):e13466. doi: 10.1097/MD.0000000000013466.

Hirashima C, Ogoyama M, Abe M, Shiraishi S, Sugase T, Niki T, Matsubara S, Ohkuchi A. Clinical usefulness of serum levels of soluble fms-like tyrosine kinase 1/placental growth factor ratio to rule out preeclampsia in women with new-onset lupus nephritis during pregnancy. CEN Case Rep. 2018 Dec 18. doi: 10.1007/s13730-018-0373-7.

Tanabe K, Nakamura S, Hyuga T, Kawai S, Yamazaki M, Kawashima Y, Furukawa R, Niki T, Ono S, Nakai H. Pediatric Primary Alveolar Soft Part Sarcoma of the Bladder. Case Rep Urol. 2018 Nov 26;2018:1284756. doi: 10.1155/2018/1284756.

Amano Y, Matsubara D, Yoshimoto T, Tamura T, Nishino H, Mori Y, Niki T. Expression of protein arginine methyltransferase-5 in oral squamous cell carcinoma and its significance in epithelial-to-mesenchymal transition. 2018.68:359-366.

Nakano T, Kanai Y, Amano Y, Yoshimoto T, Matsubara D, Shibano T, Tamura T, Oguni S, Katashiba S, Ito T, Murakami Y, Fukayama M, Murakami T, Endo S, Niki T. Establishment of Highly Metastatic KRAS Mutant Lung Cancer Cell Sublines by Long-term Three-dimensional Low Attachment Culture. Plos One 2017.12:e0181342.

Matsubara D, Soda M, Yoshimoto T, Amano Y, Sakuma Y, Yamato A, Ueno T, Kojima S, Shibano T, Hosono Y, Kawazu M, Yamashita Y, Endo S, Hagiwara K, Fukayama M, Takahashi T, Mano H, Niki T. Inactivating mutations and hypermethylation of the NKX2-1/TTF-1 gene in non-TRU-type lung adenocarcinomas. Cancer Sci, 2017 108:1888-1896. doi: 10.1111/cas.13313.

Yamaguchi M, Hirai S, Tanaka Y, Sumi T, Miyajima M, Mishina T, Yamada G, Otsuka M, Hasegawa T, Kojima T, Niki T, Watanabe A, Takahashi H, Sakuma Y. Fibroblastic foci, covered with alveolar epithelia exhibiting epithelial-mesenchymal transition, destroy alveolar septa by disrupting blood flow in idiopathic pulmonary fibrosis. Lab Invest. 2017; 97:232-242.

Iijima Y, Bando M, Yamasawa H, Moriyama H, Takemura T, Niki T, Sugiyama Y. A case of mixed dust pneumoconiosis with desquamative interstitial pneumonia-like reaction in an aluminum welder. Respir Med Case Rep 2017; 20:150-153.

Nakaya T1, Hyuga T, Tanaka Y, Kawai S, Nakai H, Niki T, Tanaka A. Renal dysplasia characterized by prominent cartilaginous metaplasia lesions in VACTERL association: A case report. Medicine (Baltimore). 2017 Apr;96(15):e6499. doi:10.1097/MD.0000000000006499.

Kagaya Y, Sakamoto H, Yano T, Sunada K, Lefor AK, Niki T, Yamamoto H. Mucosal healing of Crohn's disease in a patient with concurrent systemic lupus erythematosus using infliximab. Clin J Gastroenterol. 2017 Mar 31. doi: 10.1007/s12328-017-0737-0.

Ito T, Matsubara D, Tanaka I, Makiya K, Tanei ZI, Kumagai Y, Shiu SJ, Nakaoka HJ, Ishikawa S, Isagawa T, Morikawa T, Shinozaki-Ushiku A, Goto Y, Nakano T, Tsuchiya T, Tsubochi H, Komura D, Aburatani H, Dobashi Y, Nakajima J, Endo S, Fukayama M, Sekido Y, Niki T, Murakami Y. Loss of YAP1 Defines Neuroendocrine Differentiation of Lung Tumors. Cancer Sci, 2016;107:1527-1538. doi: 10.1111/cas.13013.

Sakuma Y, Nishikiori H, Hirai S, Yamaguchi M, Yamada G, Watanabe A, Hasegawa T, Kojima T, Niki T, Takahashi H. Prolyl isomerase Pin1 promotes survival in EGFR-mutant lung adenocarcinoma cells with an epithelial-mesenchymal transition phenotype. Lab Invest 2016, 96:391-398.

Koyanagi T, Fujiwara H, Usui H, Ariga H, Machida S, Takei Y, Saga Y, Shozu M, Fukushima N, Niki T, Matsubara S, Suzuki M. Ovarian nongestational choriocarcinoma and associated adenocarcinoma with the same germ cell origin determined by a molecular genetic approach: A case report. Pathol Int 2016;66:529-34.

Ito S, Takao M, Fukutake T, Hatsuta H, Funabe S, Ito N, Shimoe Y, Niki T, Nakano I, Fukayama M, Murayama S. Histopathologic Analysis of Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL): A Report of a New Genetically Confirmed Case and Comparison to 2 Previous Cases. J Neuropathol Exp Neurol. 2016; 75: 1020-1030.

Fukusato T, Soejima Y, Kondo F, Inoue M, Watanabe M, Takahashi Y, Aso T, Uozaki H, Sano K, Sanada Y, Niki T. Preserved or enhanced OATP1B3 expression in hepatocellular adenoma subtypes with nuclear accumulation of β-catenin. Hepatol Res. 2015, 45:E32-42.

Ui T, Fujii H, Hosoya Y, Nagase M, Mieno MN, Mori M, Zuiki T, Saito S, Kurashina K, Haruta H, Matsumoto S, Niki T, Lefor A, Yasuda Y. Comparison of preoperative chemotherapy using docetaxel, cisplatin and fluorouracil with cisplatin and fluorouracil in patients with advanced carcinoma of the thoracic esophagus. Dis Esophagus 2015, 28:180-7.

Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor AK, Yasuda Y, Niki T. The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma. BMC Cancer 2015 Feb 25;15:82. doi: 10.1186/s12885-015-1065-8.

Yoshimoto T, Matsubara D, Nakano T, Tamura T, Endo S, Sugiyama Y, Niki T. Frequent loss of the expression of multiple subunits of the SWI/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung. Pathol Int 2015, 65:595-602.

Sanada Y, Mizuta K, Niki T, Tashiro M, Hirata Y, Okada N, Yamada N, Ihara Y, Urahashi T, Soejima Y, Fukusato T, Kondo F. Hepatocellular nodules resulting from congenital extrahepatic portosystemic shunts can differentiate into potentially malignant hepatocellular adenomas. J Hepatobiliary Pancreat Sci. 2015, 22:746-56.

Noguchi T, Senna A, Tsuchiya Y, Toshima M, Niki T, Jinbu Y. A case of Richter’s syndrome with transformation of B-CLL to DLBCL in the mandibular condyle region. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2015, 27:513-517.

Ui T, MorishimaK, Saito S, Sakuma Y, Fujii H, Hosoya Y, Ishikawa S, Aburatani H, Fukayama M, Niki T, Yasuda Y. The Hsp 90 inhibitor, 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway. Oncol Rep 2014;31: 619-624.

Ohzawa H, Sakatani T, Niki T, Yasuda Y, Hozumi Y. Pathological responses and survival of patients with human epidermal growth factor receptor 2-positive breast cancer who received neoadjuvant chemotherapy including trastuzumab. Breast Cancer 2014: 21:563–570.

IbrahimR, Matsubara D, Osman W, Morikawa T, Goto A, Morita S, Ishikawa S, Aburatani H, Takai D, Nakajima J, Fukayama M, Niki T, Murakami Y. Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial mesenchymal transition. Hum Pathol 2014;45:1397-1405.

Saito S, Morishima K, Ui T, Matsubara D, Tamura T, Oguni S, Hosoya Y, Sata N, Lefor AT, Yasuda Y, Niki T. Stromal fibroblasts are predictors of disease-related mortality in esophageal squamous cell carcinoma. Oncol Rep 2014;32:348-54.

Matsubara D, Kishaba Y, Yoshimoto T, Sakuma Y, Sakatani T, Tamura T, Endo S, Sugiyama Y, Murakami Y, Niki T. Immunohistochemical analysis of the expression of E-cadherin and ZEB1 in non-small cell lung cancer. Pathol Int 2014; 64:560-568.

Matsubara D, Kishaba Y, Ishikawa S, Sakatani T, Oguni S, Tamura T, Hoshino H, Sugiyama Y, Endo S, Murakami Y, Aburatani H, Fukayama M, Niki T. Lung Cancer with Loss of BRG1/BRM, shows Epithelial Mesenchymal Transition Phenotype and Distinct Histologic and Genetic Features. Cancer Sci 2013;104:266-273.

Sakuma Y, Matsukuma S, Nakamura Y, Yoshihara M, Koizume S, Sekiguchi H, Saito H, Nakayama H, Kameda Y, Yokose T, Oguni S, Niki T, Miyagi Y. Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells. Lab Invest 2013:93:1137-1146.

Saito S, Hosoya Y, Morishima K, Ui T, Haruta H, Kurashina K, Meguro Y, Zuiki T, Sata N, Fujii H, Matsubara D, Niki T, Lefor AT, Yasuda Y. A clinicopathological and immunohistochemical study of gastric cancer with squamous cell carcinoma components: A clinically aggressive tumor. J Dig Dis. 2012;13:407-13.

Matsubara D, Kanai Y, Ishikawa S, Ohara S, Yoshimoto T, Sakatani T, Oguni S, Tamura T, Kataoka H, Endo S, Murakami Y, Aburatani H, Fukayama M, Niki T. Identification of CCDC6-RET Fusion in the Human Lung Adenocarcinoma Cell Line, LC-2/ad. J Thorac Oncol. 2012;7:1872-1876.

Matsubara D, Niki T. Epidermal growth factor receptor mutation and chemosensitivity. J Thorac Oncol 2012;4:771-2.

Terasaki H, Kato S, Matsuno Y, Kusumoto M, Niki T, Hayashi A, Terasaki K, Hayabuchi N. Lung Adenocarcinoma, Mixed Subtype: Histopathologic Basis for High-Resolution Computed Tomography Findings. J Thorac Imaging 2011; 26:74-81.

Goto A, Li CP, Ota S, Niki T, Ohtsuki Y, Kitajima S, Yonezawa S, Koriyama C, Akiba S, Uchima H, Lin YM, Yeh KT, Koh JS, Kim CW, Kwon KY, Nga ME, Fukayama M. Human papillomavirus infection in lung and esophageal cancers: Analysis of 485 Asian cases. J Med Virol. 2011;83:1383-90.

Kishaba Y, Matsubara D, Niki T. Heterogenous Expression of nestin in myofibroblasts of various human tissues. Pathol Int 2010;60:378–385.

Sakamoto K, Sakurai S, Kanda T, Sakuma Y, Hishima T, Hironaka M, Bamba T, Keira Y, Takano Y, Niki T, Hasegawa T, Hirota S. Niki T, Hasegawa T, Hirota S.Pleomorphic phenotypes of gastrointestinal stromal tumors at metastatic sites with or without imatinib treatment. Cancer Sci 2010;101:1270-1278.

Matsubara D, Ishikawa S, Oguni S, Aburatani H, Fukayama M, Niki T. Molecular predictors of sensitivity to the MET inhibitor PHA665752 in lung carcinoma cells. J Thorac Oncol 2010;5:1317-1324.

Matsubara D, Ishikawa S, Oguni S, Aburatani H, Fukayama M, Niki T. Co-activation of epidermal growth factor receptor and c-MET defines a distinct subset of lung adenocarcinomas. Am J Pathol 2010;177:2191-2204.

Matsubara D, Morikawa T, Goto A, Nakajima J, Fukayama M, Niki T. Subepithelial myofibroblast in lung adenocarcinoma: a histologic indicator of excellent prognosis. Mod Pathol 2009;22:776-85.

Saito S, Hosoya Y, Zuiki T, Hyodo M, Alan Lefor, Sata N, Nagase M, Nakazawa M, Matsubara D, Niki T, Yasuda Y. A clinicopathologic study of basaloid squamous carcinoma of the esophagus. Esophagus 2009;6:177–181.

Zuiki T, Hosoya Y, Ui T, Haruta H, Kurashina K, Saito S, Alan Lefor, Niki T, Nakazawa M, Yasuda Y. Therapeutic effectiveness of chemoradiotherapy for carcinosarcoma of the esophagus: two case reports and a review of the literature. Esophagus 2009;6:189-95.

Nakamura Y, Matsubara D, Goto A, Ota S, Oguni S, Ishikawa S, Aburatani H, Miyazawa K, Fukayama M, Niki T. Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines. Cancer Sci 2008;99:14-22.

Inamura K, Takeuchi K, Togashi Y, Nomura K, Ninomiya H, Okui M, Satoh Y, Okumura S, Nakagawa K, Soda M, Lim CY, Niki T, Mano H, Ishikawa Y.EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. J Thorac Oncol. 2008;3:13-7.

Li CP, Goto A, Watanabe A, Murata K, Ota S, Niki T, Aburatani H, Fukayama M. AKR1B10 in usual interstitial pneumonia: Expression in squamous metaplasia in association with smoking and lung cancer. Pathol Res Pract. 2008;204:295-304.

Haruta H, Hosoya Y, Sakuma K, Shibusawa H, Satoh K, Yamamoto H, Tanaka A, Niki T, Sugano K, Yasuda Y. Clinicopathological study of lymph-node metastasis in 1,389 patients with early gastric cancer: assessment of indications for endoscopic resection. J Dig Dis. 2008;9:213-218.

Wang T, Niki T, Goto A, Ota S, Morikawa T, Nakamura Y, Ohara E, Ishikawa S, Aburatani H, Nakajima J, Fukayama M. Hypoxia increases the motility of lung adenocarcinoma cells A549 via activation of the epidermal growth factor receptor pathway. Cancer Sci 2007;98:506-11.

Nakamura Y, Niki T, Goto A, Morikawa T, Miyazawa K, Nakajima J, Fukayama M. c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis. Cancer Sci. 2007;98:1006-13.

Murata K, Ota S, Niki T, Goto A, Li C-P, Ruriko UMR, Ishikawa S, Aburatani H, Kuriyama T, Fukayama M. p63 – key molecule in early phase of epithelial abnormality in idiopathic pulmonary fibrosis. Exp Mol Pathol. 2007;83:367-7.

Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448:561-566.

Narahashi T, Niki T, Wang T, Goto A, Matsubara D, Funata N, Fukayama M. Cytoplasmic localization of p63 is associated with poor patient survival in lung adenocarcinoma. Histopathology. 2006;49:349-57.

Fukumoto S, Yamauchi N, Moriguchi H, Hippo Y, Watanabe A, Shibahara J, Taniguchi H, Ishikawa S, Ito H, Yamamoto S, Iwanari H, Hironaka M, Ishikawa Y, Niki T, Sohara Y, Kodama T, Nishimura M, Fukayama M, Dosaka-Akita H, Aburatani H. Over-expression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers’ non-small cell lung carcinomas. Clin Cancer Res 2005;11:1776-1785.

Goto A, Nakajima J, Hara K, Niki T, Fukayama M. Lung adenocarcinoma associated with familial adenomatous polyposis. Clear cell carcinoma with beta-catenin accumulation accompanied by atypical adenomatous hyperplasia. Virchows Arch. 2005;446:73-77.

Uozaki H, Chong JM, Fujimoto E, Itoh M, Saito M, Sakuma K, Sudo M, Ushiku T, Niki T, Nagai H, Takada K, Fukayama M. Soft and hard keratin expression in Epstein-Barr-virus-associated gastric carcinoma. Anticancer Res. 2005;25:3183-3190.

Goto A, Niki T, Chi-Pin L, Matsubara D, Murakami Y, Funata N, Fukayama M. Loss of TSLC1 expression in lung adenocarcinoma: Relationships with histological subtypes, sex and prognostic significance. Cancer Sci. 2005;96:480-486.

Yamauchi N, Watanabe A, Hishinuma M, Ohashi KI, Midorikawa Y, Morishita Y, Niki T, Shibahara J, Mori M, Makuuchi M, Hippo Y, Kodama T, Iwanari H, Aburatani H, Fukayama M. The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma. Mod Pathol. 2005;18:1591-8.

Matsubara D, Niki T, Ishikawa S, Goto A, Ohara E, Yokomizo T, Heizmann CW, Aburatani H, Moriyama S, Moriyama H, Nishimura Y, Funata N, Fukayama M Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathologic significance, relationship to p53, and identification of their target genes. Cancer Sci 2005;96:844-57.

Shibahara J, Goto A, Niki T, Tanaka M, Nakajima J, Fukayama M. Primary pulmonary paraganglioma: report of a functioning case with immunohistochemical and ultrastructural study. Am J Surg Pathol. 2004,28:825-829.

Goto A, Niki T, Terado Y, Fukushima J, Fukayama M. Prevalence of CD99 protein expression in pancreatic endocrine tumours (PETS). Histopathology. 2004;45:384-392.

Goto A, Niki T, Moriyama S, Funata N, Moriyama H, Nishimura Y, Tsuchida R, Kato JY, Fukayama M. Immunohistochemical study of Skp2 and Jab1, two key molecules in the degradation of P27, in lung adenocarcinoma. Pathol Int. 2004;54:675-681.

Terasaki H, Niki T, Matsuno Y, Yamada T, Maeshima A, Asamura H, Hayabuchi N, Hirohashi S. Lung adenocarcinoma with mixed bronchiolo-alveolar and invasive components: clinicopathological features, subclassification by extent of invasive foci, and immunohistochemical characterization. Am J Surg Pathol 2003;27:937-951.

Kitagawa H, Goto A, Minami M, Nakajima J, Niki T, Fukayama M. Sclerosing hemangioma of the lung with cystic appearance. Jpn J Clin Oncol. 2003;33:360-363.

Kitagawa H, Goto A, Niki T, Hironaka M, Nakajima J, Fukayama M. Lung adenocarcinoma associated with atypical adenomatous hyperplasia. A clinicopathological study with special reference to smoking and cancer multiplicity. Pathol Int. 2003,53:823-827.

Niki T, Kohno T, Iba S, Moriya Y, Takahashi Y, Saito M, Maeshima A, Yamada T, Matsuno Y, Fukayama M, Yokota J, Hirohashi S. Frequent co-localization of cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas. Am J Pathol. 2002;160: 1129-1141.

Tomizawa Y, Kohno T, Kondo H, Otsuka A, Nishioka M, Niki T, Yamada T, Maeshima A, Yoshimura K, Saito R, Minna JD, Yokota J. Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma. Clin Cancer Res. 2002;8:2362-2368.

Maeshima AM, Niki T, Maeshima A, Yamada T, Kondo H, Matsuno Y. Modified scar grade: a prognostic indicator in small peripheral lung adenocarcinoma. Cancer 2002;95:2546-2554.

Rombouts K, Niki T, Greenwel P, Vandermonde A, Wielant A, Hellemans K, De Bleser P, Yoshida M, Schuppan D, Rojkind M, Geerts A. Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts. Exp Cell Res. 2002;278:184-197.

Takei H, Asamura H, Maeshima A, Suzuki K, Kondo H, Niki T, Yamada T, Tsuchiya R, Matsuno Y. Large cell neuroendocrine carcinoma of the lung: A clinicopathologic study of eighty-seven cases. J Thorac Cardiovasc Surg. 2002;124: 285-292.

Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J. MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer. Proc Natl Acad Sci U S A. 2002;99:12269-12274.

Rombouts K, Niki T, Wielant A, Hellemans K, Schuppan D, Kormoss N and Geerts A. Effect of aldosterone on collagen steady state levels in primary and subcultured rat hepatic stellate cells. J Hepatol 2001; 34: 230-8

Geerts A, Eliasson C, Niki T, Wielant A, Vaeyens F, Pekny M. Formation of normal desmin intermediate filaments in mouse hepatic stellate cells requires vimentin. Hepatology 2001; 33: 177-188.

Tokunou M, Niki T, Eguchi K, Tsuda H, Yamada T, Matsuno Y, Kondo H, Saitoh Y, Imamura H, Hirohashi S. c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma. Am J Pathol 2001; 158: 1451-1463.

Niki T, Iba S, Yamada T, Matsuno Y, Enholm B, Hirohashi S. Expression of vascular endothelial growth factor receptor 3 in blood and lymphatic vessels of lung adenocarcinoma. J Pathol 2001; 193: 450-457.

Moriya Y, Niki T, Yamada T, Matsuno Y, Kondo H, Hirohashi S. Increased expression of laminin-5 and its prognostic significance in small-sized lung adenocarcinoma: an immunohistochemical analysis of 102 cases. Cancer 2001; 91: 1129-1141.

Terasaki H, Niki T, Hasegawa T, Yamada T, Suzuki, Kusumoto M, Fujimoto K, Hayabuchi N, Matsuno Y, Shimoda T. Primary synovial sarcoma of the lung: a case report confirmed by molecular detection of SYT-SSX fusion gene transcript. Jpn J Clin Oncol 2001; 31: 212-216.

Kitamura H, Kobayashi T, Kaneko M, Kusumoto M, Kodama T, Matsuno Y, Niki T. Pulmonary amyloidosis diagnosed by CT-guided transbronchial biopsy: a case report. Jpn J Clin Oncol. 2001; 31: 209-211.

Rombouts K, Niki T, Wielant A, Hellemans K, Geerts A. Trichostatin A, lead compound for development of antifibrogenic drugs. Acta Gastroenterol Belg. 2001;64:239-246.

Niki T, Iba S, Tokunou M, Yamada T, Matsuno Y, Hirohashi S. Expression of vascular endothelial growth factors A, B, C, and D and their relationships to lymph node status in lung adenocarcinoma. Clin Cancer Res 2000; 6: 2431-2439.

Manda R, Kohno T, Niki T, Yamada T, Takenoshita S, Kuwano H, Yokota J. Differential expression of the LAMB3 and LAMC2 genes between small cell and non-small cell lung carcinomas. Biochem Biophys Res Commun 2000; 275: 440-445.

Tokunou M, Niki T, Saitoh Y, Imamura H, Sakamoto M, Hirohashi S. Altered expression of the ERM proteins in lung adenocarcinoma. Lab Invest 2000; 80: 1643-1650.

Yamaguchi T, Suzuki K, Asamura H, Kondo H, Niki T, Yamada T, Tsuchiya R. Lung carcinoma with polypoid growth in the main pulmonary artery: Report of two cases. Jpn J Clin Oncol 2000; 30: 358-361.

Nishioka M, Kohno T, Takahashi M, Niki T, Yamada T, Sone S, Yokota J. Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line. Oncogene 2000; 19: 6251-6260.

Ono Y, Nakanishi Y, Ino Y, Niki T, Yamada T, Yoshimura K, Saikawa M, Nakajima T, Hirohashi S. Clinicopathologic significance of laminin-5 gamma2 chain expression in squamous cell carcinoma of the tongue. Immunohistochemical analysis of 67 lesions. Cancer 1999; 85: 2315-2321.

Niki T, Rombouts K, De Bleser PJ, De Smet K, Rogiers V, Schuppan D, Yoshida M, Gabbiani G, Geerts A. A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. Hepatology 1999;29:858-867.

Niki T, Pekny M, Hellemans K, De Bleser PJ, Van Den Berg K, Vaeyens F, Quartier E, Schuit F, Geerts A. Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells. Hepatology 1999; 29: 520-527.

Geerts A, Niki T, Hellemans K, De Craemer D, Van Den Berg K, Lazou JM, Stange G, Van den Winkel M. Purification of rat hepatic stellate cells by side scatter-activated cell sorting. Hepatology 1998; 27:590-598.

Hasegawa T, Matsuno Y, Niki T, Hirohashi S, Shimoda T, Takayama J, Watanabe C, Kaneko A, Sano T, Sato M, Suzuki J. Second primary rhabdomyosarcomas in patients with bilateral retinoblastoma: a clinicopathologic and immunohistochemical study. Am J Surg Pathol 1998;22:1351-1360.

Xu G, Niki T, Virtanen I, Rogiers V, De Bleser P, Geerts A. Gene expression and synthesis of fibronectin isoforms in rat hepatic stellate cells. Comparison with liver parenchymal cells and skin fibroblasts. J Pathol 1997; 183:90-98.

De Bleser PJ, Niki T, Rogiers V, Geerts A. Transforming growth factor-beta gene expression in normal and fibrotic rat liver. J Hepatol 1997; 26:886-893.

De Bleser PJ, Niki T, Xu G, Rogiers V, Geerts A. Localization and cellular sources of activins in normal and fibrotic rat liver. Hepatology 1997; 26:905-912.

De Bleser PJ, Scott CD, Niki T, Xu G, Wisse E, Geerts A. Insulin-like growth factor II/mannose 6-phosphate-receptor expression in liver and serum during acute CCl4 intoxication in the rat. Hepatology 1996; 23:1530-1537.

Niki T, Schuppan D, De Bleser PJ, Vrijsen R, Pipeleers-Marichal M, Beyaert R, Wisse E, Geerts A. Dexamethasone alters messenger RNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat-storing cells. Hepatology 1996; 23:1673-1681.

Niki T, De Bleser PJ, Xu G, Van Den Berg K, Wisse E, Geerts A. Comparison of glial fibrillary acidic protein and desmin staining in normal and CCl4-induced fibrotic rat livers. Hepatology 1996; 23:1538-1545.

Niki T, Oka T, Shiga J, Takahashi K, Geerts A, Machinami R. Increased S-100 protein-immunoreactivity of Kupffer cells is associated with lymphohematological malignancy. Pathol Int 1995;45:742-747.

Niki T, Oka T, Shiga J, Machinami R. Kupffer cells in multiple organ failure --their activation as revealed by immunohistochemistry for lysozyme, alpha 1-antichymotrypsin, and lectins. Gen Diagn Pathol 1995;141:21-27.

De Bleser PJ, Jannes P, van Buul-Offers SC, Hoogerbrugge CM, van Schravendijk CF, Niki T, Rogiers V, Van den Brande JL, Wisse E, Geerts A. Insulin-like growth factor-II/mannose 6-phosphate receptor is expressed on CCl4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-beta in cocultures with sinusoidal endothelial cells. Hepatology 1995; 21:1429-1437.

Kurita M, Niwa Y, Hamada E, Hata Y, Oshima M, Mutoh H, Shiina S, Nakata R, Ota S, Terano A, Sugimoto T, Ono M, Sawada T, Mori M, Niki T, Oka T Churg-Strauss-Syndrome (Allegic granulomatrous angitis) with multiple perforating ulcers of the small intestine, multiple ulcers of the colon, and mononeuritis multiplex. J Gastroenterology 1994; 29: 208-213.

Minami M, Kawauchi N, Itai Y, Niki T, Sasaki Y. Gastric tumors: radiologic-pathologic correlation and accuracy of T staging with dynamic CT. Radiology 1992;185:173-178.

Minami M, Itai Y, Ohtomo K, Ohnishi S, Niki T, Kokubo T, Yoshikawa K, Ilio M. Siderotic nodules in the spleen: MR imaging of portal hypertension. Radiology 1989;172:681-684.

Kitamura K, Nibu K, Asai M, Shitara N, Niki T. Chondromyxoid fibroma of the mastoid invading the occipital bone. Arch Otolaryngol Head Neck Surg 1989;115:384-386.

(72 articles; total impact factor=389.435; as of July 1, 2013)