トップ > 医学部 > 分子薬理学部門 > 研究業績
自治医科大学医学部薬理学講座 分子薬理学部門
研究業績
- Sakai, N., Saito, Y., Fujiwara, Y., Shiraki, T., Imanishi, Y., Koshimizu, T.A., and Shibata, K., Identification of protein arginine N-methyltransferase 5 (PRMT5) as a novel interacting protein with the tumor suppressor protein RASSF1A. Biochem Biophys Res Commun, 2015. Accepted.
- Kashiwazaki, A., Fujiwara, Y., Tsuchiya, H., Sakai, N., Shibata, K., and Koshimizu, T.A., Subcellular localization and internalization of the vasopressin V receptor. Eur J Pharmacol, 2015. 765: p. 291-299.
- Ishikura, T., Suzuki, H., Shoguchi, K., Koreeda, Y., Aritomi, T., Matsuura, T., Yoshimura, M., Ohkubo, J.I., Maruyama, T., Kawasaki, M., Ohnishi, H., Sakai, A., Mizuno, A., Suzuki, M., and Ueta, Y., Possible involvement of TRPV1 and TRPV4 in nociceptive stimulation- induced nocifensive behavior and neuroendocrine response in mice. Brain Res Bull, 2015. 118: p. 7-16.
- Arai, K., Kashiwazaki, A., Fujiwara, Y., Tsuchiya, H., Sakai, N., Shibata, K., and Koshimizu, T.A., Pharmacological lineage analysis revealed the binding affinity of broad-spectrum substance P antagonists to receptors for gonadotropin-releasing peptide. Eur J Pharmacol, 2015. 749: p. 98-106.
- Aijima, R., Wang, B., Takao, T., Mihara, H., Kashio, M., Ohsaki, Y., Zhang, J.Q., Mizuno, A., Suzuki, M., Yamashita, Y., Masuko, S., Goto, M., Tominaga, M., and Kido, M.A., The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia. FASEB J, 2015. 29(1): p. 182-92.
- Tsuchiya, H., Sato, J., Tsuda, H., Fujiwara, Y., Yamada, T., Fujimura, A., and Koshimizu, T.A., Serum amyloid A upsurge precedes standard biomarkers of hepatotoxicity in ritodrine-injected mice. Toxicology, 2013. 305: p. 79-88.
- Tamaki, Y., Iwanaga, Y., Niizuma, S., Kawashima, T., Kato, T., Inuzuka, Y., Horie, T., Morooka, H., Takase, T., Akahashi, Y., Kobuke, K., Ono, K., Shioi, T., Sheikh, S.P., Ambartsumian, N., Lukanidin, E., Koshimizu, T.A., Miyazaki, S., and Kimura, T., Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts. J Mol Cell Cardiol, 2013. 57: p. 72-81.
- Masuki, S., Sumiyoshi, E., Koshimizu, T.A., Qian, J., Higuchi, K., Tsujimoto, G., and Nose, H., Voluntary locomotion linked with cerebral activation is mediated by vasopressin V1a receptors in free-moving mice. J Physiol, 2013. 591(Pt 14): p. 3651-65.
- Kumazaki, M., Ando, H., Kakei, M., Ushijima, K., Taniguchi, Y., Yoshida, M., Yamato, S., Washino, S., Koshimizu, T.A., and Fujimura, A., alpha-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs. Eur J Pharmacol, 2013. 705(1-3): p. 1-10.
- Tsuchiya, H., Ushijima, K., Fujiwara, Y., Fujimura, A., and Koshimizu, T.A., Chronic ritodrine treatment induces refractoriness of glucose-lowering beta2 adrenoceptor signal in female mice. Regul Toxicol Pharmacol, 2012. 62(3): p. 561-7.
- Koshimizu, T.A., Nakamura, K., Egashira, N., Hiroyama, M., Nonoguchi, H., and Tanoue, A., Vasopressin V1a and V1b receptors: from molecules to physiological systems. Physiol Rev, 2012. 92(4): p. 1813-64.
- Ichimura, A., Hirasawa, A., Poulain-Godefroy, O., Bonnefond, A., Hara, T., Yengo, L., Kimura, I., Leloire, A., Liu, N., Iida, K., Choquet, H., Besnard, P., Lecoeur, C., Vivequin, S., Ayukawa, K., Takeuchi, M., Ozawa, K., Tauber, M., Maffeis, C., Morandi, A., Buzzetti, R., Elliott, P., Pouta, A., Jarvelin, M.R., Korner, A., Kiess, W., Pigeyre, M., Caiazzo, R., Van, H.W., Van, G.L., Horber, F., Balkau, B., Levy-Marchal, C., Rouskas, K., Kouvatsi, A., Hebebrand, J., Hinney, A., Scherag, A., Pattou, F., Meyre, D., Koshimizu, T.A., Wolowczuk, I., Tsujimoto, G., and Froguel, P., Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature, 2012. 483(7389): p. 350-4.
- Fujiwara, Y., Tanoue, A., Tsujimoto, G., and Koshimizu, T.A., The roles of V1a vasopressin receptors in blood pressure homeostasis: a review of studies on V1a receptor knockout mice. Clinical and experimental nephrology, 2012. 16(1): p. 30-4.
- Kumazaki, M., Ando, H., Sasaki, A., Koshimizu, T.A., Ushijima, K., Hosohata, K., Oshima, Y., and Fujimura, A., Protective effect of alpha-lipoic acid against arsenic trioxide-induced acute cardiac toxicity in rats. Journal of pharmacological sciences, 2011. 115(2): p. 244-8.
- Fujiwara, Y., Tsuchiya, H., Sakai, N., Shibata, K., Fujimura, A., and Koshimizu, T.A., Proximal tubules and podocytes are toxicity targets of bucillamine in a mouse model of drug-induced kidney injury. Eur J Pharmacol, 2011. 670(1): p. 208-15.
- Muto, S., Hata, M., Taniguchi, J., Tsuruoka, S., Moriwaki, K., Saitou, M., Furuse, K., Sasaki, H., Fujimura, A., Imai, M., Kusano, E., Tsukita, S., and Furuse, M., Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. Proc Natl Acad Sci U S A, 2010. 107(17): p. 8011-6.
- Koshimizu, T.A., Tsuchiya, H., Tsuda, H., Fujiwara, Y., Shibata, K., Hirasawa, A., Tsujimoto, G., and Fujimura, A., Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment. Biochem Biophys Res Commun, 2010. 392(4): p. 603-7.
- Koshimizu, T.A., Fujiwara, Y., Sakai, N., Shibata, K., and Tsuchiya, H., Oxytocin stimulates expression of a noncoding RNA tumor marker in a human neuroblastoma cell line. Life Sci, 2010. 86(11-12): p. 455-60.
- Ushijima, K., Tsuruoka, S., Tsuda, H., Hasegawa, G., Obi, Y., Kaneda, T., Takahashi, M., Maekawa, T., Sasaki, T., Koshimizu, T.A., and Fujimura, A., Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. Br J Clin Pharmacol, 2009. 68(2): p. 194-200.
- Stojilkovic, S.S., He, M.L., Koshimizu, T.A., Balik, A., and Zemkova, H., Signaling by purinergic receptors and channels in the pituitary gland. Mol Cell Endocrinol, 2009. 314(2): p. 184-91.
- Koshimizu, T.A. and Tsujimoto, G., New topics in vasopressin receptors and approach to novel drugs: vasopressin and pain perception. J Pharmacol Sci, 2009. 109(1): p. 33-7.
- Kojima, Y., Sasaki, S., Oda, N., Koshimizu, T.A., Hayashi, Y., Kiniwa, M., Tsujimoto, G., and Kohri, K., Prostate growth inhibition by subtype-selective alpha(1)-adrenoceptor antagonist naftopidil in benign prostatic hyperplasia. Prostate, 2009. 69(14): p. 1521-8.
- Hara, T., Hirasawa, A., Sun, Q., Sadakane, K., Itsubo, C., Iga, T., Adachi, T., Koshimizu, T.A., Hashimoto, T., Asakawa, Y., and Tsujimoto, G., Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch Pharmacol, 2009. 380(3): p. 247-55.
- Hara, T., Hirasawa, A., Sun, Q., Koshimizu, T.A., Itsubo, C., Sadakane, K., Awaji, T., and Tsujimoto, G., Flow cytometry-based binding assay for GPR40 (FFAR1; free fatty acid receptor 1). Mol Pharmacol, 2009. 75(1): p. 85-91.
- Aoyagi, T., Koshimizu, T.A., and Tanoue, A., Vasopressin regulation of blood pressure and volume: findings from V1a receptor-deficient mice. Kidney Int, 2009. 76(10): p. 1035-9.
- Tsuchiya, H., Oka, T., Nakamura, K., Ichikawa, A., Saper, C.B., and Sugimoto, Y., Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors. J Biol Chem, 2008. 283(16): p. 11064-71.
- Tanaka, T., Yano, T., Adachi, T., Koshimizu, T.A., Hirasawa, A., and Tsujimoto, G., Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells. Naunyn Schmiedebergs Arch Pharmacol, 2008. 377(4-6): p. 515-22.
- Tanaka, T., Katsuma, S., Koshimizu, T.A., Hirasawa, A., and Tsujimoto, G., Free fatty acids induce cholecystokinin secretion through GPR120. Naunyn Schmiedebergs Arch Pharmacol, 2008. 377(4-6): p. 523-7.
- Mizuno, A., [TRP channels and mechanical stress]. Clin Calcium, 2008. 18(9): p. 1304-11.
- Hirasawa, A., Itsubo, C., Sadakane, K., Hara, T., Shinagawa, S., Koga, H., Nose, H., Koshimizu, T.A., and Tsujimoto, G., Production and characterization of a monoclonal antibody against GPR40 (FFAR1; free fatty acid receptor 1). Biochem Biophys Res Commun, 2008. 365(1): p. 22-8.
- Taniguchi, J., Tsuruoka, S., Mizuno, A., Sato, J., Fujimura, A., and Suzuki, M., TRPV4 as a flow sensor in flow-dependent K+ secretion from the cortical collecting duct. Am J Physiol Renal Physiol, 2007. 292(2): p. F667-73.
- Myoumoto, A., Nakatani, K., Koshimizu, T.A., Matsubara, H., Adachi, S., and Tsujimoto, G., Glucocorticoid-induced granzyme A expression can be used as a marker of glucocorticoid sensitivity for acute lymphoblastic leukemia therapy. J Hum Genet, 2007. 52(4): p. 328-33.
- Koshimizu, T.A., Tanoue, A., and Tsujimoto, G., Clinical implications from studies of alpha1 adrenergic receptor knockout mice. Biochem Pharmacol, 2007. 73(8): p. 1107-12.
- Taniguchi, J. and Imai, M., Computer analysis of the significance of the effective osmolality for urea across the inner medullary collecting duct in the operation of a single effect for the counter-current multiplication system. Clin Exp Nephrol, 2006. 10(4): p. 236-43.
- Koshimizu, T.A. and Tsujimoto, G., Functional Role of Spliced Cytoplasmic Tails in P2X(2)-Receptor-Mediated Cellular Signaling. J Pharmacol Sci, 2006. 101(4): p. 261-6.
- Koshimizu, T.A., Nasa, Y., Tanoue, A., Oikawa, R., Kawahara, Y., Kiyono, Y., Adachi, T., Tanaka, T., Kuwaki, T., Mori, T., Takeo, S., Okamura, H., and Tsujimoto, G., V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity. Proc Natl Acad Sci U S A, 2006. 103(20): p. 7807-12.
- Koshimizu, T.A., Kretschmannova, K., He, M.L., Ueno, S., Tanoue, A., Yanagihara, N., Stojilkovic, S.S., and Tsujimoto, G., Carboxyl-terminal splicing enhances physical interactions between the cytoplasmic tails of purinergic P2X receptors. Mol Pharmacol, 2006. 69(5): p. 1588-98.
- Adachi, T., Tanaka, T., Takemoto, K., Koshimizu, T.A., Hirasawa, A., and Tsujimoto, G., Free fatty acids administered into the colon promote the secretion of glucagon-like peptide-1 and insulin. Biochem Biophys Res Commun, 2006. 340(1): p. 332-7.
- Yamada, M., Katsuma, S., Adachi, T., Hirasawa, A., Shiojima, S., Kadowaki, T., Okuno, Y., Koshimizu, T.A., Fujii, S., Sekiya, Y., Miyamoto, Y., Tamura, M., Yumura, W., Nihei, H., Kobayashi, M., and Tsujimoto, G., Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis. Proc Natl Acad Sci U S A, 2005. 102(21): p. 7736-41.
- Stojilkovic, S.S., Tomic, M., He, M.L., Yan, Z., Koshimizu, T.A., and Zemkova, H., Molecular Dissection of Purinergic P2X Receptor Channels. Ann N Y Acad Sci, 2005. 1048: p. 116-30.
- Hosoda, C., Tanoue, A., Shibano, M., Tanaka, Y., Hiroyama, M., Koshimizu, T.A., Cotecchia, S., Kitamura, T., Tsujimoto, G., and Koike, K., Correlation between vasoconstrictor roles and mRNA expression of alpha1-adrenoceptor subtypes in blood vessels of genetically engineered mice. Br J Pharmacol, 2005. 146(3): p. 456-66.
- Hosoda, C., Koshimizu, T.A., Tanoue, A., Nasa, Y., Oikawa, R., Tomabechi, T., Fukuda, S., Shinoura, H., Oshikawa, S., Takeo, S., Kitamura, T., Cotecchia, S., and Tsujimoto, G., Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation. Mol Pharmacol, 2005. 67(3): p. 912-22.
- Zemkova, H., He, M.L., Koshimizu, T.A., and Stojilkovic, S.S., Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors. J Neurosci, 2004. 24(31): p. 6968-78.
- Todaka, H., Taniguchi, J., Satoh, J., Mizuno, A., and Suzuki, M., Warm temperature-sensitive transient receptor potential vanilloid 4 (TRPV4) plays an essential role in thermal hyperalgesia. J Biol Chem, 2004. 279(34): p. 35133-8.
- Tanoue, A., Koshimizu, T.A., Tsujimoto, G., Nakata, H., Hirose, S., Fukuzawa, T., Abe, J., and Kurose, H., Heterogeneity of G protein-coupled receptor generated by post-translational mechanisms and its clinical meanings. Nippon Yakurigaku Zasshi, 2004. 124(4): p. 235-43.
- Tanoue, A., Ito, S., Honda, K., Oshikawa, S., Kitagawa, Y., Koshimizu, T.A., Mori, T., and Tsujimoto, G., The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions. J Clin Invest, 2004. 113(2): p. 302-9.
- Suzuki, M. and Mizuno, A., A novel human Cl(-) channel family related to Drosophila flightless locus. J Biol Chem, 2004. 279(21): p. 22461-8.
- Oshikawa, S., Tanoue, A., Koshimizu, T.A., Kitagawa, Y., and Tsujimoto, G., Vasopressin stimulates insulin release from islet cells through V1b receptors: a combined pharmacological/knockout approach. Mol Pharmacol, 2004. 65(3): p. 623-9.
- Koshimizu, T.A., Tsujimoto, G., Hirasawa, A., Kitagawa, Y., and Tanoue, A., Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors. Cardiovasc Res, 2004. 63(4): p. 662-72.
- Tanoue, A., Koshimizu, T.A., Shibata, K., Nasa, Y., Takeo, S., and Tsujimoto, G., Insights into alpha(1) adrenoceptor function in health and disease from transgenic animal studies. Trends Endocrinol Metab, 2003. 14(3): p. 107-13.
- Suzuki, M., Watanabe, Y., Oyama, Y., Mizuno, A., Kusano, E., Hirao, A., and Ookawara, S., Localization of mechanosensitive channel TRPV4 in mouse skin. Neurosci Lett, 2003. 353(3): p. 189-92.
- Suzuki, M., Mizuno, A., Kodaira, K., and Imai, M., Impaired pressure sensation in mice lacking TRPV4. J Biol Chem, 2003. 278(25): p. 22664-8.
- Suzuki, M., Hirao, A., and Mizuno, A., Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J Biol Chem, 2003. 278(51): p. 51448-53.
- Shibata, K., Katsuma, S., Koshimizu, T.A., Shinoura, H., Hirasawa, A., Tanoue, A., and Tsujimoto, G., alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1. J Biol Chem, 2003. 278(1): p. 672-8.
- Mizuno, A., Matsumoto, N., Imai, M., and Suzuki, M., Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol, 2003. 285(1): p. C96-101.
- He, M.L., Zemkova, H., Koshimizu, T.A., Tomic, M., and Stojilkovic, S.S., Intracellular calcium measurements as a method in studies on activity of purinergic P2X receptor channels. Am J Physiol Cell Physiol, 2003. 285(2): p. C467-79.
- Tanoue, A., Nasa, Y., Koshimizu, T.A., Shinoura, H., Oshikawa, S., Kawai, T., Sunada, S., Takeo, S., and Tsujimoto, G., The alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction. J Clin Invest, 2002. 109(6): p. 765-75.
- Tanoue, A., Koshimizu, T.A., and Tsujimoto, G., Transgenic studies of alpha(1)-adrenergic receptor subtype function. Life Sci, 2002. 71(19): p. 2207-15.
- Tanoue, A., Koshimizu, T.A., Tsuchiya, M., Ishii, K., Osawa, M., Saeki, M., and Tsujimoto, G., Two novel transcripts for human endothelin B receptor produced by RNA editing/alternative splicing from a single gene. J Biol Chem, 2002. 277(36): p. 33205-12.
- Tanoue, A., Koba, M., Miyawaki, S., Koshimizu, T.A., Hosoda, C., Oshikawa, S., and Tsujimoto, G., Role of the alpha1D-adrenegric receptor in the development of salt-induced hypertension. Hypertension, 2002. 40(1): p. 101-6.
- Koshimizu, T.A., Ueno, S., Tanoue, A., Yanagihara, N., Stojilkovic, S.S., and Tsujimoto, G., Heteromultimerization modulates P2X receptor functions through participating extracellular and C-terminal subdomains. J Biol Chem, 2002. 277(49): p. 46891-9.
- Koshimizu, T.A., Komori, S., Ishihara, T., Kohno, I., Umetani, K., Sawanobori, T., Ijiri, H., and Tamura, K., Restored atrial excitability after late recanalization in a patient with atrial standstill and acute myocardial infarction. Pacing Clin Electrophysiol, 2002. 25(2): p. 217-9.
- He, M.L., Koshimizu, T.A., Tomic, M., and Stojilkovic, S.S., Purinergic P2X(2) receptor desensitization depends on coupling between ectodomain and C-terminal domain. Mol Pharmacol, 2002. 62(5): p. 1187-97.
- Stojilkovic, S.S. and Koshimizu, T.A., Signaling by extracellular nucleotides in anterior pituitary cells. Trends Endocrinol Metab, 2001. 12(5): p. 218-25.
- Andric, S.A., Kostic, T.S., Tomic, M., Koshimizu, T.A., and Stojilkovic, S.S., Dependence of soluble guanylyl cyclase activity on calcium signaling in pituitary cells. J Biol Chem, 2001. 276(1): p. 844-9.
- Stojilkovic, S.S., Tomic, M., Van Goor, F., and Koshimizu, T.A., Expression of purinergic P2X2 receptor-channels and their role in calcium signaling in pituitary cells. Biochem Cell Biol, 2000. 78(3): p. 393-404.
- Stojilkovic, S.S., Tomic, M., Koshimizu, T.A., and Van Goor, F., Calcium ions as intracellular messengers: pathways and action, in Molecular Regulation, Conn, M., Means, A. R., Editor. 2000, Humana press: Totowa, NJ.
- Koshimizu, T.A., Van Goor, F., Tomic, M., Wong, A.O., Tanoue, A., Tsujimoto, G., and Stojilkovic, S.S., Characterization of calcium signaling by purinergic receptor-channels expressed in excitable cells. Mol Pharmacol, 2000. 58(5): p. 936-45.
- Koshimizu, T.A., Tomic, M., Wong, A.O., Zivadinovic, D., and Stojilkovic, S.S., Characterization of purinergic receptors and receptor-channels expressed in anterior pituitary cells. Endocrinology, 2000. 141(11): p. 4091-9
- Tomic, M., Zivadinovic, D., Van Goor, F., Yuan, D., Koshimizu, T., and Stojilkovic, S.S. Expression of Ca(2+)-mobilizing endothelin(A) receptors and their role in the control of Ca(2+) influx and growth hormone secretion in pituitary somatotrophs. J Neurosci 19:7721-7731. (1999)
- Tomic, M., Koshimizu, T., Yuan, D., Andric, S.A., Zivadinovic, D., and Stojilkovic, S.S. Characterization of a plasma membrane calcium oscillator in rat pituitary somatotrophs. J Biol Chem 274:35693-35702. (1999)
- Koshimizu, T., Koshimizu, M., and Stojilkovic, S.S. Contributions of the C-terminal domain to the control of P2X receptor desensitization. J Biol Chem 274:37651-37657. (1999)
- Katzur, A.C., Koshimizu, T., Tomic, M., Schultze-Mosgau, A., Ortmann, O., and Stojilkovic, S.S. Expression and responsiveness of P2Y2 receptors in human endometrial cancer cell lines. J Clin Endocrinol Metab 84:4085-4091. (1999)
- Koshimizu, T., Tomic, M., Van Goor, F., and Stojilkovic, S.S. Functional role of alternative splicing in pituitary P2X2 receptor-channel activation and desensitization. Mol Endocrinol 12:901-913. (1998)
- Koshimizu, T., Tomic, M., Koshimizu, M., and Stojilkovic, S.S. Identification of amino acid residues contributing to desensitization of the P2X2 receptor channel. J Biol Chem 273:12853-12857. (1998)
- Koshimizu, T., Tsujimoto, G., Ono, K., Masaki, T., and Sakamoto, A. Truncation of the receptor carboxyl terminus impairs membrane signaling but not ligand binding of human ETB endothelin receptor. Biochem Biophys Res Commun 217:354-362. (1995)