自治医科大学医学部生理学講座統合生理学部門 中條研究室

2020-2025

[原著論文]
Ca2+ influx through muscle-type nicotinic acetylcholine receptors in zebrafish contributes to contractions and development of slow muscle cells in early development
Zempo B, Ono F, Nakajo K
Open Biol. 15, 250226, 2025
Pubmed:link 　　　　　

[原著論文]
Compound heterozygous variants of CACNA1H change channel properties and contribute to intractable epilepsy with myoclonic-atonic seizures
Matsumoto M, Kasuya G, Tumurbaatar S, Masuda T, Wakabayashi K, Kawada M, Higashikuni Y, Muramatsu K, Nakajo K, Osaka H, Matsumura T
J Hum Genet. 2025 Nov 22 Epub ahead of print.
Pubmed:link 　　　　　

[原著論文]
Extracellular salt bridge networks around S4 implicated in HCN channel gating and heart disease
Ryu K, Kasuya G, Nakajo K
Proc Natl Acad Sci U S A. 122, e2502136122, 2025
Pubmed:link

[総説]
Bridging structural insight and clinical impact in channelopathies
Nakajo K.
The Journal of Precision Medicine: Health and Disease Volume 3, 100014, 2025
Pubmed:link 　 　　　　　

[原著論文]
Identification of KCNE6, a new member of the KCNE family of potassium channel auxiliary subunits
Kasuya G, Zempo B, Yamamoto Y, Ryu K, Ono F, Nakajo K.
Communications biology 7, 1662, 2024
Pubmed:link 　　　　　

[原著論文]
A Photoactivatable Version of Ivabradine Enables Light-Induced Block of HCN Current In Vivo
Porro A, Armano E, Brandalise F, Appiani R, Beltrame M, Saponaro A, Dallanoce C, Nakajo K, Ryu K, Leone R, Thiel G, Pallavicini M, Moroni A, Bolchiya C.
Journal of Medicinal Chemistry 67, 16209-16221, 2024
Pubmed:link 　　　　　

[総説]
Modulation of potassium channels by transmembrane auxiliary subunits via voltage-sensing domains
Nakajo K, Kasuya G.
Physiological Reports 12, e15980, 2024
Pubmed:link 　　　　　

[原著論文]
Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex
Yamanouchi D, Kasuya G, Nakajo K, Kise Y, Nureki O.
Molecular Cell 83, 4555-4569, 2023
Pubmed:link

[原著論文]
Optimized tight binding between the S1 segment and KCNE3 is required for the constitutively open nature of the KCNQ1-KCNE3 channel complex
Kasuya G, Nakajo K.
eLife. 11, e81683, 2022
Pubmed: link

[原著論文]
Two HCN4 Channels Play Functional Roles in the Zebrafish Heart.
Liu J, Kasuya G, Zempo B, Nakajo K.
Front Physiol. 13, 901571, 2022
Pubmed: link

[原著論文]
Structural basis of gating modulation of Kv4 channel complexes.
Kise Y, Kasuya G, Okamoto HH, Yamanouchi D, Kobayashi K, Kusakizako T, Nishizawa T, Nakajo K, Nureki O.
Nature 599, 158-164, 2021
Pubmed:link

[原著論文]
Gastrointestinal Neurons Expressing HCN4 Regulate Retrograde Peristalsis
Fujii K, Nakajo K, Egashira Y, Yamamoto Y, Kitada K, Taniguchi K, Kawai M, Tomiyama H, Kawakami K, Uchiyama K, Ono F.
Cell Rep. 30, 2879-2888 (2020)
Pubmed: link

2010-2019

[原著論文]
Gating modulation of the KCNQ1 channel by KCNE proteins studied by voltage-clamp fluorometry (review)
Nakajo K.
Biophysics and Physicobiology. 16, 121-126 (2019)
J-STAGE: link

[原著論文]
Structural properties determining low K affinity of the selectivity filter in the TWIK1 K channel Tsukamoto H, Higashi M, Motoki H, Watanabe H, Ganser C, Nakajo K, Kubo Y, Uchihashi T, Furutani Y.
J Biol Chem. 293, 6969-6984 (2018)
PubMed: link

[原著論文]
Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel
Taruno A, Sun H, Nakajo K, Murakami T, Ohsaki Y, Kido MA, Ono F, Marunaka Y.
J Physiol. 595, 6121-6145 (2017)
PubMed: link

[総説]
KCNQ1 channel modulation by KCNE proteins via the voltage-sensing domain
Nakajo K, Kubo Y.
J Physiol. 593, 2617-25 (2015)
PubMed: link

[原著論文]
Kv4.2 and accessory dipeptidyl peptidase-like protein 10 (DPP10) subunit preferentially form a 4:2 (Kv4.2:DPP10) channel complex
Kitazawa M, Kubo Y, Nakajo K.
J Biol Chem. 290, 22724-33 (2015)
PubMed: link

[原著論文]
Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening
Nakajo K, Kubo Y.
Nat Commun. 5, 4100 (2014)
PubMed: link

[原著論文]
The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level
Kitazawa M, Kubo Y, Nakajo K.
J Biol Chem. 289, 17597-609 (2014)
PubMed: link

[原著論文]
KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue
Nakajo K, Nishino A, Okamura Y, Kubo Y.
J Gen Physiol. 138, 521-35 (2011)
PubMed: link

[総説]
Nano-environmental changes by KCNE proteins modify KCNQ channel function
Nakajo K, Kubo Y.
Channels (Austin). 5, 397-401 (2011)
PubMed: link

[原著論文]
Identification and characterization of Cs+-permeable K+ channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation
Ishii H, Nakajo K, Yanagawa Y, Kubo Y.
Eur J Neurosci. 32, 736-48 (2010)
PubMed: link

[原著論文]
Stoichiometry of the KCNQ1 - KCNE1 ion channel complex
Nakajo K, Ulbrich MH, Kubo Y, Isacoff EY.
Proc Natl Acad Sci U S A. 107, 18862-7 (2010)
PubMed: link

[総説]
Structual and functional dynamics of the ATP receptor channel P2X2
Kubo Y, Fujiwara Y, Keceli B, Nakajo K.
Brain Nerve. 62, 1323-9 (2010)
PubMed: link

[原著論文]
The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression
Nagatomo K, Ishii H, Yamamoto T, Nakajo K, Kubo Y.
Biophys J. 99, 3609-18 (2010)
PubMed: link

1999-2009

[総説]
Dynamic aspects of functional regulation of the ATP receptor channel P2X2
Kubo Y, Fujiwara Y, Keceli B, Nakajo K.
J Physiol. 587, 5317-24 (2009)
PubMed: link

[原著論文]
Voltage- and [ATP]-dependent gating of the P2X(2) ATP receptor channel
Fujiwara Y, Keceli B, Nakajo K, Kubo Y.
J Gen Physiol. 133, 93-109 (2009)
PubMed: link

[原著論文]
Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates
Hill AS, Nishino A, Nakajo K, Zhang G, Fineman JR, Selzer ME, Okamura Y, Cooper EC.
PLoS Genet. 12, e1000317 (2008)
PubMed: link

[原著論文]
Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks
Nakajo K, Kubo Y.
J Physiol. 586, 2827-40 (2008)
PubMed: link

[原著論文]
KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channel
Nakajo K, Kubo Y.
J Gen Physiol. 130, 269-81 (2007)
PubMed: link

[原著論文]
Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes
Okamura Y, Nishino A, Murata Y, Nakajo K, Iwasaki H, Ohtsuka Y, Tanaka-Kunishima M, Takahashi N, Hara Y, Yoshida T, Nishida M, Okado H, Watari H, Meinertzhagen IA, Satoh N, Takahashi K, Satou Y, Okada Y, Mori Y.
Physiol Genomics. 22, 269-82 (2005)
PubMed: link

[原著論文]
Protein kinase C shifts the voltage dependence of KCNQ/M channels expressed in Xenopus oocytes
Nakajo K, Kubo Y.
J Physiol. 569, 59-74 (2005)
PubMed: link

[原著論文]
Development of transient outward currents coupled with Ca2+-induced Ca2+ release mediates oscillatory membrane potential in ascidian muscle cells
Nakajo K, Okamura Y.
J Neurohysiol. 92, 1056-66 (2004)
PubMed: link

[原著論文]
Primary structure, functional characterization and developmental expression of the ascidian Kv4-class potassium channel
Nakajo K, Katsuyama Y, Ono F, Ohtsuka Y, Okamura Y.
Neurosci Res. 45, 59-70 (2003)
PubMed: link

[原著論文]
The ascidian dihydropyridine-resistant calcium channel as the prototype of chordate L-type calcium channel (review)
Okamura Y, Izumi-Nakaseko H, Nakajo K, Ohtsuka Y, Ebihara T.
Neurosignals. 12, 142-58 (2003)
PubMed: link

[原著論文]
The maternal transcript for truncated voltage-dependent Ca2+ channels in the ascidian embryo: a potential suppressive role in Ca2+ channel expression
Okagaki R, Izumi H, Okada T, Nagahora H, Nakajo K, Okamura Y.
Dev Biol. 230, 258-77 (2001)
PubMed: link

[原著論文]
Subfamily-specific posttranscriptional mechanism underlies K(+) channel expression in a developing neuronal blastomere
Ono F, Katsuyama Y, Nakajo K, Okamura Y.
J Neurosci. 19, 6874-86 (1999)
PubMed: link

[原著論文]
Cross-coupling between voltage-dependent Ca2+ channels and ryanodine receptors in developing ascidian muscle blastomeres
Nakajo K, Chen L, Okamura Y.
J Physiol. 515, 695-710 (1999)
PubMed: link