自治医科大学医学部生理学講座統合生理学部門 中條研究室

2020-2024

Identification of KCNE6, a new member of the KCNE family of potassium channel auxiliary subunits
Go Kasuya, Buntaro Zempo, Yasuhiro Yamamoto, Kaei Ryu, Fumihito Ono , Koichi Nakajo
communications biology
Pubmed:link

A Photoactivatable Version of Ivabradine Enables Light-Induced Block of HCN Current In Vivo
Alessandro Porro, Edoardo Armano, Federico Brandalise, Rebecca Appiani, Monica Beltrame, Andrea Saponaro, Clelia Dallanoce, Koichi Nakajo, Kaei Ryu, Roberta Leone, Gerhard Thiel, Marco Pallavicini, Anna Moroni, Cristiano Bolchiya
Journal of Medicinal Chemistry
Pubmed:link 　　　　　

Modulation of potassium channels by transmembrane auxiliary subunits via voltage-sensing domains
Nakajo K,Kasuya G
Physiological Reports 12, e15980, 2024
Pubmed:link 　　　　　

Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex
Yamanouchi D, Kasuya G, Nakajo K, Kise Y, Nureki O.
Molecular Cell 83, 4555-4569, 2023
Pubmed:link

Optimized tight binding between the S1 segment and KCNE3 is required for the constitutively open nature of the KCNQ1-KCNE3 channel complex
Kasuya G, Nakajo K.
eLife. 11, e81683, 2022
Pubmed: link

Two HCN4 Channels Play Functional Roles in the Zebrafish Heart.
Liu J, Kasuya G, Zempo B, Nakajo K.
Front Physiol. 13, 901571, 2022
Pubmed: link

High-speed camera recordings uncover previously unidentified elements of zebrafish mating behaviors integral to successful fertilization.
Zempo B, Tanaka N, Daikoku E, Ono F.
Sci Rep. 11, 20228, 2021
Pubmed: link

Structural basis of gating modulation of Kv4 channel complexes.
Kise Y, Kasuya G, Okamoto HH, Yamanouchi D, Kobayashi K, Kusakizako T, Nishizawa T, Nakajo K, Nureki O.
Nature 599, 158-164, 2021
Pubmed:link

Gastrointestinal Neurons Expressing HCN4 Regulate Retrograde Peristalsis
Fujii K, Nakajo K, Egashira Y, Yamamoto Y, Kitada K, Taniguchi K, Kawai M, Tomiyama H, Kawakami K, Uchiyama K, Ono F.
Cell Rep. 30, 2879-2888 (2020)
Pubmed: link

2010-2019

Gating modulation of the KCNQ1 channel by KCNE proteins studied by voltage-clamp fluorometry (review)
Nakajo K.
Biophysics and Physicobiology. 16, 121-126 (2019)
J-STAGE: link

Structural properties determining low K affinity of the selectivity filter in the TWIK1 K channel Tsukamoto H, Higashi M, Motoki H, Watanabe H, Ganser C, Nakajo K, Kubo Y, Uchihashi T, Furutani Y.
J Biol Chem. 293, 6969-6984 (2018)
PubMed: link

Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel
Taruno A, Sun H, Nakajo K, Murakami T, Ohsaki Y, Kido MA, Ono F, Marunaka Y.
J Physiol. 595, 6121-6145 (2017)
PubMed: link

KCNQ1 channel modulation by KCNE proteins via the voltage-sensing domain (review)
Nakajo K, Kubo Y.
J Physiol. 593, 2617-25 (2015)
PubMed: link

Kv4.2 and accessory dipeptidyl peptidase-like protein 10 (DPP10) subunit preferentially form a 4:2 (Kv4.2:DPP10) channel complex
Kitazawa M, Kubo Y, Nakajo K.
J Biol Chem. 290, 22724-33 (2015)
PubMed: link

Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening
Nakajo K, Kubo Y.
Nat Commun. 5, 4100 (2014)
PubMed: link

The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level
Kitazawa M, Kubo Y, Nakajo K.
J Biol Chem. 289, 17597-609 (2014)
PubMed: link

KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue
Nakajo K, Nishino A, Okamura Y, Kubo Y.
J Gen Physiol. 138, 521-35 (2011)
PubMed: link

Nano-environmental changes by KCNE proteins modify KCNQ channel function (review)
Nakajo K, Kubo Y.
Channels (Austin). 5, 397-401 (2011)
PubMed: link

Identification and characterization of Cs+-permeable K+ channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation
Ishii H, Nakajo K, Yanagawa Y, Kubo Y.
Eur J Neurosci. 32, 736-48 (2010)
PubMed: link

Stoichiometry of the KCNQ1 - KCNE1 ion channel complex
Nakajo K, Ulbrich MH, Kubo Y, Isacoff EY.
Proc Natl Acad Sci U S A. 107, 18862-7 (2010)
PubMed: link

Structual and functional dynamics of the ATP receptor channel P2X2 (review)
Kubo Y, Fujiwara Y, Keceli B, Nakajo K.
Brain Nerve. 62, 1323-9 (2010)
PubMed: link

The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression
Nagatomo K, Ishii H, Yamamoto T, Nakajo K, Kubo Y.
Biophys J. 99, 3609-18 (2010)
PubMed: link

1999-2009

Dynamic aspects of functional regulation of the ATP receptor channel P2X2 (review)
Kubo Y, Fujiwara Y, Keceli B, Nakajo K.
J Physiol. 587, 5317-24 (2009)
PubMed: link

Voltage- and [ATP]-dependent gating of the P2X(2) ATP receptor channel
Fujiwara Y, Keceli B, Nakajo K, Kubo Y.
J Gen Physiol. 133, 93-109 (2009)
PubMed: link

Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates
Hill AS, Nishino A, Nakajo K, Zhang G, Fineman JR, Selzer ME, Okamura Y, Cooper EC.
PLoS Genet. 12, e1000317 (2008)
PubMed: link

Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks
Nakajo K, Kubo Y.
J Physiol. 586, 2827-40 (2008)
PubMed: link

KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channel
Nakajo K, Kubo Y.
J Gen Physiol. 130, 269-81 (2007)
PubMed: link

Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes
Okamura Y, Nishino A, Murata Y, Nakajo K, Iwasaki H, Ohtsuka Y, Tanaka-Kunishima M, Takahashi N, Hara Y, Yoshida T, Nishida M, Okado H, Watari H, Meinertzhagen IA, Satoh N, Takahashi K, Satou Y, Okada Y, Mori Y.
Physiol Genomics. 22, 269-82 (2005)
PubMed: link

Protein kinase C shifts the voltage dependence of KCNQ/M channels expressed in Xenopus oocytes
Nakajo K, Kubo Y.
J Physiol. 569, 59-74 (2005)
PubMed: link

Development of transient outward currents coupled with Ca2+-induced Ca2+ release mediates oscillatory membrane potential in ascidian muscle cells
Nakajo K, Okamura Y.
J Neurohysiol. 92, 1056-66 (2004)
PubMed: link

Primary structure, functional characterization and developmental expression of the ascidian Kv4-class potassium channel
Nakajo K, Katsuyama Y, Ono F, Ohtsuka Y, Okamura Y.
Neurosci Res. 45, 59-70 (2003)
PubMed: link

The ascidian dihydropyridine-resistant calcium channel as the prototype of chordate L-type calcium channel (review)
Okamura Y, Izumi-Nakaseko H, Nakajo K, Ohtsuka Y, Ebihara T.
Neurosignals. 12, 142-58 (2003)
PubMed: link

The maternal transcript for truncated voltage-dependent Ca2+ channels in the ascidian embryo: a potential suppressive role in Ca2+ channel expression
Okagaki R, Izumi H, Okada T, Nagahora H, Nakajo K, Okamura Y.
Dev Biol. 230, 258-77 (2001)
PubMed: link

Subfamily-specific posttranscriptional mechanism underlies K(+) channel expression in a developing neuronal blastomere
Ono F, Katsuyama Y, Nakajo K, Okamura Y.
J Neurosci. 19, 6874-86 (1999)
PubMed: link

Cross-coupling between voltage-dependent Ca2+ channels and ryanodine receptors in developing ascidian muscle blastomeres
Nakajo K, Chen L, Okamura Y.
J Physiol. 515, 695-710 (1999)
PubMed: link